)| PMID |
17317654 ( ) |
|---|---|
| Title | The X-linked adrenoleukodystrophy (X-ALD) and oxidative stress. |
| Abstract | Most of the studies indicate that there is as yet no complete cure for X-ALD. However, methods of the treatment seem to slow rather than treat the disease. One method is the use of Lorenzo's oil in conjunction with a low fat diet, which may help in cerebral X-ALD. X-ALD is in very close resemblance to another neurodegenerative disease, amyotrophic lateral sclerosis (ALS). One of the believed pathomechanisms of ALS is oxidative stress; therefore, this article's emphasis on the role of reactive oxygen species in X-ALD. The aim of the present study was to review the literature concerning the advances in the treatment of X-adrenoleukodystrophy (X-ALD, OMIM # 300100) in the last two decades and to shed more light on the link between oxidative stress and X-ALD. This review article may point to a deficit in reactive oxygen species (ROS) scavenging and/or ROS overproduction being involved in the aetiopathology of these neurodegenerative diseases. Consequently, one of the useful neuronal rescue strategies could be the treatment with antioxidant agents. University, Riyadh, Saudi Arabia. drmohammed1423@yahoo.co.uk |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 61 | ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | 3 | adrenoleukodystrophy | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 61 | ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | adrenoleukodystrophy | 0.5 | The X-linked adrenoleukodystrophy (X-ALD) X-ALD and oxidative stress |
| 61 | ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | adrenoleukodystrophy | 1.0 | the x linked adrenoleukodystrophy x ald and oxidative stress. |
| 61 | ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | adrenoleukodystrophy | 1.0 | the aim of the present study was to review the literature concerning the advances in the treatment of x adrenoleukodystrophy x ald omim # 300100 in the last two decades and to shed more light on the link between oxidative stress and x ald. |