Current Target Information
| HUGO ID | 7873 |
|---|---|
| Symbol | NOS2A |
| Name | nitric oxide synthase 2A (inducible, hepatocytes) |
| #Occurrence | 172 |
| #Paper | 34 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 11173059 | Pharmacogenomics of neurodegenerative diseases. | 64 | | Eur J Pharmacol |
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18464922 | Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease. | 35 | | PPAR Res |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 15081582 | Neuroinflammation, COX-2, and ALS--a dual role? | 25 | | Exp Neurol |
| 17018025 | Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. | 23 | | J Neurochem |
| 17555556 | Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. | 18 | | J Neurochem |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 10525172 | Neurodegenerative disorders: the role of peroxynitrite. | 17 | | Brain Res Brain Res Rev |
| 16766086 | PPARgamma as a therapeutic target in central nervous system diseases. | 16 | | Neurochem Int |
| 17350694 | The endocannabinoid system in targeting inflammatory neurodegenerative diseases. | 16 | | Trends Pharmacol Sci |
| 15649489 | Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. | 14 | | Exp Neurol |
| 17418957 | Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons. | 14 | | Neuroscience |
| 15571972 | Clinical potential of minocycline for neurodegenerative disorders. | 14 | | Neurobiol Dis |
| 16120782 | The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. | 13 | | J Neurosci |
| 17574754 | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 13 | | Neurosci Lett |
| 18436268 | Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. | 12 | | Neuropharmacology |
| 16436205 | Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | 11 | | J Neuroinflammation |
| 16014720 | Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. | 10 | | J Neurosci |
| 18539342 | Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study. | 10 | | J Neuroimmunol |
| 16179515 | Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. | 9 | | Ann N Y Acad Sci |
| 12060810 | Minocycline delays disease onset and mortality in a transgenic model of ALS. | 7 | | Neuroreport |
| 16909005 | Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. | 6 | | Neurodegener Dis |
| 18246426 | Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India. | 6 | | Neurochem Res |
| 15799549 | Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells. | 5 | | Amyotroph Lateral Scler Other Motor Neuron Disord |
| 17034351 | On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. | 4 | | Antioxid Redox Signal |
| 12076984 | Role of nitric oxide in inflammation-mediated neurodegeneration. | 2 | | Ann N Y Acad Sci |
| 16637591 | [S100B: astrocyte specific protein] | 2 | | Nihon Shinkei Seishin Yakurigaku Zasshi |