HUGO ID Detailed Result 9605


HUGO ID 9605
Symbol PTGS2
Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
#Occurrence 10
#Paper 2

 


PMID Match String Actual String Score Flanking text Edited by Edit
12909279COX2COX21.3proteins such as nitric oxide synthase (NOS) NOS 93 and COX2 70 that might be involved in mechanisms of inflammation-mediated neurodegenerationJunguk Hur
12909279COX2COX21.3Indeed COX2 and NOS activity are dramatically increased in post-mortem spinal cordJunguk Hur
12909279COX2COX21.3Increased levels of COX2 and of the pro-inflammatory prostaglandin PGE2 were found in theJunguk Hur
12909279COX2COX21.3Treatment with a selective COX2 inhibitor markedly inhibits production of PGE2 in the spinal cordJunguk Hur
14698606COX-2COX-21.0role for inflammation inhibitors of the enzyme cyclooxygenase 2 (COX-2) COX-2 have shown beneficial effects in SOD1 mutant mouse models 49 
12909279cox 2cox21.0nf _amp_#x3ba;b modulates the expression of several proteins such as nitric oxide synthase nos [ 93 ] and cox2 [ 70 ] that might be involved in mechanisms of inflammation mediated neurodegeneration and be crucial in the pathogenesis of als.  
12909279cox 2cox21.0indeed cox2 and nos activity are dramatically increased in post mortem spinal cord samples from sporadic als patients and in astrocytes from fals mice [ 2 and 15 ].  
12909279cox 2cox21.0increased levels of cox2 and of the pro inflammatory prostaglandin pge2 were found in the cerebrospinal fluid from als patients [ 3 ].  
12909279cox 2cox21.0treatment with a selective cox2 inhibitor markedly inhibits production of pge2 in the spinal cord of als mice protecting motor neurones and significantly prolonging survival [ 23 ].  
14698606cox 2cox 21.0supporting a role for inflammation inhibitors of the enzyme cyclooxygenase 2 cox 2 have shown beneficial effects in sod1 mutant mouse models [ 49 and 50 ].