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| 8910880 | amyloid | amyloid | 1.3 | damage aberrant calcium homeostasis metabolic compromise and under certain circumstances amyloid precursor protein mismetabolism | Junguk Hur |  |
| 9337068 | amyloid | amyloid | 1.3 | disease has not been reached yet the involvement of the amyloid precursor protein (APP) APP and betaA4 (A A beta in | Junguk Hur | |
| 9337068 | APP | APP | 0.6 | reached yet the involvement of the amyloid precursor protein (APP) APP and betaA4 (A A beta in the pathologic changes advances | | |
| 9337068 | APP | APP | 0.6 | oxidation and that free oxygen radicals may be involved in APP metabolism | | |
| 9337068 | APP | APP | 0.6 | reduction of Cu(II) Cu II to Cu(I) Cu I by APP involves an electron-transfer reaction and could also lead to a | | |
| 9675268 | amyloid | amyloid | 1.0 | and peptides (e.g e.g nitric oxide synthase xanthine oxidase _amp_#x3b2 -amyloid etc. present in the brain | Junguk Hur | |
| 9745361 | amyloid | amyloid | 1.0 | A fragment of _amp_#x3b2 -amyloid (A_amp_#x3b2;), A_amp_#x3b2 the central constituent of neuritic plaques in Alzheimer's | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | factors for familial Alzheimer's disease have been localized to the amyloid precursor protein apolipoprotein E presenilin 1 and presenilin 2 genes | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | mechanisms of action of these diverse molecules include regulation of amyloid production and of the metabolism of reactive oxygen intermediates so | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | that malfunctioning of these gene products causes elevated generation of amyloid _amp_#x3b2 protein and of reactive oxygen species ( Table 1 | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | stress may sensitize neurons to the apoptotic signals induced by amyloid (see see later creating a double burden | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | -catenin can activate _amp_#x3b3 -secretase the enzyme that releases the amyloid fragment A_amp_#x3b2;(1-42), A_amp_#x3b2 1-42 with a consequent increase in the | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | A_amp_#x3b2;(1-42), A_amp_#x3b2 1-42 with a consequent increase in the excreted amyloid _amp_#x3b2 | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | Apolipoprotein E may also protect from _amp_#x3b2 -amyloid peptide toxicity by binding to amyloid _amp_#x3b2 and under certain | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | also protect from _amp_#x3b2 -amyloid peptide toxicity by binding to amyloid _amp_#x3b2 and under certain circumstances acting as kinetic inhibitor of | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | _amp_#x3b2 and under certain circumstances acting as kinetic inhibitor of amyloid formation 18 | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | The major proteinaceous component of plaques is _amp_#x3b2 -amyloid the abnormal cleavage product of the amyloid precursor protein (APP) | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | plaques is _amp_#x3b2 -amyloid the abnormal cleavage product of the amyloid precursor protein (APP) APP | Junguk Hur | |
| 10643818 | APP | APP | 0.3 | the abnormal cleavage product of the amyloid precursor protein (APP) APP | | |
| 10643818 | amyloid | amyloid | 1.8 | Various metals can bind to amyloid precursor protein and influence its conformation stability and homophilic interactions | Junguk Hur | |
| 10643818 | APP | APP | 0.3 | APP may bind copper and catalyze a redox reaction that reduces | | |
| 10643818 | amyloid | amyloid | 1.8 | Cu I and gives rise to cystine formation in the amyloid precursor protein | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | the binding of zinc which can lead to precipitation of amyloid protein 20 may also be associated with changes in the | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | While the function of amyloid precursor protein as a free radical generator may contribute to | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | generator may contribute to affecting neuron viability the concentrations of amyloid _amp_#x3b2 required to generate free radicals are in general moderately | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | Furthermore the accumulation of intercellular masses of amyloid in contrast to the soluble molecules is not suitable to | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | An alternative mechanism by which amyloid _amp_#x3b2 may cause oxidative stress in neurons as well as | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | -acetylcysteine 23 and inhibition of lipoxygenase protects hippocampal neurons from amyloid _amp_#x3b2 toxicity 24 | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | The oxidative stress generated via production of free radicals by amyloid or via amyloid-dependent signaling can be increased by the common | Junguk Hur | |
| 10643818 | amyloid | amyloid-dependent | 1.0 | generated via production of free radicals by amyloid or via amyloid-dependent signaling can be increased by the common risk factors through | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | affected in Alzheimer's disease share two common mechanisms control of amyloid _amp_#x3b2 secretion and of oxidative stress leading to apoptosis | Junguk Hur | |
| 10643818 | amyloid | amyloid | 1.8 | The mechanism of apoptosis induction by amyloid _amp_#x3b2 converges with the signal transduction cascade that mediates long-term | Junguk Hur | |
| 10742195 | amyloid | amyloid | 1.0 | Familial AD-linked mutations of amyloid precursor protein (APP), APP presenilin-1 and presenilin-2 increase both cerebral | Junguk Hur | |
| 10742195 | APP | APP | 0.3 | Familial AD-linked mutations of amyloid precursor protein (APP), APP presenilin-1 and presenilin-2 increase both cerebral A_amp_#x3b2 burden and A_amp_#x3b2 | | |
| 10742195 | amyloid | amyloid | 1.0 | minor free soluble species in biological fluids is enriched in amyloid deposits | Junguk Hur | |
| 10742195 | amyloid | amyloid | 1.0 | perhaps explaining why these animals do not form cerebral A_amp_#x3b2 amyloid | Junguk Hur | |
| 10742195 | amyloid | amyloid | 1.0 | Zn 2 in A_amp_#x3b2 amyloid deposits has recently been detected by histological fluorescent techniques in | Junguk Hur | |
| 10742195 | amyloid | amyloid | 1.0 | that we have found on human A_amp_#x3b2 extracted from AD amyloid | Junguk Hur | |
| 10742195 | APP | APP | 0.3 | Therefore it is especially intriguing that APP the A_amp_#x3b2 precursor which has second Cu 2 -binding and | | |
| 11978481 | amyloid | amyloid | 1.0 | The neuropathologic hallmarks are senile plaques containing _amp_#x3b2 -amyloid and neurofibrillary tangles which occur in pyramidal neurons of the | Junguk Hur | |
| 11978481 | amyloid | amyloid | 1.0 | Histochemical methods showed 4-hydroxynonenal staining of amyloid deposits 32 | Junguk Hur | |
| 12663085 | amyloid | amyloid | 1.0 | al demonstrated that RAGE and SR mediate cell adhesion to amyloid _amp_#x3b2 protein (A_amp_#x3b2;) A_amp_#x3b2 and induction of oxidative stress 118 | Junguk Hur | |
| 12663085 | amyloid | amyloid | 1.0 | In this study most of the amyloid core of a subset of senile plaques showed no staining | Junguk Hur | |
| 12663085 | amyloid | amyloid | 1.0 | al reported preliminary findings suggesting that cross-link breakers can disaggregate amyloid deposits 111 | Junguk Hur | |
| 12893007 | amyloid | amyloid | 1.0 | These patients carry mutant genes for membrane spanning amyloid precursor protein (APP) APP | Junguk Hur | |
| 12893007 | APP | APP | 0.6 | carry mutant genes for membrane spanning amyloid precursor protein (APP) APP | | |
| 12893007 | APP | APP | 0.6 | APP have tree isoforms ( containing 695 751 and 770 amino | | |
| 12893007 | amyloid | amyloid | 1.0 | The core of these plaques contains a distinct form of amyloid _amp_#x3b2 -protein (BAP), BAP which is 40 amino acids in | Junguk Hur | |
| 12893007 | APP | APP | 0.6 | BAP is derived by proteolysis from a much larger APP | | |
| 12893007 | APP | APP | 0.6 | Normally degradation of APP involves a proteolytic cleavage in the middle of the BAP | | |
| 12893007 | APP | APP | 0.6 | In AD the APP molecule is cut at both ends of the BAP domain | | |
| 12893007 | amyloid | amyloid | 1.0 | molecule which is toxic and accumulates in neuritic plaques as amyloid fibrils ([ Price et al . | Junguk Hur | |
| 12893007 | amyloid | amyloid | 1.0 | However argument against the amyloid cascade toxicity in AD are cognitively normal individuals who have | Junguk Hur | |
| 14739060 | amyloid | amyloid | 1.0 | forms missense mutation have been identified for gene encoding _amp_#x3b2 -amyloid precursor protein as well as presenilin 1 (PSEN1) PSEN1 and | Junguk Hur | |
| 14739060 | amyloid | amyloid | 1.0 | for the former accumulation of several aggregated proteins (_amp_#x3b2;-amyloid, _amp_#x3b2 -amyloid especially its toxic form A_amp_#x3b2 42 APOE 43 hyperphosphorylated tau | Junguk Hur | |
| 14739060 | amyloid | amyloid | 1.0 | 2 with an inflammatory reaction around the deposit of _amp_#x3b2 -amyloid for the latter 38 | Junguk Hur | |
| 15031734 | amyloid | amyloid | 1.0 | peptide (A A beta that is cleaved from the membrane-bound amyloid precursor protein (APP) APP 33 34 35 | Junguk Hur | |
| 15031734 | APP | APP | 0.3 | that is cleaved from the membrane-bound amyloid precursor protein (APP) APP 33 34 35 | | |
| 15031734 | APP | APP | 0.3 | Although the function of APP is unknown recent evidence suggests it functions in maintaining copper | | |
| 15031734 | amyloid | amyloid | 1.0 | Recent results have highlighted the importance of Zn 2 in amyloid plaque formation for example age- and female-sex-related plaque formation in | Junguk Hur | |
| 15031734 | amyloid | amyloid | 1.0 | neurotransmission high concentrations of Zn (300 300 beta precipitation into amyloid commences in the synapse 36 41 | Junguk Hur | |
| 15031734 | amyloid | amyloid | 1.0 | Notably the Fe that is found within the amyloid deposits of human brain and in amyloid-bearing APP transgenic mice | Junguk Hur | |
| 15031734 | APP | APP | 0.3 | within the amyloid deposits of human brain and in amyloid-bearing APP transgenic mice is redox-active 38 48 | | |
| 15031734 | amyloid | amyloid | 1.0 | how zinc originating from the synapse becomes so enriched in amyloid in AD | Junguk Hur | |
| 15031734 | amyloid | amyloid | 1.0 | The Zn 2 in the amyloid mass partially quenches H 2 O 2 production which explains | Junguk Hur | |
| 15031734 | amyloid | amyloid | 1.0 | quenches H 2 O 2 production which explains why plaque amyloid burden correlates poorly with clinical dementia 54 whereas soluble A | Junguk Hur | |
| 15105254 | amyloid | amyloid | 1.3 | In Alzheimer's disease (AD), AD the amyloid beta-peptide generates reactive oxygen species and induces MAOS resulting in | Junguk Hur | |
| 15896810 | amyloid | amyloid | 1.0 | Accordingly the recent finding that _amp_#x3b2 -amyloid fragment 25_amp_#x2013 35 selectively decreases complex IV activity in isolated | Junguk Hur | |
| 15896810 | amyloid | amyloid | 1.0 | of heat shock proteins is closely related to that of amyloid precursor protein (APP), APP heat-shock proteins have been studied in | Junguk Hur | |
| 15896810 | APP | APP | 0.3 | is closely related to that of amyloid precursor protein (APP), APP heat-shock proteins have been studied in brains of patients with | | |
| 16194581 | APP | APP | 0.3 | Amyloid precursor protein/presenilin-1 protein presenilin-1 (APP/PSl) APP PSl transgenic mice have been used as a murine model | | |
| 16194581 | amyloid | amyloid | 1.0 | for AD since these mutations facilitate the production of beta amyloid and consequently Alzheimer-like plaques in several regions of the brain | Junguk Hur | |
| 16194581 | APP | APP | 0.3 | of plaques was observed between the BB-supplemented and non-supplemented APP/PSl APP PSl mice even though behavioral deficits were prevented in the | | |
| 16194581 | APP | APP | 0.3 | formation and improved Y-maze performance seen in the BB-supplemented APP/PSl APP PSl mice versus the non-supplemented APP/PSl APP PSl mice might | | |
| 16194581 | APP | APP | 0.3 | the BB-supplemented APP/PSl APP PSl mice versus the non-supplemented APP/PSl APP PSl mice might be due to alterations in signaling pathways | | |
| 16194581 | APP | APP | 0.3 | kinase C (PKC) PKC were elevated in the BB-supplemented APP/PSl APP PSl mice as compared to those found in the non-supplemented | | |
| 16227974 | amyloid | amyloid | 1.0 | characteristic feature of Alzheimer's disease is the formation of extracellular amyloid plaques that contain cleavage products amyloid-beta (A A beta of | Junguk Hur | |
| 16227974 | amyloid | amyloid | 1.0 | plaques that contain cleavage products amyloid-beta (A A beta of amyloid precursor protein ( APP | Junguk Hur | |
| 16227974 | APP | APP | 0.6 | products amyloid-beta (A A beta of amyloid precursor protein ( APP | | |
| 16227974 | APP | APP | 0.6 | forms of Alzheimer's disease have been linked to mutations in APP or in gene products that are involved in APP processing | | |
| 16227974 | APP | APP | 0.6 | in APP or in gene products that are involved in APP processing | | |
| 16227974 | APP | APP | 0.6 | alpha-synuclein APP ATM JunD parkin peroxiredoxin I PINK1 Ras seladin-1 SIRT1 SIRT3 | | |
| 16406002 | amyloid | amyloid | 1.0 | lipid aldehyde-mediated _amp_#x3b2 PKC activation induced an increase in intracellular amyloid production | Junguk Hur | |
| 17174478 | amyloid | amyloid-like | 1.0 | post-mortem studies of FALS patients and bind dyes that detect amyloid-like structure | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | as a novel nutritional approach to reduce oxidative damage and amyloid pathology in AD | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | It is characterized pathologically by deposition of amyloid B-peptide (AB) AB in senile (neuritic) neuritic plaques and the | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | intracellular immunoreactive deposits as well as the formation of intracellular amyloid 89 | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | received considerable attention as it has been demonstrated that the amyloid precursor protein (APP) APP decreases HO activity thus reducing the | Junguk Hur | |
| 17191135 | APP | APP | 0.3 | it has been demonstrated that the amyloid precursor protein (APP) APP decreases HO activity thus reducing the intracellular levels of bilirubin | | |
| 17191135 | amyloid | amyloid | 1.3 | s quality control system becomes overwhelmed conformational changes occur to amyloid polypeptide intermediates generating stable oligomers with an anti-parallel crossed B-pleated | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | Although it is clear why mutant proteins form amyloid it is harder to rationalize why a wild-type protein adopts | Junguk Hur | |
| 17191135 | amyloid | amyloid | 1.3 | discrepancy suggests that another event likely triggers misfolding in sporadic amyloid disease | Junguk Hur | |
| 17937892 | amyloid | amyloid | 1.3 | protect against axonal degeneration and to decrease the accumulation of amyloid beta peptides the hallmark of Alzheimer disease in cultured murine | Junguk Hur | |
| 18219386 | amyloid | amyloid | 1.0 | to rotenone-induced neuronal death ( 18 and Alzheimer disease_amp_#x02013 linked amyloid peptides (derived derived from neurons activate microglial cells to produce | Junguk Hur | |
| 8858182 | amyloid-beta protein | amyloid beta protein | 1.0 | amyloid beta protein precursor|dna mitochondrial|free radicals|hd protein human|nerve tissue proteins|nuclear proteins|reactive oxygen species|electron transport complex iv| | | |
| 8910880 | amyloid-beta protein | amyloid beta protein | 1.0 | amyloid beta protein precursor|reactive oxygen species|calcium| | | |
| 9311102 | amyloid-beta protein | amyloid beta protein | 1.0 | amyloid beta protein|cytokines|excitatory amino acids|nerve growth factors|reactive oxygen species| | | |
| 9337068 | amyloid-beta protein | amyloid beta protein | 1.0 | amyloid beta protein|amyloid beta protein precursor|reactive oxygen species|superoxide dismutase| | | |
| 17937892 | amyloid-beta protein | amyloid beta protein | 1.0 | amyloid beta protein|neuroprotective agents|reactive oxygen species|stilbenes|transcription factors|peroxisome proliferator activated receptor gamma coactivator 1|resveratrol|sirt1 protein human|sirt1 protein mouse|sirtu | | |