Current Target Information
| HUGO ID | 11179 |
|---|---|
| Symbol | SOD1 |
| Name | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) |
| #Occurrence | 1372 |
| #Paper | 62 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 15210305 | Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis. | 66 | | Brain Res Brain Res Rev |
| 11173059 | Pharmacogenomics of neurodegenerative diseases. | 64 | | Eur J Pharmacol |
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17015226 | ALS: a disease of motor neurons and their nonneuronal neighbors. | 51 | | Neuron |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18513389 | New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. | 42 | | BMC Bioinformatics |
| 18464922 | Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease. | 35 | | PPAR Res |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 15081582 | Neuroinflammation, COX-2, and ALS--a dual role? | 25 | | Exp Neurol |
| 16510725 | Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. | 24 | | J Neurosci |
| 17018025 | Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. | 23 | | J Neurochem |
| 17582695 | Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides? | 21 | | Med Hypotheses |
| 17555556 | Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. | 18 | | J Neurochem |
| 10525172 | Neurodegenerative disorders: the role of peroxynitrite. | 17 | | Brain Res Brain Res Rev |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 17008387 | Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. | 16 | | Mol Pharmacol |
| 17350694 | The endocannabinoid system in targeting inflammatory neurodegenerative diseases. | 16 | | Trends Pharmacol Sci |
| 18598679 | The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury. | 16 | | Brain Res |
| 14960605 | Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. | 15 | | J Neurosci |
| 15657392 | Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. | 15 | | J Cell Biol |
| 17306794 | Differential expression of cathepsin X in aging and pathological central nervous system of mice. | 15 | | Exp Neurol |
| 15571972 | Clinical potential of minocycline for neurodegenerative disorders. | 14 | | Neurobiol Dis |
| 15649489 | Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. | 14 | | Exp Neurol |
| 17418957 | Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons. | 14 | | Neuroscience |
| 17853944 | Redox modifier genes in amyotrophic lateral sclerosis in mice. | 14 | | J Clin Invest |
| 17997855 | Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury. | 14 | | BMC Infect Dis |
| 16120782 | The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. | 13 | | J Neurosci |
| 16877542 | The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. | 13 | | Proc Natl Acad Sci U S A |
| 18436268 | Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. | 12 | | Neuropharmacology |
| 12417341 | Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. | 11 | | FEBS Lett |
| 14511332 | Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. | 11 | | Eur J Neurosci |
| 16436205 | Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | 11 | | J Neuroinflammation |
| 12843244 | Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. | 10 | | J Neurosci |
| 12124437 | Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. | 9 | | J Neurochem |
| 16179515 | Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. | 9 | | Ann N Y Acad Sci |
| 18312546 | Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis. | 8 | | Neuropathology |
| 12060810 | Minocycline delays disease onset and mortality in a transgenic model of ALS. | 7 | | Neuroreport |
| 16380619 | Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia? | 7 | | Neurology |
| 16909005 | Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. | 6 | | Neurodegener Dis |
| 16737688 | Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. | 5 | | Brain Res |
| 18397603 | Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model. | 5 | | Neurol Res |
| 15691215 | Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis. | 4 | | BioDrugs |
| 17034351 | On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. | 4 | | Antioxid Redox Signal |
| 11796754 | Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. | 3 | | J Neurochem |
| 14597108 | Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. | 3 | | J Neuroimmunol |
| 10417811 | Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration. | 3 | | Glia |
| 11220737 | Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. | 2 | | Ann Neurol |
| 15804265 | Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS. | 2 | | Eur J Neurol |
| 16781706 | AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. | 2 | | Eur J Pharmacol |
| 8605177 | Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. | 2 | | Biochemistry |
| 12194501 | Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. | 1 | | Neuroscientist |
| 12270689 | Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. | 1 | | Neurobiol Dis |
| 16892030 | ALS: life and death in a bad neighborhood. | 1 | | Nat Med |
| 17214440 | [The causes and mechanism of selective motor neuron death in amyotrophic lateral sclerosis] | 1 | | Verh K Acad Geneeskd Belg |
| 18370853 | Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications. | 1 | | Antioxid Redox Signal |
| 12387699 | Therapeutic developments in the treatment of amyotrophic lateral sclerosis. | 1 | | Expert Opin Investig Drugs |
| 12528305 | Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis. | 1 | | Curr Opin Investig Drugs |
| 16425674 | AEOL-10150 (Aeolus). | 1 | | Curr Opin Investig Drugs |