HUGO ID Detailed Result 9237


HUGO ID 9237
Symbol PPARGC1A
Name peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
#Occurrence 8
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
17937892PGC1PGC-12.1[SIRT1/PGC-1: SIRT1 PGC-1 a neuroprotective axis 
17937892PGC1PGC-12.1has been recently demonstrated that activation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway in a metabolic context promotes mitochondrial function we performed 
17937892PGC1PGC-12.1Interestingly transgenic mice with impaired PGC-1 expression have neurodegenerative lesions and show behavioural abnormalities 
17937892PGC1PGC-12.1results strongly suggest that the modulation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway which has not been well documented in the central 
17937892pgc 1pgc 11.0[sirt1/pgc 1: a neuroprotective axis?]  
17937892pgc 1pgc 11.0since it has been recently demonstrated that activation of the sirt1/pgc 1 pathway in a metabolic context promotes mitochondrial function we performed a detailed literature review on the implication of this pathway in neurodegeneration.  
17937892pgc 1pgc 11.0interestingly transgenic mice with impaired pgc 1 expression have neurodegenerative lesions and show behavioural abnormalities.  
17937892pgc 1pgc 11.0taken together these results strongly suggest that the modulation of the sirt1/pgc 1 pathway which has not been well documented in the central nervous system could become the cornerstone for new therapeutical approaches to combat neurodegeneration.