Current Target Information
| HUGO ID | 620 |
|---|---|
| Symbol | APP |
| Name | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) |
| #Occurrence | 156 |
| #Paper | 29 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 15210305 | Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis. | 66 | | Brain Res Brain Res Rev |
| 11173059 | Pharmacogenomics of neurodegenerative diseases. | 64 | | Eur J Pharmacol |
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 18040778 | Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. | 20 | | J Neuroimmune Pharmacol |
| 17597167 | Inflammation in the nervous system--physiological and pathophysiological aspects. | 19 | | Physiol Behav |
| 10525172 | Neurodegenerative disorders: the role of peroxynitrite. | 17 | | Brain Res Brain Res Rev |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 16766086 | PPARgamma as a therapeutic target in central nervous system diseases. | 16 | | Neurochem Int |
| 17350694 | The endocannabinoid system in targeting inflammatory neurodegenerative diseases. | 16 | | Trends Pharmacol Sci |
| 17306794 | Differential expression of cathepsin X in aging and pathological central nervous system of mice. | 15 | | Exp Neurol |
| 15571972 | Clinical potential of minocycline for neurodegenerative disorders. | 14 | | Neurobiol Dis |
| 17997855 | Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury. | 14 | | BMC Infect Dis |
| 16120782 | The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. | 13 | | J Neurosci |
| 17574754 | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 13 | | Neurosci Lett |
| 9762518 | The importance of inflammatory mechanisms in Alzheimer disease. | 7 | | Exp Gerontol |
| 15681814 | New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. | 5 | | Ann N Y Acad Sci |
| 17901552 | Function of COX-2 and prostaglandins in neurological disease. | 5 | | J Mol Neurosci |
| 10417811 | Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration. | 3 | | Glia |
| 16781706 | AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. | 2 | | Eur J Pharmacol |
| 9769023 | Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. | 1 | | Alzheimer Dis Assoc Disord |
| 9850924 | Mechanisms of cell death in Alzheimer disease--immunopathology. | 1 | | J Neural Transm Suppl |
| 16445350 | 2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases. | 1 | | Expert Rev Proteomics |
| 16983747 | Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. | 1 | | J Neuroimmunol |