)| PMID |
7841373 ( ) |
|---|---|
| Title | bcl-2 protein expression in aged brain and neurodegenerative diseases. |
| Abstract | The proto-oncogene bcl-2 is involved in the regulation of cell death and is able to block apoptosis in neurones through reduced generation of reactive oxygen species (ROS). We have studied the immunohistochemical expression of bcl-2 protein in the aged brain and in various human neurodegenerative diseases. In all cases, bcl-2 was strongly enriched within lipofuscin and autophagic vacuoles of neurones, glial and vascular cells. Our data show that accumulation of bcl-2 is not disease-specific and represents a general cellular response which accompanies the increased formation of lipofuscin. Since oxidative stress is directly involved in lipofuscinogenesis, accumulation of bcl-2 may reflect a mechanism for counterbalancing ROS-mediated damage, or it might represent the impairment of bcl-2-dependent protection from ROS. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 990 | BCL2 | B-cell CLL/lymphoma 2 | 7 | bcl 2 | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | bcl 2 protein expression in aged brain and neurodegenerative diseases. |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | the proto oncogene bcl 2 is involved in the regulation of cell death and is able to block apoptosis in neurones through reduced generation of reactive oxygen species ros . |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | we have studied the immunohistochemical expression of bcl 2 protein in the aged brain and in various human neurodegenerative diseases. |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | in all cases bcl 2 was strongly enriched within lipofuscin and autophagic vacuoles of neurones glial and vascular cells. |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | our data show that accumulation of bcl 2 is not disease specific and represents a general cellular response which accompanies the increased formation of lipofuscin. |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | since oxidative stress is directly involved in lipofuscinogenesis accumulation of bcl 2 may reflect a mechanism for counterbalancing ros mediated damage or it might represent the impairment of bcl 2 dependent protection from ros. |
| 990 | BCL2 | B-cell CLL/lymphoma 2 | bcl 2 | 1.0 | lipofuscin|proto oncogene proteins|proto oncogene proteins c bcl 2|gtp binding proteins| |