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| 14960605 | IFN-gamma | IFN-gamma | 1.1 | tissue of these animals did not exhibit positive signal for IFN-gamma transcript | |  |
| 14960605 | IFN-gamma | IFN-gamma | 1.1 | cord and brain tissues using highly sensitive probes for interferon-gamma IFN-gamma and IL-12 two cytokines essential for the transfer from the | | |
| 14960605 | IFN-gamma | IFN-gamma | 1.1 | However in situ hybridization failed to detect positive signal for IFN-gamma transcript in the brain and spinal cord of SOD1 mice | | |
| 14960605 | IFN-gamma | IFN-gamma | 1.1 | The Scripps Research Institute La Jolla CA for the mouse IFN-gamma cDNA Dr K Pahan (University University of Nebraska Lincoln NE | | |
| 15210305 | IFN-gamma | IFN-gamma | 0.8 | uninfected microglia exposed to inflammatory stimuli such as lipopolysaccharide and IFN-gamma as well as prion protein (PrP) PrP amyloid 5 | | |
| 15453089 | IFN | IFN- | 0.3 | classical pro-inflammatory mediators such as IL-1 IL-6 TNF- alpha and IFN- gamma were not detected in significant amount in a murine | | |
| 15572176 | IFN | IFN-G | 1.6 | Cytokines such as interferon-_amp_#x3b3 (IFN-_amp_#x3b3;) IFN-_amp_#x3b3 are among the most potent inducers of class II MHC | | |
| 15777251 | IFN-gamma | IFN-gamma | 0.8 | experimental autoimmune encephalomyelitis (EAE) EAE display gender specific alterations of IFN-gamma and IL-12 variations of TNF and IL-6 were associated with | | |
| 16510725 | IFN | IFN | 0.3 | No changes were detected in IL-12p35 IL-10 IL-18 IFN gamma or IFN beta IL-6 TGF-beta3 and LT alpha or | | |
| 16510725 | IFN | IFN | 0.3 | changes were detected in IL-12p35 IL-10 IL-18 IFN gamma or IFN beta IL-6 TGF-beta3 and LT alpha or LT beta (data | | |
| 16624536 | IFN | IFN-G | 0.6 | death induced by microglia activated with LPS and interferon-gamma (IFN-_amp_#x3b3;), IFN-_amp_#x3b3 in a dose-dependent manner | | |
| 16624536 | IFN | IFN- | 0.6 | cytokines (e.g., e.g. IL-6 IL-8 colony stimulating factors (CSFs), CSFs IFN- _amp_#x3b2 and can also have a trophic effect | | |
| 16624536 | IFN | IFN-G | 0.6 | antigen to Th1 cells which can in turn produce IL-1 IFN-_amp_#x3b3 TNF-_amp_#x3b2 and further activate macrophages | | |
| 16624536 | IFN | IFN-G | 0.6 | with CNS-specific self-antigens may arise from stimulation of microglia with IFN-_amp_#x3b3 which is produced by reactive helper T cells | | |
| 16624536 | IFN | IFN-G | 0.6 | In addition IFN-_amp_#x3b3 -stimulated microglia had greater antigen-presenting capability and were therefore able | | |
| 16753239 | IFN | IFN-G | 0.2 | Additionally this agonist suppressed IFN-_amp_#x3b3 IL-10 and IL-4 production by activated lymphocytes ( Diab et | | |
| 17018025 | IFN | IFN | 0.3 | production in human microglia activated by TNF-A or interferon (IFN)-G IFN -G | | |
| 17018025 | IFNG | IFN-G | 0.3 | from microglia when given 24 h after the triggering signals IFN-G and lipopolysaccharide ( Chao et al 1993 we found that | | |
| 17191135 | IFNG | IFN-G | 0.8 | glial cells treatment with lipopolysaccaride (LPS) LPS and interferon-G (IFN-G) IFN-G promotes a rapid increase in both iNOS expression and nitrite | | |
| 18246426 | IFNG | IFN-G | 0.8 | We evaluated tumor necrosis factor-alpha (TNF-A), TNF-A interferon-G (IFN-G) IFN-G and nitric oxide (NO) NO levels in the serum of | | |
| 18246426 | IFNG | IFN-G | 0.8 | Serum TNF-A levels and IFN-G levels were significantly ( P _lt_ 0.001 elevated in ALS | | |
| 18246426 | IFNG | IFN-G | 0.8 | such as tumor necrosis factor-A (TNF-A) TNF-A and interferon-G (IFN-G) IFN-G as potential mediators during the progression of brain injury is | | |
| 18246426 | IFNG | IFN-G | 0.8 | T cells have the ability to produce TNF-A along with IFN-G that acts in both innate and specific cell-mediated immunities 16 | | |
| 18246426 | IFNG | IFN-G | 0.8 | The mixture of both TNF-A and IFN-G may therefore be harmful to neuronal elements | | |
| 18246426 | IFNG | IFN-G | 0.8 | In this regard transgenic mice expressing IFN-G in hippocampus exhibit profound enhanced microglial reactivity to lesion-induced neuronal | | |
| 18246426 | IFNG | IFN-G | 0.8 | profound enhanced microglial reactivity to lesion-induced neuronal injury indicating that IFN-G acts as an amplifier of the response 17 | | |
| 18246426 | IFNG | IFN-G | 0.8 | Four days of treatment with IFN-G failed to alter cell survival or myelin basic protein gene | | |
| 18246426 | IFNG | IFN-G | 0.8 | this study is to measure the systemic inflammatory markers TNF-A IFN-G and nitric oxide in ALS patients and evaluate their role | | |
| 18246426 | IFNG | IFN-G | 0.8 | TNF-A and IFN-G assay The serum thus obtained was stored at _amp_#8722 80C | | |
| 18246426 | IFNG | IFN-G | 0.8 | stored at _amp_#8722 80C and was used for TNF-A and IFN-G estimation by ELISA | | |
| 18246426 | IFNG | IFN-G | 0.8 | Elisa kits for the estimation of TNF-A and IFN-G were obtained from R_amp_D Systems Minneapolis MN USA | | |
| 18246426 | IFNG | IFN-G | 0.8 | noticed a significant elevation ( P _lt_ 0.001 in serum IFN-G NO levels in ALS patients versus controls (Figs Figs 2 | | |
| 18246426 | IFNG | IFN-G | 0.8 | Fig 2 Serum mean IFN-G (pg/ml pg ml SEM levels in ALS patients ( n | | |
| 18246426 | IFNG | IFN-G | 0.8 | it can be seen that in ALS patients serum TNF-A IFN-G and NO levels (Figs Figs 4 -6 respectively started to | | |
| 18246426 | IFNG | IFN-G | 0.8 | Fig 5 Second degree polynomial regression plot showing IFN-G levels (pg/ml pg ml SEM versus duration of illness in | | |
| 18246426 | IFNG | IFN-G | 0.8 | present study we observed significant elevation in serum TNF-A and IFN-G levels in ALS patients and also this increase was most | | |
| 18246426 | IFNG | IFN-G | 0.8 | The source for the increased serum TNF-A and IFN-G in the present study could be peripheral immune cells | | |
| 18246426 | IFNG | IFN-G | 0.8 | Moreover Holmoy et al 31 could not detect TNF-A and IFN-G levels in the CSF of ALS patients using a cytometric | | |
| 18246426 | IFNG | IFN-G | 0.8 | To conclude serum TNF-A and IFN-G levels peaked around 24 months from the onset in these | | |
| 18375019 | IFN | IFN | 1.1 | astrocytes and U-373 MG cells were stimulated with interferon (IFN)-gamma IFN -gamma (150U/ml), 150U ml their supernatants significantly reduced SH-SY5Y cell | | |
| 18375019 | IFN-gamma | IFN-gamma | 1.1 | These combinations were also unable to enhance the IFN-gamma effect | | |
| 18375019 | IFN-gamma | IFN-gamma | 1.1 | result indicates that the neurotoxic effect was proceeding through the IFN-gamma receptor (IFNGR)-JAK-STAT IFNGR -JAK-STAT intracellular pathway | | |
| 18375019 | IFN-gamma | IFN-gamma | 1.1 | suggest that activated astrocytes may become neurotoxic when stimulated by IFN-gamma and may therefore exacerbate the pathology in a spectrum of | | |
| 18464925 | IFN | IFN-G | 0.3 | in the presence of microglial activators such as LPS and IFN-_amp_#x003b3 | | |
| 18464925 | IFN | IFN-G | 0.3 | prevented LPS-induced iNOS expression and TNF-_amp_#x003b1 production as well as IFN-_amp_#x003b3 -induced expression of major histocompatibility complex (MHC) MHC class II | | |
| 18464925 | IFN | IFN-G | 0.3 | of STAT-1 and NF-_amp_#x003ba B which are known to mediate IFN-_amp_#x003b3 and LPS signaling 76 | | |
| 18464925 | IFN | IFN-G | 0.3 | N9 activated either by LPS alone or in combination with IFN-_amp_#x003b3 or TNF-_amp_#x003b1 63 77 15d-PGJ 2 attenuated microglial activation also | | |
| 18539342 | IFN | IFN | 0.3 | Epiplexus cells have been shown to respond to LPS or IFN gamma injection blast injury and other stimuli with ultrastructural modifications | | |
| 14960605 | interferon, gamma | interferon gamma | 1.0 | to determine whether upregulated innate immunity transfers to the adaptive form we performed in situ hybridization on spinal cord and brain tissues using highly sensitive probes for interferon gamma ifn gamma and il 12 two cytokines essential for the transfer from the innate to the acquired immunity. | | |
| 15572176 | interferon, gamma | interferon gamma | 1.0 | some inflammatory molecules such as fibroblast growth factor [ 64 ] major histocompatibility complex encoded antigens [ 89 ] interferon gamma [ 70 and 89 ] and nos [ 70 ] have been found elevated in motor neurons after nerve lesions or spinal cord injury and proposed to signal between motor neurons and glia. | | |
| 16436205 | interferon, gamma | interferon gamma | 1.0 | cells were treated with recombinant murine tnf_amp_#x003b1; and/or interferon gamma ifn_amp_#x003b3; bd pharmingen san diego ca usa as indicated in specific experiments. | | |
| 16624536 | interferon, gamma | interferon gamma | 1.0 | ne cell culture experiments fractalkine suppressed the production of nitric oxide no il 6 and tnf by activated microglia and suppressed neuronal cell death induced by microglia activated with lps and interferon gamma ifn _amp_#x3b3; in a dose dependent manner. | | |
| 17582695 | interferon, gamma | interferon gamma | 1.0 | apoptotic mechanisms are associated with activation of caspase pathways and functional interplay between proinflammatory cytokines interferon gamma and nitric oxide is suggested associated with oxidative stress and glial activation. | | |
| 17582695 | interferon, gamma | interferon gamma | 1.0 | apoptotic mechanisms are associated with activation of caspase pathways and functional interplay between proinflammatory cytokines interferon gamma and nitric oxide is suggested associated with oxidative stress and glial activation in als [33] . | | |
| 18375019 | interferon, gamma | interferon gamma | 1.0 | interferon gamma dependent cytotoxic activation of human astocytes and astrocytoma cells. | | |