)| PMID |
14698606 ( ) |
|---|---|
| Title | Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Irvine, Irvine, CA 92697-4292, USA. |
| Abstract |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11 | superoxide dismutase 1 | SOD1 | SOD | |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 5 | EAAT-2 | GLT-1 | glt 1 | |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 2 | COX-2 | cox 2 | |
| 19986 | CYCS | cytochrome c, somatic | 1 | cytochrome c | |
| 4572 | GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 1 | GluR2 | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | linked to mutations in the enzyme superoxide dismutase 1 (SOD1) SOD1 |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | recent years has addressed crucial issues including actions of mutant SOD1 modulation of glutamate transport roles of inflammation and the formation |
| 4572 | GRIA2 | glutamate receptor, ionotropic, AMPA 2 | GluR2 | 1.6 | appear to comprise AMPA receptor subunits but to lack the GluR2 AMPA subunit which blocks Ca 2 permeability in heteromeric channels |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | GLT-1 | 1.0 | Specifically the astrocytic glutamate transporter GLT-1 (also also known as the excitatory amino acid transporter EAAT-2 |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | EAAT-2 | 1.0 | GLT-1 (also also known as the excitatory amino acid transporter EAAT-2 appears to be particularly affected 34 and 35 |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | reported in end-stage ALS 34 as well as in some SOD1 transgenic mice 37 |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | transporter peptides have been reported in both ALS and the SOD1 mutant mouse model 46 and 47 |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 | 1.0 | role for inflammation inhibitors of the enzyme cyclooxygenase 2 (COX-2) COX-2 have shown beneficial effects in SOD1 mutant mouse models 49 |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | enzyme cyclooxygenase 2 (COX-2) COX-2 have shown beneficial effects in SOD1 mutant mouse models 49 and 50 |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD | 2.2 | Another potential cause of aberrant oxidation is the mutant SOD itself |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | GLT-1 | 1.0 | Indeed the GLT-1 transporter which is damaged in ALS is concentrated in astrocytic |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | occurs in an annular pattern immediately surrounding motor neurons in SOD1 mutant mice 54 ( Figure 2c |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | explain how seemingly disparate inciting factors (for for instance mutant SOD1 environmental toxins trauma inflammation or infection could converge into a |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | are integrally involved in disease pathogenesis expression of the mutant SOD1 in either motor neurons or astrocytes alone did not cause |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | SOD1 | 2.2 | Furthermore recent studies of mutant SOD1 chimeras indicate the dependence of motor neuron survival on the |
| 11179 | SOD1 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | superoxide dismutase 1 | 1.0 | most cases are sporadic although a subset 10% is familial with 20% of these being linked to mutations in the enzyme superoxide dismutase 1 sod1 . |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | glt 1 | 1.0 | specifically the astrocytic glutamate transporter glt 1 also known as the excitatory amino acid transporter eaat 2 appears to be particularly affected [ 34 and 35 ]. |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cox 2 | 1.0 | supporting a role for inflammation inhibitors of the enzyme cyclooxygenase 2 cox 2 have shown beneficial effects in sod1 mutant mouse models [ 49 and 50 ]. |
| 10940 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | glt 1 | 1.0 | indeed the glt 1 transporter which is damaged in als is concentrated in astrocytic processes directly abutting motor neurons [ 55 ]. |
| 19986 | CYCS | cytochrome c, somatic | cytochrome c | 1.0 | they are also compatible with possible apoptotic contributions to motor neuron loss in als [ 58 ] because mitochondria which contain cytochrome c and other apoptotic mediators are crucial regulators of apoptosis. |