Current Target Information
| HUGO ID | 11179 |
|---|---|
| Symbol | SOD1 |
| Name | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) |
| #Occurrence | 1982 |
| #Paper | 91 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 15896810 | Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. | 55 | | J Neurol Sci |
| 11679167 | Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. | 44 | | Mol Aspects Med |
| 17496232 | Mitochondrial nitric oxide in the signaling of cell integrated responses. | 43 | | Am J Physiol Cell Physiol |
| 17174478 | Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. | 42 | | Neuroscience |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 12663085 | Glycation--a sweet tempter for neuronal death. | 26 | | Brain Res Brain Res Rev |
| 10643818 | Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. | 25 | | Neurosci Biobehav Rev |
| 11050436 | Mitochondria, oxygen free radicals, disease and ageing. | 24 | | Trends Biochem Sci |
| 15031734 | Neurodegenerative diseases and oxidative stress. | 23 | | Nat Rev Drug Discov |
| 16227974 | Radical medicine: treating ageing to cure disease. | 23 | | Nat Rev Mol Cell Biol |
| 17105868 | Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. | 22 | | Mol Pharmacol |
| 17634371 | Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. | 22 | | J Neurosci |
| 10742195 | Metals and neuroscience. | 20 | | Curr Opin Chem Biol |
| 12654515 | VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. | 17 | | Brain Res Mol Brain Res |
| 12909279 | Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals. | 17 | | Brain Res Bull |
| 14648077 | Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models. | 17 | | Acta Neuropathol |
| 16046141 | Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis. | 16 | | Neurobiol Dis |
| 18219386 | Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. | 16 | | J Clin Invest |
| 10671549 | Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. | 14 | | J Biol Chem |
| 16194581 | The beneficial effects of fruit polyphenols on brain aging. | 14 | | Neurobiol Aging |
| 12893007 | 4-hydroxynonenal and neurodegenerative diseases. | 13 | | Mol Aspects Med |
| 16877542 | The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. | 13 | | Proc Natl Acad Sci U S A |
| 17956327 | Respiratory plasticity following intermittent hypoxia: roles of protein phosphatases and reactive oxygen species. | 13 | | Biochem Soc Trans |
| 15863242 | Proteome analysis in hippocampus of mice overexpressing human Cu/Zn-superoxide dismutase 1. | 12 | | Neurochem Int |
| 17150307 | Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo. | 12 | | Neuroscience |
| 16050975 | Mitochondrial dysfunction and its role in motor neuron degeneration in ALS. | 11 | | Mitochondrion |
| 15964487 | Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. | 10 | | Neuroscience |
| 16043017 | Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis. | 10 | | Free Radic Biol Med |
| 17099894 | Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. | 10 | | J Comp Neurol |
| 9745361 | Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? | 9 | | Trends Pharmacol Sci |
| 10077670 | The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis. | 9 | | Proc Natl Acad Sci U S A |
| 16624679 | Neurodegeneration induced by complex I inhibition in a cellular model of familial amyotrophic lateral sclerosis. | 9 | | Brain Res Bull |
| 17584954 | Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. | 9 | | Am J Physiol Regul Integr Comp Physiol |
| 12614931 | Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. | 8 | | J Neurol Sci |
| 16026864 | Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS. | 7 | | Trends Neurosci |
| 12392777 | A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. | 6 | | Neurobiol Aging |
| 12901835 | Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine. | 6 | | Neurobiol Dis |
| 15812313 | Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity. | 6 | | Neuroreport |
| 16188953 | Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride]. | 6 | | J Pharmacol Exp Ther |
| 10930589 | Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1. | 5 | | J Neurol Sci |
| 12684448 | Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. | 5 | | J Neurosci |
| 14698606 | Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Irvine, Irvine, CA 92697-4292, USA. | 5 | | Trends Neurosci |
| 15208263 | Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells. | 5 | | FASEB J |
| 15850589 | Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells. | 5 | | J Neurol Sci |
| 17368952 | Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis. | 5 | | Neuroscience |
| 18308427 | Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease. | 5 | | Neurochem Int |
| 11513882 | Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin. | 4 | | FEBS Lett |
| 11905995 | Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival. | 4 | | J Neurochem |
| 14660707 | Impact of mitochondrial inhibition on excitability and cytosolic Ca2+ levels in brainstem motoneurones from mouse. | 4 | | J Physiol |
| 14690536 | Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. | 4 | | J Neurochem |
| 17719032 | Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. | 4 | | Exp Neurol |
| 12618129 | Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells. | 4 | | Exp Neurol |
| 17192933 | Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord. | 4 | | Ann Neurol |
| 9172131 | Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue. | 3 | | Neuroreport |
| 10593879 | The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. | 3 | | FASEB J |
| 12368231 | Overexpression of SOD1 protects vulnerable motor neurons after spinal cord injury by attenuating mitochondrial cytochrome c release. | 3 | | FASEB J |
| 12437573 | Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases. | 3 | | J Neurochem |
| 16681429 | Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. | 3 | | Clin Chem Lab Med |
| 11223912 | N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. | 3 | | J Neurosci Res |
| 15266948 | Neuroprotective role of melatonin in oxidative stress vulnerable brain. | 3 | | Indian J Physiol Pharmacol |
| 8841988 | Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis. | 2 | | J Neurosci Res |
| 8899665 | Evidence against increased oxidative stress in fibroblasts from patients with non-superoxide-dismutase-1 mutant familial amyotrophic lateral sclerosis. | 2 | | J Neurol Sci |
| 9462746 | A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. | 2 | | Nat Genet |
| 9633809 | Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. | 2 | | Glia |
| 9856861 | Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons. | 2 | | J Neurosci Res |
| 11796206 | In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast. | 2 | | Free Radic Biol Med |
| 12718737 | Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics. | 2 | | Expert Opin Biol Ther |
| 12753090 | Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS. | 2 | | J Neurochem |
| 9044305 | Oxidative stress caused by glycation of Cu,Zn-superoxide dismutase and its effects on intracellular components. | 1 | | Nephrol Dial Transplant |
| 9092140 | [Amyotrophic lateral sclerosis and superoxide dismutase--a review] | 1 | | Ugeskr Laeger |
| 9620775 | Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. | 1 | | Nat Genet |
| 10385054 | Cells from individuals with SOD-1 associated familial amyotrophic lateral sclerosis do not have an increased susceptibility to radiation-induced free radical production or DNA damage. | 1 | | J Neurol Sci |
| 10795881 | Oxidative stress in amyotrophic lateral sclerosis. | 1 | | J Neurol |
| 10826922 | Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: less reactive oxidant formation but high spontaneous aggregation and precipitation. | 1 | | Free Radic Res |
| 10899935 | Calcineurin activity is regulated both by redox compounds and by mutant familial amyotrophic lateral sclerosis-superoxide dismutase. | 1 | | J Neurochem |
| 11396274 | Neurochemistry of SOD1 and familial amyotrophic lateral sclerosis. Neurobiology, Rome, Italy. carri@bio.uniroma2.it | 1 | | Funct Neurol |
| 11701756 | Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis. | 1 | | J Neurochem |
| 12218958 | Superoxide dismutase--applications and relevance to human diseases. | 1 | | Med Sci Monit |
| 14572730 | The sinister side of Italian soccer. simone.beretta@unimib.it | 1 | | Lancet Neurol |
| 14625013 | Zinc amplifies mSOD1-mediated toxicity in a transgenic mouse model of amyotrophic lateral sclerosis. | 1 | | Neurosci Lett |
| 15289674 | Detection method of the adjacent motor neuronal death in an in vitro co-culture model of familial ALS-associated Cu/Zn superoxide dismutase. | 1 | | Biotechnol Lett |
| 15333927 | Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni. | 1 | | Acta Crystallogr D Biol Crystallogr |
| 16895581 | Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis. | 1 | | J Neurochem |
| 17014688 | Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. | 1 | | J Pineal Res |
| 17987632 | Optimizing separation efficiency of 2-DE procedures for visualization of different superoxide dismutase forms in a cellular model of amyotrophic lateral sclerosis. | 1 | | Electrophoresis |
| 8588576 | Reduced fecundity in male ALS gene-carriers. | 1 | | Am J Med Genet |
| 9007410 | Superoxide dismutase and oxygen radical neurotoxicity. | 1 | | Curr Opin Neurol |
| 10544701 | [Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis] | 1 | | Presse Med |
| 13678536 | Cross talk of nitric oxide, oxygen radicals, and superoxide dismutase regulates the energy metabolism and cell death and determines the fates of aerobic life. | 1 | | Antioxid Redox Signal |
| 18270519 | Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. | 1 | | J Cereb Blood Flow Metab |