Current Target Information
| HUGO ID | 6018 |
|---|---|
| Symbol | IL6 |
| Name | interleukin 6 (interferon, beta 2) |
| #Occurrence | 287 |
| #Paper | 25 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 16104843 | The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. | 64 | | Clin Sci (Lond) |
| 11173059 | Pharmacogenomics of neurodegenerative diseases. | 64 | | Eur J Pharmacol |
| 16647138 | Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. | 59 | | Brain Res Rev |
| 16624536 | Innate immunity in amyotrophic lateral sclerosis. | 54 | | Biochim Biophys Acta |
| 17569578 | PPARs in the brain. | 42 | | Biochim Biophys Acta |
| 18464925 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. | 35 | | PPAR Res |
| 16753239 | Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. | 32 | | Neurochem Int |
| 15572176 | A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. | 27 | | Brain Res Brain Res Rev |
| 15081582 | Neuroinflammation, COX-2, and ALS--a dual role? | 25 | | Exp Neurol |
| 16510725 | Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. | 24 | | J Neurosci |
| 17018025 | Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. | 23 | | J Neurochem |
| 17582695 | Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides? | 21 | | Med Hypotheses |
| 18040778 | Microglia as a pharmacological target in infectious and inflammatory diseases of the brain. | 20 | | J Neuroimmune Pharmacol |
| 17597167 | Inflammation in the nervous system--physiological and pathophysiological aspects. | 19 | | Physiol Behav |
| 17555556 | Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. | 18 | | J Neurochem |
| 10525172 | Neurodegenerative disorders: the role of peroxynitrite. | 17 | | Brain Res Brain Res Rev |
| 15453089 | Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. | 17 | | J Neuropathol Exp Neurol |
| 18436268 | Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice. | 12 | | Neuropharmacology |
| 14511332 | Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. | 11 | | Eur J Neurosci |
| 16436205 | Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. | 11 | | J Neuroinflammation |
| 16380619 | Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia? | 7 | | Neurology |
| 9562310 | Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. | 6 | | J Neurol Sci |
| 18246426 | Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India. | 6 | | Neurochem Res |
| 15777251 | Estrogen and cytokines production - the possible cause of gender differences in neurological diseases. | 3 | | Curr Pharm Des |
| 14597108 | Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. | 3 | | J Neuroimmunol |