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PMID	11937300 ( )
Title	Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.
Abstract	The neutrophil oxidative burst reaction differentiates ALR/Lt mice, known for an unusual systemic elevation of antioxidant defenses, from ALS/Lt mice, a related strain known for reduced ability to withstand oxidative stress. Neutrophils from marrow of ALS mice produced a normal neutrophil oxidative burst following phorbol ester stimulation. In contrast, ALR mice exhibited a markedly suppressed superoxide burst. F1 progeny from reciprocal outcrosses between ALR and ALS mice exhibited an intermediate burst level, higher than ALR but significantly lower than ALS. To elucidate the genetic basis for this strain difference, F1 mice were backcrossed to ALS mice, and marrow neutrophils isolated from the progeny were phenotyped for oxidative burst capacity. A genome-wide sweep using polymorphic markers distinguishing the two parental strains was performed to map the trait. A 1:1 phenotypic distribution was observed, and a locus (Suppressor of superoxide production, Susp) controlling this phenotype was mapped to Chromosome 3 near D3Mit241 at 33.1 cM. This locus probably represents an important regulatory element in the overall ALR strain resistance to oxidative stress, since diminished ability to mount a neutrophil burst in backcross segregants correlated with elevated hepatic superoxide dismutase 1 (SOD1) activity, an ALR strain characteristic.

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Targets by SciMiner Summary

HUGO ID	Symbol	Target Name	#Occur	ActualStr
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	26	superoxide dismutase 1 \| SOD1 \| SOD \| SOD1-specific \|
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	10	nadph oxidase \|
2577	CYBA	cytochrome b-245, alpha polypeptide	9	p22 phox \|
6871	MAPK1	mitogen-activated protein kinase 1	6	p40 \| p38 \|
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	5	p67 phox \|
2578	CYBB	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	4	gp91 phox \|
9802	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	4	rac2 \|
6876	MAPK14	mitogen-activated protein kinase 14	4	p38 map kinase \|
6735	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	3	lyn \|
1516	CAT	catalase	3	catalase \|
3483	ETFDH	electron-transferring-flavoprotein dehydrogenase	2	Etfdh \| ETFDH \|
6149	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	2	mac 1 \| Mac-1 \|
5969	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	2	Il12a \| interleukin 12a \|
6081	INS	insulin	2	insulin \|
700	ARNT	aryl hydrocarbon receptor nuclear translocator	2	aryl hydrocarbon receptor nuclear translocator \| Arnt \|
6019	IL6R	interleukin 6 receptor	2	Il6ra \| interleukin 6 receptor \|
10486	S100A1	S100 calcium binding protein A1	1	S100 \|
4623	GSR	glutathione reductase	1	glutathione reductase \|
9855	RAP1A	RAP1A, member of RAS oncogene family	1	Rap1a \|
7662	NCF4	neutrophil cytosolic factor 4, 40kDa	1	p40 \|

Targets by SciMiner Full list

HUGO ID	Symbol	Name	ActualStr	Score	FlankingText
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	backcross segregants correlated with elevated hepatic superoxide dismutase 1 (SOD1) SOD1 activity an ALR strain characteristic
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD	2.2	of glutathione peroxidase glutathione reductase catalase total superoxide dismutase (SOD), SOD and SOD1 were measured in multiple tissues including liver spleen
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	peroxidase glutathione reductase catalase total superoxide dismutase (SOD), SOD and SOD1 were measured in multiple tissues including liver spleen kidney pancreas
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD	2.2	from ALS/Lt ALS Lt mice is a systemic increase in SOD activity that includes lymphoid tissue
9802	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	rac2	0.3	NADPH oxidase system components (gp91, gp91 p22 p47 p67 and rac2
2577	CYBA	cytochrome b-245, alpha polypeptide	p22	0.0	differences in levels of NADPH oxidase system components (gp91, gp91 p22 p47 p67 and rac2
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	p67	0.1	levels of NADPH oxidase system components (gp91, gp91 p22 p47 p67 and rac2
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	burst correlated with ALR-like elevated hepatic superoxide dismutase 1 (SOD1) SOD1 activity we infer that Susp controls in part the systemic
6149	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	Mac-1	2.5	M1 70 PharMingen for the 170-kKa _amp_#x3b1 M chain of Mac-1 for 30 min at 4_amp_#xb0 C
7662	NCF4	neutrophil cytosolic factor 4, 40kDa	p40	1.1	antibodies (1:1000 1 1000 dilution for the oxidase proteins including p40 phox p47 phox p67 phox gp91 phox and p22 phox
2577	CYBA	cytochrome b-245, alpha polypeptide	p22	0.0	including p40 phox p47 phox p67 phox gp91 phox and p22 phox
6871	MAPK1	mitogen-activated protein kinase 1	p40	1.1	Antibodies to p47 phox p67 phox p40 phox gp91 phox and p22 phox were generous gifts from
2577	CYBA	cytochrome b-245, alpha polypeptide	p22	0.0	to p47 phox p67 phox p40 phox gp91 phox and p22 phox were generous gifts from Dr T Leto (NIH, NIH
9802	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	rac2	0.3	In addition antibodies against lyn rac2 and p38 map kinase were also used
6871	MAPK1	mitogen-activated protein kinase 1	p38	0.8	In addition antibodies against lyn rac2 and p38 map kinase were also used
6735	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	lyn	0.2	In addition antibodies against lyn rac2 and p38 map kinase were also used
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	The activity of the antioxidant enzyme SOD1 was measured in liver
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD	2.2	was then assayed with a BIOXYTECH SOD-525 Spectrophotometric Assay for SOD Activity according to the supplier_amp_#x2019 s directions (OXIS OXIS Health
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1-specific	2.2	Absorbance of the SOD1-specific chromopore was read at 525 nm in a SpectraMax Microplate
6871	MAPK1	mitogen-activated protein kinase 1	p40	1.1	densitometric analysis of Western blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox
9802	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	rac2	0.3	for the activation of the NADPH oxidase (e.g., e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide
6871	MAPK1	mitogen-activated protein kinase 1	p38	0.8	activation of the NADPH oxidase (e.g., e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst-suppressing ALR/Lt
2577	CYBA	cytochrome b-245, alpha polypeptide	p22	0.0	for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for
6735	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	lyn	0.2	signaling for the activation of the NADPH oxidase (e.g., e.g. lyn rac2 and p38 map kinase showed no differences between the
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	SOD1 activity
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	SOD1 (Cu/Zn-SOD) Cu Zn-SOD activity in the liver was measured to
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	The results of the SOD1 assay revealed that the ALS strain had significantly lower levels
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	The F1 mice in this study possessed an intermediate SOD1 activity ( Fig 5
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	superoxide burst activity (ALS-like) ALS-like had a correspondingly lower hepatic SOD1 activity than did those segregants with a suppressed superoxide burst
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	When SOD1 activity data were stratified according to _amp_#x201c ALS-like_amp_#x201d versus _amp_#x201c
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	However individual hepatic SOD1 activities in the BC mice were more continuously distributed than
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	phenotype of ALR/Lt ALR Lt did correlate inversely with hepatic SOD1 activity
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD	2.2	Elevated hepatic and pancreatic superoxide dismutase total activity and cytosolic SOD (SOD1, SOD1 copper-zinc activity distinguished ALR from ALS 3 and
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	and pancreatic superoxide dismutase total activity and cytosolic SOD (SOD1, SOD1 copper-zinc activity distinguished ALR from ALS 3 and 4
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD	2.2	SOD converts the superoxide anion and water to hydrogen peroxide
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	free radicals as evidenced by the correlation to increased hepatic SOD1 activity
3483	ETFDH	electron-transferring-flavoprotein dehydrogenase	Etfdh	0.5	This is Etfdh currently positioned at 31.8 cM on Chr 3 1.2 cM
3483	ETFDH	electron-transferring-flavoprotein dehydrogenase	ETFDH	0.5	This gene encodes the electron transport flavoprotein-ubiquinone oxidoreductase (ETFDH) ETFDH
9855	RAP1A	RAP1A, member of RAS oncogene family	Rap1a	0.6	Another interesting candidate gene is the RAS-related protein 1 ( Rap1a specifying one of the components of the NADPH oxidase 11
5969	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	Il12a	0.9	genes in the region of linkage are interleukin 12a ( Il12a and interleukin 6 receptor a ( Il6ra
6019	IL6R	interleukin 6 receptor	Il6ra	2.6	interleukin 12a ( Il12a and interleukin 6 receptor a ( Il6ra
10486	S100A1	S100 calcium binding protein A1	S100	1.9	candidates are the genes encoding the calcium binding protein subfamily S100
700	ARNT	aryl hydrocarbon receptor nuclear translocator	Arnt	2.5	Lastly the gene encoding aryl hydrocarbon receptor nuclear translocator ( Arnt could also be a candidate gene as its expression is
6871	MAPK1	mitogen-activated protein kinase 1	p40	1.1	10 5 cells were used in immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox
9802	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	rac2	0.3	phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase 8
6871	MAPK1	mitogen-activated protein kinase 1	p38	0.8	p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase 8
2577	CYBA	cytochrome b-245, alpha polypeptide	p22	0.0	immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase
6735	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	lyn	0.3	p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase 8
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1	2.2	High SOD1 activity levels correlate well with suppressed neutrophil superoxide burst
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	SOD1-specific	2.2	Absorbance of the SOD1-specific chromopore was read at 525 nm
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	superoxide dismutase 1	1.0	an important regulatory element in the overall alr strain resistance to oxidative stress since diminished ability to mount a neutrophil burst in backcross segregants correlated with elevated hepatic superoxide dismutase 1 sod1 activity an alr strain characteristic.
6081	INS	insulin	insulin	1.0	alloxan al is a potent diabetogen destroying pancreatic beta cells via generation of intracellular hydroxyl radicals and producing insulin dependent diabetes within 48 h after administration [ 1 ].
4623	GSR	glutathione reductase	glutathione reductase	1.0	higher levels of glutathione peroxidase glutathione reductase catalase total superoxide dismutase sod and sod1 were measured in multiple tissues including liver spleen kidney pancreas and pancreatic islets [ 3 and 4 ].
1516	CAT	catalase	catalase	1.0	higher levels of glutathione peroxidase glutathione reductase catalase total superoxide dismutase sod and sod1 were measured in multiple tissues including liver spleen kidney pancreas and pancreatic islets [ 3 and 4 ].
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	superoxide dismutase	1.0	higher levels of glutathione peroxidase glutathione reductase catalase total superoxide dismutase sod and sod1 were measured in multiple tissues including liver spleen kidney pancreas and pancreatic islets [ 3 and 4 ].
6081	INS	insulin	insulin	1.0	al induced diabetes to map genes conferring resistance to free radical diabetogenic stress was uncovered by our discovery that al untreated als/lt male mice were prone to spontaneously develop a non insulin dependent diabetes [ 5 ].
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	neutrophils generate high levels of superoxide through nadph oxidase activation in response to bacterial cell wall components such as lipopolysaccharides lps or phorbol esters such as phorbol 12 myristate 13 acetate pma .
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	increases in antioxidant status decrease superoxide generation by the nadph oxidase system [ 6 ] while increases of pro oxidant status increase the activity of the nadph oxidase [ 7 ].
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	however western blot analysis revealed no differences in levels of nadph oxidase system components gp91 p22 p47 p67 and rac2 .
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	superoxide dismutase 1	1.0	because suppression of the normal neutrophil burst correlated with alr like elevated hepatic superoxide dismutase 1 sod1 activity we infer that susp controls in part the systemic ability of the alr/lt to dissipate oxidative stress.
6149	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	mac 1	1.0	clone rb6 8c5 for the cell surface proteins gr1 fitc clone rb6 8c5 pharmingen san diego ca usa and with allophycocyanin apc labeled m1/70 clone m1/70 pharmingen for the 170 kka _amp_#x3b1; m chain of mac 1 for 30 min at 4_amp_#xb0;c.
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	immunoblotting was performed to detect components of the nadph oxidase complex and other proteins that may be involved in the signal transduction leading to superoxide production by neutrophils.
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	p67 phox	1.0	proteins were transferred to nitrocellulose membranes biorad hercules ca usa and probed with antibodies 1:1000 dilution for the oxidase proteins including p40 phox p47 phox p67 phox gp91 phox and p22 phox .
2578	CYBB	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	gp91 phox	1.0	proteins were transferred to nitrocellulose membranes biorad hercules ca usa and probed with antibodies 1:1000 dilution for the oxidase proteins including p40 phox p47 phox p67 phox gp91 phox and p22 phox .
2577	CYBA	cytochrome b-245, alpha polypeptide	p22 phox	1.0	proteins were transferred to nitrocellulose membranes biorad hercules ca usa and probed with antibodies 1:1000 dilution for the oxidase proteins including p40 phox p47 phox p67 phox gp91 phox and p22 phox .
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	p67 phox	1.0	antibodies to p47 phox p67 phox p40 phox gp91 phox and p22 phox were generous gifts from dr. t. leto nih bethesda md usa and dr. m. dineauer indiana university bloomington in usa respectively [ 8 ].
2578	CYBB	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	gp91 phox	1.0	antibodies to p47 phox p67 phox p40 phox gp91 phox and p22 phox were generous gifts from dr. t. leto nih bethesda md usa and dr. m. dineauer indiana university bloomington in usa respectively [ 8 ].
2577	CYBA	cytochrome b-245, alpha polypeptide	p22 phox	1.0	antibodies to p47 phox p67 phox p40 phox gp91 phox and p22 phox were generous gifts from dr. t. leto nih bethesda md usa and dr. m. dineauer indiana university bloomington in usa respectively [ 8 ].
6876	MAPK14	mitogen-activated protein kinase 14	p38 map kinase	1.0	in addition antibodies against lyn rac2 and p38 map kinase were also used.
6876	MAPK14	mitogen-activated protein kinase 14	p38 map kinase	1.0	anti p38 map kinase antibodies and anti tyrosine kinase lyn antibodies were obtained from new england biolabs beverly ma usa and the anti rac2 antibody from santa cruz laboratory santa cruz ca usa .
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	this inability of alr/lt neutrophils to express a robust pma stimulated superoxide burst was not due to absence of the major components of the nadph oxidase machinery required for superoxide generation.
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	p67 phox	1.0	as shown in fig. 2 densitometric analysis of western blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for the activation of the nadph oxidase e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst suppr
2578	CYBB	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	gp91 phox	1.0	as shown in fig. 2 densitometric analysis of western blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for the activation of the nadph oxidase e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst suppressing alr
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	2 densitometric analysis of western blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for the activation of the nadph oxidase e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst suppressing alr/lt strain and the normal burst generating als/lt strain.
6876	MAPK14	mitogen-activated protein kinase 14	p38 map kinase	1.0	ern blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for the activation of the nadph oxidase e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst suppressing alr/lt strain and the normal burst generating als/lt strain.
2577	CYBA	cytochrome b-245, alpha polypeptide	p22 phox	1.0	as shown in fig. 2 densitometric analysis of western blots made using antibodies specific for p40 phox p47 phox p67 phox gp91 phox and p22 phox as well as for molecules involved in signaling for the activation of the nadph oxidase e.g. lyn rac2 and p38 map kinase showed no differences between the superoxide burst suppressing alr/lt strain an
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	we have shown that this suppressed burst in alr was not due to a defect in the nadph oxidase machinery nor was it due to fewer neutrophils in the bone marrow of alr as compared to als.
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	this finding in combination with demonstration of a seemingly intact nadph oxidase system suggests that the superoxide radical may be generated followed pma activation but rapidly dissipated enzymatically.
11179	SOD1	superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))	superoxide dismutase	1.0	elevated hepatic and pancreatic superoxide dismutase [total activity and cytosolic sod sod1 copper zinc activity] distinguished alr from als [ 3 and 4 ].
1516	CAT	catalase	catalase	1.0	this peroxide is then converted to h 2 o by catalase in the cytosol or by gsh utilizing glutathione peroxidase gpx in the mitochondria.
1516	CAT	catalase	catalase	1.0	comparable catalase activity was observed in all tissues of both strains including low activity in whole pancreas of als.
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	another interesting candidate gene is the ras related protein 1 rap1a specifying one of the components of the nadph oxidase [ 11 ].
5969	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	interleukin 12a	1.0	two other possible candidate genes in the region of linkage are interleukin 12a il12a and interleukin 6 receptor a il6ra .
6019	IL6R	interleukin 6 receptor	interleukin 6 receptor	1.0	two other possible candidate genes in the region of linkage are interleukin 12a il12a and interleukin 6 receptor a il6ra .
700	ARNT	aryl hydrocarbon receptor nuclear translocator	aryl hydrocarbon receptor nuclear translocator	1.0	lastly the gene encoding aryl hydrocarbon receptor nuclear translocator arnt could also be a candidate gene as its expression is stimulated by stress to the cell [ 15 ].
14874	NOX5	NADPH oxidase, EF-hand calcium binding domain 5	nadph oxidase	1.0	expression of nadph oxidase components in bone marrow cells from als/lt and alr/lt mice.
7661	NCF2	neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)	p67 phox	1.0	bone marrow cells 6 _amp_#xd7; 10 5 cells were used in immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase [ 8 ].
2578	CYBB	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	gp91 phox	1.0	bone marrow cells 6 _amp_#xd7; 10 5 cells were used in immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase [ 8 ].
6876	MAPK14	mitogen-activated protein kinase 14	p38 map kinase	1.0	bone marrow cells 6 _amp_#xd7; 10 5 cells were used in immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase [ 8 ].
2577	CYBA	cytochrome b-245, alpha polypeptide	p22 phox	1.0	bone marrow cells 6 _amp_#xd7; 10 5 cells were used in immunoblot analysis to detect p40 phox p47 phox p67 phox p22 phox and gp91 phox rac2 lyn and p38 map kinase [ 8 ].