Current Target Information
| HUGO ID | 4235 |
|---|---|
| Symbol | GFAP |
| Name | glial fibrillary acidic protein |
| #Occurrence | 95 |
| #Paper | 22 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 15210305 | Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis. | 66 | | Brain Res Brain Res Rev |
| 17191135 | Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. | 60 | | Neurochem Res |
| 17015226 | ALS: a disease of motor neurons and their nonneuronal neighbors. | 51 | | Neuron |
| 18464922 | Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease. | 35 | | PPAR Res |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 16510725 | Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. | 24 | | J Neurosci |
| 17008387 | Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. | 16 | | Mol Pharmacol |
| 15657392 | Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. | 15 | | J Cell Biol |
| 17306794 | Differential expression of cathepsin X in aging and pathological central nervous system of mice. | 15 | | Exp Neurol |
| 15649489 | Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. | 14 | | Exp Neurol |
| 16877542 | The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. | 13 | | Proc Natl Acad Sci U S A |
| 18436268 | Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. | 12 | | Neuropharmacology |
| 14511332 | Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. | 11 | | Eur J Neurosci |
| 16436205 | Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | 11 | | J Neuroinflammation |
| 12843244 | Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. | 10 | | J Neurosci |
| 16014720 | Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. | 10 | | J Neurosci |
| 16179515 | Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. | 9 | | Ann N Y Acad Sci |
| 18312546 | Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis. | 8 | | Neuropathology |
| 16909005 | Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. | 6 | | Neurodegener Dis |
| 16737688 | Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. | 5 | | Brain Res |
| 16793728 | Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells. | 2 | | Cytotherapy |