Current Target Information
| HUGO ID | 11892 |
|---|---|
| Symbol | TNF |
| Name | tumor necrosis factor (TNF superfamily, member 2) |
| #Occurrence | 475 |
| #Paper | 43 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 11173059 | Pharmacogenomics of neurodegenerative diseases. | 64 | | Eur J Pharmacol |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17015226 | ALS: a disease of motor neurons and their nonneuronal neighbors. | 51 | | Neuron |
| 18513389 | New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. | 42 | | BMC Bioinformatics |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18464922 | Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease. | 35 | | PPAR Res |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 15081582 | Neuroinflammation, COX-2, and ALS--a dual role? | 25 | | Exp Neurol |
| 16510725 | Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. | 24 | | J Neurosci |
| 17018025 | Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. | 23 | | J Neurochem |
| 17582695 | Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides? | 21 | | Med Hypotheses |
| 18040778 | Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. | 20 | | J Neuroimmune Pharmacol |
| 17597167 | Inflammation in the nervous system--physiological and pathophysiological aspects. | 19 | | Physiol Behav |
| 17555556 | Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. | 18 | | J Neurochem |
| 10525172 | Neurodegenerative disorders: the role of peroxynitrite. | 17 | | Brain Res Brain Res Rev |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 17008387 | Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. | 16 | | Mol Pharmacol |
| 17350694 | The endocannabinoid system in targeting inflammatory neurodegenerative diseases. | 16 | | Trends Pharmacol Sci |
| 14960605 | Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. | 15 | | J Neurosci |
| 15657392 | Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. | 15 | | J Cell Biol |
| 17418957 | Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons. | 14 | | Neuroscience |
| 15649489 | Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. | 14 | | Exp Neurol |
| 18436268 | Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. | 12 | | Neuropharmacology |
| 16436205 | Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | 11 | | J Neuroinflammation |
| 12124437 | Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. | 9 | | J Neurochem |
| 16380619 | Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia? | 7 | | Neurology |
| 9562310 | Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. | 6 | | J Neurol Sci |
| 16909005 | Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. | 6 | | Neurodegener Dis |
| 18246426 | Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India. | 6 | | Neurochem Res |
| 15681814 | New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. | 5 | | Ann N Y Acad Sci |
| 18414597 | Altered Lipid Metabolism in Brain Injury and Disorders. | 5 | | Subcell Biochem |
| 18422522 | Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection. | 5 | | J Neurochem |
| 18751914 | Altered lipid metabolism in brain injury and disorders. | 5 | | Subcell Biochem |
| 17034351 | On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. | 4 | | Antioxid Redox Signal |
| 11796754 | Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. | 3 | | J Neurochem |
| 15777251 | Estrogen and cytokines production - the possible cause of gender differences in neurological diseases. | 3 | | Curr Pharm Des |
| 18375019 | Interferon-gamma-dependent cytotoxic activation of human astocytes and astrocytoma cells. | 3 | | Neurobiol Aging |
| 11847479 | Tumor necrosis factor and motoneuronal degeneration: an open problem. | 1 | | Neuroimmunomodulation |
| 17908040 | TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. | 1 | | Curr Alzheimer Res |