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| 10077670 | CYPA | CyPA | 1.3 | supported by experiments showing that overexpressed wild-type cyclophilin A (CyPA), CyPA but not CyPA with a rotamase active site point mutation | |  |
| 10077670 | CYPA | CyPA | 1.3 | showing that overexpressed wild-type cyclophilin A (CyPA), CyPA but not CyPA with a rotamase active site point mutation protected cells from | | |
| 10077670 | CYPA | CyPA | 1.3 | CyPA (histidine-tagged) histidine-tagged ( 17 expression was detected by immunostaining with | | |
| 10077670 | CYPA | CyPA | 1.3 | For some experiments involving CyPA we used a wild-type CyPA (CyPAWT) CyPAWT cDNA or isomerase-deficient | | |
| 10077670 | CYPA | CyPA | 1.3 | For some experiments involving CyPA we used a wild-type CyPA (CyPAWT) CyPAWT cDNA or isomerase-deficient mutant CyPA(R55A) CyPA R55A cDNA | | |
| 10077670 | CYPA | CyPA | 1.3 | a wild-type CyPA (CyPAWT) CyPAWT cDNA or isomerase-deficient mutant CyPA(R55A) CyPA R55A cDNA isolated from rat brain and cloned into pcDNA1/AMP | | |
| 10077670 | CYPA | CyPA | 1.3 | PC12 cells were transfected with either CyPAWT cDNA or CyPA(R55A) CyPA R55A cDNA by using polyethylenimine as described ( 18 19 | | |
| 10077670 | CYPA | CyPA | 1.3 | SOD-induced cell death we transfected NGF-differentiated PC12 cells with wild-type CyPA (CyPAWT) CyPAWT cDNA or CyPA(R55A) CyPA R55A cDNA that contains | | |
| 10077670 | CYPA | CyPA | 1.3 | PC12 cells with wild-type CyPA (CyPAWT) CyPAWT cDNA or CyPA(R55A) CyPA R55A cDNA that contains a point mutation in the putative | | |
| 10077670 | CYPA | CyPA | 1.3 | CyPA immunohistochemical staining showed transfection efficiencies of 68 _amp_#x000b1 2_amp_#x00025 ( | | |
| 10077670 | CYPA | CyPA | 1.3 | cells that overexpressed CyPAWT but not PC12 cells overexpressing CyPA(R55A), CyPA R55A exhibited reduced cell death after SODV148G expression (Fig Fig | | |
| 10077670 | CYPA | CyPA | 1.3 | transfection of a control cDNA (CD8); CD8 transfection of CyPA(R55A) CyPA R55A was not protective | | |
| 10077670 | CYPA | CyPA | 1.3 | These results suggest that the rotamase function of CyPA protects cells from death induced by SODV148G | | |
| 10077670 | CYPA | CyPA | 1.3 | In contrast overexpression of CyPAWT or CyPA(R55A) CyPA R55A in cells infected with AdSODWT or in mock-infected cells | | |
| 10077670 | CYPA | CyPA | 1.3 | Furthermore overexpression of either CyPAWT or CyPA(R55A) CyPA R55A did not significantly protect cells from death induced by | | |
| 10077670 | CYPA | CyPA | 1.3 | To further investigate these issues we tested whether CyPA rescue of mutant SOD-induced cell death would be decreased with | | |
| 10077670 | CYPA | CyPA | 1.3 | Table 2 shows that overexpression of CyPA (but but not CD8 _amp_#x0201c control_amp_#x0201d overexpression significantly reduced SODV148G-induced | | |
| 10077670 | CYPA | CyPA | 1.3 | cell death (from from 49.1 to 21.9_amp_#x00025 and that the CyPA rescue was decreased by CsA (changing changing cell death from | | |
| 10077670 | CYPA | CyPA | 1.3 | after expression of CyPAWT vs an isomerase activity-deficient mutant CyPA(R55A) CyPA R55A | | |
| 10077670 | CYPA | CyPA | 1.3 | The WT but not the mutant CyPA protected cells from death induced by mutant SOD expression | | |
| 10077670 | CYPA | CyPA | 1.3 | Although a recent report concluded that CyPA(R55A) CyPA R55A may have more rotamase activity than previously suspected ( | | |
| 10077670 | CYPA | CyPA | 1.3 | In fact CyPA has been shown to be transported by slow axonal transport | | |
| 10077670 | CYPA | CyPA | 1.3 | 5 Effect of overexpression of WTCyPA or an isomerase-deficient CyPA(R55A) CyPA R55A on PC12 cell death induced by SODV148G expression ( | | |
| 10077670 | CYPA | CyPA | 1.3 | Table 2 CyPA overexpression rescues PC12 cells from SODV148G-induced death as well as | | |