)| PMID |
15799549 ( ) |
|---|---|
| Title | Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells. |
| Abstract | Recent studies have shown inflammatory markers in affected neural tissues of amyotrophic lateral sclerosis (ALS) patients. We examined immunocytochemically spinal cord tissues of six patients with ALS, two with corticospinal tract degeneration secondary to cerebral infarcts and three control subjects without neuropathologic abnormalities. ALS spinal cords had dense macrophage infiltration (one log greater than control spinal cords) involving the white and gray matter, with heaviest infiltration of lateral and ventral columns and, in one patient, prefrontal gyrus and the occipital lobes of the brain. Macrophages in ALS spinal cord showed strong expression of cyclooxygenase-2 (COX-2) (one log greater than control tissues) and inducible nitric oxide synthase. In the gray matter, macrophages surrounded and appeared to phagocytize neurons (NeuN-positive) that appeared to be dying. Vessels showed damage to the tight junction protein ZO-1 in relation to perivascular CD40 receptor-positive macrophages and CD40 ligand-positive T lymphocytes. ALS spinal cords, but not control cords, were sparsely infiltrated with mast cells. In control cases with corticospinal tract degeneration following hemispheric cerebral infarction, macrophage infiltration of the white matter was COX-2-negative and restricted to lateral and anterior corticospinal tracts. Our data suggest that inflammation in ALS spinal cord and cortex is based on innate immune responses by macrophages and mast cells and adaptive immune responses by T cells. Angeles, CA 90095-1668, USA. publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 4 | COX-2 | COX-2-negative | cox 2 | |
| 11827 | TJP1 | tight junction protein 1 (zona occludens 1) | 3 | zo 1 | tight junction protein zo 1 | ZO-1 | |
| 11919 | CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2 | CD40 | |
| 7873 | NOS2A | nitric oxide synthase 2A (inducible, hepatocytes) | 1 | nitric oxide synthase | |
| 11935 | CD40LG | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 1 | cd40 ligand | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 | 1.8 | in ALS spinal cord showed strong expression of cyclooxygenase-2 (COX-2) COX-2 (one one log greater than control tissues and inducible nitric |
| 11827 | TJP1 | tight junction protein 1 (zona occludens 1) | ZO-1 | 4.0 | Vessels showed damage to the tight junction protein ZO-1 in relation to perivascular CD40 receptor-positive macrophages and CD40 ligand-positive |
| 11919 | CD40 | CD40 molecule, TNF receptor superfamily member 5 | CD40 | 0.3 | to the tight junction protein ZO-1 in relation to perivascular CD40 receptor-positive macrophages and CD40 ligand-positive T lymphocytes |
| 11919 | CD40 | CD40 molecule, TNF receptor superfamily member 5 | CD40 | 0.3 | protein ZO-1 in relation to perivascular CD40 receptor-positive macrophages and CD40 ligand-positive T lymphocytes |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2-negative | 0.0 | hemispheric cerebral infarction macrophage infiltration of the white matter was COX-2-negative and restricted to lateral and anterior corticospinal tracts |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cox 2 | 1.0 | macrophages in als spinal cord showed strong expression of cyclooxygenase 2 cox 2 one log greater than control tissues and inducible nitric oxide synthase. |
| 7873 | NOS2A | nitric oxide synthase 2A (inducible, hepatocytes) | nitric oxide synthase | 1.0 | macrophages in als spinal cord showed strong expression of cyclooxygenase 2 cox 2 one log greater than control tissues and inducible nitric oxide synthase. |
| 11935 | CD40LG | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | cd40 ligand | 1.0 | vessels showed damage to the tight junction protein zo 1 in relation to perivascular cd40 receptor positive macrophages and cd40 ligand positive t lymphocytes. |
| 11827 | TJP1 | tight junction protein 1 (zona occludens 1) | zo 1 | 1.0 | vessels showed damage to the tight junction protein zo 1 in relation to perivascular cd40 receptor positive macrophages and cd40 ligand positive t lymphocytes. |
| 11827 | TJP1 | tight junction protein 1 (zona occludens 1) | tight junction protein zo 1 | 1.0 | vessels showed damage to the tight junction protein zo 1 in relation to perivascular cd40 receptor positive macrophages and cd40 ligand positive t lymphocytes. |
| 9605 | PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | cox 2 | 1.0 | in control cases with corticospinal tract degeneration following hemispheric cerebral infarction macrophage infiltration of the white matter was cox 2 negative and restricted to lateral and anterior corticospinal tracts. |