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| 14511332 | COX-1 | COX-1 | 5.4 | two different isoforms of the cyclooxygenase (COX) COX enzyme namely COX-1 and COX-2 | |  |
| 14511332 | COX-1 | COX-1 | 5.4 | Therefore we investigated the expression of COX-1 and COX-2 in the spinal cord of seven human sporadic | | |
| 14511332 | COX-1 | COX-1 | 5.4 | In contrast COX-1 expression was predominantly confined to microglia and no apparent difference | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Currently two COX isoforms are known namely COX-1 and COX-2 ( Vane et al . 1998 | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Whereas COX-1 mainly subserves _amp_#8216 house-keeping_amp_#8217 functions COX-2 is the product of | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Therefore we compared the spinal expression of COX-1 and COX-2 in sALS and control patients by means of | | |
| 14511332 | COX-1 | COX-1 | 5.4 | COX-1 expression did not differ between sALS and control tissues | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Briefly goat polyclonal antisera raised against human COX-1 and COX-2 protein (Santa Santa Cruz Biotechnology Santa Cruz CA | | |
| 14511332 | COX-1 | COX-1 | 5.4 | To further differentiate the cellular distributions of COX-1 and COX-2 proteins a double staining procedure using a mouse | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Specimens were coded and assessed observer-blinded for presence of COX-1 and COX-2 immunoreactivity (IR) IR | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Membranes were probed with polyclonal goat antihuman COX-1 or COX-2 serum (diluted diluted 1 1000 followed by a | | |
| 14511332 | COX-1 | COX-1 | 5.4 | immunohistochemistry we performed Western blotting experiments for the detection of COX-1 and COX-2 protein with spinal protein extracts from human donors | | |
| 14511332 | COX-1 | COX-1 | 5.4 | cords (segments segments L1-L5 left lane run alongside purified sheep COX-1 protein (right right lane in a Western blot that has | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Western blot that has been incubated with the same polyclonal COX-1 antibody as that used for immunohistochemistry | | |
| 14511332 | COX-1 | COX-1 | 5.4 | 75 kDa consistent with the reported molecular mass of human COX-1 protein in the literature (74 74 kDa ( Vane et | | |
| 14511332 | COX-1 | COX-1 | 5.4 | the two COX isoforms we determined the specifity with purified COX-1 and COX-2 protein by Western blotting | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Figure 1C shows that the goat antihuman polyclonal COX-1 antibody exclusively detected COX-1 protein and not COX-2 protein | | |
| 14511332 | COX-1 | COX-1 | 5.4 | shows that the goat antihuman polyclonal COX-1 antibody exclusively detected COX-1 protein and not COX-2 protein | | |
| 14511332 | COX-1 | COX-1 | 5.4 | antihuman polyclonal COX-2 antibody detected only COX-2 protein and not COX-1 protein | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Expression of COX-1 protein was predominantly confined to some small cells with the | | |
| 14511332 | COX-1 | COX-1 | 5.4 | This could also be demonstrated by the costaining of COX-1 with the microglial marker MAC-1 ( Fig 2L | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Thirdly COX-1 expression was predominately confined to glial cells | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Furthermore no study has yet investigated the cellular expression of COX-1 in sALS | | |
| 14511332 | COX-1 | COX-1 | 5.4 | neurons and predominantly in astroglia although no apparent differences in COX-1 expression were seen between mSOD1 mice and controls | | |
| 14511332 | COX-1 | COX-1 | 5.4 | . 2003 and were shown to be specific for the COX-1 and COX-2 protein respectively | | |
| 14511332 | COX-1 | COX-1 | 5.4 | have intentionally focused on the in situ expression of both COX-1 and COX-2 proteins in human ALS spinal cords | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Expression of COX-1 protein | | |
| 14511332 | COX-1 | COX-1 | 5.4 | In contrast to the COX-2 protein COX-1 expression was predominantly found in microglia cells and showed no | | |
| 14511332 | COX-1 | COX-1 | 5.4 | Expression of COX-1 in microglia is consistent with our previous animal study and | | |
| 14511332 | COX-1 | COX-1 | 5.4 | (2001 2001 who reported a similar content of COX-1 mRNA in sALS and controls | | |
| 14511332 | COX-1 | COX-1 | 5.4 | The unaltered expression of COX-1 in sALS implies that there is no or only a | | |
| 14511332 | COX-1 | COX-1 | 5.4 | was detected between controls and sALS with regard to the COX-1 protein | | |
| 15081582 | COX-1 | COX-1 | 1.3 | There are two distinct COX isoenzymes known as COX-1 and COX-2 that are 65% homologous | | |
| 15081582 | COX-1 | COX-1 | 1.3 | COX-1 is constitutively expressed in most tissues and produces prostaglandins that | | |
| 15081582 | COX-1 | COX-1 | 1.3 | The COX enzymes (COX-1 COX-1 and COX-2 are more completely termed prostaglandin G/H G H | | |
| 15081582 | COX-1 | COX-1 | 1.3 | permit us to form a hypothesis regarding the roles of COX-1 and -2 under normal conditions and during disease | | |
| 15081582 | COX-1 | COX-1 | 1.3 | COX-1 is constitutively expressed throughout the normal brain ( Kawasaki et | | |
| 15081582 | COX-1 | COX-1 | 1.3 | is attenuated by a COX-2 inhibitor but not with a COX-1 selective inhibitor ( Hewett et al. 2000 | | |
| 15081582 | COX-1 | COX-1 | 1.3 | There is no correlate change in COX-1 mRNA | | |
| 15081582 | COX-1 | COX-1 | 1.3 | types in the CNS microglia appear to predominantly express the COX-1 isoform ( Yermakova et al. 1999 | | |
| 15081582 | COX-1 | COX-1 | 1.3 | In addition COX-1 positive microglia accumulate at sites of neuronal degeneration including traumatic | | |
| 15081582 | COX-1 | COX-1 | 1.3 | Although increased COX-1 in microglia is observed injury paradigms there are little data | | |
| 15081582 | COX-1 | COX-1 | 1.3 | in which the significance of the differential expression of the COX-1 and COX-2 isoforms may arise | | |
| 15081582 | COX-1 | COX-1 | 1.3 | Since COX-1 increases in activated microglia and is not regulated by NF-_amp_#x3ba | | |
| 15081582 | COX-1 | COX-1 | 1.3 | mSOD1 mice there is increased expression of COX-2 but not COX-1 mRNA | | |
| 15081582 | COX-1 | COX-1 | 1.3 | slowly in COX-2 inhibitor-treated animals possibly through the slower microglial COX-1 upregulation and likely through multiple additional regulatory mechanisms | | |
| 15453089 | COX-1 | COX-1 | 2.3 | Besides a constitutive isoform (COX-1), COX-1 which is widely distributed in virtually all cell types and | | |
| 15453089 | COX-1 | COX-1 | 2.3 | COX-1 and COX-2 are coded by 2 distinct genes located on | | |
| 15453089 | COX-1 | COX-1 | 2.3 | On the contrary the COX-1 gene represents a classical _amp_#147 housekeeping_amp_#148 gene lacking of a | | |
| 15453089 | COX-1 | COX-1 | 2.3 | 2 isoenzymes which could account for the different sensitivities of COX-1 and COX-2 to specific inhibitors ( 5 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | insert near the COX-2 C-terminus which is not present in COX-1 and has allowed the production of specific antibodies | | |
| 15453089 | COX-1 | COX-1 | 2.3 | In the majority of the tissues COX-1 appears to be the only isoform constitutively expressed confirming the | | |
| 15453089 | COX-1 | COX-1 | 2.3 | However in brain testes and kidney macula densa cells both COX-1 and COX-2 are expressed under physiological conditions ( 2 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | In rat brain COX-1 and COX-2 immunoreactivities are present in discrete neuronal populations distributed | | |
| 15453089 | COX-1 | COX-1 | 2.3 | In other regions such as midbrain pons and medulla COX-1 immunoreactivity prevails ( 6 7 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | Similarly mRNAs for both COX-1 and COX-2 are present in several regions of human brain | | |
| 15453089 | COX-1 | COX-1 | 2.3 | The relative contribution of COX-1 and COX-2 activity to brain pathology and physiology has been | | |
| 15453089 | COX-1 | COX-1 | 2.3 | On one side it has been argued that COX-1 activity in brain diseases has been overlooked on the other | | |
| 15453089 | COX-1 | COX-1 | 2.3 | studies it is clear that the popular paradigm by which COX-1 serves physiological functions and COX-2 is responsible for _amp_#147 pathological_amp_#148 | | |
| 15453089 | COX3 | COX-3 | 0.3 | Recently a third variant of COX named COX-3 and 2 partial COX-1 proteins (PCOX-1 PCOX-1 proteins have been | | |
| 15453089 | COX-1 | COX-1 | 2.3 | a third variant of COX named COX-3 and 2 partial COX-1 proteins (PCOX-1 PCOX-1 proteins have been identified from canine and | | |
| 15453089 | PCOX1 | PCOX-1 | 0.8 | of COX named COX-3 and 2 partial COX-1 proteins (PCOX-1 PCOX-1 proteins have been identified from canine and human cerebral cortex | | |
| 15453089 | COX3 | COX-3 | 0.3 | COX-3 and one of the PCOX-1 are products of the COX-1 | | |
| 15453089 | PCOX1 | PCOX-1 | 0.8 | COX-3 and one of the PCOX-1 are products of the COX-1 gene but retain intron 1 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | COX-3 and one of the PCOX-1 are products of the COX-1 gene but retain intron 1 in their mRNA | | |
| 15453089 | COX-1 | COX-1 | 2.3 | in the in cerebral cortex where the expression of the COX-1 variant gene accounts for ~5_amp_#37 of COX-1 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | expression of the COX-1 variant gene accounts for ~5_amp_#37 of COX-1 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | As its counterpart COX-1 COX-3 is not induced by acute inflammatory stimulation ( 13 | | |
| 15453089 | COX3 | COX-3 | 0.3 | As its counterpart COX-1 COX-3 is not induced by acute inflammatory stimulation ( 13 | | |
| 15453089 | COX3 | COX-3 | 0.3 | COX-3 but not PCOX-1 exhibits enzymatic activity that is glycosylation-dependent and | | |
| 15453089 | PCOX1 | PCOX-1 | 0.8 | COX-3 but not PCOX-1 exhibits enzymatic activity that is glycosylation-dependent and especially sensitive to | | |
| 15453089 | COX3 | COX-3 | 0.3 | Thus COX-3 could represent the brain-specific COX isoform the existence of which | | |
| 15453089 | COX3 | COX-3 | 0.3 | Nonetheless the functional role of COX-3 is largely unknown and more intense research is required to | | |
| 15453089 | COX3 | COX-3 | 0.3 | more intense research is required to elucidate the contribution of COX-3 to the overall PG production in brain | | |
| 15453089 | COX-1 | COX-1 | 2.3 | first post-natal week showed decreased levels of COX-2 but not COX-1 in the hippocampus at adulthood | | |
| 15453089 | COX-1 | COX-1 | 2.3 | COX-2 inhibitors but not COX-1 selective inhibitors administered systemically shortly after training in the Morris | | |
| 15453089 | COX-1 | COX-1 | 2.3 | formed during the enzymatic activity of COX-2 rather than of COX-1 could participate to synaptic plasticity through several mechanisms including modulation | | |
| 15453089 | COX-1 | COX-1 | 2.3 | In addition significant compensatory effects of COX-1 and possibly COX-3 cannot be ruled out | | |
| 15453089 | COX3 | COX-3 | 0.3 | In addition significant compensatory effects of COX-1 and possibly COX-3 cannot be ruled out | | |
| 15453089 | COX-1 | COX-1 | 2.3 | Macrophage/ Macrophage microglia-like cells expressing COX-1 were disseminated throughout the brain parenchyma of control animals | | |
| 15453089 | COX | COX-1-positive | 0.0 | In EAE the number of COX-1-positive macrophages increased along with that of COX-2-positive cells | Junguk Hur | |
| 15453089 | COX-1 | COX-1 | 2.3 | In contrast COX-1 immunoreactivity was confined to some microglial cells and there was | | |
| 15453089 | COX-1 | COX-1 | 2.3 | Moderate COX-1 immunoreactivity was observed in some neuronal somata and processes and | | |
| 15453089 | COX-1 | COX-1 | 2.3 | that MPTP neurodegeneration was mitigated in COX-2 but not in COX-1 knock out mice | | |
| 15453089 | COX | COX-1-positive | 0.0 | Few scattered COX-1-positive microglia-like cells were found in control and infected brains ( | Junguk Hur | |
| 15453089 | COX-1 | COX-1 | 2.3 | results were reported in a recent study in which both COX-1 and COX-2 were increased in sporadic CJD cortex ( 58 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | COX-1 immunoreactivity was present in macrophages/microglial macrophages microglial cells whereas COX-2 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | in neuroblastoma cells PrP peptides increase PGE 2 levels and COX-1 inhibitors protect against PrP toxicity ( 62 | | |
| 15453089 | COX-1 | COX-1 | 2.3 | Over the last 10 years several analyses of COX-1 and COX-2 expressions have been carried out in animal models | | |
| 15453089 | COX-1 | COX-1 | 2.3 | In contrast to COX-2 the levels of COX-1 mRNA and protein were not significantly altered in AD brains | | |
| 15453089 | COX-1 | COX-1 | 2.3 | COX-1 appeared to be mainly expressed by microglial cells found in | | |
| 16101543 | COX-1 | COX-1 | 0.3 | by two isoforms of the cyclooxygenase (COX) COX enzyme namely COX-1 and COX-2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Three forms of COX enzymes designated as COX-1 COX-2 and COX-3 occur in mammalian tissues | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 is a constitutively expressed in brain tissue and is responsible | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 and COX-2 are homodimers | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 contains Val at the 434 and 523 positions whereas COX-2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | flexible substrate and inhibitor binding sites in COX-2 than in COX-1 ( Kurumbail et al. 1996 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The amino acid sequences of COX-1 and COX-2 also differ from each other at the N- | | |
| 16647138 | COX-1 | COX-1 | 4.9 | of COX-2 is larger and more accommodating than that of COX-1 and COX-1 displays negative allosterism at low concentrations of AA | | |
| 16647138 | COX-1 | COX-1 | 4.9 | of COX-2 is larger and more accommodating than that of COX-1 and COX-1 displays negative allosterism at low concentrations of AA | | |
| 16647138 | COX-1 | COX-1 | 4.9 | is larger and more accommodating than that of COX-1 and COX-1 displays negative allosterism at low concentrations of AA | | |
| 16647138 | COX-1 | COX-1 | 4.9 | AA is the preferred substrate for COX-1 and COX-2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The COX-2 gene is 8.3 kb whereas the COX-1 gene is much larger (22 22 kb ( Vane et | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 mRNA is approximately 2.8 kb while COX-2 mRNA is approximately | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Analysis of the 5_amp_#x2032 -flanking untranslated regions of COX-1 and COX-2 indicates that the COX-1 gene is associated with | | |
| 16647138 | COX-1 | COX-1 | 4.9 | -flanking untranslated regions of COX-1 and COX-2 indicates that the COX-1 gene is associated with housekeeping activities whereas the COX-2 gene | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Tazawa et al. 1994 whereas the same region in the COX-1 gene has no canonic TATA box ( Wu 1995 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The COX-1 gene also has some putative regulatory sites such as Sp-1 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 does not respond to NF-_amp_#x3ba B as intensely as COX-2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | In rat and ovine brain COX-1 and COX-2 immunoreactivities are present in discrete neuronal populations distributed | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 immunoreactivity is enriched in midbrain pons and medulla ( Breder | | |
| 16647138 | COX-1 | COX-1 | 4.9 | different pharmacological properties have been described for COX-3 compared with COX-1 or COX-2 enzymes many investigators consider it to be a | | |
| 16647138 | COX-1 | COX-1 | 4.9 | many investigators consider it to be a splice variant of COX-1 ( Chandrasekharan et al. 2002 and Davies et al. 2004 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Thus COX-3 is a product of the COX-1 gene but retains intron 1 in its mRNA | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Comparison of canine COX-3 activity with murine COX-1 and COX-2 demonstrates that analgesic/antipyretic analgesic antipyretic drugs such as | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Sequence analysis indicated that the 98-base-pair intron 1 of COX-1 gene remains unprocessed in COX-3 inducing a frameshift mutation and | | |
| 16647138 | COX-1 | COX-1 | 4.9 | of affecting the cerebral circulation in a comparable manner to COX-1 and 2 pathways | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 and COX-2 play a central role in the induction of | | |
| 16647138 | COX-1 | COX-1 | 4.9 | the most abundant prostaglandins generated in the brain through COX-1/COX-2 COX-1 COX-2 pathways (PGE PGE 2 PGF 2a and PGD 2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | s and both the non-selective inhibitor indomethacin and the selective COX-1 inhibitor SC-560 reduced photolysis-induced hyperemia | | |
| 16647138 | COX-1 | COX-1 | 4.9 | not play a significant role in vasodilation as compared to COX-1 metabolites | | |
| 16647138 | COX-1 | COX-1 | 4.9 | (2006) 2006 observed dense immunohistochemical staining for COX-1 but not COX-2 in the astrocytic endfeet that ensheath cortical | | |
| 16647138 | COX-1 | COX-1 | 4.9 | that is initiated by neural activity using a mechanism involving COX-1 metabolites | | |
| 16647138 | COX-1 | COX-1 | 4.9 | of long-term potentiation in hippocampal dentate granule neurons whereas a COX-1 inhibitor was not effective ( Chen et al. 2002 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | is a profound difference between NSAIDs with different selectivities for COX-1 and COX-2 with regard to their effects on the synthesis | | |
| 16647138 | COX-1 | COX-1 | 4.9 | NSAIDs displaying an inhibitory action on COX-1 increased brain KYNA formation whereas COX-2 selective inhibitors had the | | |
| 16647138 | COX-1 | COX-1 | 4.9 | acid formation induced by NSAIDs displaying an inhibitory action on COX-1 could possibly contribute to a reduction in glutamatergic transmission along | | |
| 16647138 | COX-1 | COX-1 | 4.9 | because of the well-known analgesic and temperature-reducing effects of COX-1/-2 COX-1 -2 inhibitors on patients experiencing these conditions | | |
| 16647138 | COX-1 | COX-1 | 4.9 | has allowed investigators to study the individual roles of the COX-1 and COX-2 isoforms | | |
| 16647138 | COX-1 | COX-1 | 4.9 | At 30 to 40 min after IL-1_amp_#x3b2 COX-1 KO mice showed a smaller reduction in milk intake in | | |
| 16647138 | COX-1 | COX-1 | 4.9 | IL-1_amp_#x3b2 administration COX-2 KO mice showed only small responses while COX-1 KO mice responded normally | | |
| 16647138 | COX-1 | COX-1 | 4.9 | This result suggests that while COX-1 is primarily involved in the early phase of milk intake | | |
| 16647138 | COX-1 | COX-1 | 4.9 | assessed the febrile response to injection of intraperitoneal LPS in COX-1 and COX-2-deficient mice | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The wild-type and COX-1 _amp_#x2212;/_amp_#x2212; _amp_#x2212 _amp_#x2212 mice responded to LPS with a 1_amp_#xb0 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | A persistent accumulation of microglial cells and macrophages expressing COX-1 was also observed in human and rat traumatic brain injuries | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Studies on COX-1 and COX-2 gene deletion provided some information on the roles | | |
| 16647138 | COX-1 | COX-1 | 4.9 | were not able to confirm the harmful effect of losing COX-1 activity in a permanent endovascular middle cerebral artery occlusion (MCAO) | | |
| 16647138 | COX-1 | COX-1 | 4.9 | PLA 2 activation may be converted to prostaglandins by both COX-1 and COX-2 during the immediate response and predominantly by COX-2 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | 2000 and is functionally coupled with COX-2 but not with COX-1 ( Balsinde et al. 1998 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | In another human study COX-1 expressed intensely in microglia but weakly in neurons in control | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Pretreatment with indomethacin an inhibitor of COX-1 and COX-2 reduced infarct size following focal ischemia with reperfusion | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Ibuprofen which also inhibits both COX-1 and COX-2 reduced neuronal injury and improved cerebral blood flow | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Selective inhibition of COX-1 by valerylsalicylate or of COX-2 by rofecoxib was used to | | |
| 16647138 | COX-1 | COX-1 | 4.9 | suppresses COX-2 at low nanomolar levels but does not affect COX-1 | | |
| 16647138 | COX-1 | COX-1 | 4.9 | blocked by the infusion of NMDA antagonists as well as COX-1 and COX-2 inhibitors indicating that both COX-1 and COX-2 contribute | | |
| 16647138 | COX-1 | COX-1 | 4.9 | as well as COX-1 and COX-2 inhibitors indicating that both COX-1 and COX-2 contribute to the prostaglandin synthesis and oxidative damage | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Induction of COX-2 but not COX-1 gene expression has been demonstrated to precede apoptosis in the | | |
| 16647138 | COX-1 | COX-1 | 4.9 | A marked increase of COX-1 and COX-2 expression and immunoreactivity in cerebral cortex and hippocampal | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The neuroprotective effects of COX-1 and COX-2 inhibitors (NSAID) NSAID strongly support the view that | | |
| 16647138 | COX-1 | COX-1 | 4.9 | The molecular mechanism by which COX-1 and COX-2 promote amyloidogenic accumulation of _amp_#x3b2 -amyloid peptide is | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-1 and COX-2 potentiate _amp_#x3b2 -amyloid peptide generation through mechanisms that | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Using RT-PCR and Western blotting both COX-1 and COX-2 are significantly increased in brains from CJD patients | | |
| 16647138 | COX-1 | COX-1 | 4.9 | and in brain homogenates of scrapie-infected mice the upregulation of COX-1 and COX-2 is accompanied by a several-fold increase in concentrations | | |
| 16647138 | COX-1 | COX-1 | 4.9 | In contrast indomethacin a COX-1 and COX-2 inhibitor and baicalein a 12-LOX inhibitor do not | | |
| 16647138 | COX-1 | COX-1 | 4.9 | In astrocytes TGF_amp_#x3b2 1 upregulates COX-1 expression and serum increases COX-2 expression | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Neither TGF_amp_#x3b2 1 nor serum affects COX-1 and COX-2 expression in neurons | | |
| 16647138 | COX-1 | COX-1 | 4.9 | Furthermore COX-1 compensates for the loss of COX-2 in the COX-2 knockout | | |
| 16647138 | COX-1 | COX-1 | 4.9 | COX-2 _amp_#x2212;/_amp_#x2212; _amp_#x2212 _amp_#x2212 shows a compensatory increase in brain COX-1 expression and activity (with with exogenous arachidonic acid in brain | | |
| 17574754 | COX-1 | COX-1 | 0.0 | signaling molecules derived from the metabolism of arachidonic acid by COX-1 and the inducible COX-2 | | |
| 18040778 | COX-1 | COX-1 | 0.1 | Hypothetically by inhibiting microglial cell cyclooxygenases (COX-1 COX-1 or COX-2 the metabolism of arachadonic acid is curtailed and | | |