)| PMID |
17937892 ( ) |
|---|---|
| Title | [SIRT1/PGC-1: a neuroprotective axis?] |
| Abstract | Neurodegenerative diseases are more and more prevalent in our aging societies. A rapid overview of the etiology of many neurodegenerative diseases like Alzheimer, Parkinson, Huntington disease and amyotrophic lateral sclerosis suggests a tight link with mitochondrial dysfunction. Since it has been recently demonstrated that activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function, we performed a detailed literature review on the implication of this pathway in neurodegeneration. Interestingly, transgenic mice with impaired PGC-1 expression have neurodegenerative lesions and show behavioural abnormalities. As evidenced from independent investigations, enhanced SIRT1 activity has been demonstrated to protect against axonal degeneration and to decrease the accumulation of amyloid beta peptides, the hallmark of Alzheimer disease, in cultured murine embryonic neurons. In addition, several studies suggest that resveratrol, a specific activator of SIRT1, could have protective effects in animal models of neurodegenerative diseases. Taken together, these results strongly suggest that the modulation of the SIRT1/PGC-1 pathway, which has not been well documented in the central nervous system, could become the cornerstone for new therapeutical approaches to combat neurodegeneration. CNRS/Inserm/ULP, 1, rue Laurent Fries, 67404 Illkirch, France. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 8 | pgc 1 | PGC-1 | |
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | 5 | SIRT1 | |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 2 | amyloid | amyloid beta protein | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | SIRT1 | 1.0 | [SIRT1/PGC-1: SIRT1 PGC-1 a neuroprotective axis |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PGC-1 | 2.1 | [SIRT1/PGC-1: SIRT1 PGC-1 a neuroprotective axis |
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | SIRT1 | 1.0 | it has been recently demonstrated that activation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway in a metabolic context promotes mitochondrial function we |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PGC-1 | 2.1 | has been recently demonstrated that activation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway in a metabolic context promotes mitochondrial function we performed |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PGC-1 | 2.1 | Interestingly transgenic mice with impaired PGC-1 expression have neurodegenerative lesions and show behavioural abnormalities |
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | SIRT1 | 1.0 | As evidenced from independent investigations enhanced SIRT1 activity has been demonstrated to protect against axonal degeneration and |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | amyloid | 1.3 | protect against axonal degeneration and to decrease the accumulation of amyloid beta peptides the hallmark of Alzheimer disease in cultured murine |
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | SIRT1 | 1.0 | addition several studies suggest that resveratrol a specific activator of SIRT1 could have protective effects in animal models of neurodegenerative diseases |
| 14929 | SIRT1 | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | SIRT1 | 1.0 | these results strongly suggest that the modulation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway which has not been well documented in the |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PGC-1 | 2.1 | results strongly suggest that the modulation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway which has not been well documented in the central |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | pgc 1 | 1.0 | [sirt1/pgc 1: a neuroprotective axis?] |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | pgc 1 | 1.0 | since it has been recently demonstrated that activation of the sirt1/pgc 1 pathway in a metabolic context promotes mitochondrial function we performed a detailed literature review on the implication of this pathway in neurodegeneration. |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | pgc 1 | 1.0 | interestingly transgenic mice with impaired pgc 1 expression have neurodegenerative lesions and show behavioural abnormalities. |
| 9237 | PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | pgc 1 | 1.0 | taken together these results strongly suggest that the modulation of the sirt1/pgc 1 pathway which has not been well documented in the central nervous system could become the cornerstone for new therapeutical approaches to combat neurodegeneration. |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | amyloid beta protein | 1.0 | amyloid beta protein|neuroprotective agents|reactive oxygen species|stilbenes|transcription factors|peroxisome proliferator activated receptor gamma coactivator 1|resveratrol|sirt1 protein human|sirt1 protein mouse|sirtu |