SciMiner Pathway Enrichment Full Result

SciMiner Pathway Enrichment Full Result

Full Enrichment Result Pathways (sorted by p-value)

# of targets in test set	1026	# of targets in background set	25254	Switch table detail

Rank	PathwayID	Title	t+	t-	b+	b-	p-value	t-ratio	b-ratio	enrichment folds
1	hsa04510	Focal adhesion - Homo sapiens (human)	75	951	197	25057	2.36e-42	0.07	0.01	9.4
2	hsa04210	Apoptosis - Homo sapiens (human)	49	977	83	25171	6.68e-35	0.05	0.00	14.5
3	hsa04010	MAPK signaling pathway - Homo sapiens (human)	73	953	259	24995	4.29e-34	0.07	0.01	6.9
4	109582	Hemostasis	62	964	172	25082	4.54e-34	0.06	0.01	8.9
5	hsa05215	Prostate cancer - Homo sapiens (human)	49	977	93	25161	3.78e-33	0.05	0.00	13.0
6	hsa04920	Adipocytokine signaling pathway - Homo sapiens (human)	45	981	72	25182	5.99e-33	0.04	0.00	15.4
7	hsa04910	Insulin signaling pathway - Homo sapiens (human)	53	973	137	25117	1.68e-30	0.05	0.01	9.5
8	hsa05212	Pancreatic cancer - Homo sapiens (human)	42	984	74	25180	1.42e-29	0.04	0.00	14.0
9	168256	Signaling in Immune system	72	954	312	24942	5.52e-29	0.07	0.01	5.7
10	hsa05222	Small cell lung cancer - Homo sapiens (human)	43	983	87	25167	2.28e-28	0.04	0.00	12.2
11	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)	41	985	77	25177	4.46e-28	0.04	0.00	13.1
12	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)	46	980	120	25134	1.69e-26	0.04	0.00	9.4
13	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)	43	983	102	25152	3.55e-26	0.04	0.00	10.4
14	166520	Signalling by NGF	46	980	125	25129	6.86e-26	0.04	0.00	9.1
15	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)	61	965	255	24999	2.02e-25	0.06	0.01	5.9
16	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)	56	970	214	25040	4.73e-25	0.05	0.01	6.4
17	hsa04012	ErbB signaling pathway - Homo sapiens (human)	39	987	87	25167	1.24e-24	0.04	0.00	11.0
18	187037	TRKA signalling from the plasma membrane	36	990	75	25179	1.25e-23	0.04	0.00	11.8
19	hsa05214	Glioma - Homo sapiens (human)	34	992	65	25189	2.56e-23	0.03	0.00	12.9
20	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)	34	992	75	25179	9.06e-22	0.03	0.00	11.2
21	hsa03320	PPAR signaling pathway - Homo sapiens (human)	32	994	69	25185	8.40e-21	0.03	0.00	11.4
22	hsa05210	Colorectal cancer - Homo sapiens (human)	34	992	84	25170	1.57e-20	0.03	0.00	10.0
23	hsa05221	Acute myeloid leukemia - Homo sapiens (human)	29	997	57	25197	7.79e-20	0.03	0.00	12.5
24	hsa04630	Jak-STAT signaling pathway - Homo sapiens (human)	42	984	153	25101	9.33e-20	0.04	0.01	6.8
25	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)	34	992	92	25162	1.57e-19	0.03	0.00	9.1
26	hsa05218	Melanoma - Homo sapiens (human)	31	995	72	25182	1.86e-19	0.03	0.00	10.6
27	hsa04640	Hematopoietic cell lineage - Homo sapiens (human)	33	993	88	25166	3.75e-19	0.03	0.00	9.2
28	hsa05120	Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)	30	996	68	25186	4.15e-19	0.03	0.00	10.9
29	hsa05211	Renal cell carcinoma - Homo sapiens (human)	30	996	69	25185	5.74e-19	0.03	0.00	10.7
30	hsa04370	VEGF signaling pathway - Homo sapiens (human)	30	996	70	25184	7.90e-19	0.03	0.00	10.5
31	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)	38	988	130	25124	8.91e-19	0.04	0.01	7.2
32	hsa05223	Non-small cell lung cancer - Homo sapiens (human)	27	999	54	25200	2.06e-18	0.03	0.00	12.3
33	hsa04912	GnRH signaling pathway - Homo sapiens (human)	33	993	97	25157	4.13e-18	0.03	0.00	8.4
34	109581	Apoptosis	29	997	69	25185	4.58e-18	0.03	0.00	10.3
35	hsa04930	Type II diabetes mellitus - Homo sapiens (human)	24	1002	45	25209	5.21e-17	0.02	0.00	13.1
36	hsa05219	Bladder cancer - Homo sapiens (human)	23	1003	41	25213	1.01e-16	0.02	0.00	13.8
37	198203	PI3K/AKT signalling	20	1006	31	25223	1.39e-15	0.02	0.00	15.9
38	hsa04520	Adherens junction - Homo sapiens (human)	27	999	76	25178	1.89e-15	0.03	0.00	8.7
39	73923	Lipid and lipoprotein metabolism	36	990	156	25098	4.05e-15	0.04	0.01	5.7
40	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)	24	1002	63	25191	1.98e-14	0.02	0.00	9.4
41	hsa00010	Glycolysis / Gluconeogenesis - Homo sapiens (human)	24	1002	64	25190	2.63e-14	0.02	0.00	9.2
42	71387	Metabolism of carbohydrates	28	998	95	25159	2.83e-14	0.03	0.00	7.3
43	hsa05213	Endometrial cancer - Homo sapiens (human)	22	1004	52	25202	4.37e-14	0.02	0.00	10.4
44	163685	Integration of energy metabolism	24	1002	69	25185	1.01e-13	0.02	0.00	8.6
45	71406	Pyruvate metabolism and TCA cycle	17	1009	25	25229	1.01e-13	0.02	0.00	16.7
46	hsa00020	Citrate cycle (TCA cycle) - Homo sapiens (human)	17	1009	27	25227	2.53e-13	0.02	0.00	15.5
47	hsa04115	p53 signaling pathway - Homo sapiens (human)	23	1003	66	25188	3.18e-13	0.02	0.00	8.6
48	hsa00590	Arachidonic acid metabolism - Homo sapiens (human)	21	1005	53	25201	4.58e-13	0.02	0.00	9.8
49	75178	Formation of Platelet plug	23	1003	69	25185	6.82e-13	0.02	0.00	8.2
50	202733	Cell surface interactions at the vascular wall	23	1003	70	25184	8.74e-13	0.02	0.00	8.1
51	hsa04540	Gap junction - Homo sapiens (human)	26	1000	95	25159	9.87e-13	0.03	0.00	6.7
52	hsa04080	Neuroactive ligand-receptor interaction - Homo sapiens (human)	45	981	302	24952	1.78e-12	0.04	0.01	3.7
53	hsa04020	Calcium signaling pathway - Homo sapiens (human)	34	992	176	25078	1.90e-12	0.03	0.01	4.8
54	hsa01510	Neurodegenerative Diseases - Homo sapiens (human)	18	1008	39	25215	2.82e-12	0.02	0.00	11.4
55	71291	Metabolism of amino acids	25	1001	92	25162	3.08e-12	0.02	0.00	6.7
56	74752	Signaling by Insulin receptor	18	1008	43	25211	1.03e-11	0.02	0.00	10.3
57	hsa04150	mTOR signaling pathway - Homo sapiens (human)	18	1008	47	25207	3.37e-11	0.02	0.00	9.4
58	hsa04916	Melanogenesis - Homo sapiens (human)	24	1002	101	25153	9.05e-11	0.02	0.00	5.8
59	140192	Metabolism of xenobiotics	23	1003	93	25161	1.13e-10	0.02	0.00	6.1
60	70326	Glucose metabolism	19	1007	60	25194	1.41e-10	0.02	0.00	7.8
61	hsa00480	Glutathione metabolism - Homo sapiens (human)	16	1010	39	25215	1.84e-10	0.02	0.00	10.1
62	hsa04110	Cell cycle - Homo sapiens (human)	25	1001	115	25139	1.88e-10	0.02	0.00	5.4
63	71403	Citric acid cycle (TCA cycle)	12	1014	16	25238	2.01e-10	0.01	0.00	18.5
64	71408	Metabolism of small molecules	21	1005	79	25175	2.35e-10	0.02	0.00	6.5
65	202403	TCR signaling	17	1009	47	25207	2.44e-10	0.02	0.00	8.9
66	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)	22	1004	89	25165	2.88e-10	0.02	0.00	6.1
67	77389	IRS-related events	15	1011	35	25219	4.21e-10	0.01	0.00	10.5
68	hsa00620	Pyruvate metabolism - Homo sapiens (human)	16	1010	42	25212	4.44e-10	0.02	0.00	9.4
69	74751	Insulin receptor signalling cascade	15	1011	36	25218	5.76e-10	0.01	0.00	10.3
70	hsa04730	Long-term depression - Homo sapiens (human)	20	1006	76	25178	7.30e-10	0.02	0.00	6.5
71	168898	Toll Receptor Cascades	16	1010	44	25210	7.72e-10	0.02	0.00	9.0
72	hsa04940	Type I diabetes mellitus - Homo sapiens (human)	16	1010	44	25210	7.72e-10	0.02	0.00	9.0
73	hsa04720	Long-term potentiation - Homo sapiens (human)	19	1007	68	25186	8.31e-10	0.02	0.00	6.9
74	202424	Downstream TCR signaling	15	1011	39	25215	1.40e-09	0.01	0.00	9.5
75	hsa00330	Arginine and proline metabolism - Homo sapiens (human)	14	1012	35	25219	3.30e-09	0.01	0.00	9.8
76	168249	Innate Immunity Signaling	17	1009	59	25195	4.35e-09	0.02	0.00	7.1
77	hsa00071	Fatty acid metabolism - Homo sapiens (human)	16	1010	51	25203	4.48e-09	0.02	0.00	7.7
78	hsa00251	Glutamate metabolism - Homo sapiens (human)	13	1013	31	25223	7.65e-09	0.01	0.00	10.3
79	112399	IRS-mediated signalling	13	1013	32	25222	1.04e-08	0.01	0.00	10.0
80	hsa04514	Cell adhesion molecules (CAMs) - Homo sapiens (human)	24	1002	133	25121	1.09e-08	0.02	0.01	4.4
81	hsa04310	Wnt signaling pathway - Homo sapiens (human)	25	1001	147	25107	1.54e-08	0.02	0.01	4.2
82	168164	Toll Like Receptor 3 (TLR3) Cascade	11	1015	21	25233	1.85e-08	0.01	0.00	12.9
83	70268	Cori Cycle (interconversion of glucose and lactate)	13	1013	34	25220	1.86e-08	0.01	0.00	9.4
84	76005	Response to elevated platelet cytosolic Ca++	15	1011	50	25204	2.24e-08	0.01	0.00	7.4
85	hsa04512	ECM-receptor interaction - Homo sapiens (human)	19	1007	86	25168	2.25e-08	0.02	0.00	5.4
86	hsa05010	Alzheimer's disease - Homo sapiens (human)	12	1014	28	25226	2.39e-08	0.01	0.00	10.5
87	168180	TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade	10	1016	18	25236	5.44e-08	0.01	0.00	13.7
88	177929	Signaling by EGFR	14	1012	46	25208	5.68e-08	0.01	0.00	7.5
89	109606	Intrinsic Pathway for Apoptosis	12	1014	31	25223	5.89e-08	0.01	0.00	9.5
90	hsa05216	Thyroid cancer - Homo sapiens (human)	12	1014	31	25223	5.89e-08	0.01	0.00	9.5
91	hsa05040	Huntington's disease - Homo sapiens (human)	12	1014	31	25223	5.89e-08	0.01	0.00	9.5
92	hsa00252	Alanine and aspartate metabolism - Homo sapiens (human)	12	1014	33	25221	1.03e-07	0.01	0.00	9.0
93	15869	Nucleotide metabolism	19	1007	99	25155	1.57e-07	0.02	0.00	4.7
94	hsa05130	Pathogenic Escherichia coli infection - EHEC - Homo sapiens (human)	14	1012	51	25203	1.66e-07	0.01	0.00	6.8
95	hsa05131	Pathogenic Escherichia coli infection - EPEC - Homo sapiens (human)	14	1012	51	25203	1.66e-07	0.01	0.00	6.8
96	163200	Electron Transport Chain	16	1010	70	25184	1.92e-07	0.02	0.00	5.6
97	73847	Purine metabolism	13	1013	44	25210	2.25e-07	0.01	0.00	7.3
98	70263	Gluconeogenesis	10	1016	22	25232	2.32e-07	0.01	0.00	11.2
99	hsa00710	Carbon fixation - Homo sapiens (human)	10	1016	23	25231	3.21e-07	0.01	0.00	10.7
100	hsa00650	Butanoate metabolism - Homo sapiens (human)	13	1013	46	25208	3.46e-07	0.01	0.00	7.0
101	114611	Exocytosis of Alpha granule	13	1013	46	25208	3.46e-07	0.01	0.00	7.0
102	114608	Platelet degranulation	13	1013	47	25207	4.26e-07	0.01	0.00	6.8
103	73887	Death Receptor Signalling	8	1018	12	25242	4.35e-07	0.01	0.00	16.4
104	109607	Extrinsic Pathway for Apoptosis	8	1018	12	25242	4.35e-07	0.01	0.00	16.4
105	140191	Phase 1 functionalization	10	1016	24	25230	4.39e-07	0.01	0.00	10.3
106	hsa04950	Maturity onset diabetes of the young - Homo sapiens (human)	10	1016	25	25229	5.94e-07	0.01	0.00	9.8
107	hsa05060	Prion disease - Homo sapiens (human)	8	1018	13	25241	6.79e-07	0.01	0.00	15.1
108	74231	Purine biosynthesis	10	1016	27	25227	1.05e-06	0.01	0.00	9.1
109	hsa04530	Tight junction - Homo sapiens (human)	20	1006	126	25128	1.09e-06	0.02	0.00	3.9
110	187687	Signalling to ERKs	11	1015	35	25219	1.16e-06	0.01	0.00	7.7
111	hsa00680	Methane metabolism - Homo sapiens (human)	7	1019	10	25244	1.87e-06	0.01	0.00	17.2
112	hsa00260	Glycine, serine and threonine metabolism - Homo sapiens (human)	12	1014	46	25208	2.00e-06	0.01	0.00	6.4
113	hsa00360	Phenylalanine metabolism - Homo sapiens (human)	10	1016	30	25224	2.30e-06	0.01	0.00	8.2
114	hsa04610	Complement and coagulation cascades - Homo sapiens (human)	14	1012	69	25185	3.76e-06	0.01	0.00	5.0
115	hsa00410	beta-Alanine metabolism - Homo sapiens (human)	9	1017	25	25229	4.42e-06	0.01	0.00	8.9
116	198323	AKT phosphorylates targets in the cytosol	7	1019	12	25242	4.52e-06	0.01	0.00	14.4
117	112412	SOS-mediated signalling	7	1019	12	25242	4.52e-06	0.01	0.00	14.4
118	111471	Apoptotic factor-mediated response	6	1020	7	25247	4.73e-06	0.01	0.00	21.1
119	167044	Signalling to RAS	9	1017	26	25228	5.74e-06	0.01	0.00	8.5
120	74226	ATP formation	8	1018	19	25235	6.01e-06	0.01	0.00	10.4
121	hsa05030	Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)	8	1018	19	25235	6.01e-06	0.01	0.00	10.4
122	hsa00280	Valine, leucine and isoleucine degradation - Homo sapiens (human)	11	1015	44	25210	7.53e-06	0.01	0.00	6.2
123	77388	SHC-related events	7	1019	14	25240	9.74e-06	0.01	0.00	12.3
124	hsa00190	Oxidative phosphorylation - Homo sapiens (human)	17	1009	113	25141	1.28e-05	0.02	0.00	3.7
125	210990	PECAM1 interactions	6	1020	9	25245	1.29e-05	0.01	0.00	16.4
126	198693	AKT phosphorylates targets in the nucleus	6	1020	9	25245	1.29e-05	0.01	0.00	16.4
127	hsa00930	Caprolactam degradation - Homo sapiens (human)	7	1019	15	25239	1.38e-05	0.01	0.00	11.5
128	hsa05050	Dentatorubropallidoluysian atrophy (DRPLA) - Homo sapiens (human)	7	1019	15	25239	1.38e-05	0.01	0.00	11.5
129	109704	PI3K Cascade	8	1018	22	25232	1.43e-05	0.01	0.00	9.0
130	hsa00561	Glycerolipid metabolism - Homo sapiens (human)	12	1014	59	25195	1.80e-05	0.01	0.00	5.0
131	70171	Glycolysis	8	1018	23	25231	1.86e-05	0.01	0.00	8.6
132	198725	Nuclear Events (kinase and transcription factor activation)	8	1018	23	25231	1.86e-05	0.01	0.00	8.6
133	170984	ARMS-mediated activation	7	1019	16	25238	1.92e-05	0.01	0.00	10.8
134	169893	Prolonged ERK activation events	7	1019	16	25238	1.92e-05	0.01	0.00	10.8
135	170968	Frs2-mediated activation	7	1019	16	25238	1.92e-05	0.01	0.00	10.8
136	hsa00350	Tyrosine metabolism - Homo sapiens (human)	12	1014	60	25194	2.08e-05	0.01	0.00	4.9
137	hsa00052	Galactose metabolism - Homo sapiens (human)	9	1017	33	25221	2.84e-05	0.01	0.00	6.7
138	hsa00640	Propanoate metabolism - Homo sapiens (human)	9	1017	33	25221	2.84e-05	0.01	0.00	6.7
139	hsa00720	Reductive carboxylate cycle (CO2 fixation) - Homo sapiens (human)	6	1020	11	25243	2.98e-05	0.01	0.00	13.4
140	77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	6	1020	11	25243	2.98e-05	0.01	0.00	13.4
141	198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	12	1014	63	25191	3.18e-05	0.01	0.00	4.7
142	111459	Activation of caspases through apoptosome-mediated cleavage	5	1021	6	25248	3.41e-05	0.00	0.00	20.5
143	75157	FasL/ CD95L signaling	5	1021	6	25248	3.41e-05	0.00	0.00	20.5
144	111461	Cytochrome c-mediated apoptotic response	5	1021	6	25248	3.41e-05	0.00	0.00	20.5
145	hsa00030	Pentose phosphate pathway - Homo sapiens (human)	8	1018	26	25228	3.86e-05	0.01	0.00	7.6
146	74749	Signal attenuation	6	1020	12	25242	4.33e-05	0.01	0.00	12.3
147	hsa04360	Axon guidance - Homo sapiens (human)	17	1009	127	25127	4.89e-05	0.02	0.01	3.3
148	hsa00940	Phenylpropanoid biosynthesis - Homo sapiens (human)	5	1021	7	25247	5.66e-05	0.00	0.00	17.6
149	140181	Cytochrome p450	6	1020	13	25241	6.11e-05	0.01	0.00	11.4
150	75153	Apoptotic execution phase	7	1019	21	25233	7.80e-05	0.01	0.00	8.2
151	111465	Cleavage of cellular proteins by active caspases	7	1019	21	25233	7.80e-05	0.01	0.00	8.2
152	77289	Mitochondrial Fatty Acid Beta-Oxidation	6	1020	14	25240	8.45e-05	0.01	0.00	10.5
153	hsa00310	Lysine degradation - Homo sapiens (human)	10	1016	49	25205	8.69e-05	0.01	0.00	5.0
154	140534	Caspase-8 is formed from procaspase-8	5	1021	8	25246	8.90e-05	0.00	0.00	15.4
155	180292	Gab1 signalosome	5	1021	8	25246	8.90e-05	0.00	0.00	15.4
156	75205	Dissolution of Fibrin Clot	5	1021	8	25246	8.90e-05	0.00	0.00	15.4
157	204174	Regulation of pyruvate dehydrogenase complex (PDC)	5	1021	8	25246	8.90e-05	0.00	0.00	15.4
158	69416	Activation of Pro-Caspase 8	5	1021	8	25246	8.90e-05	0.00	0.00	15.4
159	hsa01430	Cell Communication - Homo sapiens (human)	17	1009	135	25119	9.67e-05	0.02	0.01	3.1
160	210993	Tie2 Signaling	6	1020	15	25239	1.14e-04	0.01	0.00	9.8
161	114509	Platelet activation triggers	6	1020	15	25239	1.14e-04	0.01	0.00	9.8
162	71064	Lysine catabolism	5	1021	9	25245	1.34e-04	0.00	0.00	13.7
163	109869	MAP kinase cascade	5	1021	9	25245	1.34e-04	0.00	0.00	13.7
164	190375	FGFR2c ligand binding and activation	6	1020	16	25238	1.52e-04	0.01	0.00	9.2
165	hsa01040	Polyunsaturated fatty acid biosynthesis - Homo sapiens (human)	6	1020	16	25238	1.52e-04	0.01	0.00	9.2
166	166016	Toll Like Receptor 4 (TLR4) Cascade	7	1019	24	25230	1.57e-04	0.01	0.00	7.2
167	hsa04612	Antigen processing and presentation - Homo sapiens (human)	13	1013	89	25165	1.70e-04	0.01	0.00	3.6
168	hsa04614	Renin-angiotensin system - Homo sapiens (human)	6	1020	17	25237	1.99e-04	0.01	0.00	8.7
169	76002	Platelet Activation	6	1020	17	25237	1.99e-04	0.01	0.00	8.7
170	196854	Metabolism of vitamins and cofactors	10	1016	56	25198	2.28e-04	0.01	0.00	4.4
171	hsa00564	Glycerophospholipid metabolism - Homo sapiens (human)	11	1015	68	25186	2.42e-04	0.01	0.00	4.0
172	111463	SMAC binds to IAPs	4	1022	5	25249	2.49e-04	0.00	0.00	19.7
173	199418	Negative regulation of the PI3K/AKT network	4	1022	5	25249	2.49e-04	0.00	0.00	19.7
174	111469	SMAC-mediated apoptotic response	4	1022	5	25249	2.49e-04	0.00	0.00	19.7
175	111464	SMAC-mediated dissociation of IAP:caspase complexes	4	1022	5	25249	2.49e-04	0.00	0.00	19.7
176	198753	ERK/MAPK targets	6	1020	18	25236	2.57e-04	0.01	0.00	8.2
177	112410	SHC-mediated signalling	5	1021	11	25243	2.74e-04	0.00	0.00	11.2
178	168927	Viral dsRNA:TLR3:TRIF Complex Activates RIP1	5	1021	11	25243	2.74e-04	0.00	0.00	11.2
179	163359	Glucagon signaling in metabolic regulation	7	1019	27	25227	2.89e-04	0.01	0.00	6.4
180	hsa04320	Dorso-ventral axis formation - Homo sapiens (human)	7	1019	28	25226	3.49e-04	0.01	0.00	6.2
181	190376	FGFR ligand binding and activation	7	1019	28	25226	3.49e-04	0.01	0.00	6.2
182	163210	Formation of ATP by chemiosmotic coupling	5	1021	12	25242	3.75e-04	0.00	0.00	10.3
183	71397	Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase	4	1022	6	25248	4.02e-04	0.00	0.00	16.4
184	75158	TRAIL signaling	4	1022	6	25248	4.02e-04	0.00	0.00	16.4
185	75893	TNF signaling	4	1022	6	25248	4.02e-04	0.00	0.00	16.4
186	156580	Phase II conjugation	8	1018	40	25214	4.94e-04	0.01	0.00	4.9
187	140877	Formation of Fibrin Clot (Clotting Cascade)	7	1019	30	25224	5.00e-04	0.01	0.00	5.7
188	194138	Signaling by VEGF	5	1021	13	25241	5.03e-04	0.00	0.00	9.5
189	hsa00630	Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)	5	1021	13	25241	5.03e-04	0.00	0.00	9.5
190	69615	G1/S DNA Damage Checkpoints	5	1021	13	25241	5.03e-04	0.00	0.00	9.5
191	164378	PKA activation in glucagon signalling	5	1021	13	25241	5.03e-04	0.00	0.00	9.5
192	190241	FGFR2 ligand binding and activation	6	1020	21	25233	5.10e-04	0.01	0.00	7.0
193	190236	Signaling by FGFR	7	1019	31	25223	5.92e-04	0.01	0.00	5.6
194	196836	Vitamin C (ascorbate) metabolism	4	1022	7	25247	6.12e-04	0.00	0.00	14.1
195	74713	IRS activation	4	1022	7	25247	6.12e-04	0.00	0.00	14.1
196	196849	Metabolism of water-soluble vitamins and cofactors	8	1018	42	25212	6.57e-04	0.01	0.00	4.7
197	187706	Signalling to p38 via RIT and RIN	5	1021	14	25240	6.61e-04	0.00	0.00	8.8
198	hsa04070	Phosphatidylinositol signaling system - Homo sapiens (human)	11	1015	78	25176	6.88e-04	0.01	0.00	3.5
199	190239	FGFR3 ligand binding and activation	5	1021	15	25239	8.53e-04	0.00	0.00	8.2
200	190372	FGFR3c ligand binding and activation	5	1021	15	25239	8.53e-04	0.00	0.00	8.2
201	114696	Thrombin-activated activation cascade	4	1022	8	25246	8.89e-04	0.00	0.00	12.3
202	114665	G-protein cascades	4	1022	8	25246	8.89e-04	0.00	0.00	12.3
203	111458	Formation of apoptosome	3	1023	3	25251	1.09e-03	0.00	0.00	24.6
204	167826	The fatty acid cycling model	3	1023	3	25251	1.09e-03	0.00	0.00	24.6
205	166187	Mitochondrial Uncoupling Proteins	3	1023	3	25251	1.09e-03	0.00	0.00	24.6
206	70102	Phosphoenolpyruvate and ADP react to form pyruvate and ATP	3	1023	3	25251	1.09e-03	0.00	0.00	24.6
207	167827	The proton buffering model	3	1023	3	25251	1.09e-03	0.00	0.00	24.6
208	hsa00380	Tryptophan metabolism - Homo sapiens (human)	11	1015	84	25170	1.19e-03	0.01	0.00	3.2
209	69580	p53-Dependent G1/S DNA damage checkpoint	4	1022	9	25245	1.25e-03	0.00	0.00	10.9
210	hsa00430	Taurine and hypotaurine metabolism - Homo sapiens (human)	4	1022	9	25245	1.25e-03	0.00	0.00	10.9
211	69563	p53-Dependent G1 DNA Damage Response	4	1022	9	25245	1.25e-03	0.00	0.00	10.9
212	69236	G1 Phase	5	1021	17	25237	1.36e-03	0.00	0.00	7.2
213	69231	Cyclin D associated events in G1	5	1021	17	25237	1.36e-03	0.00	0.00	7.2
214	190322	FGFR4 ligand binding and activation	5	1021	17	25237	1.36e-03	0.00	0.00	7.2
215	69242	S Phase	9	1017	60	25194	1.41e-03	0.01	0.00	3.7
216	hsa04130	SNARE interactions in vesicular transport - Homo sapiens (human)	7	1019	38	25216	1.68e-03	0.01	0.00	4.5
217	164385	G(s)-alpha mediated events in glucagon signalling	5	1021	18	25236	1.68e-03	0.00	0.00	6.8
218	77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	3	1023	4	25250	1.85e-03	0.00	0.00	18.5
219	hsa00471	D-Glutamine and D-glutamate metabolism - Homo sapiens (human)	3	1023	4	25250	1.85e-03	0.00	0.00	18.5
220	163680	AMPK inhibits chREBP transcriptional activation activity	3	1023	4	25250	1.85e-03	0.00	0.00	18.5
221	75894	Synthesis of lysophosphatidic acid from glycerol-3-phosphate	3	1023	4	25250	1.85e-03	0.00	0.00	18.5
222	202427	Phosphorylation of CD3 and TCR zeta chains	5	1021	19	25235	2.05e-03	0.00	0.00	6.5
223	170834	Signaling by TGF beta	5	1021	19	25235	2.05e-03	0.00	0.00	6.5
224	hsa00903	Limonene and pinene degradation - Homo sapiens (human)	6	1020	29	25225	2.15e-03	0.01	0.00	5.1
225	140875	Common Pathway	4	1022	11	25243	2.23e-03	0.00	0.00	9.0
226	75892	Platelet Adhesion to exposed collagen	4	1022	11	25243	2.23e-03	0.00	0.00	9.0
227	166054	Activated TLR4 signalling	5	1021	20	25234	2.49e-03	0.00	0.00	6.2
228	hsa00220	Urea cycle and metabolism of amino groups - Homo sapiens (human)	6	1020	30	25224	2.49e-03	0.01	0.00	4.9
229	hsa00790	Folate biosynthesis - Homo sapiens (human)	7	1019	42	25212	2.78e-03	0.01	0.00	4.1
230	75815	Ubiquitin-dependent degradation of Cyclin D	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
231	194306	Neurophilin interactions with VEGF and VEGFR	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
232	69229	Ubiquitin-dependent degradation of Cyclin D1	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
233	70614	Aspartate, asparagine, glutamate, and glutamine metabolism	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
234	114666	G alpha Q cascade	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
235	140182	P450 Epoxidations	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
236	187577	SCF(Skp2)-mediated degradation of p27/p21	3	1023	5	25249	2.87e-03	0.00	0.00	14.8
237	202433	Generation of second messenger molecules	5	1021	21	25233	2.98e-03	0.00	0.00	5.9
238	69206	G1/S Transition	8	1018	55	25199	3.03e-03	0.01	0.00	3.6
239	hsa00051	Fructose and mannose metabolism - Homo sapiens (human)	7	1019	43	25211	3.12e-03	0.01	0.00	4.0
240	hsa00980	Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)	9	1017	70	25184	3.62e-03	0.01	0.00	3.2
241	75109	Triacylglyceride Biosynthesis	4	1022	13	25241	3.66e-03	0.00	0.00	7.6
242	114592	Collagen adhesion via alpha 2 beta 1 glycoprotein	3	1023	6	25248	4.18e-03	0.00	0.00	12.3
243	77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	3	1023	6	25248	4.18e-03	0.00	0.00	12.3
244	179812	Grb2 events in EGFR signaling	3	1023	6	25248	4.18e-03	0.00	0.00	12.3
245	77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	3	1023	6	25248	4.18e-03	0.00	0.00	12.3
246	77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	3	1023	6	25248	4.18e-03	0.00	0.00	12.3
247	190373	FGFR1c ligand binding and activation	4	1022	14	25240	4.56e-03	0.00	0.00	7.0
248	hsa00591	Linoleic acid metabolism - Homo sapiens (human)	6	1020	35	25219	4.88e-03	0.01	0.00	4.2
249	hsa00592	alpha-Linolenic acid metabolism - Homo sapiens (human)	4	1022	15	25239	5.60e-03	0.00	0.00	6.6
250	171007	p38MAPK events	4	1022	15	25239	5.60e-03	0.00	0.00	6.6
251	202670	ERKs are inactivated	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
252	195399	VEGF binds to VEGFR leading to receptor dimerization	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
253	71288	Creatine metabolism	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
254	112407	RAF phosphorylates MEK	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
255	110049	MEK activation	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
256	77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
257	109312	Hydrolysis of nucleoside 5'-monophosphates to nucleosides plus orthophosphate	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
258	180336	Shc events in EGFR signaling	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
259	71182	Phenylalanine and tyrosine catabolism	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
260	70153	Glucose uptake	3	1023	7	25247	5.79e-03	0.00	0.00	10.5
261	hsa00562	Inositol phosphate metabolism - Homo sapiens (human)	7	1019	50	25204	6.54e-03	0.01	0.00	3.4
262	168176	Toll Like Receptor 5 (TLR5) Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
263	202430	Translocation of ZAP-70 to Immunological synapse	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
264	166058	MyD88 cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
265	168142	Toll Like Receptor 10 (TLR10) Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
266	168188	Toll Like Receptor TLR6:TLR2 Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
267	181438	Toll Like Receptor 2 Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
268	168179	Toll Like Receptor TLR1:TLR2 Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
269	168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
270	69656	Cyclin A:Cdk2-associated events at S phase entry	4	1022	16	25238	6.79e-03	0.00	0.00	6.2
271	69239	Synthesis of DNA	7	1019	51	25203	7.19e-03	0.01	0.00	3.4
272	69052	Switching of origins to a post-replicative state	5	1021	27	25227	7.53e-03	0.00	0.00	4.6
273	68949	Orc1 removal from chromatin	5	1021	27	25227	7.53e-03	0.00	0.00	4.6
274	173107	Binding and entry of HIV virion	3	1023	8	25246	7.74e-03	0.00	0.00	9.2
275	156581	Methylation	3	1023	8	25246	7.74e-03	0.00	0.00	9.2
276	71384	Ethanol catabolism	3	1023	8	25246	7.74e-03	0.00	0.00	9.2
277	200409	Activated AMPK stimulates fatty-acid oxidation in muscle	3	1023	8	25246	7.74e-03	0.00	0.00	9.2
278	202131	Metabolism of nitric oxide	4	1022	17	25237	8.13e-03	0.00	0.00	5.8
279	156590	Glutathione conjugation	4	1022	17	25237	8.13e-03	0.00	0.00	5.8
280	69304	Regulation of DNA replication	5	1021	28	25226	8.59e-03	0.00	0.00	4.4
281	69300	Removal of licensing factors from origins	5	1021	28	25226	8.59e-03	0.00	0.00	4.4
282	170822	Negative Regulation of Glucokinase by Glucokinase Regulatory Protein	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
283	111807	Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
284	198765	Signalling to ERK5	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
285	111457	Release of apoptotic factors from the mitochondria	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
286	111804	Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
287	212718	EGFR interacts with phospholipase C-gamma	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
288	112409	ERK activation	2	1024	2	25252	8.67e-03	0.00	0.00	24.6
289	hsa00860	Porphyrin and chlorophyll metabolism - Homo sapiens (human)	6	1020	41	25213	9.56e-03	0.01	0.00	3.6
290	hsa00760	Nicotinate and nicotinamide metabolism - Homo sapiens (human)	6	1020	41	25213	9.56e-03	0.01	0.00	3.6
291	69202	Cyclin E associated events during G1/S transition	4	1022	18	25236	9.63e-03	0.00	0.00	5.5
292	hsa00271	Methionine metabolism - Homo sapiens (human)	4	1022	18	25236	9.63e-03	0.00	0.00	5.5
293	140837	Intrinsic Pathway	4	1022	18	25236	9.63e-03	0.00	0.00	5.5
294	168138	Toll Like Receptor 9 (TLR9) Cascade	4	1022	18	25236	9.63e-03	0.00	0.00	5.5
295	194313	VEGF ligand-receptor interactions	3	1023	9	25245	1.00e-02	0.00	0.00	8.2
296	190371	FGFR3b ligand binding and activation	3	1023	9	25245	1.00e-02	0.00	0.00	8.2
297	159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	3	1023	9	25245	1.00e-02	0.00	0.00	8.2
298	75877	Conversion of Fatty Acyl-CoA to Phosphatidic Acid	3	1023	9	25245	1.00e-02	0.00	0.00	8.2
299	hsa00521	Streptomycin biosynthesis - Homo sapiens (human)	3	1023	9	25245	1.00e-02	0.00	0.00	8.2
300	hsa05217	Basal cell carcinoma - Homo sapiens (human)	7	1019	55	25199	1.03e-02	0.01	0.00	3.1
301	hsa00230	Purine metabolism - Homo sapiens (human)	13	1013	147	25107	1.18e-02	0.01	0.01	2.2
302	hsa04120	Ubiquitin mediated proteolysis - Homo sapiens (human)	12	1014	128	25126	1.26e-02	0.01	0.01	2.3
303	174800	Chylomicron-mediated lipid transport	3	1023	10	25244	1.26e-02	0.00	0.00	7.4
304	199920	CREB phosphorylation	3	1023	10	25244	1.26e-02	0.00	0.00	7.4
305	174824	Lipoprotein metabolism	3	1023	10	25244	1.26e-02	0.00	0.00	7.4
306	hsa00062	Fatty acid elongation in mitochondria - Homo sapiens (human)	3	1023	10	25244	1.26e-02	0.00	0.00	7.4
307	163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	3	1023	10	25244	1.26e-02	0.00	0.00	7.4
308	hsa02010	ABC transporters - General - Homo sapiens (human)	6	1020	44	25210	1.28e-02	0.01	0.00	3.4
309	190242	FGFR1 ligand binding and activation	4	1022	20	25234	1.32e-02	0.00	0.00	4.9
310	174403	Glutathione synthesis	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
311	111752	Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
312	180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
313	114516	Disinhibition of SNARE formation	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
314	140187	P450 Prostaglandin isomerizations	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
315	71037	Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
316	77378	Formation of Cytosolic Glycerol-3-phosphate	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
317	75944	Transcription from mitochondrial promoters	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
318	165158	Activation of PKB	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
319	163282	Mitochondrial transcription initiation	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
320	77387	Insulin receptor recycling	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
321	71401	Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
322	75852	Formation of Malonyl-ACP on the other FAS monomer	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
323	111751	Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)	2	1024	3	25251	1.41e-02	0.00	0.00	16.4
324	hsa00960	Alkaloid biosynthesis II - Homo sapiens (human)	4	1022	21	25233	1.52e-02	0.00	0.00	4.7
325	159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	3	1023	11	25243	1.56e-02	0.00	0.00	6.7
326	159740	Gamma-carboxylation of protein precursors	3	1023	11	25243	1.56e-02	0.00	0.00	6.7
327	111748	Synthesis of deoxyribonucleoside 5'-diphosphates from ribonucleoside 5'-diphosphates	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
328	74744	SHC activation	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
329	168782	Proteolytic cleavage of SNARE complex proteins	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
330	166020	LPS transferred from LBP carrier to CD14	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
331	75107	Butyryl-ACP biosynthesis	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
332	69017	CDK-mediated phosphorylation and removal of Cdc6	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
333	110029	RAF activation	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
334	139943	PLC-mediated hydrolysis	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
335	76000	Assembly of the RAD51-ssDNA nucleoprotein complex	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
336	77108	Utilization of Ketone Bodies	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
337	76420	Simple hydroxylation	2	1024	4	25250	2.06e-02	0.00	0.00	12.3
338	162594	Early Phase of HIV Life Cycle	3	1023	13	25241	2.27e-02	0.00	0.00	5.7
339	159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	3	1023	13	25241	2.27e-02	0.00	0.00	5.7
340	69278	Cell Cycle, Mitotic	14	1012	178	25076	2.30e-02	0.01	0.01	1.9
341	69002	DNA Replication Pre-Initiation	5	1021	37	25217	2.31e-02	0.00	0.00	3.3
342	70221	Glycogen breakdown (glycogenolysis)	3	1023	14	25240	2.68e-02	0.00	0.00	5.3
343	hsa00600	Sphingolipid metabolism - Homo sapiens (human)	5	1021	39	25215	2.77e-02	0.00	0.00	3.2
344	76010	Homologous DNA pairing and strand exchange	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
345	70114	Glucose + ATP => glucose-6-phosphate + ADP	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
346	140186	P450 Hydroxylations	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
347	74219	dGTP formation	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
348	hsa00950	Alkaloid biosynthesis I - Homo sapiens (human)	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
349	74257	Xanthine formation	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
350	114508	Phospholipase-mediated signalling	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
351	hsa00281	Geraniol degradation - Homo sapiens (human)	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
352	140834	Extrinsic Pathway	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
353	74230	dATP formation	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
354	76003	Presynaptic phase of homologous DNA pairing and strand exchange	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
355	74259	Purine catabolism	2	1024	5	25249	2.81e-02	0.00	0.00	9.8
356	hsa00361	gamma-Hexachlorocyclohexane degradation - Homo sapiens (human)	4	1022	26	25228	2.82e-02	0.00	0.00	3.8
357	164952	The role of Nef in HIV-1 replication and disease pathogenesis	4	1022	28	25226	3.49e-02	0.00	0.00	3.5
358	hsa05110	Cholera - Infection - Homo sapiens (human)	5	1021	42	25212	3.56e-02	0.00	0.00	2.9
359	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)	6	1020	57	25197	3.60e-02	0.01	0.00	2.6
360	166166	TRAM Cascade	2	1024	6	25248	3.65e-02	0.00	0.00	8.2
361	114664	G alpha 12 cascade	2	1024	6	25248	3.65e-02	0.00	0.00	8.2
362	hsa00061	Fatty acid biosynthesis - Homo sapiens (human)	2	1024	6	25248	3.65e-02	0.00	0.00	8.2
363	168253	Host Interactions with Influenza Factors	2	1024	6	25248	3.65e-02	0.00	0.00	8.2
364	hsa00632	Benzoate degradation via CoA ligation - Homo sapiens (human)	4	1022	29	25225	3.85e-02	0.00	0.00	3.4
365	hsa04140	Regulation of autophagy - Homo sapiens (human)	4	1022	29	25225	3.85e-02	0.00	0.00	3.4
366	hsa00531	Glycosaminoglycan degradation - Homo sapiens (human)	3	1023	17	25237	4.12e-02	0.00	0.00	4.3
367	70895	Branched-chain amino acid catabolism	3	1023	17	25237	4.12e-02	0.00	0.00	4.3
368	hsa04330	Notch signaling pathway - Homo sapiens (human)	5	1021	45	25209	4.48e-02	0.00	0.00	2.7
369	74182	Ketone body metabolism	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
370	164944	Nef and signal transduction	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
371	114604	Collagen-mediated activation cascade	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
372	110097	Reversible phosphorylation of nucleoside monophosphates	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
373	142033	Ethanol Catabolism	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
374	76604	Ribonucleotide salvage	2	1024	7	25247	4.57e-02	0.00	0.00	7.0
375	hsa00565	Ether lipid metabolism - Homo sapiens (human)	4	1022	31	25223	4.64e-02	0.00	0.00	3.2
376	192076	Steroid metabolism	6	1020	61	25193	4.64e-02	0.01	0.00	2.4
377	114452	Activation of BH3-only proteins	3	1023	18	25236	4.67e-02	0.00	0.00	4.1
378	162909	Host Interactions of HIV factors	7	1019	78	25176	4.84e-02	0.01	0.00	2.2
379	168799	Botulinum neurotoxicity	3	1023	19	25235	0.05	0.00	0.00	3.9
380	68962	Activation of the pre-replicative complex	4	1022	33	25221	0.06	0.00	0.00	3.0
381	74217	Purine salvage reactions	2	1024	8	25246	0.06	0.00	0.00	6.2
382	190370	FGFR1b ligand binding and activation	2	1024	8	25246	0.06	0.00	0.00	6.2
383	203615	eNOS activation	2	1024	8	25246	0.06	0.00	0.00	6.2
384	71336	Pentose phosphate pathway (hexose monophosphate shunt)	2	1024	8	25246	0.06	0.00	0.00	6.2
385	hsa00460	Cyanoamino acid metabolism - Homo sapiens (human)	2	1024	8	25246	0.06	0.00	0.00	6.2
386	114711	vWF interaction with collagen	2	1024	8	25246	0.06	0.00	0.00	6.2
387	190377	FGFR2b ligand binding and activation	2	1024	8	25246	0.06	0.00	0.00	6.2
388	73848	Pyrimidine metabolism	3	1023	21	25233	0.07	0.00	0.00	3.5
389	70172	Phosphorylase kinase activates glycogen phosphorylase	2	1024	9	25245	0.07	0.00	0.00	5.5
390	hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human)	2	1024	9	25245	0.07	0.00	0.00	5.5
391	111447	Activation of BAD and translocation to mitochondria	2	1024	9	25245	0.07	0.00	0.00	5.5
392	167021	PLC-gamma1 signalling	2	1024	9	25245	0.07	0.00	0.00	5.5
393	73648	Pyrimidine biosynthesis (interconversion)	2	1024	9	25245	0.07	0.00	0.00	5.5
394	164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	3	1023	22	25232	0.07	0.00	0.00	3.4
395	180786	Extension of Telomeres	3	1023	22	25232	0.07	0.00	0.00	3.4
396	109368	Hydrolysis of cytosolic nucleoside 5'-monophosphates by 5'-nucleotidase cytosolic IA	1	1025	1	25253	0.08	0.00	0.00	24.6
397	191650	Regulation of gap junction activity	1	1025	1	25253	0.08	0.00	0.00	24.6
398	hsa00472	D-Arginine and D-ornithine metabolism - Homo sapiens (human)	1	1025	1	25253	0.08	0.00	0.00	24.6
399	140180	COX reactions	1	1025	1	25253	0.08	0.00	0.00	24.6
400	74243	Hypoxanthine formation	1	1025	1	25253	0.08	0.00	0.00	24.6
401	171052	LDL endocytosis	1	1025	1	25253	0.08	0.00	0.00	24.6
402	109471	Hydrolysis of cytosolic nucleoside 5'- and 3'-monophosphates by 5',3'-nucleotidase, cytosolic	1	1025	1	25253	0.08	0.00	0.00	24.6
403	71383	Acetate, ATP, and coenzyme A react to form acetyl CoA, AMP, and pyrophosphate	1	1025	1	25253	0.08	0.00	0.00	24.6
404	110056	ERK1 activation	1	1025	1	25253	0.08	0.00	0.00	24.6
405	112411	ERK2 activation	1	1025	1	25253	0.08	0.00	0.00	24.6
406	70105	1,3-bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP	1	1025	1	25253	0.08	0.00	0.00	24.6
407	181546	BoNT Light Chain Types A, C1, E cleave SNAP-25	1	1025	1	25253	0.08	0.00	0.00	24.6
408	70109	Dihydroxyacetone phosphate is isomerized to form glyceraldehyde-3-phosphate	1	1025	1	25253	0.08	0.00	0.00	24.6
409	171319	Telomere Extension By Telomerase	1	1025	1	25253	0.08	0.00	0.00	24.6
410	109279	Hydrolysis of extracellular nucleoside 5'-monophosphates by plasma membrane-bound 5'-nucleotidase	1	1025	1	25253	0.08	0.00	0.00	24.6
411	70112	Glucose 6-phosphate is isomerized to form fructose-6-phosphate	1	1025	1	25253	0.08	0.00	0.00	24.6
412	193144	Estrogen biosynthesis	1	1025	1	25253	0.08	0.00	0.00	24.6
413	191647	c-src mediated regulation of Cx43 function and closure of gap junctions	1	1025	1	25253	0.08	0.00	0.00	24.6
414	199997	COPI Mediated Transport	2	1024	10	25244	0.08	0.00	0.00	4.9
415	70894	Valine catabolism	2	1024	10	25244	0.08	0.00	0.00	4.9
416	70845	Isoleucine catabolism	2	1024	10	25244	0.08	0.00	0.00	4.9
417	167590	Nef Mediated CD4 Down-regulation	2	1024	10	25244	0.08	0.00	0.00	4.9
418	199983	Golgi to ER Retrograde Transport	2	1024	10	25244	0.08	0.00	0.00	4.9
419	hsa00120	Bile acid biosynthesis - Homo sapiens (human)	4	1022	39	25215	0.09	0.00	0.00	2.5
420	hsa00910	Nitrogen metabolism - Homo sapiens (human)	3	1023	24	25230	0.09	0.00	0.00	3.1
421	69306	DNA Replication	8	1018	106	25148	0.09	0.01	0.00	1.9
422	hsa00140	C21-Steroid hormone metabolism - Homo sapiens (human)	2	1024	11	25243	0.09	0.00	0.00	4.5
423	hsa00500	Starch and sucrose metabolism - Homo sapiens (human)	7	1019	85	25169	0.09	0.01	0.00	2.0
424	201451	Signaling by BMP	3	1023	25	25229	0.09	0.00	0.00	3.0
425	69620	Cell Cycle Checkpoints	9	1017	119	25135	0.10	0.01	0.00	1.9
426	hsa00290	Valine, leucine and isoleucine biosynthesis - Homo sapiens (human)	2	1024	12	25242	0.10	0.00	0.00	4.1
427	196071	Steroid hormone biosynthesis	2	1024	12	25242	0.10	0.00	0.00	4.1
428	165159	mTOR signalling	2	1024	12	25242	0.10	0.00	0.00	4.1
429	109703	PKB-mediated events	2	1024	12	25242	0.10	0.00	0.00	4.1
430	203765	eNOS activation and regulation	2	1024	12	25242	0.10	0.00	0.00	4.1
431	72649	Translation initiation complex formation	5	1021	59	25195	0.10	0.00	0.00	2.1
432	72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	5	1021	60	25194	0.11	0.00	0.00	2.1
433	168769	BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin	1	1025	2	25252	0.11	0.00	0.00	12.3
434	73728	RNA Polymerase I Promoter Opening	1	1025	2	25252	0.11	0.00	0.00	12.3
435	140188	P450 Dehalogenation	1	1025	2	25252	0.11	0.00	0.00	12.3
436	169131	Inhibition of PKR	1	1025	2	25252	0.11	0.00	0.00	12.3
437	75854	Formation of Acetyl-FAS on one FAS monomer	1	1025	2	25252	0.11	0.00	0.00	12.3
438	74236	Inosine formation	1	1025	2	25252	0.11	0.00	0.00	12.3
439	163765	ChREBP activates metabolic gene expression	1	1025	2	25252	0.11	0.00	0.00	12.3
440	111495	Conversion of cytosolic inosine 5'-monophosphate, L-aspartate, and GTP to adenylosuccinate, guanosine 5'-diphosphate, and orthophosphate	1	1025	2	25252	0.11	0.00	0.00	12.3
441	141333	Monoamines are oxidized to aldehydes, producing NH3 and H2O2	1	1025	2	25252	0.11	0.00	0.00	12.3
442	hsa00902	Monoterpenoid biosynthesis - Homo sapiens (human)	1	1025	2	25252	0.11	0.00	0.00	12.3
443	142048	Aldehyde Dehydrogenase	1	1025	2	25252	0.11	0.00	0.00	12.3
444	70525	Alanine metabolism	1	1025	2	25252	0.11	0.00	0.00	12.3
445	114294	Activation, translocation and oligomerization of BAX	1	1025	2	25252	0.11	0.00	0.00	12.3
446	110131	Reversible phosphorylation of mitochondrial nucleoside monophosphates by adenylate kinase 2	1	1025	2	25252	0.11	0.00	0.00	12.3
447	163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	1	1025	2	25252	0.11	0.00	0.00	12.3
448	168277	Influenza Virus Induced Apoptosis	1	1025	2	25252	0.11	0.00	0.00	12.3
449	110123	Reversible phosphorylation of cytosolic nucleoside monophosphates by adenylate kinase 1	1	1025	2	25252	0.11	0.00	0.00	12.3
450	hsa00031	Inositol metabolism - Homo sapiens (human)	1	1025	2	25252	0.11	0.00	0.00	12.3
451	156579	P450 oxidation	1	1025	2	25252	0.11	0.00	0.00	12.3
452	111452	Activation and oligomerization of BAK protein	1	1025	2	25252	0.11	0.00	0.00	12.3
453	71364	Acetaldehyde is oxidized by NAD+ to form acetate, NADH, and H+	1	1025	2	25252	0.11	0.00	0.00	12.3
454	198745	Signalling to STAT3	1	1025	2	25252	0.11	0.00	0.00	12.3
455	69481	G2/M Checkpoints	4	1022	44	25210	0.12	0.00	0.00	2.2
456	194068	Metabolism of bile acids and bile salts	3	1023	28	25226	0.12	0.00	0.00	2.6
457	194315	Signaling by Rho GTPases	9	1017	132	25122	0.13	0.01	0.01	1.7
458	69166	Removal of the Flap Intermediate	2	1024	14	25240	0.13	0.00	0.00	3.5
459	73951	Homologous recombination repair of replication-independent double-strand breaks	2	1024	14	25240	0.13	0.00	0.00	3.5
460	hsa00603	Glycosphingolipid biosynthesis - globoseries - Homo sapiens (human)	2	1024	14	25240	0.13	0.00	0.00	3.5
461	73888	Homologous Recombination Repair	2	1024	14	25240	0.13	0.00	0.00	3.5
462	210500	Neuronal Glutamate cycle	2	1024	14	25240	0.13	0.00	0.00	3.5
463	69183	Processive synthesis on the lagging strand	2	1024	14	25240	0.13	0.00	0.00	3.5
464	hsa01032	Glycan structures - degradation - Homo sapiens (human)	3	1023	29	25225	0.13	0.00	0.00	2.5
465	157858	Gap junction trafficking and regulation	3	1023	29	25225	0.13	0.00	0.00	2.5
466	hsa00450	Selenoamino acid metabolism - Homo sapiens (human)	3	1023	30	25224	0.14	0.00	0.00	2.5
467	hsa00641	3-Chloroacrylic acid degradation - Homo sapiens (human)	2	1024	15	25239	0.14	0.00	0.00	3.3
468	69091	Polymerase switching	2	1024	15	25239	0.14	0.00	0.00	3.3
469	69109	Leading Strand Synthesis	2	1024	15	25239	0.14	0.00	0.00	3.3
470	174411	Polymerase switching on the C-strand of the telomere	2	1024	15	25239	0.14	0.00	0.00	3.3
471	hsa00530	Aminosugars metabolism - Homo sapiens (human)	3	1023	31	25223	0.15	0.00	0.00	2.4
472	254954	PI3K/AKT signalling	1	1025	3	25251	0.15	0.00	0.00	8.2
473	163767	PP2A-mediated dephosphorylation of key metabolic factors	1	1025	3	25251	0.15	0.00	0.00	8.2
474	111742	Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin)	1	1025	3	25251	0.15	0.00	0.00	8.2
475	hsa00401	Novobiocin biosynthesis - Homo sapiens (human)	1	1025	3	25251	0.15	0.00	0.00	8.2
476	254774	Signalling by NGF	1	1025	3	25251	0.15	0.00	0.00	8.2
477	140179	Amine Oxidase reactions	1	1025	3	25251	0.15	0.00	0.00	8.2
478	254985	AKT phosphorylates targets in the cytosol	1	1025	3	25251	0.15	0.00	0.00	8.2
479	180534	Vpu mediated degradation of CD4	1	1025	3	25251	0.15	0.00	0.00	8.2
480	166144	Mal Cascade	1	1025	3	25251	0.15	0.00	0.00	8.2
481	73927	Depurination	1	1025	3	25251	0.15	0.00	0.00	8.2
482	166662	Lectin pathway of complement activation	1	1025	3	25251	0.15	0.00	0.00	8.2
483	70853	Oxidative decarboxylation of alpha-ketoisovalerate to isobutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase	1	1025	3	25251	0.15	0.00	0.00	8.2
484	114593	Collagen adhesion via Gp IV	1	1025	3	25251	0.15	0.00	0.00	8.2
485	111747	Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and glutaredoxin	1	1025	3	25251	0.15	0.00	0.00	8.2
486	139910	Activation of BMF and translocation to mitochondria	1	1025	3	25251	0.15	0.00	0.00	8.2
487	75899	Conversion of Phosphatidic Acid to Diacylglycerol	1	1025	3	25251	0.15	0.00	0.00	8.2
488	110330	Recognition and association of DNA glycosylase with site containing an affected purine	1	1025	3	25251	0.15	0.00	0.00	8.2
489	254773	TRKA signalling from the plasma membrane	1	1025	3	25251	0.15	0.00	0.00	8.2
490	110331	Cleavage of the damaged purine	1	1025	3	25251	0.15	0.00	0.00	8.2
491	70726	Oxidative decarboxylation of alpha-ketoisocaproate to isovaleryl-CoA by branched-chain alpha-ketoacid dehydrogenase	1	1025	3	25251	0.15	0.00	0.00	8.2
492	69541	Stabilization of p53	1	1025	3	25251	0.15	0.00	0.00	8.2
493	71032	Propionyl-CoA catabolism	1	1025	3	25251	0.15	0.00	0.00	8.2
494	165181	Inhibition of TSC complex formation by PKB	1	1025	3	25251	0.15	0.00	0.00	8.2
495	70794	Oxidative decarboxylation of alpha-keto-beta-methylvalerate to alpha-methylbutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase	1	1025	3	25251	0.15	0.00	0.00	8.2
496	hsa00670	One carbon pool by folate - Homo sapiens (human)	2	1024	16	25238	0.15	0.00	0.00	3.1
497	hsa00053	Ascorbate and aldarate metabolism - Homo sapiens (human)	2	1024	16	25238	0.15	0.00	0.00	3.1
498	hsa00740	Riboflavin metabolism - Homo sapiens (human)	2	1024	16	25238	0.15	0.00	0.00	3.1
499	69190	DNA strand elongation	3	1023	32	25222	0.16	0.00	0.00	2.3
500	212436	Generic Transcription Pathway	2	1024	17	25237	0.17	0.00	0.00	2.9
501	73890	Double-Strand Break Repair	2	1024	17	25237	0.17	0.00	0.00	2.9
502	hsa00272	Cysteine metabolism - Homo sapiens (human)	2	1024	17	25237	0.17	0.00	0.00	2.9
503	70216	Poly{(1,4)-alpha-glucosyl} glycogenin reacts with n orthophosphates to form glycogenin and n D-glucose 1-phosphates	1	1025	4	25250	0.18	0.00	0.00	6.2
504	69610	p53-Independent DNA Damage Response	1	1025	4	25250	0.18	0.00	0.00	6.2
505	hsa00830	Retinol metabolism - Homo sapiens (human)	1	1025	4	25250	0.18	0.00	0.00	6.2
506	196843	Vitamin B2 (riboflavin) metabolism	1	1025	4	25250	0.18	0.00	0.00	6.2
507	77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	1	1025	4	25250	0.18	0.00	0.00	6.2
508	166786	Creation of C4 and C2 activators	1	1025	4	25250	0.18	0.00	0.00	6.2
509	68911	G2 Phase	1	1025	4	25250	0.18	0.00	0.00	6.2
510	76605	Deoxyribonucleotide salvage	1	1025	4	25250	0.18	0.00	0.00	6.2
511	70182	Glycogen-glycogenin reacts with n orthophosphates, yielding n glucose 1-phosphates and limit dextrin-glycogenin	1	1025	4	25250	0.18	0.00	0.00	6.2
512	69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	1	1025	4	25250	0.18	0.00	0.00	6.2
513	168276	NS1 Mediated Effects on Host Pathways	1	1025	4	25250	0.18	0.00	0.00	6.2
514	77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	1	1025	4	25250	0.18	0.00	0.00	6.2
515	69613	p53-Independent G1/S DNA damage checkpoint	1	1025	4	25250	0.18	0.00	0.00	6.2
516	196299	Beta-catenin phosphorylation cascade	1	1025	4	25250	0.18	0.00	0.00	6.2
517	111446	Activation of BIM and translocation to mitochondria	1	1025	4	25250	0.18	0.00	0.00	6.2
518	140189	P450 Dehydrogenation of alkanes to form alkenes	1	1025	4	25250	0.18	0.00	0.00	6.2
519	200425	Import of palmitoyl-CoA into the mitochondrial matrix	1	1025	4	25250	0.18	0.00	0.00	6.2
520	168936	Viral dsRNA:TLR3:TRIF Complex Activates TBK1	1	1025	4	25250	0.18	0.00	0.00	6.2
521	77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	1	1025	4	25250	0.18	0.00	0.00	6.2
522	176187	Activation of ATR in response to replication stress	3	1023	36	25218	0.19	0.00	0.00	2.1
523	69186	Lagging Strand Synthesis	2	1024	19	25235	0.20	0.00	0.00	2.6
524	192105	Synthesis of bile acids and bile salts	2	1024	20	25234	0.21	0.00	0.00	2.5
525	hsa00300	Lysine biosynthesis - Homo sapiens (human)	1	1025	5	25249	0.21	0.00	0.00	4.9
526	70108	Glyceraldehyde 3-phosphate, NAD+, and orthophosphate react to form 1,3-bisphosphoglycerate, NADH, and H+	1	1025	5	25249	0.21	0.00	0.00	4.9
527	187015	Activation of TRKA receptors	1	1025	5	25249	0.21	0.00	0.00	4.9
528	hsa00750	Vitamin B6 metabolism - Homo sapiens (human)	1	1025	5	25249	0.21	0.00	0.00	4.9
529	75108	Activation, myristolyation of BID and translocation to mitochondria	1	1025	5	25249	0.21	0.00	0.00	4.9
530	71338	Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+	1	1025	5	25249	0.21	0.00	0.00	4.9
531	203927	MicroRNA biogenesis	1	1025	5	25249	0.21	0.00	0.00	4.9
532	71240	Tryptophan catabolism	1	1025	5	25249	0.21	0.00	0.00	4.9
533	165720	S6K1 signalling	1	1025	5	25249	0.21	0.00	0.00	4.9
534	142045	Alcohol Dehydrogenase	1	1025	5	25249	0.21	0.00	0.00	4.9
535	187024	NGF-independant TRKA activation	1	1025	5	25249	0.21	0.00	0.00	4.9
536	69478	G2/M DNA replication checkpoint	1	1025	5	25249	0.21	0.00	0.00	4.9
537	113510	E2F mediated regulation of DNA replication	2	1024	21	25233	0.23	0.00	0.00	2.3
538	199991	Membrane Trafficking	2	1024	21	25233	0.23	0.00	0.00	2.3
539	174417	Telomere C-strand (Lagging Strand) Synthesis	2	1024	21	25233	0.23	0.00	0.00	2.3
540	68867	Assembly of the pre-replicative complex	2	1024	22	25232	0.24	0.00	0.00	2.2
541	68874	M/G1 Transition	2	1024	22	25232	0.24	0.00	0.00	2.2
542	196757	Metabolism of folate and pterines	1	1025	6	25248	0.24	0.00	0.00	4.1
543	75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	1	1025	6	25248	0.24	0.00	0.00	4.1
544	163358	PKA-mediated phosphorylation of key metabolic factors	1	1025	6	25248	0.24	0.00	0.00	4.1
545	69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	1	1025	6	25248	0.24	0.00	0.00	4.1
546	194002	Glucocorticoid biosynthesis	1	1025	6	25248	0.24	0.00	0.00	4.1
547	hsa00340	Histidine metabolism - Homo sapiens (human)	3	1023	42	25212	0.26	0.00	0.00	1.8
548	hsa00100	Biosynthesis of steroids - Homo sapiens (human)	2	1024	24	25230	0.27	0.00	0.00	2.1
549	166207	S6K1-mediated signalling	1	1025	7	25247	0.27	0.00	0.00	3.5
550	195253	Degradation of beta-catenin by the destruction complex	1	1025	7	25247	0.27	0.00	0.00	3.5
551	176417	Phosphorylation of Emi1	1	1025	7	25247	0.27	0.00	0.00	3.5
552	167242	Abortive elongation of HIV-1 transcript in the absence of Tat	1	1025	7	25247	0.27	0.00	0.00	3.5
553	73614	Pyrimidine salvage reactions	1	1025	7	25247	0.27	0.00	0.00	3.5
554	hsa00232	Caffeine metabolism - Homo sapiens (human)	1	1025	7	25247	0.27	0.00	0.00	3.5
555	72695	Formation of the ternary complex, and subsequently, the 43S complex	4	1022	52	25202	0.28	0.00	0.00	1.9
556	hsa00624	1- and 2-Methylnaphthalene degradation - Homo sapiens (human)	2	1024	25	25229	0.28	0.00	0.00	2.0
557	hsa00040	Pentose and glucuronate interconversions - Homo sapiens (human)	2	1024	25	25229	0.28	0.00	0.00	2.0
558	hsa00150	Androgen and estrogen metabolism - Homo sapiens (human)	4	1022	56	25198	0.30	0.00	0.00	1.8
559	hsa03030	DNA replication - Homo sapiens (human)	2	1024	26	25228	0.30	0.00	0.00	1.9
560	70635	Urea synthesis	1	1025	8	25246	0.30	0.00	0.00	3.1
561	174414	Processive synthesis on the C-strand of the telomere	1	1025	8	25246	0.30	0.00	0.00	3.1
562	166663	Initial triggering of complement	1	1025	8	25246	0.30	0.00	0.00	3.1
563	159231	Transport of Mature mRNA Derived from an Intronless Transcript	1	1025	8	25246	0.30	0.00	0.00	3.1
564	68952	DNA replication initiation	1	1025	8	25246	0.30	0.00	0.00	3.1
565	hsa00625	Tetrachloroethene degradation - Homo sapiens (human)	1	1025	8	25246	0.30	0.00	0.00	3.1
566	hsa00130	Ubiquinone biosynthesis - Homo sapiens (human)	1	1025	8	25246	0.30	0.00	0.00	3.1
567	73929	Base-Excision Repair, AP Site Formation	1	1025	8	25246	0.30	0.00	0.00	3.1
568	70693	Ornithine metabolism	1	1025	8	25246	0.30	0.00	0.00	3.1
569	174437	Removal of the Flap Intermediate from the C-strand	1	1025	8	25246	0.30	0.00	0.00	3.1
570	72731	Recycling of eIF2:GDP	1	1025	8	25246	0.30	0.00	0.00	3.1
571	111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1	1025	8	25246	0.30	0.00	0.00	3.1
572	174430	Telomere C-strand synthesis initiation	1	1025	8	25246	0.30	0.00	0.00	3.1
573	70302	Glycogen synthesis	1	1025	8	25246	0.30	0.00	0.00	3.1
574	72702	Ribosomal scanning and start codon recognition	4	1022	59	25195	0.31	0.00	0.00	1.7
575	157279	3' -UTR-mediated translational regulation	6	1020	103	25151	0.32	0.01	0.00	1.4
576	156827	L13a-mediated translational silencing of Ceruloplasmin expression	6	1020	103	25151	0.32	0.01	0.00	1.4
577	176408	Regulation of APC/C activators between G1/S and early anaphase	2	1024	28	25226	0.33	0.00	0.00	1.8
578	166208	mTORC1-mediated signalling	1	1025	9	25245	0.33	0.00	0.00	2.7
579	hsa00072	Synthesis and degradation of ketone bodies - Homo sapiens (human)	1	1025	9	25245	0.33	0.00	0.00	2.7
580	70793	Leucine catabolism	1	1025	9	25245	0.33	0.00	0.00	2.7
581	110357	Displacement of DNA glycosylase by APE1	1	1025	9	25245	0.33	0.00	0.00	2.7
582	189451	Heme biosynthesis	1	1025	9	25245	0.33	0.00	0.00	2.7
583	176033	Interactions of Vpr with host cellular proteins	2	1024	29	25225	0.34	0.00	0.00	1.7
584	164940	Nef mediated downregulation of MHC class I complex cell surface expression	1	1025	10	25244	0.35	0.00	0.00	2.5
585	199220	Vitamin B5 (pantothenate) metabolism	1	1025	10	25244	0.35	0.00	0.00	2.5
586	159234	Transport of Mature mRNAs Derived from Intronless Transcripts	1	1025	10	25244	0.35	0.00	0.00	2.5
587	73930	Base-free sugar-phosphate removal via the single-nucleotide replacement pathway	1	1025	10	25244	0.35	0.00	0.00	2.5
588	189445	Porphyrin metabolism	1	1025	10	25244	0.35	0.00	0.00	2.5
589	156584	Cytosolic sulfonation of small molecules	1	1025	10	25244	0.35	0.00	0.00	2.5
590	113501	Inhibition of replication initiation of damaged DNA by Rb/E2F1	1	1025	10	25244	0.35	0.00	0.00	2.5
591	69473	G2/M DNA damage checkpoint	1	1025	10	25244	0.35	0.00	0.00	2.5
592	hsa04740	Olfactory transduction - Homo sapiens (human)	2	1024	31	25223	0.37	0.00	0.00	1.6
593	174143	APC/C-mediated degradation of cell cycle proteins	2	1024	31	25223	0.37	0.00	0.00	1.6
594	162599	Late Phase of HIV Life Cycle	1	1025	75	25179	0.37	0.00	0.00	0.3
595	77595	Processing of Intronless Pre-mRNAs	1	1025	11	25243	0.38	0.00	0.00	2.2
596	110381	Resolution of AP sites via the single-nucleotide replacement pathway	1	1025	11	25243	0.38	0.00	0.00	2.2
597	113507	E2F-enabled inhibition of pre-replication complex formation	1	1025	11	25243	0.38	0.00	0.00	2.2
598	191345	Transformation of lanosterol to cholesterol	1	1025	11	25243	0.38	0.00	0.00	2.2
599	69298	Association of licensing factors with the pre-replicative complex	1	1025	11	25243	0.38	0.00	0.00	2.2
600	75071	mRNA Processing	3	1023	145	25109	0.39	0.00	0.01	0.5
601	156902	Peptide chain elongation	5	1021	83	25171	0.40	0.00	0.00	1.5
602	196807	Nicotinate metabolism	1	1025	12	25242	0.40	0.00	0.00	2.1
603	70694	Ornithine and proline metabolism	1	1025	12	25242	0.40	0.00	0.00	2.1
604	69273	Cyclin A/B1 associated events during G2/M transition	1	1025	12	25242	0.40	0.00	0.00	2.1
605	159418	Recycling of bile acids and salts	1	1025	12	25242	0.40	0.00	0.00	2.1
606	156842	Eukaryotic Translation Elongation	5	1021	86	25168	0.41	0.00	0.00	1.4
607	69275	G2/M Transition	1	1025	13	25241	0.43	0.00	0.00	1.9
608	68827	CDT1 association with the CDC6:ORC:origin complex	1	1025	13	25241	0.43	0.00	0.00	1.9
609	109977	Repair synthesis for gap-filling by DNA polymerase in TC-NER	1	1025	13	25241	0.43	0.00	0.00	1.9
610	74967	Repair synthesis of patch ~27-30 bases long by DNA polymerase	1	1025	13	25241	0.43	0.00	0.00	1.9
611	176974	Unwinding of DNA	1	1025	13	25241	0.43	0.00	0.00	1.9
612	163841	Post-translational protein modification	3	1023	44	25210	0.43	0.00	0.00	1.7
613	109979	Gap-filling DNA repair synthesis and ligation in TC-NER	1	1025	14	25240	0.45	0.00	0.00	1.8
614	74969	Gap-filling DNA repair synthesis and ligation in GG-NER	1	1025	14	25240	0.45	0.00	0.00	1.8
615	167290	Pausing and recovery of HIV-1 elongation	1	1025	14	25240	0.45	0.00	0.00	1.8
616	110362	Removal of DNA patch containing abasic residue	1	1025	14	25240	0.45	0.00	0.00	1.8
617	hsa00920	Sulfur metabolism - Homo sapiens (human)	1	1025	14	25240	0.45	0.00	0.00	1.8
618	194840	Rho GTPase cycle	6	1020	106	25148	0.46	0.01	0.00	1.4
619	72613	Eukaryotic Translation Initiation	6	1020	111	25143	0.47	0.01	0.00	1.3
620	72737	Cap-dependent Translation Initiation	6	1020	111	25143	0.47	0.01	0.00	1.3
621	162906	HIV Infection	10	1016	197	25057	0.47	0.01	0.01	1.2
622	167238	Pausing and recovery of Tat-mediated HIV-1 elongation	1	1025	15	25239	0.47	0.00	0.00	1.6
623	110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	1	1025	15	25239	0.47	0.00	0.00	1.6
624	167246	Tat-mediated elongation of the HIV-1 transcript	1	1025	15	25239	0.47	0.00	0.00	1.6
625	167243	Tat-mediated HIV-1 elongation arrest and recovery	1	1025	15	25239	0.47	0.00	0.00	1.6
626	166658	Complement cascade	1	1025	15	25239	0.47	0.00	0.00	1.6
627	hsa00511	N-Glycan degradation - Homo sapiens (human)	1	1025	15	25239	0.47	0.00	0.00	1.6
628	hsa00363	Bisphenol A degradation - Homo sapiens (human)	1	1025	15	25239	0.47	0.00	0.00	1.6
629	193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	1	1025	16	25238	0.49	0.00	0.00	1.5
630	hsa00604	Glycosphingolipid biosynthesis - ganglioseries - Homo sapiens (human)	1	1025	16	25238	0.49	0.00	0.00	1.5
631	167287	HIV-1 elongation arrest and recovery	1	1025	16	25238	0.49	0.00	0.00	1.5
632	73933	Resolution of Abasic Sites (AP sites)	1	1025	16	25238	0.49	0.00	0.00	1.5
633	73884	Base Excision Repair	1	1025	16	25238	0.49	0.00	0.00	1.5
634	75983	Formation and Maturation of mRNA Transcript	3	1023	130	25124	0.50	0.00	0.01	0.6
635	hsa00440	Aminophosphonate metabolism - Homo sapiens (human)	1	1025	17	25237	0.51	0.00	0.00	1.4
636	211000	Regulatory RNA pathways	1	1025	17	25237	0.51	0.00	0.00	1.4
637	182971	EGFR downregulation	1	1025	17	25237	0.51	0.00	0.00	1.4
638	176412	Phosphorylation of the APC/C	1	1025	18	25236	0.53	0.00	0.00	1.4
639	hsa00534	Heparan sulfate biosynthesis - Homo sapiens (human)	1	1025	19	25235	0.55	0.00	0.00	1.3
640	174048	APC/C:Cdc20 mediated degradation of Cyclin B	1	1025	19	25235	0.55	0.00	0.00	1.3
641	73854	RNA Polymerase I Promoter Clearance	1	1025	19	25235	0.55	0.00	0.00	1.3
642	hsa05020	Parkinson's disease - Homo sapiens (human)	1	1025	20	25234	0.57	0.00	0.00	1.2
643	73864	RNA Polymerase I Transcription	1	1025	20	25234	0.57	0.00	0.00	1.2
644	72764	Eukaryotic Translation Termination	4	1022	80	25174	0.57	0.00	0.00	1.2
645	191273	Cholesterol biosynthesis	1	1025	21	25233	0.58	0.00	0.00	1.2
646	72203	Processing of Capped Intron-Containing Pre-mRNA	2	1024	88	25166	0.59	0.00	0.00	0.6
647	73857	RNA Polymerase II Transcription	2	1024	91	25163	0.59	0.00	0.00	0.5
648	112168	Processing of Capped pre-mRNA	2	1024	92	25162	0.59	0.00	0.00	0.5
649	112297	Post-Elongation Processing of Intronless pre-mRNA	1	1025	22	25232	0.60	0.00	0.00	1.1
650	176409	APC/C:Cdc20 mediated degradation of mitotic proteins	1	1025	22	25232	0.60	0.00	0.00	1.1
651	75067	Processing of Capped Intronless Pre-mRNA	1	1025	22	25232	0.60	0.00	0.00	1.1
652	73894	DNA Repair	5	1021	100	25154	0.61	0.00	0.00	1.2
653	167158	Formation of the HIV-1 Early Elongation Complex	1	1025	23	25231	0.62	0.00	0.00	1.1
654	hsa00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human)	1	1025	23	25231	0.62	0.00	0.00	1.1
655	176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	1	1025	23	25231	0.62	0.00	0.00	1.1
656	72706	GTP hydrolysis and joining of the 60S ribosomal subunit	5	1021	104	25150	0.62	0.00	0.00	1.2
657	hsa01030	Glycan structures - biosynthesis 1 - Homo sapiens (human)	3	1023	115	25139	0.63	0.00	0.00	0.6
658	72766	Translation	7	1019	155	25099	0.68	0.01	0.01	1.1
659	hsa00510	N-Glycan biosynthesis - Homo sapiens (human)	2	1024	41	25213	0.68	0.00	0.00	1.2
660	168254	Influenza Infection	5	1021	164	25090	0.69	0.00	0.01	0.8
661	hsa04742	Taste transduction - Homo sapiens (human)	1	1025	53	25201	0.72	0.00	0.00	0.5
662	157579	Telomere Maintenance	3	1023	68	25186	0.76	0.00	0.00	1.1
663	72163	mRNA Splicing - Major Pathway	2	1024	85	25169	0.78	0.00	0.00	0.6
664	72172	mRNA Splicing	2	1024	85	25169	0.78	0.00	0.00	0.6
665	162587	HIV Life Cycle	4	1022	88	25166	0.78	0.00	0.00	1.1
666	hsa00240	Pyrimidine metabolism - Homo sapiens (human)	4	1022	90	25164	0.79	0.00	0.00	1.1
667	72689	Formation of a pool of free 40S subunits	4	1022	92	25162	0.79	0.00	0.00	1.1
668	112295	Elongation and Processing of Capped Transcripts	3	1023	108	25146	0.80	0.00	0.00	0.7
669	76043	Elongation of Intron-Containing Transcripts and co-transcriptional mRNA splicing	3	1023	108	25146	0.80	0.00	0.00	0.7
670	74160	Gene Expression	13	1013	352	24902	0.89	0.01	0.01	0.9
671	74159	Transcription	6	1020	155	25099	1.00	0.01	0.01	1.0
672	195721	Signaling by Wnt	2	1024	58	25196	1.00	0.00	0.00	0.8
673	109970	Global Genomic NER (GG-NER)	1	1025	30	25224	1.00	0.00	0.00	0.8
674	168273	Influenza Viral RNA Transcription and Replication	1	1025	36	25218	1.00	0.00	0.00	0.7
675	168255	Influenza Life Cycle	1	1025	40	25214	1.00	0.00	0.00	0.6
676	112386	Pausing and recovery of elongation	1	1025	27	25227	1.00	0.00	0.00	0.9
677	167172	Transcription of the HIV genome	1	1025	46	25208	1.00	0.00	0.00	0.5
678	167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	1	1025	24	25230	1.00	0.00	0.00	1.0
679	hsa00512	O-Glycan biosynthesis - Homo sapiens (human)	1	1025	30	25224	1.00	0.00	0.00	0.8
680	72187	mRNA 3'-end processing	1	1025	28	25226	1.00	0.00	0.00	0.9
681	112296	Post-Elongation Processing of Intron-Containing pre-mRNA	1	1025	28	25226	1.00	0.00	0.00	0.9
682	168325	Viral Messenger RNA Synthesis	1	1025	36	25218	1.00	0.00	0.00	0.7
683	75955	RNA Polymerase II Transcription Elongation	1	1025	37	25217	1.00	0.00	0.00	0.7
684	113418	Formation of the Early Elongation Complex	1	1025	28	25226	1.00	0.00	0.00	0.9
685	167169	HIV-1 Transcription Elongation	1	1025	30	25224	1.00	0.00	0.00	0.8
686	109688	Cleavage of Growing Transcript in the Termination Region	1	1025	39	25215	1.00	0.00	0.00	0.6
687	112382	Formation of RNA Pol II elongation complex	1	1025	37	25217	1.00	0.00	0.00	0.7
688	76044	Post-Elongation Processing of the Transcript	1	1025	39	25215	1.00	0.00	0.00	0.6
689	73856	RNA Polymerase II Transcription Termination	1	1025	39	25215	1.00	0.00	0.00	0.6
690	72202	Transport of Mature Transcript to Cytoplasm	1	1025	26	25228	1.00	0.00	0.00	0.9
691	112387	Elongation arrest and recovery	1	1025	27	25227	1.00	0.00	0.00	0.9
692	73937	Transcription-coupled NER (TC-NER)	1	1025	41	25213	1.00	0.00	0.00	0.6
693	73885	Nucleotide Excision Repair	1	1025	45	25209	1.00	0.00	0.00	0.5

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