Current Target Information
| HUGO ID | 1516 |
|---|---|
| Symbol | CAT |
| Name | catalase |
| #Occurrence | 82 |
| #Paper | 30 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 15896810 | Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. | 55 | | J Neurol Sci |
| 11679167 | Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. | 44 | | Mol Aspects Med |
| 17496232 | Mitochondrial nitric oxide in the signaling of cell integrated responses. | 43 | | Am J Physiol Cell Physiol |
| 17174478 | Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. | 42 | | Neuroscience |
| 12663085 | Glycation--a sweet tempter for neuronal death. | 26 | | Brain Res Brain Res Rev |
| 10643818 | Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle. | 25 | | Neurosci Biobehav Rev |
| 11050436 | Mitochondria, oxygen free radicals, disease and ageing. | 24 | | Trends Biochem Sci |
| 15031734 | Neurodegenerative diseases and oxidative stress. | 23 | | Nat Rev Drug Discov |
| 12654515 | VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. | 17 | | Brain Res Mol Brain Res |
| 12909279 | Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals. | 17 | | Brain Res Bull |
| 14648077 | Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to SOD1-mutated motor neurons in humans and animal models. | 17 | | Acta Neuropathol |
| 16194581 | The beneficial effects of fruit polyphenols on brain aging. | 14 | | Neurobiol Aging |
| 12893007 | 4-hydroxynonenal and neurodegenerative diseases. | 13 | | Mol Aspects Med |
| 16877542 | The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. | 13 | | Proc Natl Acad Sci U S A |
| 17150307 | Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo. | 12 | | Neuroscience |
| 18210200 | Novel nanomaterials for clinical neuroscience. | 11 | | J Neuroimmune Pharmacol |
| 12614931 | Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid. | 8 | | J Neurol Sci |
| 12392777 | A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. | 6 | | Neurobiol Aging |
| 16188953 | Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride]. | 6 | | J Pharmacol Exp Ther |
| 18308427 | Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease. | 5 | | Neurochem Int |
| 10930589 | Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1. | 5 | | J Neurol Sci |
| 12684448 | Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. | 5 | | J Neurosci |
| 17368952 | Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis. | 5 | | Neuroscience |
| 14690536 | Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. | 4 | | J Neurochem |
| 16681429 | Alterations in anti-oxidative defence enzymes in erythrocytes from sporadic amyotrophic lateral sclerosis (SALS) and familial ALS patients. | 3 | | Clin Chem Lab Med |
| 10593879 | The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. | 3 | | FASEB J |
| 15266948 | Neuroprotective role of melatonin in oxidative stress vulnerable brain. | 3 | | Indian J Physiol Pharmacol |
| 9856861 | Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons. | 2 | | J Neurosci Res |
| 12718737 | Oxidative stress in neurodegenerative diseases: therapeutic implications for superoxide dismutase mimetics. | 2 | | Expert Opin Biol Ther |