Current Target Information
| HUGO ID | 990 |
|---|---|
| Symbol | BCL2 |
| Name | B-cell CLL/lymphoma 2 |
| #Occurrence | 139 |
| #Paper | 16 |
| PMID | TITLE | # of Targets | Links | Journal |
|---|---|---|---|---|
| 15896810 | Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. | 55 | | J Neurol Sci |
| 11679167 | Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. | 44 | | Mol Aspects Med |
| 17496232 | Mitochondrial nitric oxide in the signaling of cell integrated responses. | 43 | | Am J Physiol Cell Physiol |
| 14739060 | Neurodegenerative diseases and oxidative stress. | 33 | | Biomed Pharmacother |
| 11050436 | Mitochondria, oxygen free radicals, disease and ageing. | 24 | | Trends Biochem Sci |
| 17105868 | Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis. | 22 | | Mol Pharmacol |
| 16046141 | Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis. | 16 | | Neurobiol Dis |
| 10671549 | Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. | 14 | | J Biol Chem |
| 16050975 | Mitochondrial dysfunction and its role in motor neuron degeneration in ALS. | 11 | | Mitochondrion |
| 16242643 | Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. | 10 | | Neurobiol Dis |
| 16624679 | Neurodegeneration induced by complex I inhibition in a cellular model of familial amyotrophic lateral sclerosis. | 9 | | Brain Res Bull |
| 12392777 | A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. | 6 | | Neurobiol Aging |
| 15850589 | Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells. | 5 | | J Neurol Sci |
| 8922414 | Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine. | 5 | | J Neurosci |
| 7764323 | As we live and breathe: free radicals and aging. Correlative evidence from a number of fields suggests they may be key. | 1 | | Biotechnology (N Y) |
| 7841373 | bcl-2 protein expression in aged brain and neurodegenerative diseases. | 1 | | Neuroreport |