#PathwayID Name t-total t+ t- b+ b- b-total p-value t-ratiot b-ratio (t-ratio)/(b-ratio) SigTest hsa04510 Focal adhesion - Homo sapiens (human) 1026 75 951 197 25057 25254 2.356e-42 0.07 0.01 9.4 Nominal_Sig hsa04210 Apoptosis - Homo sapiens (human) 1026 49 977 83 25171 25254 6.683e-35 0.05 0.00 14.5 Nominal_Sig hsa04010 MAPK signaling pathway - Homo sapiens (human) 1026 73 953 259 24995 25254 4.292e-34 0.07 0.01 6.9 Nominal_Sig 109582 Hemostasis 1026 62 964 172 25082 25254 4.542e-34 0.06 0.01 8.9 Nominal_Sig hsa05215 Prostate cancer - Homo sapiens (human) 1026 49 977 93 25161 25254 3.785e-33 0.05 0.00 13.0 Nominal_Sig hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) 1026 45 981 72 25182 25254 5.991e-33 0.04 0.00 15.4 Nominal_Sig hsa04910 Insulin signaling pathway - Homo sapiens (human) 1026 53 973 137 25117 25254 1.676e-30 0.05 0.01 9.5 Nominal_Sig hsa05212 Pancreatic cancer - Homo sapiens (human) 1026 42 984 74 25180 25254 1.419e-29 0.04 0.00 14.0 Nominal_Sig 168256 Signaling in Immune system 1026 72 954 312 24942 25254 5.520e-29 0.07 0.01 5.7 Nominal_Sig hsa05222 Small cell lung cancer - Homo sapiens (human) 1026 43 983 87 25167 25254 2.281e-28 0.04 0.00 12.2 Nominal_Sig hsa05220 Chronic myeloid leukemia - Homo sapiens (human) 1026 41 985 77 25177 25254 4.460e-28 0.04 0.00 13.1 Nominal_Sig hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) 1026 46 980 120 25134 25254 1.689e-26 0.04 0.00 9.4 Nominal_Sig hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) 1026 43 983 102 25152 25254 3.553e-26 0.04 0.00 10.4 Nominal_Sig 166520 Signalling by NGF 1026 46 980 125 25129 25254 6.862e-26 0.04 0.00 9.1 Nominal_Sig hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 1026 61 965 255 24999 25254 2.025e-25 0.06 0.01 5.9 Nominal_Sig hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 1026 56 970 214 25040 25254 4.731e-25 0.05 0.01 6.4 Nominal_Sig hsa04012 ErbB signaling pathway - Homo sapiens (human) 1026 39 987 87 25167 25254 1.240e-24 0.04 0.00 11.0 Nominal_Sig 187037 TRKA signalling from the plasma membrane 1026 36 990 75 25179 25254 1.254e-23 0.04 0.00 11.8 Nominal_Sig hsa05214 Glioma - Homo sapiens (human) 1026 34 992 65 25189 25254 2.560e-23 0.03 0.00 12.9 Nominal_Sig hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) 1026 34 992 75 25179 25254 9.058e-22 0.03 0.00 11.2 Nominal_Sig hsa03320 PPAR signaling pathway - Homo sapiens (human) 1026 32 994 69 25185 25254 8.404e-21 0.03 0.00 11.4 Nominal_Sig hsa05210 Colorectal cancer - Homo sapiens (human) 1026 34 992 84 25170 25254 1.571e-20 0.03 0.00 10.0 Nominal_Sig hsa05221 Acute myeloid leukemia - Homo sapiens (human) 1026 29 997 57 25197 25254 7.792e-20 0.03 0.00 12.5 Nominal_Sig hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) 1026 42 984 153 25101 25254 9.326e-20 0.04 0.01 6.8 Nominal_Sig hsa04660 T cell receptor signaling pathway - Homo sapiens (human) 1026 34 992 92 25162 25254 1.571e-19 0.03 0.00 9.1 Nominal_Sig hsa05218 Melanoma - Homo sapiens (human) 1026 31 995 72 25182 25254 1.862e-19 0.03 0.00 10.6 Nominal_Sig hsa04640 Hematopoietic cell lineage - Homo sapiens (human) 1026 33 993 88 25166 25254 3.753e-19 0.03 0.00 9.2 Nominal_Sig hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) 1026 30 996 68 25186 25254 4.155e-19 0.03 0.00 10.9 Nominal_Sig hsa05211 Renal cell carcinoma - Homo sapiens (human) 1026 30 996 69 25185 25254 5.743e-19 0.03 0.00 10.7 Nominal_Sig hsa04370 VEGF signaling pathway - Homo sapiens (human) 1026 30 996 70 25184 25254 7.903e-19 0.03 0.00 10.5 Nominal_Sig hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) 1026 38 988 130 25124 25254 8.912e-19 0.04 0.01 7.2 Nominal_Sig hsa05223 Non-small cell lung cancer - Homo sapiens (human) 1026 27 999 54 25200 25254 2.058e-18 0.03 0.00 12.3 Nominal_Sig hsa04912 GnRH signaling pathway - Homo sapiens (human) 1026 33 993 97 25157 25254 4.129e-18 0.03 0.00 8.4 Nominal_Sig 109581 Apoptosis 1026 29 997 69 25185 25254 4.585e-18 0.03 0.00 10.3 Nominal_Sig hsa04930 Type II diabetes mellitus - Homo sapiens (human) 1026 24 1002 45 25209 25254 5.214e-17 0.02 0.00 13.1 Nominal_Sig hsa05219 Bladder cancer - Homo sapiens (human) 1026 23 1003 41 25213 25254 1.010e-16 0.02 0.00 13.8 Nominal_Sig 198203 PI3K/AKT signalling 1026 20 1006 31 25223 25254 1.387e-15 0.02 0.00 15.9 Nominal_Sig hsa04520 Adherens junction - Homo sapiens (human) 1026 27 999 76 25178 25254 1.893e-15 0.03 0.00 8.7 Nominal_Sig 73923 Lipid and lipoprotein metabolism 1026 36 990 156 25098 25254 4.047e-15 0.04 0.01 5.7 Nominal_Sig hsa04662 B cell receptor signaling pathway - Homo sapiens (human) 1026 24 1002 63 25191 25254 1.981e-14 0.02 0.00 9.4 Nominal_Sig hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) 1026 24 1002 64 25190 25254 2.625e-14 0.02 0.00 9.2 Nominal_Sig 71387 Metabolism of carbohydrates 1026 28 998 95 25159 25254 2.829e-14 0.03 0.00 7.3 Nominal_Sig hsa05213 Endometrial cancer - Homo sapiens (human) 1026 22 1004 52 25202 25254 4.369e-14 0.02 0.00 10.4 Nominal_Sig 163685 Integration of energy metabolism 1026 24 1002 69 25185 25254 1.007e-13 0.02 0.00 8.6 Nominal_Sig 71406 Pyruvate metabolism and TCA cycle 1026 17 1009 25 25229 25254 1.012e-13 0.02 0.00 16.7 Nominal_Sig hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) 1026 17 1009 27 25227 25254 2.534e-13 0.02 0.00 15.5 Nominal_Sig hsa04115 p53 signaling pathway - Homo sapiens (human) 1026 23 1003 66 25188 25254 3.183e-13 0.02 0.00 8.6 Nominal_Sig hsa00590 Arachidonic acid metabolism - Homo sapiens (human) 1026 21 1005 53 25201 25254 4.578e-13 0.02 0.00 9.8 Nominal_Sig 75178 Formation of Platelet plug 1026 23 1003 69 25185 25254 6.824e-13 0.02 0.00 8.2 Nominal_Sig 202733 Cell surface interactions at the vascular wall 1026 23 1003 70 25184 25254 8.735e-13 0.02 0.00 8.1 Nominal_Sig hsa04540 Gap junction - Homo sapiens (human) 1026 26 1000 95 25159 25254 9.873e-13 0.03 0.00 6.7 Nominal_Sig hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 1026 45 981 302 24952 25254 1.784e-12 0.04 0.01 3.7 Nominal_Sig hsa04020 Calcium signaling pathway - Homo sapiens (human) 1026 34 992 176 25078 25254 1.902e-12 0.03 0.01 4.8 Nominal_Sig hsa01510 Neurodegenerative Diseases - Homo sapiens (human) 1026 18 1008 39 25215 25254 2.819e-12 0.02 0.00 11.4 Nominal_Sig 71291 Metabolism of amino acids 1026 25 1001 92 25162 25254 3.075e-12 0.02 0.00 6.7 Nominal_Sig 74752 Signaling by Insulin receptor 1026 18 1008 43 25211 25254 1.028e-11 0.02 0.00 10.3 Nominal_Sig hsa04150 mTOR signaling pathway - Homo sapiens (human) 1026 18 1008 47 25207 25254 3.368e-11 0.02 0.00 9.4 Nominal_Sig hsa04916 Melanogenesis - Homo sapiens (human) 1026 24 1002 101 25153 25254 9.047e-11 0.02 0.00 5.8 Nominal_Sig 140192 Metabolism of xenobiotics 1026 23 1003 93 25161 25254 1.128e-10 0.02 0.00 6.1 Nominal_Sig 70326 Glucose metabolism 1026 19 1007 60 25194 25254 1.413e-10 0.02 0.00 7.8 Nominal_Sig hsa00480 Glutathione metabolism - Homo sapiens (human) 1026 16 1010 39 25215 25254 1.843e-10 0.02 0.00 10.1 Nominal_Sig hsa04110 Cell cycle - Homo sapiens (human) 1026 25 1001 115 25139 25254 1.883e-10 0.02 0.00 5.4 Nominal_Sig 71403 Citric acid cycle (TCA cycle) 1026 12 1014 16 25238 25254 2.008e-10 0.01 0.00 18.5 Nominal_Sig 71408 Metabolism of small molecules 1026 21 1005 79 25175 25254 2.353e-10 0.02 0.00 6.5 Nominal_Sig 202403 TCR signaling 1026 17 1009 47 25207 25254 2.438e-10 0.02 0.00 8.9 Nominal_Sig hsa04350 TGF-beta signaling pathway - Homo sapiens (human) 1026 22 1004 89 25165 25254 2.879e-10 0.02 0.00 6.1 Nominal_Sig 77389 IRS-related events 1026 15 1011 35 25219 25254 4.214e-10 0.01 0.00 10.5 Nominal_Sig hsa00620 Pyruvate metabolism - Homo sapiens (human) 1026 16 1010 42 25212 25254 4.438e-10 0.02 0.00 9.4 Nominal_Sig 74751 Insulin receptor signalling cascade 1026 15 1011 36 25218 25254 5.756e-10 0.01 0.00 10.3 Nominal_Sig hsa04730 Long-term depression - Homo sapiens (human) 1026 20 1006 76 25178 25254 7.301e-10 0.02 0.00 6.5 Nominal_Sig 168898 Toll Receptor Cascades 1026 16 1010 44 25210 25254 7.716e-10 0.02 0.00 9.0 Nominal_Sig hsa04940 Type I diabetes mellitus - Homo sapiens (human) 1026 16 1010 44 25210 25254 7.716e-10 0.02 0.00 9.0 Nominal_Sig hsa04720 Long-term potentiation - Homo sapiens (human) 1026 19 1007 68 25186 25254 8.313e-10 0.02 0.00 6.9 Nominal_Sig 202424 Downstream TCR signaling 1026 15 1011 39 25215 25254 1.400e-09 0.01 0.00 9.5 Nominal_Sig hsa00330 Arginine and proline metabolism - Homo sapiens (human) 1026 14 1012 35 25219 25254 3.298e-09 0.01 0.00 9.8 Nominal_Sig 168249 Innate Immunity Signaling 1026 17 1009 59 25195 25254 4.346e-09 0.02 0.00 7.1 Nominal_Sig hsa00071 Fatty acid metabolism - Homo sapiens (human) 1026 16 1010 51 25203 25254 4.483e-09 0.02 0.00 7.7 Nominal_Sig hsa00251 Glutamate metabolism - Homo sapiens (human) 1026 13 1013 31 25223 25254 7.647e-09 0.01 0.00 10.3 Nominal_Sig 112399 IRS-mediated signalling 1026 13 1013 32 25222 25254 1.037e-08 0.01 0.00 10.0 Nominal_Sig hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 1026 24 1002 133 25121 25254 1.088e-08 0.02 0.01 4.4 Nominal_Sig hsa04310 Wnt signaling pathway - Homo sapiens (human) 1026 25 1001 147 25107 25254 1.538e-08 0.02 0.01 4.2 Nominal_Sig 168164 Toll Like Receptor 3 (TLR3) Cascade 1026 11 1015 21 25233 25254 1.849e-08 0.01 0.00 12.9 Nominal_Sig 70268 Cori Cycle (interconversion of glucose and lactate) 1026 13 1013 34 25220 25254 1.858e-08 0.01 0.00 9.4 Nominal_Sig 76005 Response to elevated platelet cytosolic Ca++ 1026 15 1011 50 25204 25254 2.244e-08 0.01 0.00 7.4 Nominal_Sig hsa04512 ECM-receptor interaction - Homo sapiens (human) 1026 19 1007 86 25168 25254 2.247e-08 0.02 0.00 5.4 Nominal_Sig hsa05010 Alzheimer's disease - Homo sapiens (human) 1026 12 1014 28 25226 25254 2.390e-08 0.01 0.00 10.5 Nominal_Sig 168180 TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade 1026 10 1016 18 25236 25254 5.442e-08 0.01 0.00 13.7 Nominal_Sig 177929 Signaling by EGFR 1026 14 1012 46 25208 25254 5.676e-08 0.01 0.00 7.5 Nominal_Sig 109606 Intrinsic Pathway for Apoptosis 1026 12 1014 31 25223 25254 5.889e-08 0.01 0.00 9.5 Nominal_Sig hsa05216 Thyroid cancer - Homo sapiens (human) 1026 12 1014 31 25223 25254 5.889e-08 0.01 0.00 9.5 Nominal_Sig hsa05040 Huntington's disease - Homo sapiens (human) 1026 12 1014 31 25223 25254 5.889e-08 0.01 0.00 9.5 Nominal_Sig hsa00252 Alanine and aspartate metabolism - Homo sapiens (human) 1026 12 1014 33 25221 25254 1.027e-07 0.01 0.00 9.0 Nominal_Sig 15869 Nucleotide metabolism 1026 19 1007 99 25155 25254 1.565e-07 0.02 0.00 4.7 Nominal_Sig hsa05130 Pathogenic Escherichia coli infection - EHEC - Homo sapiens (human) 1026 14 1012 51 25203 25254 1.664e-07 0.01 0.00 6.8 Nominal_Sig hsa05131 Pathogenic Escherichia coli infection - EPEC - Homo sapiens (human) 1026 14 1012 51 25203 25254 1.664e-07 0.01 0.00 6.8 Nominal_Sig 163200 Electron Transport Chain 1026 16 1010 70 25184 25254 1.923e-07 0.02 0.00 5.6 Nominal_Sig 73847 Purine metabolism 1026 13 1013 44 25210 25254 2.252e-07 0.01 0.00 7.3 Nominal_Sig 70263 Gluconeogenesis 1026 10 1016 22 25232 25254 2.320e-07 0.01 0.00 11.2 Nominal_Sig hsa00710 Carbon fixation - Homo sapiens (human) 1026 10 1016 23 25231 25254 3.213e-07 0.01 0.00 10.7 Nominal_Sig hsa00650 Butanoate metabolism - Homo sapiens (human) 1026 13 1013 46 25208 25254 3.462e-07 0.01 0.00 7.0 Nominal_Sig 114611 Exocytosis of Alpha granule 1026 13 1013 46 25208 25254 3.462e-07 0.01 0.00 7.0 Nominal_Sig 114608 Platelet degranulation 1026 13 1013 47 25207 25254 4.263e-07 0.01 0.00 6.8 Nominal_Sig 73887 Death Receptor Signalling 1026 8 1018 12 25242 25254 4.353e-07 0.01 0.00 16.4 Nominal_Sig 109607 Extrinsic Pathway for Apoptosis 1026 8 1018 12 25242 25254 4.353e-07 0.01 0.00 16.4 Nominal_Sig 140191 Phase 1 functionalization 1026 10 1016 24 25230 25254 4.393e-07 0.01 0.00 10.3 Nominal_Sig hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) 1026 10 1016 25 25229 25254 5.935e-07 0.01 0.00 9.8 Nominal_Sig hsa05060 Prion disease - Homo sapiens (human) 1026 8 1018 13 25241 25254 6.791e-07 0.01 0.00 15.1 Nominal_Sig 74231 Purine biosynthesis 1026 10 1016 27 25227 25254 1.049e-06 0.01 0.00 9.1 Nominal_Sig hsa04530 Tight junction - Homo sapiens (human) 1026 20 1006 126 25128 25254 1.086e-06 0.02 0.00 3.9 Nominal_Sig 187687 Signalling to ERKs 1026 11 1015 35 25219 25254 1.158e-06 0.01 0.00 7.7 Nominal_Sig hsa00680 Methane metabolism - Homo sapiens (human) 1026 7 1019 10 25244 25254 1.868e-06 0.01 0.00 17.2 Nominal_Sig hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) 1026 12 1014 46 25208 25254 1.996e-06 0.01 0.00 6.4 Nominal_Sig hsa00360 Phenylalanine metabolism - Homo sapiens (human) 1026 10 1016 30 25224 25254 2.295e-06 0.01 0.00 8.2 Nominal_Sig hsa04610 Complement and coagulation cascades - Homo sapiens (human) 1026 14 1012 69 25185 25254 3.756e-06 0.01 0.00 5.0 Nominal_Sig hsa00410 beta-Alanine metabolism - Homo sapiens (human) 1026 9 1017 25 25229 25254 4.419e-06 0.01 0.00 8.9 Nominal_Sig 198323 AKT phosphorylates targets in the cytosol 1026 7 1019 12 25242 25254 4.519e-06 0.01 0.00 14.4 Nominal_Sig 112412 SOS-mediated signalling 1026 7 1019 12 25242 25254 4.519e-06 0.01 0.00 14.4 Nominal_Sig 111471 Apoptotic factor-mediated response 1026 6 1020 7 25247 25254 4.730e-06 0.01 0.00 21.1 Nominal_Sig 167044 Signalling to RAS 1026 9 1017 26 25228 25254 5.744e-06 0.01 0.00 8.5 Nominal_Sig 74226 ATP formation 1026 8 1018 19 25235 25254 6.012e-06 0.01 0.00 10.4 Nominal_Sig hsa05030 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 1026 8 1018 19 25235 25254 6.012e-06 0.01 0.00 10.4 Nominal_Sig hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) 1026 11 1015 44 25210 25254 7.529e-06 0.01 0.00 6.2 Nominal_Sig 77388 SHC-related events 1026 7 1019 14 25240 25254 9.737e-06 0.01 0.00 12.3 Nominal_Sig hsa00190 Oxidative phosphorylation - Homo sapiens (human) 1026 17 1009 113 25141 25254 1.282e-05 0.02 0.00 3.7 Nominal_Sig 210990 PECAM1 interactions 1026 6 1020 9 25245 25254 1.290e-05 0.01 0.00 16.4 Nominal_Sig 198693 AKT phosphorylates targets in the nucleus 1026 6 1020 9 25245 25254 1.290e-05 0.01 0.00 16.4 Nominal_Sig hsa00930 Caprolactam degradation - Homo sapiens (human) 1026 7 1019 15 25239 25254 1.380e-05 0.01 0.00 11.5 Nominal_Sig hsa05050 Dentatorubropallidoluysian atrophy (DRPLA) - Homo sapiens (human) 1026 7 1019 15 25239 25254 1.380e-05 0.01 0.00 11.5 Nominal_Sig 109704 PI3K Cascade 1026 8 1018 22 25232 25254 1.428e-05 0.01 0.00 9.0 Nominal_Sig hsa00561 Glycerolipid metabolism - Homo sapiens (human) 1026 12 1014 59 25195 25254 1.797e-05 0.01 0.00 5.0 Nominal_Sig 70171 Glycolysis 1026 8 1018 23 25231 25254 1.859e-05 0.01 0.00 8.6 Nominal_Sig 198725 Nuclear Events (kinase and transcription factor activation) 1026 8 1018 23 25231 25254 1.859e-05 0.01 0.00 8.6 Nominal_Sig 170984 ARMS-mediated activation 1026 7 1019 16 25238 25254 1.917e-05 0.01 0.00 10.8 Nominal_Sig 169893 Prolonged ERK activation events 1026 7 1019 16 25238 25254 1.917e-05 0.01 0.00 10.8 Nominal_Sig 170968 Frs2-mediated activation 1026 7 1019 16 25238 25254 1.917e-05 0.01 0.00 10.8 Nominal_Sig hsa00350 Tyrosine metabolism - Homo sapiens (human) 1026 12 1014 60 25194 25254 2.081e-05 0.01 0.00 4.9 Nominal_Sig hsa00052 Galactose metabolism - Homo sapiens (human) 1026 9 1017 33 25221 25254 2.837e-05 0.01 0.00 6.7 Nominal_Sig hsa00640 Propanoate metabolism - Homo sapiens (human) 1026 9 1017 33 25221 25254 2.837e-05 0.01 0.00 6.7 Nominal_Sig hsa00720 Reductive carboxylate cycle (CO2 fixation) - Homo sapiens (human) 1026 6 1020 11 25243 25254 2.982e-05 0.01 0.00 13.4 Nominal_Sig 77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 1026 6 1020 11 25243 25254 2.982e-05 0.01 0.00 13.4 Nominal_Sig 198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1026 12 1014 63 25191 25254 3.178e-05 0.01 0.00 4.7 Nominal_Sig 111459 Activation of caspases through apoptosome-mediated cleavage 1026 5 1021 6 25248 25254 3.409e-05 0.00 0.00 20.5 Nominal_Sig 75157 FasL/ CD95L signaling 1026 5 1021 6 25248 25254 3.409e-05 0.00 0.00 20.5 Nominal_Sig 111461 Cytochrome c-mediated apoptotic response 1026 5 1021 6 25248 25254 3.409e-05 0.00 0.00 20.5 Nominal_Sig hsa00030 Pentose phosphate pathway - Homo sapiens (human) 1026 8 1018 26 25228 25254 3.856e-05 0.01 0.00 7.6 Nominal_Sig 74749 Signal attenuation 1026 6 1020 12 25242 25254 4.325e-05 0.01 0.00 12.3 Nominal_Sig hsa04360 Axon guidance - Homo sapiens (human) 1026 17 1009 127 25127 25254 4.890e-05 0.02 0.01 3.3 Nominal_Sig hsa00940 Phenylpropanoid biosynthesis - Homo sapiens (human) 1026 5 1021 7 25247 25254 5.656e-05 0.00 0.00 17.6 Nominal_Sig 140181 Cytochrome p450 1026 6 1020 13 25241 25254 6.113e-05 0.01 0.00 11.4 Nominal_Sig 75153 Apoptotic execution phase 1026 7 1019 21 25233 25254 7.804e-05 0.01 0.00 8.2 Nominal_Sig 111465 Cleavage of cellular proteins by active caspases 1026 7 1019 21 25233 25254 7.804e-05 0.01 0.00 8.2 Nominal_Sig 77289 Mitochondrial Fatty Acid Beta-Oxidation 1026 6 1020 14 25240 25254 8.445e-05 0.01 0.00 10.5 Nominal_Sig hsa00310 Lysine degradation - Homo sapiens (human) 1026 10 1016 49 25205 25254 8.686e-05 0.01 0.00 5.0 Nominal_Sig 140534 Caspase-8 is formed from procaspase-8 1026 5 1021 8 25246 25254 8.895e-05 0.00 0.00 15.4 Nominal_Sig 180292 Gab1 signalosome 1026 5 1021 8 25246 25254 8.895e-05 0.00 0.00 15.4 Nominal_Sig 75205 Dissolution of Fibrin Clot 1026 5 1021 8 25246 25254 8.895e-05 0.00 0.00 15.4 Nominal_Sig 204174 Regulation of pyruvate dehydrogenase complex (PDC) 1026 5 1021 8 25246 25254 8.895e-05 0.00 0.00 15.4 Nominal_Sig 69416 Activation of Pro-Caspase 8 1026 5 1021 8 25246 25254 8.895e-05 0.00 0.00 15.4 Nominal_Sig hsa01430 Cell Communication - Homo sapiens (human) 1026 17 1009 135 25119 25254 9.670e-05 0.02 0.01 3.1 Nominal_Sig 210993 Tie2 Signaling 1026 6 1020 15 25239 25254 1.143e-04 0.01 0.00 9.8 Nominal_Sig 114509 Platelet activation triggers 1026 6 1020 15 25239 25254 1.143e-04 0.01 0.00 9.8 Nominal_Sig 71064 Lysine catabolism 1026 5 1021 9 25245 25254 1.339e-04 0.00 0.00 13.7 Nominal_Sig 109869 MAP kinase cascade 1026 5 1021 9 25245 25254 1.339e-04 0.00 0.00 13.7 Nominal_Sig 190375 FGFR2c ligand binding and activation 1026 6 1020 16 25238 25254 1.520e-04 0.01 0.00 9.2 Nominal_Sig hsa01040 Polyunsaturated fatty acid biosynthesis - Homo sapiens (human) 1026 6 1020 16 25238 25254 1.520e-04 0.01 0.00 9.2 Nominal_Sig 166016 Toll Like Receptor 4 (TLR4) Cascade 1026 7 1019 24 25230 25254 1.565e-04 0.01 0.00 7.2 Nominal_Sig hsa04612 Antigen processing and presentation - Homo sapiens (human) 1026 13 1013 89 25165 25254 1.702e-04 0.01 0.00 3.6 Nominal_Sig hsa04614 Renin-angiotensin system - Homo sapiens (human) 1026 6 1020 17 25237 25254 1.989e-04 0.01 0.00 8.7 Nominal_Sig 76002 Platelet Activation 1026 6 1020 17 25237 25254 1.989e-04 0.01 0.00 8.7 Nominal_Sig 196854 Metabolism of vitamins and cofactors 1026 10 1016 56 25198 25254 2.280e-04 0.01 0.00 4.4 Nominal_Sig hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 1026 11 1015 68 25186 25254 2.424e-04 0.01 0.00 4.0 Nominal_Sig 111463 SMAC binds to IAPs 1026 4 1022 5 25249 25254 2.486e-04 0.00 0.00 19.7 Nominal_Sig 199418 Negative regulation of the PI3K/AKT network 1026 4 1022 5 25249 25254 2.486e-04 0.00 0.00 19.7 Nominal_Sig 111469 SMAC-mediated apoptotic response 1026 4 1022 5 25249 25254 2.486e-04 0.00 0.00 19.7 Nominal_Sig 111464 SMAC-mediated dissociation of IAP:caspase complexes 1026 4 1022 5 25249 25254 2.486e-04 0.00 0.00 19.7 Nominal_Sig 198753 ERK/MAPK targets 1026 6 1020 18 25236 25254 2.565e-04 0.01 0.00 8.2 Nominal_Sig 112410 SHC-mediated signalling 1026 5 1021 11 25243 25254 2.737e-04 0.00 0.00 11.2 Nominal_Sig 168927 Viral dsRNA:TLR3:TRIF Complex Activates RIP1 1026 5 1021 11 25243 25254 2.737e-04 0.00 0.00 11.2 Nominal_Sig 163359 Glucagon signaling in metabolic regulation 1026 7 1019 27 25227 25254 2.890e-04 0.01 0.00 6.4 Nominal_Sig hsa04320 Dorso-ventral axis formation - Homo sapiens (human) 1026 7 1019 28 25226 25254 3.492e-04 0.01 0.00 6.2 Nominal_Sig 190376 FGFR ligand binding and activation 1026 7 1019 28 25226 25254 3.492e-04 0.01 0.00 6.2 Nominal_Sig 163210 Formation of ATP by chemiosmotic coupling 1026 5 1021 12 25242 25254 3.754e-04 0.00 0.00 10.3 Nominal_Sig 71397 Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase 1026 4 1022 6 25248 25254 4.016e-04 0.00 0.00 16.4 Nominal_Sig 75158 TRAIL signaling 1026 4 1022 6 25248 25254 4.016e-04 0.00 0.00 16.4 Nominal_Sig 75893 TNF signaling 1026 4 1022 6 25248 25254 4.016e-04 0.00 0.00 16.4 Nominal_Sig 156580 Phase II conjugation 1026 8 1018 40 25214 25254 4.943e-04 0.01 0.00 4.9 Nominal_Sig 140877 Formation of Fibrin Clot (Clotting Cascade) 1026 7 1019 30 25224 25254 4.996e-04 0.01 0.00 5.7 Nominal_Sig 194138 Signaling by VEGF 1026 5 1021 13 25241 25254 5.031e-04 0.00 0.00 9.5 Nominal_Sig hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 1026 5 1021 13 25241 25254 5.031e-04 0.00 0.00 9.5 Nominal_Sig 69615 G1/S DNA Damage Checkpoints 1026 5 1021 13 25241 25254 5.031e-04 0.00 0.00 9.5 Nominal_Sig 164378 PKA activation in glucagon signalling 1026 5 1021 13 25241 25254 5.031e-04 0.00 0.00 9.5 Nominal_Sig 190241 FGFR2 ligand binding and activation 1026 6 1020 21 25233 25254 5.104e-04 0.01 0.00 7.0 Nominal_Sig 190236 Signaling by FGFR 1026 7 1019 31 25223 25254 5.920e-04 0.01 0.00 5.6 Nominal_Sig 196836 Vitamin C (ascorbate) metabolism 1026 4 1022 7 25247 25254 6.116e-04 0.00 0.00 14.1 Nominal_Sig 74713 IRS activation 1026 4 1022 7 25247 25254 6.116e-04 0.00 0.00 14.1 Nominal_Sig 196849 Metabolism of water-soluble vitamins and cofactors 1026 8 1018 42 25212 25254 6.566e-04 0.01 0.00 4.7 Nominal_Sig 187706 Signalling to p38 via RIT and RIN 1026 5 1021 14 25240 25254 6.609e-04 0.00 0.00 8.8 Nominal_Sig hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) 1026 11 1015 78 25176 25254 6.880e-04 0.01 0.00 3.5 Nominal_Sig 190239 FGFR3 ligand binding and activation 1026 5 1021 15 25239 25254 8.531e-04 0.00 0.00 8.2 Nominal_Sig 190372 FGFR3c ligand binding and activation 1026 5 1021 15 25239 25254 8.531e-04 0.00 0.00 8.2 Nominal_Sig 114696 Thrombin-activated activation cascade 1026 4 1022 8 25246 25254 8.891e-04 0.00 0.00 12.3 Nominal_Sig 114665 G-protein cascades 1026 4 1022 8 25246 25254 8.891e-04 0.00 0.00 12.3 Nominal_Sig 111458 Formation of apoptosome 1026 3 1023 3 25251 25254 1.086e-03 0.00 0.00 24.6 Nominal_Sig 167826 The fatty acid cycling model 1026 3 1023 3 25251 25254 1.086e-03 0.00 0.00 24.6 Nominal_Sig 166187 Mitochondrial Uncoupling Proteins 1026 3 1023 3 25251 25254 1.086e-03 0.00 0.00 24.6 Nominal_Sig 70102 Phosphoenolpyruvate and ADP react to form pyruvate and ATP 1026 3 1023 3 25251 25254 1.086e-03 0.00 0.00 24.6 Nominal_Sig 167827 The proton buffering model 1026 3 1023 3 25251 25254 1.086e-03 0.00 0.00 24.6 Nominal_Sig hsa00380 Tryptophan metabolism - Homo sapiens (human) 1026 11 1015 84 25170 25254 1.191e-03 0.01 0.00 3.2 Nominal_Sig 69580 p53-Dependent G1/S DNA damage checkpoint 1026 4 1022 9 25245 25254 1.245e-03 0.00 0.00 10.9 Nominal_Sig hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) 1026 4 1022 9 25245 25254 1.245e-03 0.00 0.00 10.9 Nominal_Sig 69563 p53-Dependent G1 DNA Damage Response 1026 4 1022 9 25245 25254 1.245e-03 0.00 0.00 10.9 Nominal_Sig 69236 G1 Phase 1026 5 1021 17 25237 25254 1.358e-03 0.00 0.00 7.2 Nominal_Sig 69231 Cyclin D associated events in G1 1026 5 1021 17 25237 25254 1.358e-03 0.00 0.00 7.2 Nominal_Sig 190322 FGFR4 ligand binding and activation 1026 5 1021 17 25237 25254 1.358e-03 0.00 0.00 7.2 Nominal_Sig 69242 S Phase 1026 9 1017 60 25194 25254 1.408e-03 0.01 0.00 3.7 Nominal_Sig hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 1026 7 1019 38 25216 25254 1.680e-03 0.01 0.00 4.5 Nominal_Sig 164385 G(s)-alpha mediated events in glucagon signalling 1026 5 1021 18 25236 25254 1.680e-03 0.00 0.00 6.8 Nominal_Sig 77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 1026 3 1023 4 25250 25254 1.845e-03 0.00 0.00 18.5 Nominal_Sig hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human) 1026 3 1023 4 25250 25254 1.845e-03 0.00 0.00 18.5 Nominal_Sig 163680 AMPK inhibits chREBP transcriptional activation activity 1026 3 1023 4 25250 25254 1.845e-03 0.00 0.00 18.5 Nominal_Sig 75894 Synthesis of lysophosphatidic acid from glycerol-3-phosphate 1026 3 1023 4 25250 25254 1.845e-03 0.00 0.00 18.5 Nominal_Sig 202427 Phosphorylation of CD3 and TCR zeta chains 1026 5 1021 19 25235 25254 2.055e-03 0.00 0.00 6.5 Nominal_Sig 170834 Signaling by TGF beta 1026 5 1021 19 25235 25254 2.055e-03 0.00 0.00 6.5 Nominal_Sig hsa00903 Limonene and pinene degradation - Homo sapiens (human) 1026 6 1020 29 25225 25254 2.146e-03 0.01 0.00 5.1 Nominal_Sig 140875 Common Pathway 1026 4 1022 11 25243 25254 2.232e-03 0.00 0.00 9.0 Nominal_Sig 75892 Platelet Adhesion to exposed collagen 1026 4 1022 11 25243 25254 2.232e-03 0.00 0.00 9.0 Nominal_Sig 166054 Activated TLR4 signalling 1026 5 1021 20 25234 25254 2.487e-03 0.00 0.00 6.2 Nominal_Sig hsa00220 Urea cycle and metabolism of amino groups - Homo sapiens (human) 1026 6 1020 30 25224 25254 2.491e-03 0.01 0.00 4.9 Nominal_Sig hsa00790 Folate biosynthesis - Homo sapiens (human) 1026 7 1019 42 25212 25254 2.779e-03 0.01 0.00 4.1 Nominal_Sig 75815 Ubiquitin-dependent degradation of Cyclin D 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 194306 Neurophilin interactions with VEGF and VEGFR 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 69229 Ubiquitin-dependent degradation of Cyclin D1 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 70614 Aspartate, asparagine, glutamate, and glutamine metabolism 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 114666 G alpha Q cascade 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 140182 P450 Epoxidations 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 187577 SCF(Skp2)-mediated degradation of p27/p21 1026 3 1023 5 25249 25254 2.867e-03 0.00 0.00 14.8 Nominal_Sig 202433 Generation of second messenger molecules 1026 5 1021 21 25233 25254 2.981e-03 0.00 0.00 5.9 Nominal_Sig 69206 G1/S Transition 1026 8 1018 55 25199 25254 3.035e-03 0.01 0.00 3.6 Nominal_Sig hsa00051 Fructose and mannose metabolism - Homo sapiens (human) 1026 7 1019 43 25211 25254 3.124e-03 0.01 0.00 4.0 Nominal_Sig hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) 1026 9 1017 70 25184 25254 3.621e-03 0.01 0.00 3.2 Nominal_Sig 75109 Triacylglyceride Biosynthesis 1026 4 1022 13 25241 25254 3.658e-03 0.00 0.00 7.6 Nominal_Sig 114592 Collagen adhesion via alpha 2 beta 1 glycoprotein 1026 3 1023 6 25248 25254 4.176e-03 0.00 0.00 12.3 Nominal_Sig 77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1026 3 1023 6 25248 25254 4.176e-03 0.00 0.00 12.3 Nominal_Sig 179812 Grb2 events in EGFR signaling 1026 3 1023 6 25248 25254 4.176e-03 0.00 0.00 12.3 Nominal_Sig 77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1026 3 1023 6 25248 25254 4.176e-03 0.00 0.00 12.3 Nominal_Sig 77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1026 3 1023 6 25248 25254 4.176e-03 0.00 0.00 12.3 Nominal_Sig 190373 FGFR1c ligand binding and activation 1026 4 1022 14 25240 25254 4.559e-03 0.00 0.00 7.0 Nominal_Sig hsa00591 Linoleic acid metabolism - Homo sapiens (human) 1026 6 1020 35 25219 25254 4.876e-03 0.01 0.00 4.2 Nominal_Sig hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) 1026 4 1022 15 25239 25254 5.599e-03 0.00 0.00 6.6 Nominal_Sig 171007 p38MAPK events 1026 4 1022 15 25239 25254 5.599e-03 0.00 0.00 6.6 Nominal_Sig 202670 ERKs are inactivated 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 195399 VEGF binds to VEGFR leading to receptor dimerization 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 71288 Creatine metabolism 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 112407 RAF phosphorylates MEK 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 110049 MEK activation 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 109312 Hydrolysis of nucleoside 5'-monophosphates to nucleosides plus orthophosphate 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 180336 Shc events in EGFR signaling 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 71182 Phenylalanine and tyrosine catabolism 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig 70153 Glucose uptake 1026 3 1023 7 25247 25254 5.794e-03 0.00 0.00 10.5 Nominal_Sig hsa00562 Inositol phosphate metabolism - Homo sapiens (human) 1026 7 1019 50 25204 25254 6.539e-03 0.01 0.00 3.4 Nominal_Sig 168176 Toll Like Receptor 5 (TLR5) Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 202430 Translocation of ZAP-70 to Immunological synapse 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 166058 MyD88 cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 168142 Toll Like Receptor 10 (TLR10) Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 168188 Toll Like Receptor TLR6:TLR2 Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 181438 Toll Like Receptor 2 Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 168179 Toll Like Receptor TLR1:TLR2 Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 69656 Cyclin A:Cdk2-associated events at S phase entry 1026 4 1022 16 25238 25254 6.785e-03 0.00 0.00 6.2 Nominal_Sig 69239 Synthesis of DNA 1026 7 1019 51 25203 25254 7.192e-03 0.01 0.00 3.4 Nominal_Sig 69052 Switching of origins to a post-replicative state 1026 5 1021 27 25227 25254 7.526e-03 0.00 0.00 4.6 Nominal_Sig 68949 Orc1 removal from chromatin 1026 5 1021 27 25227 25254 7.526e-03 0.00 0.00 4.6 Nominal_Sig 173107 Binding and entry of HIV virion 1026 3 1023 8 25246 25254 7.738e-03 0.00 0.00 9.2 Nominal_Sig 156581 Methylation 1026 3 1023 8 25246 25254 7.738e-03 0.00 0.00 9.2 Nominal_Sig 71384 Ethanol catabolism 1026 3 1023 8 25246 25254 7.738e-03 0.00 0.00 9.2 Nominal_Sig 200409 Activated AMPK stimulates fatty-acid oxidation in muscle 1026 3 1023 8 25246 25254 7.738e-03 0.00 0.00 9.2 Nominal_Sig 202131 Metabolism of nitric oxide 1026 4 1022 17 25237 25254 8.126e-03 0.00 0.00 5.8 Nominal_Sig 156590 Glutathione conjugation 1026 4 1022 17 25237 25254 8.126e-03 0.00 0.00 5.8 Nominal_Sig 69304 Regulation of DNA replication 1026 5 1021 28 25226 25254 8.590e-03 0.00 0.00 4.4 Nominal_Sig 69300 Removal of licensing factors from origins 1026 5 1021 28 25226 25254 8.590e-03 0.00 0.00 4.4 Nominal_Sig 170822 Negative Regulation of Glucokinase by Glucokinase Regulatory Protein 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 111807 Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 198765 Signalling to ERK5 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 111457 Release of apoptotic factors from the mitochondria 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 111804 Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin) 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 212718 EGFR interacts with phospholipase C-gamma 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig 112409 ERK activation 1026 2 1024 2 25252 25254 8.669e-03 0.00 0.00 24.6 Nominal_Sig hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) 1026 6 1020 41 25213 25254 9.561e-03 0.01 0.00 3.6 Nominal_Sig hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) 1026 6 1020 41 25213 25254 9.561e-03 0.01 0.00 3.6 Nominal_Sig 69202 Cyclin E associated events during G1/S transition 1026 4 1022 18 25236 25254 9.630e-03 0.00 0.00 5.5 Nominal_Sig hsa00271 Methionine metabolism - Homo sapiens (human) 1026 4 1022 18 25236 25254 9.630e-03 0.00 0.00 5.5 Nominal_Sig 140837 Intrinsic Pathway 1026 4 1022 18 25236 25254 9.630e-03 0.00 0.00 5.5 Nominal_Sig 168138 Toll Like Receptor 9 (TLR9) Cascade 1026 4 1022 18 25236 25254 9.630e-03 0.00 0.00 5.5 Nominal_Sig 194313 VEGF ligand-receptor interactions 1026 3 1023 9 25245 25254 1.002e-02 0.00 0.00 8.2 Nominal_Sig 190371 FGFR3b ligand binding and activation 1026 3 1023 9 25245 25254 1.002e-02 0.00 0.00 8.2 Nominal_Sig 159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 1026 3 1023 9 25245 25254 1.002e-02 0.00 0.00 8.2 Nominal_Sig 75877 Conversion of Fatty Acyl-CoA to Phosphatidic Acid 1026 3 1023 9 25245 25254 1.002e-02 0.00 0.00 8.2 Nominal_Sig hsa00521 Streptomycin biosynthesis - Homo sapiens (human) 1026 3 1023 9 25245 25254 1.002e-02 0.00 0.00 8.2 Nominal_Sig hsa05217 Basal cell carcinoma - Homo sapiens (human) 1026 7 1019 55 25199 25254 1.029e-02 0.01 0.00 3.1 Nominal_Sig hsa00230 Purine metabolism - Homo sapiens (human) 1026 13 1013 147 25107 25254 1.184e-02 0.01 0.01 2.2 Nominal_Sig hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 1026 12 1014 128 25126 25254 1.260e-02 0.01 0.01 2.3 Nominal_Sig 174800 Chylomicron-mediated lipid transport 1026 3 1023 10 25244 25254 1.265e-02 0.00 0.00 7.4 Nominal_Sig 199920 CREB phosphorylation 1026 3 1023 10 25244 25254 1.265e-02 0.00 0.00 7.4 Nominal_Sig 174824 Lipoprotein metabolism 1026 3 1023 10 25244 25254 1.265e-02 0.00 0.00 7.4 Nominal_Sig hsa00062 Fatty acid elongation in mitochondria - Homo sapiens (human) 1026 3 1023 10 25244 25254 1.265e-02 0.00 0.00 7.4 Nominal_Sig 163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1026 3 1023 10 25244 25254 1.265e-02 0.00 0.00 7.4 Nominal_Sig hsa02010 ABC transporters - General - Homo sapiens (human) 1026 6 1020 44 25210 25254 1.283e-02 0.01 0.00 3.4 Nominal_Sig 190242 FGFR1 ligand binding and activation 1026 4 1022 20 25234 25254 1.315e-02 0.00 0.00 4.9 Nominal_Sig 174403 Glutathione synthesis 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 111752 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 114516 Disinhibition of SNARE formation 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 140187 P450 Prostaglandin isomerizations 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 71037 Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 77378 Formation of Cytosolic Glycerol-3-phosphate 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 75944 Transcription from mitochondrial promoters 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 165158 Activation of PKB 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 163282 Mitochondrial transcription initiation 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 77387 Insulin receptor recycling 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 71401 Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 75852 Formation of Malonyl-ACP on the other FAS monomer 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig 111751 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin) 1026 2 1024 3 25251 25254 1.408e-02 0.00 0.00 16.4 Nominal_Sig hsa00960 Alkaloid biosynthesis II - Homo sapiens (human) 1026 4 1022 21 25233 25254 1.519e-02 0.00 0.00 4.7 Nominal_Sig 159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 1026 3 1023 11 25243 25254 1.564e-02 0.00 0.00 6.7 Nominal_Sig 159740 Gamma-carboxylation of protein precursors 1026 3 1023 11 25243 25254 1.564e-02 0.00 0.00 6.7 Nominal_Sig 111748 Synthesis of deoxyribonucleoside 5'-diphosphates from ribonucleoside 5'-diphosphates 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 74744 SHC activation 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 168782 Proteolytic cleavage of SNARE complex proteins 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 166020 LPS transferred from LBP carrier to CD14 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 75107 Butyryl-ACP biosynthesis 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 69017 CDK-mediated phosphorylation and removal of Cdc6 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 110029 RAF activation 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 139943 PLC-mediated hydrolysis 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 76000 Assembly of the RAD51-ssDNA nucleoprotein complex 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 77108 Utilization of Ketone Bodies 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 76420 Simple hydroxylation 1026 2 1024 4 25250 25254 2.057e-02 0.00 0.00 12.3 Nominal_Sig 162594 Early Phase of HIV Life Cycle 1026 3 1023 13 25241 25254 2.271e-02 0.00 0.00 5.7 Nominal_Sig 159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 1026 3 1023 13 25241 25254 2.271e-02 0.00 0.00 5.7 Nominal_Sig 69278 Cell Cycle, Mitotic 1026 14 1012 178 25076 25254 2.295e-02 0.01 0.01 1.9 Nominal_Sig 69002 DNA Replication Pre-Initiation 1026 5 1021 37 25217 25254 2.312e-02 0.00 0.00 3.3 Nominal_Sig 70221 Glycogen breakdown (glycogenolysis) 1026 3 1023 14 25240 25254 2.680e-02 0.00 0.00 5.3 Nominal_Sig hsa00600 Sphingolipid metabolism - Homo sapiens (human) 1026 5 1021 39 25215 25254 2.771e-02 0.00 0.00 3.2 Nominal_Sig 76010 Homologous DNA pairing and strand exchange 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 70114 Glucose + ATP => glucose-6-phosphate + ADP 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 140186 P450 Hydroxylations 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 74219 dGTP formation 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig hsa00950 Alkaloid biosynthesis I - Homo sapiens (human) 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 74257 Xanthine formation 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 114508 Phospholipase-mediated signalling 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig hsa00281 Geraniol degradation - Homo sapiens (human) 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 140834 Extrinsic Pathway 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 74230 dATP formation 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 76003 Presynaptic phase of homologous DNA pairing and strand exchange 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig 74259 Purine catabolism 1026 2 1024 5 25249 25254 2.806e-02 0.00 0.00 9.8 Nominal_Sig hsa00361 gamma-Hexachlorocyclohexane degradation - Homo sapiens (human) 1026 4 1022 26 25228 25254 2.824e-02 0.00 0.00 3.8 Nominal_Sig 164952 The role of Nef in HIV-1 replication and disease pathogenesis 1026 4 1022 28 25226 25254 3.487e-02 0.00 0.00 3.5 Nominal_Sig hsa05110 Cholera - Infection - Homo sapiens (human) 1026 5 1021 42 25212 25254 3.561e-02 0.00 0.00 2.9 Nominal_Sig hsa04340 Hedgehog signaling pathway - Homo sapiens (human) 1026 6 1020 57 25197 25254 3.597e-02 0.01 0.00 2.6 Nominal_Sig 166166 TRAM Cascade 1026 2 1024 6 25248 25254 3.646e-02 0.00 0.00 8.2 Nominal_Sig 114664 G alpha 12 cascade 1026 2 1024 6 25248 25254 3.646e-02 0.00 0.00 8.2 Nominal_Sig hsa00061 Fatty acid biosynthesis - Homo sapiens (human) 1026 2 1024 6 25248 25254 3.646e-02 0.00 0.00 8.2 Nominal_Sig 168253 Host Interactions with Influenza Factors 1026 2 1024 6 25248 25254 3.646e-02 0.00 0.00 8.2 Nominal_Sig hsa00632 Benzoate degradation via CoA ligation - Homo sapiens (human) 1026 4 1022 29 25225 25254 3.849e-02 0.00 0.00 3.4 Nominal_Sig hsa04140 Regulation of autophagy - Homo sapiens (human) 1026 4 1022 29 25225 25254 3.849e-02 0.00 0.00 3.4 Nominal_Sig hsa00531 Glycosaminoglycan degradation - Homo sapiens (human) 1026 3 1023 17 25237 25254 4.122e-02 0.00 0.00 4.3 Nominal_Sig 70895 Branched-chain amino acid catabolism 1026 3 1023 17 25237 25254 4.122e-02 0.00 0.00 4.3 Nominal_Sig hsa04330 Notch signaling pathway - Homo sapiens (human) 1026 5 1021 45 25209 25254 4.477e-02 0.00 0.00 2.7 Nominal_Sig 74182 Ketone body metabolism 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig 164944 Nef and signal transduction 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig 114604 Collagen-mediated activation cascade 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig 110097 Reversible phosphorylation of nucleoside monophosphates 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig 142033 Ethanol Catabolism 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig 76604 Ribonucleotide salvage 1026 2 1024 7 25247 25254 4.568e-02 0.00 0.00 7.0 Nominal_Sig hsa00565 Ether lipid metabolism - Homo sapiens (human) 1026 4 1022 31 25223 25254 4.636e-02 0.00 0.00 3.2 Nominal_Sig 192076 Steroid metabolism 1026 6 1020 61 25193 25254 4.645e-02 0.01 0.00 2.4 Nominal_Sig 114452 Activation of BH3-only proteins 1026 3 1023 18 25236 25254 4.673e-02 0.00 0.00 4.1 Nominal_Sig 162909 Host Interactions of HIV factors 1026 7 1019 78 25176 25254 4.835e-02 0.01 0.00 2.2 Nominal_Sig 168799 Botulinum neurotoxicity 1026 3 1023 19 25235 25254 5.259e-02 0.00 0.00 3.9 Not_Sig 68962 Activation of the pre-replicative complex 1026 4 1022 33 25221 25254 5.506e-02 0.00 0.00 3.0 Not_Sig 74217 Purine salvage reactions 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 190370 FGFR1b ligand binding and activation 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 203615 eNOS activation 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 71336 Pentose phosphate pathway (hexose monophosphate shunt) 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig hsa00460 Cyanoamino acid metabolism - Homo sapiens (human) 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 114711 vWF interaction with collagen 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 190377 FGFR2b ligand binding and activation 1026 2 1024 8 25246 25254 5.565e-02 0.00 0.00 6.2 Not_Sig 73848 Pyrimidine metabolism 1026 3 1023 21 25233 25254 6.530e-02 0.00 0.00 3.5 Not_Sig 70172 Phosphorylase kinase activates glycogen phosphorylase 1026 2 1024 9 25245 25254 6.630e-02 0.00 0.00 5.5 Not_Sig hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) 1026 2 1024 9 25245 25254 6.630e-02 0.00 0.00 5.5 Not_Sig 111447 Activation of BAD and translocation to mitochondria 1026 2 1024 9 25245 25254 6.630e-02 0.00 0.00 5.5 Not_Sig 167021 PLC-gamma1 signalling 1026 2 1024 9 25245 25254 6.630e-02 0.00 0.00 5.5 Not_Sig 73648 Pyrimidine biosynthesis (interconversion) 1026 2 1024 9 25245 25254 6.630e-02 0.00 0.00 5.5 Not_Sig 164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1026 3 1023 22 25232 25254 7.214e-02 0.00 0.00 3.4 Not_Sig 180786 Extension of Telomeres 1026 3 1023 22 25232 25254 7.214e-02 0.00 0.00 3.4 Not_Sig 109368 Hydrolysis of cytosolic nucleoside 5'-monophosphates by 5'-nucleotidase cytosolic IA 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 191650 Regulation of gap junction activity 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig hsa00472 D-Arginine and D-ornithine metabolism - Homo sapiens (human) 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 140180 COX reactions 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 74243 Hypoxanthine formation 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 171052 LDL endocytosis 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 109471 Hydrolysis of cytosolic nucleoside 5'- and 3'-monophosphates by 5',3'-nucleotidase, cytosolic 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 71383 Acetate, ATP, and coenzyme A react to form acetyl CoA, AMP, and pyrophosphate 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 110056 ERK1 activation 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 112411 ERK2 activation 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 70105 1,3-bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 181546 BoNT Light Chain Types A, C1, E cleave SNAP-25 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 70109 Dihydroxyacetone phosphate is isomerized to form glyceraldehyde-3-phosphate 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 171319 Telomere Extension By Telomerase 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 109279 Hydrolysis of extracellular nucleoside 5'-monophosphates by plasma membrane-bound 5'-nucleotidase 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 70112 Glucose 6-phosphate is isomerized to form fructose-6-phosphate 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 193144 Estrogen biosynthesis 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 191647 c-src mediated regulation of Cx43 function and closure of gap junctions 1026 1 1025 1 25253 25254 7.656e-02 0.00 0.00 24.6 Not_Sig 199997 COPI Mediated Transport 1026 2 1024 10 25244 25254 7.756e-02 0.00 0.00 4.9 Not_Sig 70894 Valine catabolism 1026 2 1024 10 25244 25254 7.756e-02 0.00 0.00 4.9 Not_Sig 70845 Isoleucine catabolism 1026 2 1024 10 25244 25254 7.756e-02 0.00 0.00 4.9 Not_Sig 167590 Nef Mediated CD4 Down-regulation 1026 2 1024 10 25244 25254 7.756e-02 0.00 0.00 4.9 Not_Sig 199983 Golgi to ER Retrograde Transport 1026 2 1024 10 25244 25254 7.756e-02 0.00 0.00 4.9 Not_Sig hsa00120 Bile acid biosynthesis - Homo sapiens (human) 1026 4 1022 39 25215 25254 8.596e-02 0.00 0.00 2.5 Not_Sig hsa00910 Nitrogen metabolism - Homo sapiens (human) 1026 3 1023 24 25230 25254 8.671e-02 0.00 0.00 3.1 Not_Sig 69306 DNA Replication 1026 8 1018 106 25148 25254 8.864e-02 0.01 0.00 1.9 Not_Sig hsa00140 C21-Steroid hormone metabolism - Homo sapiens (human) 1026 2 1024 11 25243 25254 8.936e-02 0.00 0.00 4.5 Not_Sig hsa00500 Starch and sucrose metabolism - Homo sapiens (human) 1026 7 1019 85 25169 25254 9.378e-02 0.01 0.00 2.0 Not_Sig 201451 Signaling by BMP 1026 3 1023 25 25229 25254 9.443e-02 0.00 0.00 3.0 Not_Sig 69620 Cell Cycle Checkpoints 1026 9 1017 119 25135 25254 1.011e-01 0.01 0.00 1.9 Not_Sig hsa00290 Valine, leucine and isoleucine biosynthesis - Homo sapiens (human) 1026 2 1024 12 25242 25254 1.016e-01 0.00 0.00 4.1 Not_Sig 196071 Steroid hormone biosynthesis 1026 2 1024 12 25242 25254 1.016e-01 0.00 0.00 4.1 Not_Sig 165159 mTOR signalling 1026 2 1024 12 25242 25254 1.016e-01 0.00 0.00 4.1 Not_Sig 109703 PKB-mediated events 1026 2 1024 12 25242 25254 1.016e-01 0.00 0.00 4.1 Not_Sig 203765 eNOS activation and regulation 1026 2 1024 12 25242 25254 1.016e-01 0.00 0.00 4.1 Not_Sig 72649 Translation initiation complex formation 1026 5 1021 59 25195 25254 1.044e-01 0.00 0.00 2.1 Not_Sig 72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1026 5 1021 60 25194 25254 1.096e-01 0.00 0.00 2.1 Not_Sig 168769 BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 73728 RNA Polymerase I Promoter Opening 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 140188 P450 Dehalogenation 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 169131 Inhibition of PKR 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 75854 Formation of Acetyl-FAS on one FAS monomer 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 74236 Inosine formation 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 163765 ChREBP activates metabolic gene expression 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 111495 Conversion of cytosolic inosine 5'-monophosphate, L-aspartate, and GTP to adenylosuccinate, guanosine 5'-diphosphate, and orthophosphate 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 141333 Monoamines are oxidized to aldehydes, producing NH3 and H2O2 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig hsa00902 Monoterpenoid biosynthesis - Homo sapiens (human) 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 142048 Aldehyde Dehydrogenase 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 70525 Alanine metabolism 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 114294 Activation, translocation and oligomerization of BAX 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 110131 Reversible phosphorylation of mitochondrial nucleoside monophosphates by adenylate kinase 2 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 168277 Influenza Virus Induced Apoptosis 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 110123 Reversible phosphorylation of cytosolic nucleoside monophosphates by adenylate kinase 1 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig hsa00031 Inositol metabolism - Homo sapiens (human) 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 156579 P450 oxidation 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 111452 Activation and oligomerization of BAK protein 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 71364 Acetaldehyde is oxidized by NAD+ to form acetate, NADH, and H+ 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 198745 Signalling to STAT3 1026 1 1025 2 25252 25254 1.126e-01 0.00 0.00 12.3 Not_Sig 69481 G2/M Checkpoints 1026 4 1022 44 25210 25254 1.169e-01 0.00 0.00 2.2 Not_Sig 194068 Metabolism of bile acids and bile salts 1026 3 1023 28 25226 25254 1.191e-01 0.00 0.00 2.6 Not_Sig 194315 Signaling by Rho GTPases 1026 9 1017 132 25122 25254 1.255e-01 0.01 0.01 1.7 Not_Sig 69166 Removal of the Flap Intermediate 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig 73951 Homologous recombination repair of replication-independent double-strand breaks 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig hsa00603 Glycosphingolipid biosynthesis - globoseries - Homo sapiens (human) 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig 73888 Homologous Recombination Repair 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig 210500 Neuronal Glutamate cycle 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig 69183 Processive synthesis on the lagging strand 1026 2 1024 14 25240 25254 1.274e-01 0.00 0.00 3.5 Not_Sig hsa01032 Glycan structures - degradation - Homo sapiens (human) 1026 3 1023 29 25225 25254 1.279e-01 0.00 0.00 2.5 Not_Sig 157858 Gap junction trafficking and regulation 1026 3 1023 29 25225 25254 1.279e-01 0.00 0.00 2.5 Not_Sig hsa00450 Selenoamino acid metabolism - Homo sapiens (human) 1026 3 1023 30 25224 25254 1.368e-01 0.00 0.00 2.5 Not_Sig hsa00641 3-Chloroacrylic acid degradation - Homo sapiens (human) 1026 2 1024 15 25239 25254 1.409e-01 0.00 0.00 3.3 Not_Sig 69091 Polymerase switching 1026 2 1024 15 25239 25254 1.409e-01 0.00 0.00 3.3 Not_Sig 69109 Leading Strand Synthesis 1026 2 1024 15 25239 25254 1.409e-01 0.00 0.00 3.3 Not_Sig 174411 Polymerase switching on the C-strand of the telomere 1026 2 1024 15 25239 25254 1.409e-01 0.00 0.00 3.3 Not_Sig hsa00530 Aminosugars metabolism - Homo sapiens (human) 1026 3 1023 31 25223 25254 1.459e-01 0.00 0.00 2.4 Not_Sig 254954 PI3K/AKT signalling 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 163767 PP2A-mediated dephosphorylation of key metabolic factors 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 111742 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin) 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig hsa00401 Novobiocin biosynthesis - Homo sapiens (human) 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 254774 Signalling by NGF 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 140179 Amine Oxidase reactions 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 254985 AKT phosphorylates targets in the cytosol 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 180534 Vpu mediated degradation of CD4 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 166144 Mal Cascade 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 73927 Depurination 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 166662 Lectin pathway of complement activation 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 70853 Oxidative decarboxylation of alpha-ketoisovalerate to isobutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 114593 Collagen adhesion via Gp IV 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 111747 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and glutaredoxin 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 139910 Activation of BMF and translocation to mitochondria 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 75899 Conversion of Phosphatidic Acid to Diacylglycerol 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 110330 Recognition and association of DNA glycosylase with site containing an affected purine 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 254773 TRKA signalling from the plasma membrane 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 110331 Cleavage of the damaged purine 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 70726 Oxidative decarboxylation of alpha-ketoisocaproate to isovaleryl-CoA by branched-chain alpha-ketoacid dehydrogenase 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 69541 Stabilization of p53 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 71032 Propionyl-CoA catabolism 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 165181 Inhibition of TSC complex formation by PKB 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig 70794 Oxidative decarboxylation of alpha-keto-beta-methylvalerate to alpha-methylbutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase 1026 1 1025 3 25251 25254 1.473e-01 0.00 0.00 8.2 Not_Sig hsa00670 One carbon pool by folate - Homo sapiens (human) 1026 2 1024 16 25238 25254 1.546e-01 0.00 0.00 3.1 Not_Sig hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) 1026 2 1024 16 25238 25254 1.546e-01 0.00 0.00 3.1 Not_Sig hsa00740 Riboflavin metabolism - Homo sapiens (human) 1026 2 1024 16 25238 25254 1.546e-01 0.00 0.00 3.1 Not_Sig 69190 DNA strand elongation 1026 3 1023 32 25222 25254 1.553e-01 0.00 0.00 2.3 Not_Sig 212436 Generic Transcription Pathway 1026 2 1024 17 25237 25254 1.685e-01 0.00 0.00 2.9 Not_Sig 73890 Double-Strand Break Repair 1026 2 1024 17 25237 25254 1.685e-01 0.00 0.00 2.9 Not_Sig hsa00272 Cysteine metabolism - Homo sapiens (human) 1026 2 1024 17 25237 25254 1.685e-01 0.00 0.00 2.9 Not_Sig 70216 Poly{(1,4)-alpha-glucosyl} glycogenin reacts with n orthophosphates to form glycogenin and n D-glucose 1-phosphates 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 69610 p53-Independent DNA Damage Response 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig hsa00830 Retinol metabolism - Homo sapiens (human) 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 196843 Vitamin B2 (riboflavin) metabolism 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 166786 Creation of C4 and C2 activators 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 68911 G2 Phase 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 76605 Deoxyribonucleotide salvage 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 70182 Glycogen-glycogenin reacts with n orthophosphates, yielding n glucose 1-phosphates and limit dextrin-glycogenin 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 168276 NS1 Mediated Effects on Host Pathways 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 69613 p53-Independent G1/S DNA damage checkpoint 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 196299 Beta-catenin phosphorylation cascade 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 111446 Activation of BIM and translocation to mitochondria 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 140189 P450 Dehydrogenation of alkanes to form alkenes 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 200425 Import of palmitoyl-CoA into the mitochondrial matrix 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 168936 Viral dsRNA:TLR3:TRIF Complex Activates TBK1 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1026 1 1025 4 25250 25254 1.806e-01 0.00 0.00 6.2 Not_Sig 176187 Activation of ATR in response to replication stress 1026 3 1023 36 25218 25254 1.943e-01 0.00 0.00 2.1 Not_Sig 69186 Lagging Strand Synthesis 1026 2 1024 19 25235 25254 1.970e-01 0.00 0.00 2.6 Not_Sig 192105 Synthesis of bile acids and bile salts 1026 2 1024 20 25234 25254 2.114e-01 0.00 0.00 2.5 Not_Sig hsa00300 Lysine biosynthesis - Homo sapiens (human) 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 70108 Glyceraldehyde 3-phosphate, NAD+, and orthophosphate react to form 1,3-bisphosphoglycerate, NADH, and H+ 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 187015 Activation of TRKA receptors 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig hsa00750 Vitamin B6 metabolism - Homo sapiens (human) 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 75108 Activation, myristolyation of BID and translocation to mitochondria 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 71338 Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+ 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 203927 MicroRNA biogenesis 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 71240 Tryptophan catabolism 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 165720 S6K1 signalling 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 142045 Alcohol Dehydrogenase 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 187024 NGF-independant TRKA activation 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 69478 G2/M DNA replication checkpoint 1026 1 1025 5 25249 25254 2.126e-01 0.00 0.00 4.9 Not_Sig 113510 E2F mediated regulation of DNA replication 1026 2 1024 21 25233 25254 2.259e-01 0.00 0.00 2.3 Not_Sig 199991 Membrane Trafficking 1026 2 1024 21 25233 25254 2.259e-01 0.00 0.00 2.3 Not_Sig 174417 Telomere C-strand (Lagging Strand) Synthesis 1026 2 1024 21 25233 25254 2.259e-01 0.00 0.00 2.3 Not_Sig 68867 Assembly of the pre-replicative complex 1026 2 1024 22 25232 25254 2.405e-01 0.00 0.00 2.2 Not_Sig 68874 M/G1 Transition 1026 2 1024 22 25232 25254 2.405e-01 0.00 0.00 2.2 Not_Sig 196757 Metabolism of folate and pterines 1026 1 1025 6 25248 25254 2.433e-01 0.00 0.00 4.1 Not_Sig 75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1026 1 1025 6 25248 25254 2.433e-01 0.00 0.00 4.1 Not_Sig 163358 PKA-mediated phosphorylation of key metabolic factors 1026 1 1025 6 25248 25254 2.433e-01 0.00 0.00 4.1 Not_Sig 69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 1026 1 1025 6 25248 25254 2.433e-01 0.00 0.00 4.1 Not_Sig 194002 Glucocorticoid biosynthesis 1026 1 1025 6 25248 25254 2.433e-01 0.00 0.00 4.1 Not_Sig hsa00340 Histidine metabolism - Homo sapiens (human) 1026 3 1023 42 25212 25254 2.564e-01 0.00 0.00 1.8 Not_Sig hsa00100 Biosynthesis of steroids - Homo sapiens (human) 1026 2 1024 24 25230 25254 2.698e-01 0.00 0.00 2.1 Not_Sig 166207 S6K1-mediated signalling 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig 195253 Degradation of beta-catenin by the destruction complex 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig 176417 Phosphorylation of Emi1 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig 167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig 73614 Pyrimidine salvage reactions 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig hsa00232 Caffeine metabolism - Homo sapiens (human) 1026 1 1025 7 25247 25254 2.729e-01 0.00 0.00 3.5 Not_Sig 72695 Formation of the ternary complex, and subsequently, the 43S complex 1026 4 1022 52 25202 25254 2.818e-01 0.00 0.00 1.9 Not_Sig hsa00624 1- and 2-Methylnaphthalene degradation - Homo sapiens (human) 1026 2 1024 25 25229 25254 2.845e-01 0.00 0.00 2.0 Not_Sig hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human) 1026 2 1024 25 25229 25254 2.845e-01 0.00 0.00 2.0 Not_Sig hsa00150 Androgen and estrogen metabolism - Homo sapiens (human) 1026 4 1022 56 25198 25254 2.979e-01 0.00 0.00 1.8 Not_Sig hsa03030 DNA replication - Homo sapiens (human) 1026 2 1024 26 25228 25254 2.991e-01 0.00 0.00 1.9 Not_Sig 70635 Urea synthesis 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 174414 Processive synthesis on the C-strand of the telomere 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 166663 Initial triggering of complement 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 159231 Transport of Mature mRNA Derived from an Intronless Transcript 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 68952 DNA replication initiation 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig hsa00625 Tetrachloroethene degradation - Homo sapiens (human) 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig hsa00130 Ubiquinone biosynthesis - Homo sapiens (human) 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 73929 Base-Excision Repair, AP Site Formation 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 70693 Ornithine metabolism 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 174437 Removal of the Flap Intermediate from the C-strand 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 72731 Recycling of eIF2:GDP 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 174430 Telomere C-strand synthesis initiation 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 70302 Glycogen synthesis 1026 1 1025 8 25246 25254 3.013e-01 0.00 0.00 3.1 Not_Sig 72702 Ribosomal scanning and start codon recognition 1026 4 1022 59 25195 25254 3.124e-01 0.00 0.00 1.7 Not_Sig 157279 3' -UTR-mediated translational regulation 1026 6 1020 103 25151 25254 3.235e-01 0.01 0.00 1.4 Not_Sig 156827 L13a-mediated translational silencing of Ceruloplasmin expression 1026 6 1020 103 25151 25254 3.235e-01 0.01 0.00 1.4 Not_Sig 176408 Regulation of APC/C activators between G1/S and early anaphase 1026 2 1024 28 25226 25254 3.282e-01 0.00 0.00 1.8 Not_Sig 166208 mTORC1-mediated signalling 1026 1 1025 9 25245 25254 3.285e-01 0.00 0.00 2.7 Not_Sig hsa00072 Synthesis and degradation of ketone bodies - Homo sapiens (human) 1026 1 1025 9 25245 25254 3.285e-01 0.00 0.00 2.7 Not_Sig 70793 Leucine catabolism 1026 1 1025 9 25245 25254 3.285e-01 0.00 0.00 2.7 Not_Sig 110357 Displacement of DNA glycosylase by APE1 1026 1 1025 9 25245 25254 3.285e-01 0.00 0.00 2.7 Not_Sig 189451 Heme biosynthesis 1026 1 1025 9 25245 25254 3.285e-01 0.00 0.00 2.7 Not_Sig 176033 Interactions of Vpr with host cellular proteins 1026 2 1024 29 25225 25254 3.426e-01 0.00 0.00 1.7 Not_Sig 164940 Nef mediated downregulation of MHC class I complex cell surface expression 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 199220 Vitamin B5 (pantothenate) metabolism 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 159234 Transport of Mature mRNAs Derived from Intronless Transcripts 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 73930 Base-free sugar-phosphate removal via the single-nucleotide replacement pathway 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 189445 Porphyrin metabolism 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 156584 Cytosolic sulfonation of small molecules 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 113501 Inhibition of replication initiation of damaged DNA by Rb/E2F1 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig 69473 G2/M DNA damage checkpoint 1026 1 1025 10 25244 25254 3.548e-01 0.00 0.00 2.5 Not_Sig hsa04740 Olfactory transduction - Homo sapiens (human) 1026 2 1024 31 25223 25254 3.711e-01 0.00 0.00 1.6 Not_Sig 174143 APC/C-mediated degradation of cell cycle proteins 1026 2 1024 31 25223 25254 3.711e-01 0.00 0.00 1.6 Not_Sig 162599 Late Phase of HIV Life Cycle 1026 1 1025 75 25179 25254 3.733e-01 0.00 0.00 0.3 Not_Sig 77595 Processing of Intronless Pre-mRNAs 1026 1 1025 11 25243 25254 3.800e-01 0.00 0.00 2.2 Not_Sig 110381 Resolution of AP sites via the single-nucleotide replacement pathway 1026 1 1025 11 25243 25254 3.800e-01 0.00 0.00 2.2 Not_Sig 113507 E2F-enabled inhibition of pre-replication complex formation 1026 1 1025 11 25243 25254 3.800e-01 0.00 0.00 2.2 Not_Sig 191345 Transformation of lanosterol to cholesterol 1026 1 1025 11 25243 25254 3.800e-01 0.00 0.00 2.2 Not_Sig 69298 Association of licensing factors with the pre-replicative complex 1026 1 1025 11 25243 25254 3.800e-01 0.00 0.00 2.2 Not_Sig 75071 mRNA Processing 1026 3 1023 145 25109 25254 3.882e-01 0.00 0.01 0.5 Not_Sig 156902 Peptide chain elongation 1026 5 1021 83 25171 25254 3.972e-01 0.00 0.00 1.5 Not_Sig 196807 Nicotinate metabolism 1026 1 1025 12 25242 25254 4.042e-01 0.00 0.00 2.1 Not_Sig 70694 Ornithine and proline metabolism 1026 1 1025 12 25242 25254 4.042e-01 0.00 0.00 2.1 Not_Sig 69273 Cyclin A/B1 associated events during G2/M transition 1026 1 1025 12 25242 25254 4.042e-01 0.00 0.00 2.1 Not_Sig 159418 Recycling of bile acids and salts 1026 1 1025 12 25242 25254 4.042e-01 0.00 0.00 2.1 Not_Sig 156842 Eukaryotic Translation Elongation 1026 5 1021 86 25168 25254 4.075e-01 0.00 0.00 1.4 Not_Sig 69275 G2/M Transition 1026 1 1025 13 25241 25254 4.275e-01 0.00 0.00 1.9 Not_Sig 68827 CDT1 association with the CDC6:ORC:origin complex 1026 1 1025 13 25241 25254 4.275e-01 0.00 0.00 1.9 Not_Sig 109977 Repair synthesis for gap-filling by DNA polymerase in TC-NER 1026 1 1025 13 25241 25254 4.275e-01 0.00 0.00 1.9 Not_Sig 74967 Repair synthesis of patch ~27-30 bases long by DNA polymerase 1026 1 1025 13 25241 25254 4.275e-01 0.00 0.00 1.9 Not_Sig 176974 Unwinding of DNA 1026 1 1025 13 25241 25254 4.275e-01 0.00 0.00 1.9 Not_Sig 163841 Post-translational protein modification 1026 3 1023 44 25210 25254 4.314e-01 0.00 0.00 1.7 Not_Sig 109979 Gap-filling DNA repair synthesis and ligation in TC-NER 1026 1 1025 14 25240 25254 4.498e-01 0.00 0.00 1.8 Not_Sig 74969 Gap-filling DNA repair synthesis and ligation in GG-NER 1026 1 1025 14 25240 25254 4.498e-01 0.00 0.00 1.8 Not_Sig 167290 Pausing and recovery of HIV-1 elongation 1026 1 1025 14 25240 25254 4.498e-01 0.00 0.00 1.8 Not_Sig 110362 Removal of DNA patch containing abasic residue 1026 1 1025 14 25240 25254 4.498e-01 0.00 0.00 1.8 Not_Sig hsa00920 Sulfur metabolism - Homo sapiens (human) 1026 1 1025 14 25240 25254 4.498e-01 0.00 0.00 1.8 Not_Sig 194840 Rho GTPase cycle 1026 6 1020 106 25148 25254 4.552e-01 0.01 0.00 1.4 Not_Sig 72613 Eukaryotic Translation Initiation 1026 6 1020 111 25143 25254 4.670e-01 0.01 0.00 1.3 Not_Sig 72737 Cap-dependent Translation Initiation 1026 6 1020 111 25143 25254 4.670e-01 0.01 0.00 1.3 Not_Sig 162906 HIV Infection 1026 10 1016 197 25057 25254 4.681e-01 0.01 0.01 1.2 Not_Sig 167238 Pausing and recovery of Tat-mediated HIV-1 elongation 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig 110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig 167246 Tat-mediated elongation of the HIV-1 transcript 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig 167243 Tat-mediated HIV-1 elongation arrest and recovery 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig 166658 Complement cascade 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig hsa00511 N-Glycan degradation - Homo sapiens (human) 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig hsa00363 Bisphenol A degradation - Homo sapiens (human) 1026 1 1025 15 25239 25254 4.713e-01 0.00 0.00 1.6 Not_Sig 193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1026 1 1025 16 25238 25254 4.920e-01 0.00 0.00 1.5 Not_Sig hsa00604 Glycosphingolipid biosynthesis - ganglioseries - Homo sapiens (human) 1026 1 1025 16 25238 25254 4.920e-01 0.00 0.00 1.5 Not_Sig 167287 HIV-1 elongation arrest and recovery 1026 1 1025 16 25238 25254 4.920e-01 0.00 0.00 1.5 Not_Sig 73933 Resolution of Abasic Sites (AP sites) 1026 1 1025 16 25238 25254 4.920e-01 0.00 0.00 1.5 Not_Sig 73884 Base Excision Repair 1026 1 1025 16 25238 25254 4.920e-01 0.00 0.00 1.5 Not_Sig 75983 Formation and Maturation of mRNA Transcript 1026 3 1023 130 25124 25254 4.963e-01 0.00 0.01 0.6 Not_Sig hsa00440 Aminophosphonate metabolism - Homo sapiens (human) 1026 1 1025 17 25237 25254 5.118e-01 0.00 0.00 1.4 Not_Sig 211000 Regulatory RNA pathways 1026 1 1025 17 25237 25254 5.118e-01 0.00 0.00 1.4 Not_Sig 182971 EGFR downregulation 1026 1 1025 17 25237 25254 5.118e-01 0.00 0.00 1.4 Not_Sig 176412 Phosphorylation of the APC/C 1026 1 1025 18 25236 25254 5.309e-01 0.00 0.00 1.4 Not_Sig hsa00534 Heparan sulfate biosynthesis - Homo sapiens (human) 1026 1 1025 19 25235 25254 5.492e-01 0.00 0.00 1.3 Not_Sig 174048 APC/C:Cdc20 mediated degradation of Cyclin B 1026 1 1025 19 25235 25254 5.492e-01 0.00 0.00 1.3 Not_Sig 73854 RNA Polymerase I Promoter Clearance 1026 1 1025 19 25235 25254 5.492e-01 0.00 0.00 1.3 Not_Sig hsa05020 Parkinson's disease - Homo sapiens (human) 1026 1 1025 20 25234 25254 5.668e-01 0.00 0.00 1.2 Not_Sig 73864 RNA Polymerase I Transcription 1026 1 1025 20 25234 25254 5.668e-01 0.00 0.00 1.2 Not_Sig 72764 Eukaryotic Translation Termination 1026 4 1022 80 25174 25254 5.715e-01 0.00 0.00 1.2 Not_Sig 191273 Cholesterol biosynthesis 1026 1 1025 21 25233 25254 5.838e-01 0.00 0.00 1.2 Not_Sig 72203 Processing of Capped Intron-Containing Pre-mRNA 1026 2 1024 88 25166 25254 5.874e-01 0.00 0.00 0.6 Not_Sig 73857 RNA Polymerase II Transcription 1026 2 1024 91 25163 25254 5.890e-01 0.00 0.00 0.5 Not_Sig 112168 Processing of Capped pre-mRNA 1026 2 1024 92 25162 25254 5.899e-01 0.00 0.00 0.5 Not_Sig 112297 Post-Elongation Processing of Intronless pre-mRNA 1026 1 1025 22 25232 25254 6.000e-01 0.00 0.00 1.1 Not_Sig 176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1026 1 1025 22 25232 25254 6.000e-01 0.00 0.00 1.1 Not_Sig 75067 Processing of Capped Intronless Pre-mRNA 1026 1 1025 22 25232 25254 6.000e-01 0.00 0.00 1.1 Not_Sig 73894 DNA Repair 1026 5 1021 100 25154 25254 6.085e-01 0.00 0.00 1.2 Not_Sig 167158 Formation of the HIV-1 Early Elongation Complex 1026 1 1025 23 25231 25254 6.156e-01 0.00 0.00 1.1 Not_Sig hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 1026 1 1025 23 25231 25254 6.156e-01 0.00 0.00 1.1 Not_Sig 176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1026 1 1025 23 25231 25254 6.156e-01 0.00 0.00 1.1 Not_Sig 72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1026 5 1021 104 25150 25254 6.187e-01 0.00 0.00 1.2 Not_Sig hsa01030 Glycan structures - biosynthesis 1 - Homo sapiens (human) 1026 3 1023 115 25139 25254 6.327e-01 0.00 0.00 0.6 Not_Sig 72766 Translation 1026 7 1019 155 25099 25254 6.844e-01 0.01 0.01 1.1 Not_Sig hsa00510 N-Glycan biosynthesis - Homo sapiens (human) 1026 2 1024 41 25213 25254 6.847e-01 0.00 0.00 1.2 Not_Sig 168254 Influenza Infection 1026 5 1021 164 25090 25254 6.899e-01 0.00 0.01 0.8 Not_Sig hsa04742 Taste transduction - Homo sapiens (human) 1026 1 1025 53 25201 25254 7.247e-01 0.00 0.00 0.5 Not_Sig 157579 Telomere Maintenance 1026 3 1023 68 25186 25254 7.572e-01 0.00 0.00 1.1 Not_Sig 72163 mRNA Splicing - Major Pathway 1026 2 1024 85 25169 25254 7.773e-01 0.00 0.00 0.6 Not_Sig 72172 mRNA Splicing 1026 2 1024 85 25169 25254 7.773e-01 0.00 0.00 0.6 Not_Sig 162587 HIV Life Cycle 1026 4 1022 88 25166 25254 7.838e-01 0.00 0.00 1.1 Not_Sig hsa00240 Pyrimidine metabolism - Homo sapiens (human) 1026 4 1022 90 25164 25254 7.869e-01 0.00 0.00 1.1 Not_Sig 72689 Formation of a pool of free 40S subunits 1026 4 1022 92 25162 25254 7.903e-01 0.00 0.00 1.1 Not_Sig 112295 Elongation and Processing of Capped Transcripts 1026 3 1023 108 25146 25254 8.034e-01 0.00 0.00 0.7 Not_Sig 76043 Elongation of Intron-Containing Transcripts and co-transcriptional mRNA splicing 1026 3 1023 108 25146 25254 8.034e-01 0.00 0.00 0.7 Not_Sig 74160 Gene Expression 1026 13 1013 352 24902 25254 8.914e-01 0.01 0.01 0.9 Not_Sig 74159 Transcription 1026 6 1020 155 25099 25254 1.000e+00 0.01 0.01 1.0 Not_Sig 195721 Signaling by Wnt 1026 2 1024 58 25196 25254 1.000e+00 0.00 0.00 0.8 Not_Sig 109970 Global Genomic NER (GG-NER) 1026 1 1025 30 25224 25254 1.000e+00 0.00 0.00 0.8 Not_Sig 168273 Influenza Viral RNA Transcription and Replication 1026 1 1025 36 25218 25254 1.000e+00 0.00 0.00 0.7 Not_Sig 168255 Influenza Life Cycle 1026 1 1025 40 25214 25254 1.000e+00 0.00 0.00 0.6 Not_Sig 112386 Pausing and recovery of elongation 1026 1 1025 27 25227 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 167172 Transcription of the HIV genome 1026 1 1025 46 25208 25254 1.000e+00 0.00 0.00 0.5 Not_Sig 167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 1026 1 1025 24 25230 25254 1.000e+00 0.00 0.00 1.0 Not_Sig hsa00512 O-Glycan biosynthesis - Homo sapiens (human) 1026 1 1025 30 25224 25254 1.000e+00 0.00 0.00 0.8 Not_Sig 72187 mRNA 3'-end processing 1026 1 1025 28 25226 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 112296 Post-Elongation Processing of Intron-Containing pre-mRNA 1026 1 1025 28 25226 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 168325 Viral Messenger RNA Synthesis 1026 1 1025 36 25218 25254 1.000e+00 0.00 0.00 0.7 Not_Sig 75955 RNA Polymerase II Transcription Elongation 1026 1 1025 37 25217 25254 1.000e+00 0.00 0.00 0.7 Not_Sig 113418 Formation of the Early Elongation Complex 1026 1 1025 28 25226 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 167169 HIV-1 Transcription Elongation 1026 1 1025 30 25224 25254 1.000e+00 0.00 0.00 0.8 Not_Sig 109688 Cleavage of Growing Transcript in the Termination Region 1026 1 1025 39 25215 25254 1.000e+00 0.00 0.00 0.6 Not_Sig 112382 Formation of RNA Pol II elongation complex 1026 1 1025 37 25217 25254 1.000e+00 0.00 0.00 0.7 Not_Sig 76044 Post-Elongation Processing of the Transcript 1026 1 1025 39 25215 25254 1.000e+00 0.00 0.00 0.6 Not_Sig 73856 RNA Polymerase II Transcription Termination 1026 1 1025 39 25215 25254 1.000e+00 0.00 0.00 0.6 Not_Sig 72202 Transport of Mature Transcript to Cytoplasm 1026 1 1025 26 25228 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 112387 Elongation arrest and recovery 1026 1 1025 27 25227 25254 1.000e+00 0.00 0.00 0.9 Not_Sig 73937 Transcription-coupled NER (TC-NER) 1026 1 1025 41 25213 25254 1.000e+00 0.00 0.00 0.6 Not_Sig 73885 Nucleotide Excision Repair 1026 1 1025 45 25209 25254 1.000e+00 0.00 0.00 0.5 Not_Sig