)| PMID |
8858182 ( ) |
|---|---|
| Title | Oxidative stress and mitochondrial dysfunction in neurodegeneration. |
| Abstract | Rapid advances are being made in our understanding of the pathogenesis of neurodegenerative diseases, particularly those in which specific DNA mutations have been identified. beta-amyloid has been shown to induce free radical formation both directly and via an effect on endothelial function. There is presuasive evidence for cytochrome oxidase dysfunction with oxidative stress and damage in the brains of patients with Alzheimer's disease. The confirmation of the complex II inhibitor 3-nitropropionic acid as a toxin model for Huntington's disease, together with the demonstration of reduced mitochondrial function in Huntington's disease caudate, supports the proposition that mutant huntingtin may exert its effect through an abnormality of energy metabolism. UK. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 1 | amyloid beta protein | |
| 4851 | HTT | huntingtin | 1 | huntingtin | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 4851 | HTT | huntingtin | huntingtin | 1.0 | 3 nitropropionic acid as a toxin model for huntington's disease together with the demonstration of reduced mitochondrial function in huntington's disease caudate supports the proposition that mutant huntingtin may exert its effect through an abnormality of energy metabolism. |
| 620 | APP | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | amyloid beta protein | 1.0 | amyloid beta protein precursor|dna mitochondrial|free radicals|hd protein human|nerve tissue proteins|nuclear proteins|reactive oxygen species|electron transport complex iv| |