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PMID TITLE # of Targets Links Journal
15210305Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis.66 Brain Res Brain Res Rev
16104843The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.64 Clin Sci (Lond)
11173059Pharmacogenomics of neurodegenerative diseases.64 Eur J Pharmacol
17191135Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes.60 Neurochem Res
16647138Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders.59 Brain Res Rev
16624536Innate immunity in amyotrophic lateral sclerosis.54 Biochim Biophys Acta
17015226ALS: a disease of motor neurons and their nonneuronal neighbors.51 Neuron
18513389New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.42 BMC Bioinformatics
17569578PPARs in the brain.42 Biochim Biophys Acta
18464925Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.35 PPAR Res
18464922Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease.35 PPAR Res
14739060Neurodegenerative diseases and oxidative stress.33 Biomed Pharmacother
16753239Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders.32 Neurochem Int
15572176A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis.27 Brain Res Brain Res Rev
15081582Neuroinflammation, COX-2, and ALS--a dual role?25 Exp Neurol
16510725Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.24 J Neurosci
17018025Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia.23 J Neurochem
17582695Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?21 Med Hypotheses
18040778Microglia as a pharmacological target in infectious and inflammatory diseases of the brain.20 J Neuroimmune Pharmacol
17597167Inflammation in the nervous system--physiological and pathophysiological aspects.19 Physiol Behav
17555556Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.18 J Neurochem
15453089Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases.17 J Neuropathol Exp Neurol
10525172Neurodegenerative disorders: the role of peroxynitrite.17 Brain Res Brain Res Rev
18598679The NADPH oxidase is involved in lipopolysaccharide-mediated motor neuron injury.16 Brain Res
17350694The endocannabinoid system in targeting inflammatory neurodegenerative diseases.16 Trends Pharmacol Sci
17008387Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis.16 Mol Pharmacol
16766086PPARgamma as a therapeutic target in central nervous system diseases.16 Neurochem Int
17306794Differential expression of cathepsin X in aging and pathological central nervous system of mice.15 Exp Neurol
15657392Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model.15 J Cell Biol
14960605Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.15 J Neurosci
17997855Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.14 BMC Infect Dis
17853944Redox modifier genes in amyotrophic lateral sclerosis in mice.14 J Clin Invest
17418957Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons.14 Neuroscience
15649489Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis.14 Exp Neurol
15571972Clinical potential of minocycline for neurodegenerative disorders.14 Neurobiol Dis
17574754Divergent effects of prostaglandin receptor signaling on neuronal survival.13 Neurosci Lett
16877542The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.13 Proc Natl Acad Sci U S A
16120782The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.13 J Neurosci
18436268Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice.12 Neuropharmacology
16436205Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation.11 J Neuroinflammation
14511332Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis.11 Eur J Neurosci
12417341Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis.11 FEBS Lett
18539342Involvement of the choroid plexus in multiple sclerosis autoimmune inflammation: A neuropathological study.10 J Neuroimmunol
16014720Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.10 J Neurosci
12843244Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis.10 J Neurosci
16179515Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice.9 Ann N Y Acad Sci
12124437Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.9 J Neurochem
18312546Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis.8 Neuropathology
16380619Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia?7 Neurology
14556941Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis.7 Brain Res
12060810Minocycline delays disease onset and mortality in a transgenic model of ALS.7 Neuroreport
9762518The importance of inflammatory mechanisms in Alzheimer disease.7 Exp Gerontol
18246426Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India.6 Neurochem Res
17969353[Gene expression profile of spinal ventral horn in ALS]6 Brain Nerve
16909005Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis.6 Neurodegener Dis
15668976Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis.6 Ann Neurol
9562310Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases.6 J Neurol Sci
18751914Altered lipid metabolism in brain injury and disorders.5 Subcell Biochem
18422522Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection.5 J Neurochem
18414597Altered Lipid Metabolism in Brain Injury and Disorders.5 Subcell Biochem
18397603Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model.5 Neurol Res
17901552Function of COX-2 and prostaglandins in neurological disease.5 J Mol Neurosci
16737688Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.5 Brain Res
15799549Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.5 Amyotroph Lateral Scler Other Motor Neuron Disord
15681814New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.5 Ann N Y Acad Sci
17034351On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.4 Antioxid Redox Signal
15691215Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis.4 BioDrugs
18375019Interferon-gamma-dependent cytotoxic activation of human astocytes and astrocytoma cells.3 Neurobiol Aging
17896980Neurotrophic factors--a tool for therapeutic strategies in neurological, neuropsychiatric and neuroimmunological diseases?3 Curr Med Chem
17678953Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders.3 Int Rev Neurobiol
15777251Estrogen and cytokines production - the possible cause of gender differences in neurological diseases.3 Curr Pharm Des
14597108Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration.3 J Neuroimmunol
11796754Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.3 J Neurochem
10417811Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration.3 Glia
9339959Apoptosis: clinical relevance and pharmacological manipulation.3 Drugs
9086508Rat brain mast cells: an in vitro paradigm for assessing the toxic effects of neurotropic therapeutics.3 Neurotoxicology
8493864Inflammatory cells in the peripheral nervous system in motor neuron disease.3 Acta Neuropathol
17241118The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.2 J Neurochem
17190960An acute, life-threatening, hypersensitivity reaction to riluzole. USA. sorenson.eric@mayo.edu2 Neurology
16793728Autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells.2 Cytotherapy
16781706AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis.2 Eur J Pharmacol
16637591[S100B: astrocyte specific protein]2 Nihon Shinkei Seishin Yakurigaku Zasshi
16101543Prostaglandins and cyclooxygenases in glial cells during brain inflammation.2 Curr Drug Targets Inflamm Allergy
15804265Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.2 Eur J Neurol
15507874New target against inflammatory diseases: transglutaminase 2.2 Arch Immunol Ther Exp (Warsz)
15341181Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes.2 In Vivo
12076984Role of nitric oxide in inflammation-mediated neurodegeneration.2 Ann N Y Acad Sci
11220737Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.2 Ann Neurol
8605177Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.2 Biochemistry
18459454PARP activation and inflammatory reaction in selective neurodegeneration. Department of Neurology, University of Szeged, Szeged.1 Ideggyogy Sz
18384649PPAR: a therapeutic target in Parkinson's disease.1 J Neurochem
18370853Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications.1 Antioxid Redox Signal
18077562The brain as a target for inflammatory processes and neuroprotective strategies.1 Ann N Y Acad Sci
17908040TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.1 Curr Alzheimer Res
17852013RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis.1 Amyotroph Lateral Scler
17805244Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders.1 Nat Clin Pract Neurol
17439481Recombinant human erythropoietin suppresses symptom onset and progression of G93A-SOD1 mouse model of ALS by preventing motor neuron death and inflammation.1 Eur J Neurosci
17240849[Development of therapies against neuromuscular diseases causing muscle atrophy]1 Nihon Shinkei Seishin Yakurigaku Zasshi
17214440[The causes and mechanism of selective motor neuron death in amyotrophic lateral sclerosis]1 Verh K Acad Geneeskd Belg
17127558Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex.1 Amyotroph Lateral Scler
17114826Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice.1 Neuromolecular Med
16983747Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.1 J Neuroimmunol
16892030ALS: life and death in a bad neighborhood.1 Nat Med
16533145Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies.1 Expert Rev Neurother
164453502D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases.1 Expert Rev Proteomics
16425674AEOL-10150 (Aeolus).1 Curr Opin Investig Drugs
15974901Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease.1 Curr Alzheimer Res
15962273Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis.1 Muscle Nerve
15782606[Primary progressive multiple sclerosis as a differential diagnosis of ALS: a case report]1 Rinsho Shinkeigaku
15512862Molecular targets for neuroprotection.1 Amyotroph Lateral Scler Other Motor Neuron Disord
14720207Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.1 J Neurochem
14642384An improved HPLC measurement for GSH and GSSG in human blood.1 Free Radic Biol Med
12528305Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis.1 Curr Opin Investig Drugs
12387699Therapeutic developments in the treatment of amyotrophic lateral sclerosis.1 Expert Opin Investig Drugs
12362410Inflammatory processes in amyotrophic lateral sclerosis.1 Muscle Nerve
12270689Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis.1 Neurobiol Dis
12194501Role of superoxide dismutases in oxidative damage and neurodegenerative disorders.1 Neuroscientist
12137643Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease.1 Cochrane Database Syst Rev
11847479Tumor necrosis factor and motoneuronal degeneration: an open problem.1 Neuroimmunomodulation
9850924Mechanisms of cell death in Alzheimer disease--immunopathology.1 J Neural Transm Suppl
9769023Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions.1 Alzheimer Dis Assoc Disord
7836946Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system.1 J Neurol Sci
2263315Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis.1 Neuropathol Appl Neurobiol
2241118Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis.1 Ann Neurol
3772394Significant increase in immunosuppressive acidic protein (IAP) in serum of patients with multiple sclerosis and other inflammatory neurological disorders.1 J Neurol Sci
18715147Targeting Oxidative Stress for Neuroprotection.  Antioxid Redox Signal
18691039Biochemical Markers in CSF of ALS Patients.  Curr Med Chem
18684235Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases.  CNS Neurosci Ther
18425621Thalidomide causes sinus bradycardia in ALS.  J Neurol
17678968Oxidative stress and the pathogenesis of neurodegenerative disorders.  Int Rev Neurobiol
17497670Neuroinflammation and regulation of glial glutamate uptake in neurological disorders.  J Neurosci Res
17311555Inflammatory caspases: targets for novel therapies.  Curr Pharm Des
17305588Translational therapeutic strategies in amyotrophic lateral sclerosis.  Mini Rev Med Chem
17128115[Etiological drug therapy for amyotrophic lateral sclerosis]  Rev Neurol (Paris)
17119468[Oxidative stress in human diseases]  Ann Pharm Fr
16909022Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.  Neurodegener Dis
16909020Excitotoxicity and amyotrophic lateral sclerosis.  Neurodegener Dis
16883679Are there causal relationships between the development of the inflammatory diseases amyotrophic lateral sclerosis and asthma?  P R Health Sci J
16785600Gender differences in neurological disease: role of estrogens and cytokines.  Endocrine
16326025Cooler biologically compatible core body temperatures may prolong longevity and combat neurodegenerative disorders.  Med Hypotheses
16197805Role of microglia in the central nervous system's immune response.  Neurol Res
15846792Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis.  Glia
15681803Inflammation and the degenerative diseases of aging.  Ann N Y Acad Sci
14661102Relevance of protein nitration in brain injury: a key pathophysiological mechanism in neurodegenerative, autoimmune, or inflammatory CNS diseases and stroke.  Amino Acids
14645737Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.  Physiol Genomics
12043837Harnessing the immune system for neuroprotection: therapeutic vaccines for acute and chronic neurodegenerative disorders.  Cell Mol Neurobiol
11458198The role of metals in autoimmunity and the link to neuroendocrinology.  Neuro Endocrinol Lett
11139813Neuroprotection by caspase inhibitors.  Expert Opin Investig Drugs
10225668Adenosine and neopterin levels in cerebrospinal fluid of patients with neurological disorders.  Intern Med
9270568Familial nature and continuing morbidity of the amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam.  Neurology
9125377Adenovirus-mediated gene transfer to the brain: methodological assessment.  J Neurosci Methods
8737921Mouse inoculation studies reveal no transmissible agent in amyotrophic lateral sclerosis.  Brain Pathol
7783760CT muscle imaging and the clinical assessment of neuromuscular disease.  Muscle Nerve
8787242Autoimmunity as an etiological factor in sporadic amyotrophic lateral sclerosis. USA.  Adv Neurol
8433825Pathologic findings in the retinal pigment epitheliopathy associated with the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam.  Ophthalmology
1436688Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis.  Neurosci Lett
1853774Autoimmunity and ALS: a comparison of animal models of immune-mediated motor neuron destruction and human ALS.  Adv Neurol
2673004Amyotrophic lateral sclerosis: an unconventional autoimmune disease?  Ann Neurol
2779765Electrophysiological and clinical importance of early and late components of the winking reflex and their role in diagnosis. Moscow Medical Institute.  Neurosci Behav Physiol
3358701Long-term changes in the spinal cords of patients with old poliomyelitis. Signs of continuous disease activity.  Arch Neurol
3719465An unusual form of motor neuron disease following a cat bite.  Can J Neurol Sci
3526768[Spinal endoscopy]  Zh Vopr Neirokhir Im N N Burdenko
6202282Plasmapheresis. Therapeutic or experimental procedure?  Arch Neurol
4362559Cellular inflammatory response. Findings in patients with neurological diseases.  Arch Neurol
4359365Amyotrophic lateral sclerosis. Abnormal cellular inflammatory response.  Arch Neurol
4142488The course of a model cutaneous inflammation in the scapuloperoneal syndrome and in systemic neuromuscular diseases.  J Neurol
4879405Clinical neurology.  Prog Neurol Psychiatry
5928070[Morphologic manifestations of the "inflammation" in sclerosis lateralis amyotrophica and their biologic significance] ich znaczenie biologiczne.  Neuropatol Pol

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