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PMID TITLE # of Targets Links Journal
17191135Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes.60 Neurochem Res
15896810Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia.55 J Neurol Sci
11679167Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases.44 Mol Aspects Med
17496232Mitochondrial nitric oxide in the signaling of cell integrated responses.43 Am J Physiol Cell Physiol
17174478Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.42 Neuroscience
14739060Neurodegenerative diseases and oxidative stress.33 Biomed Pharmacother
12663085Glycation--a sweet tempter for neuronal death.26 Brain Res Brain Res Rev
10643818Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle.25 Neurosci Biobehav Rev
11050436Mitochondria, oxygen free radicals, disease and ageing.24 Trends Biochem Sci
16227974Radical medicine: treating ageing to cure disease.23 Nat Rev Mol Cell Biol
15031734Neurodegenerative diseases and oxidative stress.23 Nat Rev Drug Discov
17634371Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis.22 J Neurosci
17105868Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis.22 Mol Pharmacol
10742195Metals and neuroscience.20 Curr Opin Chem Biol
14648077Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models.17 Acta Neuropathol
12909279Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals.17 Brain Res Bull
12654515VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death.17 Brain Res Mol Brain Res
18219386Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1.16 J Clin Invest
16046141Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis.16 Neurobiol Dis
16194581The beneficial effects of fruit polyphenols on brain aging.14 Neurobiol Aging
11562447Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants.14 Mol Pharmacol
10671549Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells.14 J Biol Chem
17956327Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species.13 Biochem Soc Trans
16877542The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.13 Proc Natl Acad Sci U S A
128930074-hydroxynonenal and neurodegenerative diseases.13 Mol Aspects Med
17150307Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.12 Neuroscience
15863242Proteome analysis in hippocampus of mice overexpressing human Cu/Zn-superoxide dismutase 1.12 Neurochem Int
18210200Novel nanomaterials for clinical neuroscience.11 J Neuroimmune Pharmacol
16050975Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.11 Mitochondrion
11978481Oxidatively modified proteins in aging and disease.11 Free Radic Biol Med
17099894Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.10 J Comp Neurol
16242643Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death.10 Neurobiol Dis
16043017Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.10 Free Radic Biol Med
15964487Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions.10 Neuroscience
17584954Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.9 Am J Physiol Regul Integr Comp Physiol
16624679Neurodegeneration induced by complex I inhibition in a cellular model of familial amyotrophic lateral sclerosis.9 Brain Res Bull
10077670The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis.9 Proc Natl Acad Sci U S A
9745361Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?9 Trends Pharmacol Sci
12614931Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid.8 J Neurol Sci
16406002Neuroprotective role for carbonyl reductase?7 Biochem Biophys Res Commun
16026864Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.7 Trends Neurosci
16188953Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride].6 J Pharmacol Exp Ther
15812313Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.6 Neuroreport
12901835Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine.6 Neurobiol Dis
12392777A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes.6 Neurobiol Aging
18751914Altered lipid metabolism in brain injury and disorders.5 Subcell Biochem
18422522Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection.5 J Neurochem
18414597Altered Lipid Metabolism in Brain Injury and Disorders.5 Subcell Biochem
18308427Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease.5 Neurochem Int
17368952Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis.5 Neuroscience
15850589Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells.5 J Neurol Sci
15208263Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells.5 FASEB J
14698606Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Irvine, Irvine, CA 92697-4292, USA.5 Trends Neurosci
12684448Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons.5 J Neurosci
10930589Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.5 J Neurol Sci
10627601AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.5 J Neurosci
8922414Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine.5 J Neurosci
17719032Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.4 Exp Neurol
17192933Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord.4 Ann Neurol
16764863BMAA selectively injures motor neurons via AMPA/kainate receptor activation.4 Exp Neurol
14690536Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress.4 J Neurochem
14660707Impact of mitochondrial inhibition on excitability and cytosolic Ca2+ levels in brainstem motoneurones from mouse.4 J Physiol
12618129Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.4 Exp Neurol
11905995Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival.4 J Neurochem
11513882Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin.4 FEBS Lett
11228742Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.4 Antioxid Redox Signal
9675268Effects of mitochondrial respiratory stimulation on membrane lipids and proteins: an electron paramagnetic resonance investigation.4 Biochim Biophys Acta
18588875Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations.3 Exp Eye Res
17937892[SIRT1/PGC-1: a neuroprotective axis?]3 Med Sci (Paris)
17678953Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders.3 Int Rev Neurobiol
16681429Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients.3 Clin Chem Lab Med
15480846Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.3 J Neural Transm
15266948Neuroprotective role of melatonin in oxidative stress vulnerable brain.3 Indian J Physiol Pharmacol
15105254Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders.3 Ann N Y Acad Sci
12437573Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.3 J Neurochem
12368231Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release.3 FASEB J
11223912N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.3 J Neurosci Res
10593879The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids.3 FASEB J
9172131Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue.3 Neuroreport
12753090Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS.2 J Neurochem
12718737Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics.2 Expert Opin Biol Ther
12125078Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.2 J Neurosci Res
11796206In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast.2 Free Radic Biol Med
9856861Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons.2 J Neurosci Res
9633809Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.2 Glia
9462746A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase.2 Nat Genet
8899665Evidence against increased oxidative stress in fibroblasts from patients with non-superoxide-dismutase-1 mutant familial amyotrophic lateral sclerosis.2 J Neurol Sci
8858182Oxidative stress and mitochondrial dysfunction in neurodegeneration.2 Curr Opin Neurol
8841988Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis.2 J Neurosci Res
18349520Lack of Evidence for Oxidative Stress in Sporadic Amyotrophic Lateral Sclerosis Fibroblasts.1 Neurodegener Dis
18270519Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent.1 J Cereb Blood Flow Metab
17987632Optimizing separation efficiency of 2-DE procedures for visualization of different superoxide dismutase forms in a cellular model of amyotrophic lateral sclerosis.1 Electrophoresis
17317654The X-linked adrenoleukodystrophy (X-ALD) and oxidative stress.1 J Herb Pharmacother
17127561Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis.1 Amyotroph Lateral Scler
17014688Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.1 J Pineal Res
16895581Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.1 J Neurochem
15333927Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni.1 Acta Crystallogr D Biol Crystallogr
15289674Detection method of the adjacent motor neuronal death in an in vitro co-culture model of familial ALS-associated Cu/Zn superoxide dismutase.1 Biotechnol Lett
15038597Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance.1 Neurochem Res
14625013Zinc amplifies mSOD1-mediated toxicity in a transgenic mouse model of amyotrophic lateral sclerosis.1 Neurosci Lett
14572730The sinister side of Italian soccer. simone.beretta@unimib.it1 Lancet Neurol
13678536Cross talk of nitric oxide, oxygen radicals, and superoxide dismutase regulates the energy metabolism and cell death and determines the fates of aerobic life.1 Antioxid Redox Signal
12769802Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.1 Curr Drug Targets CNS Neurol Disord
12548704Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons.1 J Neurosci Res
12373523Submolecular adventures of brain tyrosine: what are we searching for now?1 Amino Acids
12218958Superoxide dismutase--applications and relevance to human diseases.1 Med Sci Monit
11701756Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis.1 J Neurochem
11396274Neurochemistry of SOD1 and familial amyotrophic lateral sclerosis. Neurobiology, Rome, Italy. carri@bio.uniroma2.it1 Funct Neurol
11328670Invited review: manganese superoxide dismutase in disease.1 Free Radic Res
11020331Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay.1 Methods
10899935Calcineurin activity is regulated both by redox compounds and by mutant familial amyotrophic lateral sclerosis-superoxide dismutase.1 J Neurochem
10826922Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: less reactive oxidant formation but high spontaneous aggregation and precipitation.1 Free Radic Res
10795881Oxidative stress in amyotrophic lateral sclerosis.1 J Neurol
10544701[Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis]1 Presse Med
10385054Cells from individuals with SOD-1 associated familial amyotrophic lateral sclerosis do not have an increased susceptibility to radiation-induced free radical production or DNA damage.1 J Neurol Sci
9620775Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.1 Nat Genet
9350962Immunocytochemical method for investigating in vivo neuronal oxygen radical-induced lipid peroxidation.1 J Neurosci Methods
9337068Reactive oxygen species and Alzheimer's disease.1 Biochem Pharmacol
9311102Pathophysiological aspects of human neurodegenerative diseases.1 Wien Klin Wochenschr
9092140[Amyotrophic lateral sclerosis and superoxide dismutase--a review]1 Ugeskr Laeger
9007410Superoxide dismutase and oxygen radical neurotoxicity.1 Curr Opin Neurol
8910880A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis.1 Med Hypotheses
9044305Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components.1 Nephrol Dial Transplant
8588576Reduced fecundity in male ALS gene-carriers.1 Am J Med Genet
7841373bcl-2 protein expression in aged brain and neurodegenerative diseases.1 Neuroreport
7764323As we live and breathe: free radicals and aging. Correlative evidence from a number of fields suggests they may be key.1 Biotechnology (N Y)
18715147Targeting Oxidative Stress for Neuroprotection.  Antioxid Redox Signal
18574762Oxidative stress biomarkers in sporadic ALS.  Amyotroph Lateral Scler
18401228Vascular system: role of nitric oxide in cardiovascular diseases.  J Clin Hypertens (Greenwich)
18212398Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage.  J Physiol Pharmacol
18080037Cellular pathways leading to neuronal dysfunction and degeneration.  Drug News Perspect
18035718[Free radical processes in aging, neurodegenerative diseases and other pathological states]  Biomed Khim
17678968Oxidative stress and the pathogenesis of neurodegenerative disorders.  Int Rev Neurobiol
17571960Neuronal apoptosis in neurodegeneration.  Antioxid Redox Signal
17365122Effect of colloidal silver against the cytotoxicity of hydrogen peroxide and naphthazarin on primary cultured cortical astrocytes.  Int J Neurosci
17064354Mitochondrial damage modulates alternative splicing in neuronal cells: implications for neurodegeneration.  J Neurochem
17025271Mitochondria-targeted peptide antioxidants: novel neuroprotective agents.  AAPS J
16988483Mitochondrial dysfunction, oxidative stress and neurodegeneration.  J Alzheimers Dis
16546755Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population.  Amyotroph Lateral Scler
16440303Effects of cadmium on structure and enzymatic activity of Cu,Zn-SOD and oxidative status in neural cells.  J Cell Biochem
16097403Antioxidative and steroid systems in neurological and psychiatric disorders.  World J Biol Psychiatry
15535033Oxidative damage to proteins in the spinal cord in amyotrophic lateral sclerosis (ALS).  Folia Neuropathol
15201381Increased arterial carboxyhaemoglobin concentrations in patients with sporadic amyotrophic lateral sclerosis.  J Neurol Neurosurg Psychiatry
15174070Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.  J Comp Neurol
15096702Peripheral markers of oxidative stress and excitotoxicity in neurodegenerative disorders: tools for diagnosis and therapy?  J Alzheimers Dis
15076711Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis.  Neuroreport
15009657Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.  J Neurochem
12873154Prospects for the pharmacotherapy of amyotrophic lateral sclerosis : old strategies and new paradigms for the third millennium.  CNS Drugs
12447931Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.  Ann Neurol
12215226Impaired oxidative metabolism and lipid peroxidation in exercising muscle from ALS patients.  Amyotroph Lateral Scler Other Motor Neuron Disord
11884366Applied proteomics: mitochondrial proteins and effect on function.  Circ Res
11795894Free radicals and disease.  Arch Biochem Biophys
11375746Chemistry and biochemistry of oxidative stress in neurodegenerative disease.  Curr Med Chem
11280030Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts.  Novartis Found Symp
10931172Glutathione, oxidative stress and neurodegeneration.  Eur J Biochem
10621940[Neuronal response to radical stress]  Nippon Yakurigaku Zasshi
10448978Biological markers in the diagnosis and treatment of ALS.  J Neurol Sci
10229967[Oxidative stress in neurodegeneration]  Rev Neurol
10190145[Role of ryanodine receptors in hydrogen peroxide-induced DNA fragmentation and thymidine incorporation in cultured rat astrocytes]  Nippon Yakurigaku Zasshi
9919518Measurement of protein carbonyls in human brain tissue. London, United Kingdom.  Methods Enzymol
9786609Oxidative injury in the nervous system.  Acta Neurol Scand
9711902Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system.  Rev Neurosci
9441250[Molecular biology findings in amyotrophic lateral sclerosis]  Nervenarzt
9437657Aluminum potentiates glutamate-induced calcium accumulation and iron-induced oxygen free radical formation in primary neuronal cultures.  Mol Chem Neuropathol
8997453Reactive oxygen species and the neurodegenerative disorders.  Ann Clin Lab Sci
9012207[Clinical aspects of amyotrophic lateral sclerosis]  Wien Med Wochenschr
8725383Oxidative stress in neurodegenerative diseases.  Annu Rev Pharmacol Toxicol
8530129[Clinical significance of reactive oxygen species]  Immun Infekt
8586987Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study.  J Neurol Sci
7700883The relation of oxidative stress and hyperexcitation to neurological disease.  Proc Soc Exp Biol Med
8660387Oxidative stress: the paradox of aerobic life.  Biochem Soc Symp
7832426Reactive oxygen species inhibit high-affinity glutamate uptake: molecular mechanism and neuropathological implications.  Ann N Y Acad Sci

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