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| 11978481 | iNOS | iNOS | 2.7 | oxide synthase (eNOS), eNOS and inducible nitric oxide synthase (iNOS) iNOS | |  |
| 12663085 | iNOS | iNOS | 2.7 | Wong et al reported that AGE-positive astrocytes and microglia expressing iNOS were found in AD brains and concluded that the activation | | |
| 12663085 | NOS | NOS | 2.7 | by antioxidants aminoguanidine and inhibitors of nitric oxide synthase (NOS) NOS | | |
| 12663085 | NOS | NOS | 2.7 | glycation AG has antioxidant properties 81 and also inhibits inducible NOS (iNOS) iNOS 100 | | |
| 12663085 | iNOS | iNOS | 2.7 | has antioxidant properties 81 and also inhibits inducible NOS (iNOS) iNOS 100 | | |
| 12663085 | iNOS | iNOS | 2.7 | properties 81 and also inhibits inducible nitric oxide synthase (iNOS) iNOS 100 | | |
| 12663085 | NOS | NOSs | 2.7 | pentosidine were negative for stress-response proteins (SRPs), SRPs HNE acrolein NOSs and nitrotyrosine as representative markers of oxidative stress 35 | | |
| 14739060 | iNOS | iNOS | 1.9 | NO synthase (nNOS; nNOS type I inducible NO synthase (iNOS; iNOS typeII which is produced in very large amounts by activated | | |
| 14739060 | iNOS | iNOS | 1.9 | in pathologic conditions especially NO coming from activated microglia (iNOS) iNOS or and from endothelial cells (eNOS) eNOS | | |
| 15896810 | iNOS | iNOS | 2.7 | (eNOS; eNOS type III and (c) c inducible NOS (iNOS, iNOS type II | | |
| 15896810 | iNOS | iNOS | 2.7 | In contrast to nNOS and eNOS iNOS can bind to calmodulin even at very low concentration of | | |
| 15896810 | iNOS | iNOS | 2.7 | calmodulin even at very low concentration of intracellular calcium thus iNOS can exert its activity in a calcium-independent manner | | |
| 15896810 | iNOS | iNOS | 2.7 | The levels of iNOS in the CNS are generally fairly low | | |
| 15896810 | iNOS | iNOS | 2.7 | However an increased expression of iNOS in astrocytes and microglia occurs following viral infection and trauma | | |
| 15896810 | iNOS | iNOS | 2.7 | Activation of iNOS requires gene transcription and the induction can be influenced by | | |
| 15964487 | iNOS | iNOS | 2.2 | expression of cycloxygenase-2 caspase-1 and inducible nitric oxide synthase (iNOS) iNOS mRNA have been described ( Chen et al. 2000 | | |
| 15964487 | iNOS | iNOS | 2.2 | death by other mechanisms such as inhibition of methaloproteases or iNOS expression ( Chen et al 2000 and Sadowski and Steinmeyer | | |
| 16194581 | iNOS | iNOS | 2.2 | activation genes such as the inducible nitric oxide synthase (iNOS), iNOS interleukin-1_amp_#x3b2 (IL-1_amp_#x3b2;), IL-1_amp_#x3b2 tumor necrosis factor-_amp_#x3b1 (TNF-_amp_#x3b1;), TNF-_amp_#x3b1 and nuclear | | |
| 16242643 | iNOS | iNOS | 2.5 | Furthermore malonate did not induce the expression of the iNOS caspase-3 -8 and -9 genes which have been shown to | | |
| 16242643 | iNOS | iNOS | 2.5 | expression of interleukin 1 beta inducible nitric oxide synthase (iNOS), iNOS caspase-3 and -1 ( Chen et al. 2000 | | |
| 16242643 | iNOS | iNOS | 2.5 | no modifications in the expression of the mRNA's encoding for iNOS caspase-3 -8 and -9 after malonate additions were found we | | |
| 16242643 | iNOS | iNOS | 2.5 | iNOS caspase-3 -8 and -9 mRNA expression levels are not modulated | | |
| 16242643 | iNOS | iNOS | 2.5 | Among them the down-regulation of caspases and iNOS and the up-regulation of Bcl-2 have been documented recently ( | | |
| 16242643 | iNOS | iNOS | 2.5 | cell death we first analyzed the pattern of expression of iNOS caspase-3 -8 and -9 and the antiapoptotic gene Bcl-2 in | | |
| 16242643 | iNOS | iNOS | 2.5 | in cell viability does not modify the expression of the iNOS caspase-3 -8 and -9 genes | | |
| 16242643 | iNOS | iNOS | 2.5 | mRNA expression of caspase-3 -8 and -9 as well as iNOS it decreases the mRNA of the antiapoptotic protein Bcl-2 an | | |
| 16242643 | iNOS | iNOS | 2.5 | be modulated by minocycline after different neurotoxic stimuli such as iNOS and several members of the caspase family ( Chen et | | |
| 16242643 | iNOS | iNOS | 2.5 | no changes in the expression of the genes coding for iNOS caspase-3 -8 and -9 | | |
| 16242643 | iNOS | iNOS | 2.5 | Fig 6._amp_#xa0 Malonate does not affect iNOS caspase-3 -8 and -9 but significantly reduces Bcl-2 mRNA expression | | |
| 16242643 | iNOS | iNOS | 2.5 | (A) A Lack of effects of malonate on the iNOS caspase-3 -8 and -9 mRNA expression levels | | |
| 17099894 | iNOS | iNOS | 3.2 | MNs accumulate NADPH diaphorase and inducible nitric oxide synthase (iNOS)-like iNOS -like immunoreactivity and iNOS gene deletion extends significantly the life | | |
| 17099894 | iNOS | iNOS | 3.2 | and inducible nitric oxide synthase (iNOS)-like iNOS -like immunoreactivity and iNOS gene deletion extends significantly the life span of G93A-mSOD1 mice | | |
| 17099894 | NOS | NOS | 2.7 | of MN mitochondria with enhanced toxic potential from distal terminals NOS localization in MN mitochondria and peroxynitrite damage and early degeneration | | |
| 17174478 | iNOS | iNOS | 2.7 | (nNOS), nNOS endothelial NOS (eNOS) eNOS and inducible NOS (iNOS) iNOS nNOS and eNOS are constitutively expressed isozymes controlling basal NO | | |
| 17174478 | iNOS | iNOS | 2.7 | synthesizing NO in response to increases in intracellular calcium levels iNOS is expressed in response to specific cytokines growth factors or | | |
| 17191135 | iNOS | iNOS | 3.2 | and interferon-G (IFN-G) IFN-G promotes a rapid increase in both iNOS expression and nitrite levels followed by enhancement of Hsp70 3 | | |
| 17191135 | iNOS | iNOS-derived | 2.7 | 3 20 whereas the modulation of HO-1 mRNA expression by iNOS-derived NO following stimulation with LPS has also been reported in | | |
| 17191135 | iNOS | iNOS | 3.2 | Moreover the early increase in iNOS protein levels observed in endothelial cells exposed to low oxygen | | |
| 17191135 | NOS | NOS | 2.7 | (ii) ii decreasing the neuronal 3-nitrotyrosine levels and therefore inducible NOS activity and (iii) iii by the well known direct free | | |
| 9675268 | nitric oxide synthase | nitric oxide synthase | 1.0 | oxidative insult to normal neurons also results from catalytically active redox metal ions i.e iron and copper and particular ros generating enzymes and peptides e.g nitric oxide synthase xanthine oxidase _amp_#x3b2; amyloid etc. present in the brain. | | |
| 10930589 | nitric oxide synthase | nitric oxide synthase | 1.0 | neither nitroarginine a nitric oxide synthase inhibitor or vitamin e altered the ros levels. | | |
| 10930589 | nitric oxide synthase | nitric oxide synthase | 1.0 | quercetin a bio flavonoid molecule with antioxidant properties [ 26 ] showed effects similar to ascorbic acid. nitroarginine an inhibitor of nitric oxide synthase nos [ 27 ] did not affect the c dcf fluorescence in resting cells of any group. | | |
| 11223912 | nitric oxide synthase | nitric oxide synthase | 1.0 | phenylhydrazone|kainic acid|2 4 dinitrophenol|glutamic acid|calmidazolium|cyclosporine|n methylaspartate|calcium|dizocilpine maleate|alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid|dibucaine|nitric oxide synthase|nitric oxide synthase type i|nos1 protein rat|superoxide dismutase|calcium calmodulin dependent protein kinase type 2|calcium calmodulin dependent protein kinases| | | |
| 11223912 | nitric oxide synthase | nitric oxide synthase | 1.0 | |nitric oxide synthase type i|nos1 protein rat|superoxide dismutase|calcium calmodulin dependent protein kinase type 2|calcium calmodulin dependent protein kinases| | | |
| 11978481 | nitric oxide synthase | nitric oxide synthase | 1.0 | the generation of nitric oxide no _amp_#x2022; from arginine by nitric oxide synthase is a process which is involved in neurotransmission regulation of vascular relaxation and in inflammatory processes. | | |
| 11978481 | nitric oxide synthase | nitric oxide synthase | 1.0 | the source of the nitric oxide is possibly from upregulation of an inducible nitric oxide synthase in neurofibrillary tangle bearing neurons or from nitric oxide synthase in astrocytes and microglia adjacent to senile plaques [ 38 and 39 ]. | | |
| 12663085 | nitric oxide synthase | nitric oxide synthase | 1.0 | the cytotoxic effects were attenuated by antioxidants aminoguanidine and inhibitors of nitric oxide synthase nos . | | |
| 12663085 | nitric oxide synthase | nitric oxide synthase | 1.0 | in addition to its suppressive effect on glycation ag has antioxidant properties [ 81 ] and also inhibits inducible nitric oxide synthase inos [ 100 ]. | | |
| 12909279 | nitric oxide synthase | nitric oxide synthase | 1.0 | nf _amp_#x3ba;b modulates the expression of several proteins such as nitric oxide synthase nos [ 93 ] and cox2 [ 70 ] that might be involved in mechanisms of inflammation mediated neurodegeneration and be crucial in the pathogenesis of als. | | |
| 15031734 | nitric oxide synthase | nitric oxide synthase | 1.0 | n redox active metals and oxygen species via reactions such as the fenton and haber weiss reactions or via indirect pathways involving the calcium activation of metallo enzymes such as phospholipases nitric oxide synthase and xanthine dehydrogenase also known as xanthine oxidase 22 . | | |
| 15031734 | nitric oxide synthase | nitric oxide synthase | 1.0 | alzheimer's disease amyotrophic lateral sclerosis friedreich's ataxia huntington's disease nitric oxide synthase parkinson's disease stroke wilson's disease | | |
| 15208263 | nitric oxide synthase | nitric oxide synthase | 1.0 | cytokines|enzyme inhibitors|lipopolysaccharides|noc 18|nitric oxide donors|nitroso compounds|reactive oxygen species|ng nitroarginine methyl ester|interferon type ii|catalase|nitric oxide synthase|sod1 g93a protein|superoxide dismutase 1|superoxide dismutase|caspase 1| | | |
| 15896810 | nitric oxide synthase | nitric oxide synthase | 1.0 | the enzyme responsible for no synthesis is the nitric oxide synthase nos family of enzymes which catalyse the conversion of arginine to citrulline and no. | | |
| 15964487 | nitric oxide synthase | nitric oxide synthase | 1.0 | the exact mechanisms by which minocycline plays these neuroprotective effects remain unknown although a reduced expression of cycloxygenase 2 caspase 1 and inducible nitric oxide synthase inos mrna have been described chen et al. 2000 . | | |
| 16043017 | nitric oxide synthase | nitric oxide synthase | 1.0 | also elevation of inflammation related genes e.g. induced nitric oxide synthase proinflammatory cytokines occurs at 11 weeks of age in the presymptomatic stage before motor neuron death in g93a sod1 transgenic mice suggesting that neuroinflammation mediated oxidative stress is a | | |
| 16194581 | nitric oxide synthase | nitric oxide synthase | 1.0 | neuroinflammation has been connected to enhanced signal transduction leading to the activation genes such as the inducible nitric oxide synthase inos interleukin 1_amp_#x3b2; il 1_amp_#x3b2; tumor necrosis factor _amp_#x3b1; tnf _amp_#x3b1; and nuclear factor kappa b nf _amp_#x3ba;b [1] [49] [60] [65] [69] [72] [81] and [86] . | | |
| 16242643 | nitric oxide synthase | nitric oxide synthase | 1.0 | in this sense tetracyclines can inhibit the matrix metalloproteases activity and superoxide production and can also down regulate the levels of expression of interleukin 1 beta inducible nitric oxide synthase inos caspase 3 and 1 chen et al. 2000 . | | |
| 17099894 | nitric oxide synthase | nitric oxide synthase | 1.0 | mitochondria in msod1 mouse mns accumulate nadph diaphorase and inducible nitric oxide synthase inos like immunoreactivity and inos gene deletion extends significantly the life span of g93a msod1 mice. | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | keywords: amyotrophic lateral sclerosis ataxia telangiectasia like disorder werner syndrome xeroderma pigmentosum nitric oxide synthase superoxide dismutase | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | cu zn sod with essential cellular components bruijn et al. 1998 johnston et al. 2000 cleveland and rothstein 2001 and this has been demonstrated with the copper chaperone for sod ccs kato et al. 2001 nitric oxide synthase nos and phosphorylated neurofilaments chou et al. 1996 . | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | ros and nitric oxide synthase | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | no is a small easily diffusible and transient free radical whose availability is controlled at the synthesis level by the nitric oxide synthase nos enzymes. | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | ros and nitric oxide synthase | | |
| 17174478 | nitric oxide synthase | nitric oxide synthase | 1.0 | ros and nitric oxide synthase | | |
| 17191135 | nitric oxide synthase | nitric oxide synthase | 1.0 | in addition ad lymphocytes showed an increased expression of inducible nitric oxide synthase ho 1 hsp72 hsp60 and trxr [ 96 ]. | | |
| 17368952 | nitric oxide synthase | nitric oxide synthase | 1.0 | expression of inducible _amp_#xb7; nitric oxide synthase nos increases during the development of als in the g93a transgenic mice compared with normal sod1 mice and nc mice almer et al. 1999 . | | |
| 17496232 | nitric oxide synthase | nitric oxide synthase | 1.0 | peroxynitrite; hydrogen peroxide; mitochondrial nitric oxide synthase; mitogen activated protein kinase | | |
| 17634371 | nitric oxide synthase | nitric oxide synthase | 1.0 | although an exogenous source of nitric oxide is not required for ngf to induce sod1 motor neuron death n nitro l arginine methyl ester name 1 m m a general nitric oxide synthase nos inhibitor and 1 2 trifluoromethylphenyl imidazole trim 10 micro m a specific inhibitor of the neuronal isoform of nos prevented ngf induced apoptosis in sod1 motor neurons fig 3 e . | | |