Current Target Information
| HUGO ID | 9605 |
|---|---|
| Symbol | PTGS2 |
| Name | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| #Occurrence | 1448 |
| #Paper | 26 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 15210305 | Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis. | 66 | | Brain Res Brain Res Rev |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17015226 | ALS: a disease of motor neurons and their nonneuronal neighbors. | 51 | | Neuron |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18464922 | Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease. | 35 | | PPAR Res |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 15081582 | Neuroinflammation, COX-2, and ALS--a dual role? | 25 | | Exp Neurol |
| 18040778 | Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. | 20 | | J Neuroimmune Pharmacol |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 16766086 | PPARgamma as a therapeutic target in central nervous system diseases. | 16 | | Neurochem Int |
| 16120782 | The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. | 13 | | J Neurosci |
| 17574754 | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 13 | | Neurosci Lett |
| 14511332 | Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. | 11 | | Eur J Neurosci |
| 16380619 | Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia? | 7 | | Neurology |
| 15799549 | Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells. | 5 | | Amyotroph Lateral Scler Other Motor Neuron Disord |
| 17901552 | Function of COX-2 and prostaglandins in neurological disease. | 5 | | J Mol Neurosci |
| 15691215 | Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis. | 4 | | BioDrugs |
| 11220737 | Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. | 2 | | Ann Neurol |
| 15804265 | Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS. | 2 | | Eur J Neurol |
| 16101543 | Prostaglandins and cyclooxygenases in glial cells during brain inflammation. | 2 | | Curr Drug Targets Inflamm Allergy |
| 12362410 | Inflammatory processes in amyotrophic lateral sclerosis. | 1 | | Muscle Nerve |
| 14720207 | Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. | 1 | | J Neurochem |
| 15974901 | Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. | 1 | | Curr Alzheimer Res |