)| PMID |
7836946 ( ) |
|---|---|
| Title | Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. |
| Abstract | The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and serum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 5962 | IL10 | interleukin 10 | 14 | interleukin 10 | IL-10 | il 10 | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | Intrathecal synthesis of interleukin-10 (IL-10) IL-10 in viral and inflammatory diseases of the central nervous system |
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | The intrathecal synthesis of interleukin 10 (IL-10) IL-10 was investigated in 120 paired cerebrospinal fluid (CSF) CSF and |
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | IL-10 was not demonstrated in the sera but detectable levels were |
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | CNS and a patient with encephalomeningeal sarcoidosis (in in whom IL-10 was demonstrated in all CSF collected over a period of |
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | In chronic meningeal infections/inflammations, infections inflammations IL-10 seems to be continuously produced within the CSF |
| 5962 | IL10 | interleukin 10 | IL-10 | 2.3 | Our findings suggest that IL-10 a cytokine which exerts many immunosuppressive actions may play different |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | intrathecal synthesis of interleukin 10 il 10 in viral and inflammatory diseases of the central nervous system. |
| 5962 | IL10 | interleukin 10 | interleukin 10 | 1.0 | intrathecal synthesis of interleukin 10 il 10 in viral and inflammatory diseases of the central nervous system. |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | the intrathecal synthesis of interleukin 10 il 10 was investigated in 120 paired cerebrospinal fluid csf and serum specimens from patients with various inflammatory and non inflammatory diseases of the central nervous system cns . |
| 5962 | IL10 | interleukin 10 | interleukin 10 | 1.0 | the intrathecal synthesis of interleukin 10 il 10 was investigated in 120 paired cerebrospinal fluid csf and serum specimens from patients with various inflammatory and non inflammatory diseases of the central nervous system cns . |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | il 10 was not demonstrated in the sera but detectable levels were found in the csf from: patients with acute viral "aseptic" meningitis but only within 48 72 h of symptom onset; human immunodeficiency viru |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | cted patients with hiv related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary b cell lymphoma of the cns and a patient with encephalomeningeal sarcoidosis in whom il 10 was demonstrated in all csf collected over a period of 6 months . |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | in chronic meningeal infections/inflammations il 10 seems to be continuously produced within the csf. |
| 5962 | IL10 | interleukin 10 | il 10 | 1.0 | our findings suggest that il 10 a cytokine which exerts many immunosuppressive actions may play different immunomodulatory roles in cns diseases; in particular its intrathecal synthesis may explain why some infectious and inflammat |