Current Target Information
| HUGO ID | 620 |
|---|---|
| Symbol | APP |
| Name | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) |
| #Occurrence | 99 |
| #Paper | 22 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 15896810 | Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. | 55 | | J Neurol Sci |
| 17174478 | Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. | 42 | | Neuroscience |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 12663085 | Glycation--a sweet tempter for neuronal death. | 26 | | Brain Res Brain Res Rev |
| 10643818 | Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. | 25 | | Neurosci Biobehav Rev |
| 15031734 | Neurodegenerative diseases and oxidative stress. | 23 | | Nat Rev Drug Discov |
| 16227974 | Radical medicine: treating ageing to cure disease. | 23 | | Nat Rev Mol Cell Biol |
| 10742195 | Metals and neuroscience. | 20 | | Curr Opin Chem Biol |
| 18219386 | Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. | 16 | | J Clin Invest |
| 16194581 | The beneficial effects of fruit polyphenols on brain aging. | 14 | | Neurobiol Aging |
| 12893007 | 4-hydroxynonenal and neurodegenerative diseases. | 13 | | Mol Aspects Med |
| 11978481 | Oxidatively modified proteins in aging and disease. | 11 | | Free Radic Biol Med |
| 9745361 | Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? | 9 | | Trends Pharmacol Sci |
| 16406002 | Neuroprotective role for carbonyl reductase? | 7 | | Biochem Biophys Res Commun |
| 9675268 | Effects of mitochondrial respiratory stimulation on membrane lipids and proteins: an electron paramagnetic resonance investigation. | 4 | | Biochim Biophys Acta |
| 15105254 | Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders. | 3 | | Ann N Y Acad Sci |
| 17937892 | [SIRT1/PGC-1: a neuroprotective axis?] | 3 | | Med Sci (Paris) |
| 8858182 | Oxidative stress and mitochondrial dysfunction in neurodegeneration. | 2 | | Curr Opin Neurol |
| 8910880 | A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis. | 1 | | Med Hypotheses |
| 9337068 | Reactive oxygen species and Alzheimer's disease. | 1 | | Biochem Pharmacol |
| 9311102 | Pathophysiological aspects of human neurodegenerative diseases. | 1 | | Wien Klin Wochenschr |