)| PMID |
12437573 ( ) |
|---|---|
| Title | Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases. |
| Abstract | Previous evidence supports the notion of a redox regulation of protein phosphatase calcineurin that might be relevant for neurodegenerative processes where an imbalance between generation and removal of reactive oxygen species occurs. We have recently observed that calcineurin activity is depressed in human neuroblastoma cells expressing Cu,Zn superoxide dismutase (SOD1) mutant G93A and in brain areas from G93A transgenic mice, and that mutant G93A-SOD1 oxidatively inactivates calcineurin in vitro. We have studied the possibility that, by interfering directly with calcineurin activity, mutant SOD1 can modulate pathways of signal transduction mediated by redox-sensitive transcription factors. In this paper, we report a calcineurin-dependent activation of nuclear factor-kappaB (NF-kappaB) induced by the expression of familial amyotrophic lateral sclerosis (fALS)-SOD1s in human neuroblastoma cell lines. Alteration of the phosphorylation state of IkappaBalpha (the inhibitor of NF-kappaB translocation into the nucleus) and induction of cyclooxygenase 2 are consistent with the up-regulation of this transcription factor in this system. All of these modifications might be relevant to signaling pathways involved in the pathogenesis of fALS. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 3 | SOD1 | superoxide dismutase | |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2 | NF-kappaB | |
| 7797 | NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1 | ikappabalpha | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 1.2 | in human neuroblastoma cells expressing Cu Zn superoxide dismutase (SOD1) SOD1 mutant G93A and in brain areas from G93A transgenic mice |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 1.2 | the possibility that by interfering directly with calcineurin activity mutant SOD1 can modulate pathways of signal transduction mediated by redox-sensitive transcription |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | NF-kappaB | 0.6 | paper we report a calcineurin-dependent activation of nuclear factor-kappaB (NF-kappaB) NF-kappaB induced by the expression of familial amyotrophic lateral sclerosis (fALS)-SOD1s |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | NF-kappaB | 0.6 | of the phosphorylation state of IkappaBalpha (the the inhibitor of NF-kappaB translocation into the nucleus and induction of cyclooxygenase 2 are |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | superoxide dismutase | 1.0 | we have recently observed that calcineurin activity is depressed in human neuroblastoma cells expressing cu zn superoxide dismutase sod1 mutant g93a and in brain areas from g93a transgenic mice and that mutant g93a sod1 oxidatively inactivates calcineurin in vitro. |
| 7797 | NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | ikappabalpha | 1.0 | alteration of the phosphorylation state of ikappabalpha the inhibitor of nf kappab translocation into the nucleus and induction of cyclooxygenase 2 are consistent with the up regulation of this transcription factor in this system. |