HUGO ID Detailed Result 7808

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
10077670	NGF	NGF	1.2	phosphatase activity in cells expressing SODV148G or SODWT or after NGF withdrawal was normalized to activity of mock-infected cells
10077670	NGF	NGF-removal	1.2	was no decline in calcineurin activity of PC12 cells after NGF-removal a procedure that also leads to apoptotic cell death (Fig
10077670	NGF	NGF	1.2	after mock infection (Fig Fig 2 C lane 1 after NGF removal (Fig Fig 2 C lane 2 or 72 hr
10077670	NGF	NGF	1.2	Analogs on Cell Death Induced by Mutant SOD Expression or NGF Withdrawal
10077670	NGF	NGF	1.2	811 and PSC 833 protected PC12 cells from death after NGF withdrawal (Fig Fig 3 B
10077670	NGF	NGF	1.2	dansylated CsA had relatively little effect on cell death after NGF withdrawal (Fig Fig 3 B
10077670	NGF	NGF-differentiated	1.2	cyclophilin rotamase activity on mutant SOD-induced cell death we transfected NGF-differentiated PC12 cells with wild-type CyPA (CyPAWT) CyPAWT cDNA or CyPA(R55A)
10077670	NGF	NGF	1.2	R55A did not significantly protect cells from death induced by NGF withdrawal (Fig Fig 5 B indicating that the apoptotic pathway
10077670	NGF	NGF-differentiated	1.2	adenovirus as a vector to express SODWT or SODV148G in NGF-differentiated PC12 cells and hippocampal neurons to test whether calcineurin was
10077670	NGF	NGF-withdrawal	1.2	Both NGF-withdrawal and expression of SOD mutations have been associated with the
10077670	NGF	NGF	1.2	For NGF withdrawal and NMDA toxicity the ability of CsA and its
10077670	NGF	NGF	1.2	addition CsA actually decreased cell death in PC12 cells after NGF withdrawal
10077670	NGF	NGF	1.2	assayed 3 days after AdV infection or 1 day after NGF withdrawal
10077670	NGF	NGF	1.2	PC12 cells ( A and show a protective effect after NGF removal ( B
10077670	NGF	NGF	1.2	cell death induced by SODV148G expression ( A or after NGF withdrawal ( B
10077670	NGF	NGF	1.2	Zn superoxide dismutase-1 FALS familial ALS CyP cyclophilin WT wild-type NGF nerve growth factor AdV adenovirus CsA cyclosporin A NMDA N
10077670	NGF	NGF	1.2	expression of FALS-associated mutant SOD in nerve growth factor (NGF)-differentiated NGF -differentiated PC12 cells primary sympathetic neurons and hippocampal neurons leads
12901835	NGF	NGF	1.2	is not causative of death in nerve growth factor (NGF)-differentiated NGF -differentiated PC12 cells transfected with mutant SOD1s (SODMT, SODMT V148G
17191135	NGF	NGF	0.6	Recent work suggests that Trx-1 play a key role in NGF signaling pathways 74
17191135	NGF	NGF	0.6	NGF a neurotrophic factor regulating development maintenance and function of the
17634371	NGF	NGF	1.2	Nerve growth factor (NGF) NGF can induce apoptosis by signaling through the p75 neurotrophin receptor
17634371	NGF	NGF	1.2	Cultured embryonic motor neurons expressing p75 are not vulnerable to NGF unless they are exposed to an exogenous flux of nitric
17634371	NGF	NGF-induced	1.2	prevented neuronal loss further evidencing the role of mitochondria in NGF-induced apoptosis
17634371	NGF	NGF	1.2	sclerosis (ALS)-linked ALS -linked superoxide dismutase 1 (SOD1 SOD1 mutation NGF induced apoptosis even in the absence of an external source
17634371	NGF	NGF	1.2	The increased susceptibility of SOD1 motor neurons to NGF was associated to decreased nuclear factor erythroid 2-related factor 2
17634371	NGF	NGF	1.2	reproduced the effect of SOD1 expression increasing their sensitivity to NGF
17634371	NGF	NGF-induced	1.2	In contrast rising antioxidant defenses by Nrf2 activation prevented NGF-induced apoptosis
17634371	NGF	NGF	1.2	Nerve growth factor (NGF) NGF has a key role on the development and function of
17634371	NGF	NGF	1.2	In addition to promoting neuronal differentiation and survival NGF can induce apoptosis of neurons during development and may also
17634371	NGF	NGF	1.2	NGF exerts its actions through two nonhomologous transmembrane receptors the tyrosine
17634371	NGF	NGF	1.2	Adult motor neurons had been thought to be unresponsive to NGF because they lack both TrkA and p75 receptors (Henderson Henderson
17634371	NGF	NGF-induced	1.2	Induction of p75 renders motor neurons vulnerable to NGF-induced apoptosis p75 has been implicated in motor neuron death occurring
17634371	NGF	NGF-induced	1.2	Pure motor neuron cultures expressing p75 are sensitive to NGF-induced apoptosis only when physiological concentrations of exogenous nitric oxide (
17634371	NGF	NGF	1.2	Mouse NGF (2.5S) 2.5S was obtained from Harlan (Madison, Madison WI recombinant
17634371	NGF	NGF	1.2	Blocking antibodies to NGF and p75 were from Chemicon (Temecula, Temecula CA
17634371	NGF	NGF	1.2	Treatments with NGF and inhibitors were performed 3 h after motor neuron plating
17634371	NGF	NGF	1.2	mito-HE incubation cells were treated with 100 ng/ml ng ml NGF and then imaged every 15 min
17634371	NGF	NGF	1.2	GDNF (1 1 ng/ml) ng ml and then treated with NGF (100 100 ng/ml) ng ml in the presence or absence
17634371	NGF	NGF	1.2	Consistent with our previous results (Pehar Pehar et al. 2004 NGF reduced motor neuron survival by 40% only in the presence
17634371	NGF	NGF-induced	1.2	The extent of NGF-induced reduction in motor neuron survival was similar to that induced
17634371	NGF	NGF-induced	1.2	NGF-induced motor neuron death was blocked by manumycin A (10 10
17634371	NGF	NGF	1.2	of p75 under pathological conditions renders motor neurons vulnerable to NGF (Ferri Ferri et al. 1998 Wiese et al. 1999 Lowry
17634371	NGF	NGF	1.2	In the present study we show that the NGF/p75 NGF p75 -mediated motor neuron apoptosis involved increased production of mitochondrial
17634371	NGF	NGF-mediated	1.2	Moreover ALS-linked SOD1 overexpression increases motor neuron vulnerability to NGF-mediated apoptosis by reducing antioxidant defenses
17634371	NGF	NGF	1.2	In accordance pharmacological activation of Nrf2 prevented NGF/p75 NGF p75 -induced motor neuron apoptosis suggesting a potential target to
17634371	NGF	NGF	1.2	Therefore NGF signaling through p75 and the subsequent increase in ceramide production
17634371	NGF	NGF	1.2	an important source of superoxide in motor neurons exposed to NGF
17634371	NGF	NGF	1.2	and peroxynitrite scavengers completely prevent motor neuron death induced by NGF through p75 (Pehar Pehar et al. 2004
17634371	NGF	NGF-mediated	1.2	(mitoCP) mitoCP supports a role for mitochondrial oxidative damage in NGF-mediated apoptosis
17634371	NGF	NGF	1.2	prevent mitochondrial oxidative damage and neuronal death induced by NGF/p75 NGF p75 -signaling in vivo
17634371	NGF	NGF-mediated	1.2	to nontransgenic motor neurons SOD1 motor neurons are sensitive to NGF-mediated apoptosis in the absence of exogenous nitric oxide
17634371	NGF	NGF-induced	1.2	Although an external source of nitric oxide is not required NGF-induced apoptosis in SOD1 transgenic motor neurons requires endogenous production of
17634371	NGF	NGF-induced	1.2	The increased susceptibility of SOD1 motor neurons to NGF-induced apoptosis was not mediated by increased expression of p75 or
17634371	NGF	NGF-mediated	1.2	nitric oxide production was counteracted by endogenous antioxidant defenses and NGF-mediated apoptosis only proceeds in the presence of an exogenous source
17634371	NGF	NGF-mediated	1.2	NGF-mediated apoptosis will be executed only in the presence of surrounding
17634371	NGF	NGF	1.2	the increased susceptibility of SOD1 motor neurons not only to NGF but also to Fas-mediated apoptosis which also involves ROS and
17634371	NGF	NGF-	1.2	Accordingly pharmacological activation of Nrf2 by tBHQ treatment completely prevented NGF- and Fas-mediated motor neuron apoptosis in nontransgenic and SOD1 motor
17634371	NGF	NGF-induced	1.2	NGF-induced apoptosis in motor neurons involves nSMase activation and triggers cytochrome
17634371	NGF	NGF	1.2	with GDNF (1 1 ng/ml) ng ml were exposed to NGF (100 100 ng/ml) ng ml plus 10 micro M DETA-NONOate
17634371	NGF	NGF	1.2	SMase inhibitors were added 1 h before NGF and DETA-NONOate
17634371	NGF	NGF	1.2	motor neurons maintained with GDNF (control) control or exposed to NGF plus DETA-NONOate (NGF+NO) NGF NO
17634371	NGF	NGF	1.2	GDNF (control) control or exposed to NGF plus DETA-NONOate (NGF+NO) NGF NO
17634371	NGF	NGF	1.2	In the absence of NGF motor neurons showed a punctuate (mitochondrial) mitochondrial labeling of cytochrome
17634371	NGF	NGF	1.2	labeling of cytochrome c whereas 12 h after treatment with NGF NO motor neurons showed a diffuse cytoplasmic labeling
17634371	NGF	NGF	1.2	100 n M GW prevented cytochrome c release induced by NGF NO
17634371	NGF	NGF	1.2	1 ng/ml) ng ml were exposed to vehicle (Ctrl), Ctrl NGF (100 100 ng/ml), ng ml DETA-NONOate (10 10 micro M
17634371	NGF	NGF	1.2	NGF increases superoxide production by mitochondria
17634371	NGF	NGF	1.2	0.1 micro M mito-HE and after washing were exposed to NGF (100 100 ng/ml) ng ml
17634371	NGF	NGF	1.2	fluorescence emission of mito-HE ( exc 405 nm immediately after NGF addition ( t = 0 min and 40 min later
17634371	NGF	NGF	1.2	min in cultures maintained with GDNF in the absence of NGF (data data not shown
17634371	NGF	NGF	1.2	The increased mito-HE fluorescence emission induced by NGF was not observed in cultures preincubated for 24 h with
17634371	NGF	NGF	1.2	Preincubation with missense oligonucleotides did not prevent the effect of NGF
17634371	NGF	NGF	1.2	with GDNF (1 1 ng/ml) ng ml were exposed to NGF (100 100 ng/ml) ng ml plus DETA-NONOate (10 10 micro
17634371	NGF	NGF	1.2	ng/ml) ng ml plus DETA-NONOate (10 10 micro M (NGF+NO) NGF NO in the presence of vehicle (white white bar or
17634371	NGF	NGF	1.2	mean _amp_#177 SD * p _lt_ 0.05 significantly different from NGF NO
17634371	NGF	NGF-induced	1.2	Motor neurons overexpressing SOD1 show increase susceptibility to NGF-induced apoptosis
17634371	NGF	NGF	1.2	1 ng/ml) ng ml and exposed to increasing concentrations of NGF
17634371	NGF	NGF	1.2	gray bars represent motor neuron survival in cultures exposed to NGF (100 100 ng/ml) ng ml in the presence of DETA-NONOate
17634371	NGF	NGF	1.2	B SOD1 transgenic motor neurons were exposed to NGF in the presence of vehicle GW4869 (100 100 n M
17634371	NGF	NGF	1.2	mean _amp_#177 SD * p _lt_ 0.05 significantly different from NGF
17634371	NGF	NGF	1.2	maintained with GDNF and exposed to vehicle (control) control or NGF (100 100 ng/ml) ng ml
17634371	NGF	NGF	1.2	In the absence of NGF motor neurons showed a punctuate labeling of cytochrome c and
17634371	NGF	NGF	1.2	labeling of cytochrome c and 12 h after treatment with NGF a diffuse labeling was observed in affected motor neurons
17634371	NGF	NGF	1.2	( exc 405 nm in SOD1 motor neurons immediately after NGF addition ( t = 0 min and 40 min later
17634371	NGF	NGF	1.2	E SOD1 transgenic motor neurons were exposed to NGF in the presence of vehicle mitoQ (10 10 p M
17634371	NGF	NGF	1.2	mean _amp_#177 SD * p _lt_ 0.05 significantly different from NGF
17634371	NGF	NGF-induced	1.2	Glutathione levels modulate NGF-induced motor neuron apoptosis
17634371	NGF	NGF	1.2	10 n M and 24 h later were exposed to NGF (100 100 ng/ml) ng ml
17634371	NGF	NGF	1.2	Motor neuron survival was determined 48 h after NGF treatment
17634371	NGF	NGF	1.2	NGF did not affect motor neuron survival in cultures preincubated with
17634371	NGF	NGF	1.2	vehicle (control) control tBHQ prevented motor neuron death induced by NGF (100 100 ng/ml) ng ml plus DETA-NONOate (10 10 micro
17634371	NGF	NGF	1.2	100 ng/ml) ng ml plus DETA-NONOate (10 10 micro M NGF NO
17634371	NGF	NGF	1.2	Increased Nrf2 activation prevents SOD1 motor neuron death induced by NGF or sFasL
17634371	NGF	NGF	1.2	with GDNF (1 1 ng/ml) ng ml were exposed to NGF (100 100 ng/ml) ng ml in the presence of vehicle
17634371	NGF	NGF	1.2	In the absence of NGF motor neurons showed a punctate pattern of cytochrome c immunoreactivity
17634371	NGF	NGF	1.2	NGF (100 100 ng/ml) ng ml or DETA-NONOate (10 10 micro
17634371	NGF	NGF	1.2	In contrast after 12 h of NGF treatment in the presence of DETA-NONOate ~27% of motor neurons
17634371	NGF	NGF	1.2	Cytochrome c release induced by NGF in the presence of nitric oxide was prevented by the
17634371	NGF	NGF-mediated	1.2	tested for the potential involvement of mitochondrial ROS production in NGF-mediated motor neuron death
17634371	NGF	NGF	1.2	NGF (100 100 ng/ml) ng ml treatment induced a 1.7 _amp_#177
17634371	NGF	NGF-induced	1.2	Kelso et al. 2001 Dhanasekaran et al. 2005 also blocked NGF-induced motor neuron death ( Fig 2 B strengthening the role
17634371	NGF	NGF-induced	1.2	nontransgenic motor neurons SOD1 -expressing motor neurons were sensitive to NGF-induced apoptosis in the absence of the nitric oxide donor DETA-NONOate
17634371	NGF	NGF	1.2	donor DETA-NONOate even at concentrations of 10 ng/ml ng ml NGF ( Fig 3
17634371	NGF	NGF-induced	1.2	10 micro M which renders nontransgenic motor neurons sensitive to NGF-induced apoptosis did not further decrease the survival of SOD1 -expressing
17634371	NGF	NGF-induced	1.2	NGF-induced apoptosis in SOD1 -expressing motor neurons was prevented by blocking
17634371	NGF	NGF-induced	1.2	p M and mitoCP (1 1 n M also prevented NGF-induced apoptosis in SOD1 motor neurons ( Fig 3 E
17634371	NGF	NGF	1.2	an exogenous source of nitric oxide is not required for NGF to induce SOD1 motor neuron death N -nitro-L -arginine methyl
17634371	NGF	NGF-induced	1.2	a specific inhibitor of the neuronal isoform of NOS prevented NGF-induced apoptosis in SOD1 motor neurons ( Fig 3 E
17634371	NGF	NGF	1.2	These results indicate that the apoptotic pathway induced by NGF in SOD1 motor neurons required endogenous nitric oxide production by
17634371	NGF	NGF	1.2	The increased sensitivity of SOD1 motor neurons to NGF could not be explained by differential expression of p75 or
17634371	NGF	NGF	1.2	n M increased the sensitivity of nontransgenic motor neurons to NGF ( Fig 5 A
17634371	NGF	NGF-induced	1.2	Nontransgenic motor neurons previously exposed to BSO were sensitive to NGF-induced apoptosis even in the absence of DETA-NONOate ( Fig 5
17634371	NGF	NGF	1.2	et al. 2002 completely prevented motor neuron death induced by NGF in the presence of NO ( Fig 5 B
17634371	NGF	NGF-induced	1.2	Nrf2 activation by tBHQ also prevented NGF-induced apoptosis in SOD1 motor neurons ( Fig 6 A
10077670	nerve growth factor	nerve growth factor	1.0	als amyotrophic lateral sclerosis sod cu/zn superoxide dismutase 1 fals familial als cyp cyclophilin wt wild type ngf nerve growth factor adv adenovirus csa cyclosporin a nmda n methyl d aspartate mptp mitochondrial permeability transition pore
10077670	nerve growth factor	nerve growth factor	1.0	it recently has been reported that the expression of fals associated mutant sod in nerve growth factor ngf differentiated pc12 cells primary sympathetic neurons and hippocampal neurons leads to altered o 2 content and an apoptotic cell death 12 .
12901835	nerve growth factor	nerve growth factor	1.0	this is in line with the recent report [ lee et al 2002 ] that aggregation of fals sod1 is not causative of death in nerve growth factor ngf differentiated pc12 cells transfected with mutant sod1s sodmt v148g or a4v .
17105868	nerve growth factor	nerve growth factor	1.0	the neurotrophins nerve growth factor brain derived neurotrophic factor neurotrophin 3 nt 3 and nt 4/5 promote neuronal survival by preventing programmed cell death or apoptosis but they markedly enhance necrotic degeneration of neurons
17634371	nerve growth factor	nerve growth factor	1.0	nerve growth factor ngf can induce apoptosis by signaling through the p75 neurotrophin receptor p75 in several nerve cell populations.
17634371	nerve growth factor	nerve growth factor	1.0	key words: amyotrophic lateral sclerosis; mitochondria; motor neurons; nerve growth factor; nrf2; p75 ; superoxide
17634371	nerve growth factor	nerve growth factor	1.0	nerve growth factor ngf has a key role on the development and function of the nervous system snider 1994 ; chao 2003 .
17634371	nerve growth factor	nerve growth factor	1.0	enzyme inhibitors|nf e2 related factor 2|nfe2l2 protein rat|nitric oxide donors|nitroso compounds|oligodeoxyribonucleotides antisense|reactive oxygen species|receptor nerve growth factor|2 2'|cytochromes c|nerve growth factor|sod1 g93a protein|superoxide dismutase|sphingomyelin phosphodiesterase|
17634371	nerve growth factor	nerve growth factor	1.0	|2 2'|cytochromes c|nerve growth factor|sod1 g93a protein|superoxide dismutase|sphingomyelin phosphodiesterase|
18210200	nerve growth factor	nerve growth factor	1.0	another study also suggested that cnts functionalized with growth factors such as nerve growth factor or brain derived neurotrophic factor can stimulate growth of neurons on the nanotube scaffold matsumoto et al 2007 .