)| PMID |
11228742 ( ) |
|---|---|
| Title | Activation of NF-kappa B by reactive oxygen intermediates in the nervous system. |
| Abstract | Nuclear factor kappa B (NF-kappa B) is a transcription factor crucially involved in glial and neuronal function. NF-kappa B is ubiquitously distributed within the nervous system, and its inducible activity can be discerned from constitutive activity. Prototypic inducible NF-kappa B in the nervous system is composed of the DNA-binding subunits p50 and p65 complexed with an inhibitory I kappa B-alpha molecule. A number of signals from the cell surface can lead to rapid activation of NK-kappa B, thus releasing the inhibition by I kappa B. This activates translocation of NF-kappa B to the nucleus, where it binds to kappa B motifs of target genes and activates transcription. Previous findings have identified reactive oxygen intermediates (ROI) as a common denominator of NF-kappa B activating signals. More specifically, hydrogen peroxide (H2O2) might be used as second messenger in the NF-kappa B system, despite its cytotoxicity. Analysis of pathways leading to NF-kappa B activation in the nervous system has identified a number of ROI-dependent pathways such as cytokine- and neurotrophin-mediated activation, glutamatergic signal transduction, and various diseases with crucial ROI involvement (e.g., Alzheimer's disease, Parkinson's disease, experimental autoimmune encephalomyelitis, multiple sclerosis, amyotrophic lateral sclerosis, and injury). A number of NF-kappa B-specific target genes contribute to the production of ROI or are involved in detoxification of ROIs. In this review, possible mechanisms and regulatory pathways of ROI-mediated NF-kappa B activation are discussed. D-79104 Freiburg, Germany. kaltschm@uni-freiburg.edu |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 12 | nuclear factor kappa b | nf kappa b | |
| 11919 | CD40 | CD40 molecule, TNF receptor superfamily member 5 | 1 | p50 | |
| 16769 | GORASP1 | golgi reassembly stacking protein 1, 65kDa | 1 | p65 | |
| 1033 | BDNF | brain-derived neurotrophic factor | 1 | neurotrophin | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 11919 | CD40 | CD40 molecule, TNF receptor superfamily member 5 | p50 | 0.3 | in the nervous system is composed of the DNA-binding subunits p50 and p65 complexed with an inhibitory I kappa B-alpha molecule |
| 16769 | GORASP1 | golgi reassembly stacking protein 1, 65kDa | p65 | 0.1 | nervous system is composed of the DNA-binding subunits p50 and p65 complexed with an inhibitory I kappa B-alpha molecule |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | activation of nf kappa b by reactive oxygen intermediates in the nervous system. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | nuclear factor kappa b nf kappa b is a transcription factor crucially involved in glial and neuronal function. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nuclear factor kappa b | 1.0 | nuclear factor kappa b nf kappa b is a transcription factor crucially involved in glial and neuronal function. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | nf kappa b is ubiquitously distributed within the nervous system and its inducible activity can be discerned from constitutive activity. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | prototypic inducible nf kappa b in the nervous system is composed of the dna binding subunits p50 and p65 complexed with an inhibitory i kappa b alpha molecule. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | a number of signals from the cell surface can lead to rapid activation of nk kappa b thus releasing the inhibition by i kappa b. this activates translocation of nf kappa b to the nucleus where it binds to kappa b motifs of target genes and activates transcription. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | previous findings have identified reactive oxygen intermediates roi as a common denominator of nf kappa b activating signals. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | more specifically hydrogen peroxide h2o2 might be used as second messenger in the nf kappa b system despite its cytotoxicity. |
| 1033 | BDNF | brain-derived neurotrophic factor | neurotrophin | 1.0 | analysis of pathways leading to nf kappa b activation in the nervous system has identified a number of roi dependent pathways such as cytokine and neurotrophin mediated activation glutamatergic signal transduction and various diseases with crucial roi involvement e.g. alzheimer's disease parkinson's disease experimental autoimmune encephalomyelitis multiple |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | analysis of pathways leading to nf kappa b activation in the nervous system has identified a number of roi dependent pathways such as cytokine and neurotrophin mediated activation glutamatergic signal transduction and various diseases with cr |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | a number of nf kappa b specific target genes contribute to the production of roi or are involved in detoxification of rois. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | in this review possible mechanisms and regulatory pathways of roi mediated nf kappa b activation are discussed. |
| 7794 | NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | nf kappa b | 1.0 | nf kappa b|oxidants|reactive oxygen species| |