)| PMID |
16406002 ( ) |
|---|---|
| Title | Neuroprotective role for carbonyl reductase? |
| Abstract | Oxidative stress is increasingly implicated in neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, and Creutzfeld-Jakob diseases or amyotrophic lateral sclerosis. Reactive oxygen species seem to play a significant role in neuronal cell death in that they generate reactive aldehydes from membrane lipid peroxidation. Several neuronal diseases are associated with increased accumulation of abnormal protein adducts of reactive aldehydes, which mediate oxidative stress-linked pathological events, including cellular growth inhibition and apoptosis induction. Combining findings on neurodegeneration and oxidative stress in Drosophila with studies on the metabolic characteristics of the human enzyme carbonyl reductase (CR), it is clear now that CR has a potential physiological role for neuroprotection in humans. Several lines of evidence suggest that CR represents a significant pathway for the detoxification of reactive aldehydes derived from lipid peroxidation and that CR in humans is essential for neuronal cell survival and to confer protection against oxidative stress-induced brain degeneration. University Medical School Schleswig-Holstein, Campus Kiel, Brunswiker Str. 10, 24105 Kiel, Germany. maser@toxi.uni-kiel.de |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 6 | AKR1B1 | aldose reductase | |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | 6 | carbonyl reductase | |
| 412 | ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 2 | aldehyde dehydrogenase | |
| 6204 | JUN | jun oncogene | 2 | c jun | c-Jun | |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 1 | amyloid | |
| 1504 | CASP3 | caspase 3, apoptosis-related cysteine peptidase | 1 | caspase 3 | |
| 11920 | FAS | Fas (TNF receptor superfamily, member 6) | 1 | FAS-independent | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 11920 | FAS | Fas (TNF receptor superfamily, member 6) | FAS-independent | 0.3 | the activation of caspases and to DNA fragmentation through a FAS-independent and mitochondria-linked pro-apoptotic signal pathway |
| 6204 | JUN | jun oncogene | c-Jun | 1.3 | In various cell lines reactive aldehyde-induced apoptosis was accompanied by c-Jun -N-terminal kinase and caspase-3 activation |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | amyloid | 1.0 | lipid aldehyde-mediated _amp_#x3b2 PKC activation induced an increase in intracellular amyloid production |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | AKR1B1 | 1.1 | At a first glance compared to CR the enzyme AKR1B1 (previously previously named aldose reductase from the AKR superfamily exhibits |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | AKR1B1 | 1.1 | another reactive lipid aldehyde HNE from ONE may indicate that AKR1B1 is the more important catalyst for ONE and GS-ONE reduction |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | AKR1B1 | 1.1 | HNE in turn is a substrate for AKR1B1 (carbonyl carbonyl reduction and/or and or ALDH (aldehyde aldehyde dehydrogenation |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | AKR1B1 | 1.1 | 4-oxonon-2-enal GSH = reduced glutathione AR = aldose reductase (AKR1B1); AKR1B1 ALDH = aldehyde dehydrogenase CR = carbonyl reductase |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | combining findings on neurodegeneration and oxidative stress in drosophila with studies on the metabolic characteristics of the human enzyme carbonyl reductase cr it is clear now that cr has a potential physiological role for neuroprotection in humans. |
| 1504 | CASP3 | caspase 3, apoptosis-related cysteine peptidase | caspase 3 | 1.0 | in various cell lines reactive aldehyde induced apoptosis was accompanied by c jun n terminal kinase and caspase 3 activation. |
| 6204 | JUN | jun oncogene | c jun | 1.0 | in various cell lines reactive aldehyde induced apoptosis was accompanied by c jun n terminal kinase and caspase 3 activation. |
| 412 | ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | aldehyde dehydrogenase | 1.0 | in general routes of metabolism for these carbonylic lipids include spontaneous and enzyme catalyzed glutathione gsh conjugation and either oxidation by aldehyde dehydrogenase or carbonyl reduction catalyzed by enzymes from two different protein superfamilies the aldo keto reductases akr [12] and the short chain dehydrogenases sdr [13] to which sniffer belongs . |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | sniffer is a carbonyl reductase and belongs to the superfamily of short chain dehydrogenases/reductases |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | it turned out as a surprise that according to its primary structure sniffer shows similarity with human carbonyl reductase cr; secondary alcohol: nadp + oxidoreductase; ec 1.1.1.184 [14] . |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | sniffer is so far the only known functional carbonyl reductase in drosophila melanogaster which emphasizes the importance of this enzyme as a neuroprotective agent [5] . |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | carbonyl reductase plays a unique role in the detoxification of reactive aldehydes derived from lipid peroxidation |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | aldose reductase | 1.0 | at a first glance compared to cr the enzyme akr1b1 previously named aldose reductase from the akr superfamily exhibits a higher k cat / k m due to a lower k m for one and gs one reduction [18] . |
| 18985 | DCXR | dicarbonyl/L-xylulose reductase | carbonyl reductase | 1.0 | acid; hne = 4 hydroxynon 2 enal; hno = 1 hydroxynon 2 en 4 one; ona = 4 oxononanal; one = 4 oxonon 2 enal; gsh = reduced glutathione ar = aldose reductase akr1b1 ; aldh = aldehyde dehydrogenase; cr = carbonyl reductase. |
| 381 | AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | aldose reductase | 1.0 | abbreviations: dhn = 4 dihydroxynonene; hna = 4 hydroxynonan acid; hne = 4 hydroxynon 2 enal; hno = 1 hydroxynon 2 en 4 one; ona = 4 oxononanal; one = 4 oxonon 2 enal; gsh = reduced glutathione ar = aldose reductase akr1b1 ; aldh = aldehyde dehydrogenase; cr = carbonyl reductase. |
| 412 | ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | aldehyde dehydrogenase | 1.0 | nonene; hna = 4 hydroxynonan acid; hne = 4 hydroxynon 2 enal; hno = 1 hydroxynon 2 en 4 one; ona = 4 oxononanal; one = 4 oxonon 2 enal; gsh = reduced glutathione ar = aldose reductase akr1b1 ; aldh = aldehyde dehydrogenase; cr = carbonyl reductase. |