)| PMID |
16194581 ( ) |
|---|---|
| Title | The beneficial effects of fruit polyphenols on brain aging. |
| Abstract | Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and lipids. Oxidative damage is particularly detrimental to the brain, where the neuronal cells are largely post-mitotic. Therefore, damaged neurons cannot be replaced readily via mitosis. During normal aging, the brain undergoes morphological and functional modifications resulting in the observed behavioral declines such as decrements in motor and cognitive performance. These declines are augmented by neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD). Research from our laboratory has shown that nutritional antioxidants, such as the polyphenols found in blueberries, can reverse age-related declines in neuronal signal transduction as well as cognitive and motor deficits. Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper. University, Boston, MA 02111, USA. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | 9 | ERK | MAP | ERK2 | |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 6 | APP | amyloid | |
| 5464 | IGF1 | insulin-like growth factor 1 (somatomedin C) | 4 | insulin like growth factor 1 | IGF-1 | |
| 7873 | NOS2A | nitric oxide synthase 2A (inducible, hepatocytes) | 2 | iNOS | nitric oxide synthase | |
| 6877 | MAPK3 | mitogen-activated protein kinase 3 | 2 | ERK1 | |
| 11892 | TNF | tumor necrosis factor (TNF superfamily, member 2) | 2 | tumor necrosis factor | TNF-A | |
| 5465 | IGF1R | insulin-like growth factor 1 receptor | 2 | IGF-1R | |
| 727 | ARTN | artemin | 1 | neurotrophic factor | |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1 | nuclear factor kappa b | |
| 1516 | CAT | catalase | 1 | catalase | |
| 9508 | PSEN1 | presenilin 1 (Alzheimer disease 3) | 1 | presenilin 1 | |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 1 | superoxide dismutase | |
| 9393 | PRKCA | protein kinase C, alpha | 1 | protein kinase c | |
| 6879 | MAPK6 | mitogen-activated protein kinase 6 | 1 | extracellular signal regulated kinase | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 7873 | NOS2A | nitric oxide synthase 2A (inducible, hepatocytes) | iNOS | 2.2 | activation genes such as the inducible nitric oxide synthase (iNOS), iNOS interleukin-1_amp_#x3b2 (IL-1_amp_#x3b2;), IL-1_amp_#x3b2 tumor necrosis factor-_amp_#x3b1 (TNF-_amp_#x3b1;), TNF-_amp_#x3b1 and nuclear |
| 11892 | TNF | tumor necrosis factor (TNF superfamily, member 2) | TNF-A | 1.2 | synthase (iNOS), iNOS interleukin-1_amp_#x3b2 (IL-1_amp_#x3b2;), IL-1_amp_#x3b2 tumor necrosis factor-_amp_#x3b1 (TNF-_amp_#x3b1;), TNF-_amp_#x3b1 and nuclear factor-kappa B (NF-_amp_#x3ba;B) NF-_amp_#x3ba B 1 49 60 |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | 0.3 | Amyloid precursor protein/presenilin-1 protein presenilin-1 (APP/PSl) APP PSl transgenic mice have been used as a murine model |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | amyloid | 1.0 | for AD since these mutations facilitate the production of beta amyloid and consequently Alzheimer-like plaques in several regions of the brain |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | 0.3 | of plaques was observed between the BB-supplemented and non-supplemented APP/PSl APP PSl mice even though behavioral deficits were prevented in the |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | 0.3 | formation and improved Y-maze performance seen in the BB-supplemented APP/PSl APP PSl mice versus the non-supplemented APP/PSl APP PSl mice might |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | 0.3 | the BB-supplemented APP/PSl APP PSl mice versus the non-supplemented APP/PSl APP PSl mice might be due to alterations in signaling pathways |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK | 2.3 | The levels of extracellular signal regulated kinase (ERK) ERK and protein kinase C (PKC) PKC were elevated in the |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | 0.3 | kinase C (PKC) PKC were elevated in the BB-supplemented APP/PSl APP PSl mice as compared to those found in the non-supplemented |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK | 2.3 | Both ERK and PKC kinases are important in mediating cognitive function especially |
| 6877 | MAPK3 | mitogen-activated protein kinase 3 | ERK1 | 1.8 | After these tests the hippocampal expression of signaling markers including ERK1 and ERK2 as well as PKC-_amp_#x3b1 and PKC-_amp_#x3b3 were analyzed |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK2 | 2.3 | After these tests the hippocampal expression of signaling markers including ERK1 and ERK2 as well as PKC-_amp_#x3b1 and PKC-_amp_#x3b3 were analyzed |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK2 | 2.3 | tests the hippocampal expression of signaling markers including ERK1 and ERK2 as well as PKC-_amp_#x3b1 and PKC-_amp_#x3b3 were analyzed by immunoblotting |
| 6877 | MAPK3 | mitogen-activated protein kinase 3 | ERK1 | 1.8 | The expression of ERK1 and ERK2 positively correlated with inclined screen latency (measurement measurement |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK2 | 2.3 | The expression of ERK1 and ERK2 positively correlated with inclined screen latency (measurement measurement |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK2 | 2.3 | The expression of ERK1 and ERK2 positively correlated with inclined screen latency (measurement measurement of muscle |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK | 2.3 | The localized expression of ERK and insulin-like growth factor 1 (IGF-1) IGF-1 and its receptor |
| 5464 | IGF1 | insulin-like growth factor 1 (somatomedin C) | IGF-1 | 1.8 | localized expression of ERK and insulin-like growth factor 1 (IGF-1) IGF-1 and its receptor (IGF-1R) IGF-1R was also assayed by immunohistochemistry |
| 5465 | IGF1R | insulin-like growth factor 1 receptor | IGF-1R | 1.5 | insulin-like growth factor 1 (IGF-1) IGF-1 and its receptor (IGF-1R) IGF-1R was also assayed by immunohistochemistry |
| 5464 | IGF1 | insulin-like growth factor 1 (somatomedin C) | IGF-1 | 1.8 | aged rats showed significant increases in the protein levels of IGF-1 IGF-1R and ERK and these increases were also inversely correlated |
| 5465 | IGF1R | insulin-like growth factor 1 receptor | IGF-1R | 1.5 | rats showed significant increases in the protein levels of IGF-1 IGF-1R and ERK and these increases were also inversely correlated with |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | ERK | 2.3 | significant increases in the protein levels of IGF-1 IGF-1R and ERK and these increases were also inversely correlated with the number |
| 5464 | IGF1 | insulin-like growth factor 1 (somatomedin C) | IGF-1 | 1.8 | and cognitive performance via concerted mechanisms involving neurogenesis neurotrophic factor IGF-1 and its receptor and MAP kinase signal transduction cascades |
| 6871 | MAPK1 | mitogen-activated protein kinase 1 | MAP | 2.3 | mechanisms involving neurogenesis neurotrophic factor IGF-1 and its receptor and MAP kinase signal transduction cascades |
| 1516 | CAT | catalase | catalase | 1.0 | moreover the brain is not particularly endowed with antioxidant defenses: it has a very low level of catalase activity and only moderate amounts of the endogenous antioxidant enzymes superoxide dismutase and glutathione peroxidase. |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | superoxide dismutase | 1.0 | moreover the brain is not particularly endowed with antioxidant defenses: it has a very low level of catalase activity and only moderate amounts of the endogenous antioxidant enzymes superoxide dismutase and glutathione peroxidase. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nuclear factor kappa b | 1.0 | ced signal transduction leading to the activation genes such as the inducible nitric oxide synthase inos interleukin 1_amp_#x3b2; il 1_amp_#x3b2; tumor necrosis factor _amp_#x3b1; tnf _amp_#x3b1; and nuclear factor kappa b nf _amp_#x3ba;b [1] [49] [60] [65] [69] [72] [81] and [86] . |
| 11892 | TNF | tumor necrosis factor (TNF superfamily, member 2) | tumor necrosis factor | 1.0 | neuroinflammation has been connected to enhanced signal transduction leading to the activation genes such as the inducible nitric oxide synthase inos interleukin 1_amp_#x3b2; il 1_amp_#x3b2; tumor necrosis factor _amp_#x3b1; tnf _amp_#x3b1; and nuclear factor kappa b nf _amp_#x3ba;b [1] [49] [60] [65] [69] [72] [81] and [86] . |
| 7873 | NOS2A | nitric oxide synthase 2A (inducible, hepatocytes) | nitric oxide synthase | 1.0 | neuroinflammation has been connected to enhanced signal transduction leading to the activation genes such as the inducible nitric oxide synthase inos interleukin 1_amp_#x3b2; il 1_amp_#x3b2; tumor necrosis factor _amp_#x3b1; tnf _amp_#x3b1; and nuclear factor kappa b nf _amp_#x3ba;b [1] [49] [60] [65] [69] [72] [81] and [86] . |
| 9508 | PSEN1 | presenilin 1 (Alzheimer disease 3) | presenilin 1 | 1.0 | amyloid precursor protein/presenilin 1 app/psl transgenic mice have been used as a murine model for ad since these mutations facilitate the production of beta amyloid and consequently alzheimer like plaques in several regions of the brain |
| 9393 | PRKCA | protein kinase C, alpha | protein kinase c | 1.0 | the levels of extracellular signal regulated kinase erk and protein kinase c pkc were elevated in the bb supplemented app/psl mice as compared to those found in the non supplemented mice [41] . |
| 6879 | MAPK6 | mitogen-activated protein kinase 6 | extracellular signal regulated kinase | 1.0 | the levels of extracellular signal regulated kinase erk and protein kinase c pkc were elevated in the bb supplemented app/psl mice as compared to those found in the non supplemented mice [41] . |
| 5464 | IGF1 | insulin-like growth factor 1 (somatomedin C) | insulin like growth factor 1 | 1.0 | the localized expression of erk and insulin like growth factor 1 igf 1 and its receptor igf 1r was also assayed by immunohistochemistry. |
| 727 | ARTN | artemin | neurotrophic factor | 1.0 | the data indicated that bb supplementation increased hippocampal plasticity and cognitive performance via concerted mechanisms involving neurogenesis neurotrophic factor igf 1 and its receptor and map kinase signal transduction cascades. |