Current Target Information
| HUGO ID | 2578 |
|---|---|
| Symbol | CYBB |
| Name | cytochrome b-245, beta polypeptide (chronic granulomatous disease) |
| #Occurrence | 460 |
| #Paper | 49 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 17979836 | From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. | 97 | | Immunol Rev |
| 17586614 | Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance. | 59 | | Am J Physiol Heart Circ Physiol |
| 17584843 | Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. | 54 | | J Physiol |
| 17602948 | Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. | 52 | | Free Radic Biol Med |
| 18793162 | NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? | 52 | | Biochem Soc Trans |
| 17052237 | Redox signalling involving NADPH oxidase-derived reactive oxygen species. | 50 | | Biochem Soc Trans |
| 18488224 | NOX enzymes and diabetic complications. | 49 | | Semin Immunopathol |
| 18846047 | Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. | 38 | | Obesity (Silver Spring) |
| 17167116 | Oxidants in chronic kidney disease. | 32 | | J Am Soc Nephrol |
| 15840036 | Effects of NADPH oxidase inhibitor in diabetic nephropathy. | 27 | | Kidney Int |
| 15777779 | Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. | 26 | | Eur J Pharmacol |
| 11287350 | Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. | 25 | | Am J Physiol Endocrinol Metab |
| 15297385 | Protein glycation: a firm link to endothelial cell dysfunction. | 25 | | Circ Res |
| 16505175 | Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase. | 24 | | Circulation |
| 17237245 | Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes. | 24 | | Am J Physiol Heart Circ Physiol |
| 16463048 | Gemfibrozil decreases atherosclerosis in experimental diabetes in association with a reduction in oxidative stress and inflammation. | 23 | | Diabetologia |
| 16978905 | Free radicals and antioxidants in normal physiological functions and human disease. | 23 | | Int J Biochem Cell Biol |
| 18378574 | Role of NADPH oxidase in retinal vascular inflammation. | 22 | | Invest Ophthalmol Vis Sci |
| 17532345 | Regulation of LPS stimulated ROS production in peritoneal macrophages from alloxan-induced diabetic rats: involvement of high glucose and PPARgamma. | 22 | | Life Sci |
| 17023526 | Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. | 21 | | Endocrinology |
| 19118282 | A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy. | 21 | | Circ Res |
| 11786100 | Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. | 20 | | Kidney Int |
| 12874435 | ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy. | 20 | | J Am Soc Nephrol |
| 15993337 | Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. | 20 | | Free Radic Biol Med |
| 16741160 | Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. | 20 | | Circ Res |
| 11937300 | Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. | 20 | | Free Radic Biol Med |
| 15608082 | Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelin-1. | 19 | | J Pharmacol Exp Ther |
| 16135519 | Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. | 19 | | J Biol Chem |
| 18539754 | AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice. | 19 | | Am J Physiol Heart Circ Physiol |
| 17189832 | Antioxidant and antiplatelet effects of rosuvastatin in a hamster model of prediabetes. | 19 | | Free Radic Biol Med |
| 17977949 | Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. | 18 | | Diabetes |
| 19019231 | Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. | 16 | | Cardiovasc Diabetol |
| 16990215 | Inhibition of NAD(P)H oxidase alleviates impaired NOS-dependent responses of pial arterioles in type 1 diabetes mellitus. | 14 | | Microcirculation |
| 14766238 | Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats. | 14 | | Biochem Biophys Res Commun |
| 17337254 | The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice. | 13 | | Vascul Pharmacol |
| 11812764 | Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. | 12 | | Diabetes |
| 11959796 | Effects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat. | 12 | | Br J Pharmacol |
| 14514646 | Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. | 12 | | Diabetes |
| 17346751 | Induction of reactive oxygen species from isolated rat glomeruli by protein kinase C activation and TNF-alpha stimulation, and effects of a phosphodiesterase inhibitor. | 12 | | Life Sci |
| 17891166 | Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus. | 12 | | Br J Pharmacol |
| 12639760 | Enhanced vascular production of superoxide in OLETF rat after the onset of hyperglycemia. | 11 | | Diabetes Res Clin Pract |
| 15036821 | p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells. | 11 | | Diabetes Res Clin Pract |
| 17046555 | Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression. | 11 | | Metabolism |
| 16877369 | NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes. | 11 | | Am J Pathol |
| 16139267 | Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism. | 10 | | Eur J Pharmacol |
| 18302965 | Atrial natriuretic peptide prevents diabetes-induced endothelial dysfunction. | 10 | | Life Sci |
| 19056645 | Green tea (Camellia sinensis) attenuates nephropathy by downregulating Nox4 NADPH oxidase in diabetic spontaneously hypertensive rats. | 9 | | J Nutr |
| 16771662 | NADPH oxidases in cardiovascular health and disease. | 4 | | Antioxid Redox Signal |
| 17951995 | Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes. | 3 | | Am J Nephrol |