HUGO ID Detailed Result 5962

HUGO ID 5962
Symbol IL10
Name interleukin 10
#Occurrence 40
#Paper 9

 

PMID Match String Actual String Score Flanking text Edited by Edit
7836946IL-10IL-102.3Intrathecal synthesis of interleukin-10 (IL-10) IL-10 in viral and inflammatory diseases of the central nervous system 
7836946IL-10IL-102.3The intrathecal synthesis of interleukin 10 (IL-10) IL-10 was investigated in 120 paired cerebrospinal fluid (CSF) CSF and 
7836946IL-10IL-102.3IL-10 was not demonstrated in the sera but detectable levels were 
7836946IL-10IL-102.3CNS and a patient with encephalomeningeal sarcoidosis (in in whom IL-10 was demonstrated in all CSF collected over a period of 
7836946IL-10IL-102.3In chronic meningeal infections/inflammations, infections inflammations IL-10 seems to be continuously produced within the CSF 
7836946IL-10IL-102.3Our findings suggest that IL-10 a cytokine which exerts many immunosuppressive actions may play different 
15081582IL-10IL-101.3by factors that inhibit NF-_amp_#x3ba B activity such as IL-4 IL-10 and IL-13 and glucocorticoids ( O'Banion 1999 (see see Table 
16510725IL-10IL-101.3No changes were detected in IL-12p35 IL-10 IL-18 IFN gamma or IFN beta IL-6 TGF-beta3 and LT 
16647138IL-10IL-101.3Thus factors that inhibit NF-_amp_#x3ba B activity such as IL-4 IL-10 and IL-13 can specifically inhibit COX-2 upregulation 
16753239IL-10IL-101.0Additionally this agonist suppressed IFN-_amp_#x3b3 IL-10 and IL-4 production by activated lymphocytes ( Diab et al. 
17018025IL-10IL-101.3Besides IL-4 IL-10 and transforming growth factor-beta (TGF-B) TGF-B are two other major 
17018025IL-10IL-101.3We had detected the effects of IL-10 and TGF-B in our MN Mc coculture system as well 
17018025IL-10IL-101.3found that IL-4 had stronger protective effects on motoneurons than IL-10 
17018025IL-10IL-101.3Like IL-4 IL-10 inhibited iNOS expression and nitric oxide production from microglia (data 
17018025IL-10IL-101.3However IL-10 increased microglial release and also decreased rather than increased IGF-1 
17018025IL-10IL-101.3Further studies are clearly necessary to define the mechanism of IL-10 effects 
17569578IL-10IL-101.3PPAR_amp_#x3b3 ligand 15d-PGJ 2 inhibited T-cell proliferation and suppressed IFN_amp_#x3b3 IL-10 and IL-4 generation by activated lymphocytes 53 
17582695IL-10IL-101.01 25-dihydroxyvitamin D(3) D 3 may protect against MS via IL-10 11 a cytokine associated with VN activity in inflammatory contexts 
18040778IL-10IL-101.3infection there is a lasting inhibition of both IL-1 and IL-10 production (Curto Curto et al. 2004 
7836946il 10il 101.0intrathecal synthesis of interleukin 10 il 10 in viral and inflammatory diseases of the central nervous system.  
7836946interleukin 10interleukin 101.0intrathecal synthesis of interleukin 10 il 10 in viral and inflammatory diseases of the central nervous system.  
7836946il 10il 101.0the intrathecal synthesis of interleukin 10 il 10 was investigated in 120 paired cerebrospinal fluid csf and serum specimens from patients with various inflammatory and non inflammatory diseases of the central nervous system cns .  
7836946interleukin 10interleukin 101.0the intrathecal synthesis of interleukin 10 il 10 was investigated in 120 paired cerebrospinal fluid csf and serum specimens from patients with various inflammatory and non inflammatory diseases of the central nervous system cns .  
7836946il 10il 101.0il 10 was not demonstrated in the sera but detectable levels were found in the csf from: patients with acute viral "aseptic" meningitis but only within 48 72 h of symptom onset; human immunodeficiency viru 
7836946il 10il 101.0cted patients with hiv related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary b cell lymphoma of the cns and a patient with encephalomeningeal sarcoidosis in whom il 10 was demonstrated in all csf collected over a period of 6 months .  
7836946il 10il 101.0in chronic meningeal infections/inflammations il 10 seems to be continuously produced within the csf.  
7836946il 10il 101.0our findings suggest that il 10 a cytokine which exerts many immunosuppressive actions may play different immunomodulatory roles in cns diseases; in particular its intrathecal synthesis may explain why some infectious and inflammat 
15081582il 10il 101.0specific inhibition of cox 2 upregulation can be achieved by factors that inhibit nf _amp_#x3ba;b activity such as il 4 il 10 and il 13 and glucocorticoids o'banion 1999 see table 1 .  
16510725il 10il 101.0no changes were detected in il 12p35 il 10 il 18 ifn gamma or ifn beta il 6 tgf beta3 and lt alpha or lt beta data not shown .  
16647138il 10il 101.0thus factors that inhibit nf _amp_#x3ba;b activity such as il 4 il 10 and il 13 can specifically inhibit cox 2 upregulation.  
16753239il 10il 101.0additionally this agonist suppressed ifn _amp_#x3b3; il 10 and il 4 production by activated lymphocytes diab et al. 2002 .  
17018025il 10il 101.0besides il 4 il 10 and transforming growth factor beta tgf b are two other major anti inflammatory cytokines.  
17018025il 10il 101.0we had detected the effects of il 10 and tgf b in our mn + mc coculture system as well as il 4.  
17018025il 10il 101.0we found that il 4 had stronger protective effects on motoneurons than il 10.  
17018025il 10il 101.0like il 4 il 10 inhibited inos expression and nitric oxide production from microglia data not shown .  
17018025il 10il 101.0however il 10 increased microglial release and also decreased rather than increased igf 1 release from microglia data not shown .  
17018025il 10il 101.0further studies are clearly necessary to define the mechanism of il 10 effects.  
17569578il 10il 101.0c implication of this finding was further supported by a study of diab et al. showing that the endogenous ppar_amp_#x3b3; ligand 15d pgj 2 inhibited t cell proliferation and suppressed ifn_amp_#x3b3; il 10 and il 4 generation by activated lymphocytes [53] .  
17582695il 10il 101.0importantly vitamin d 3 and 1 25 dihydroxyvitamin d 3 may protect against ms via il 10 [11] a cytokine associated with vn activity in inflammatory contexts [12] .  
18040778il 10il 101.0trated that human microglia are more efficient at ingesting m. tuberculosis than virulent and avirulent strains of m. avium and that following infection there is a lasting inhibition of both il 1 and il 10 production curto et al. 2004 .