HUGO ID Detailed Result 4571


HUGO ID 4571
Symbol GRIA1
Name glutamate receptor, ionotropic, AMPA 1
#Occurrence 16
#Paper 8

 


PMID Match String Actual String Score Flanking text Edited by Edit
9745361glutamate receptorglutamate receptor1.0ber of different mechanisms may contribute to [ca 2+ ] i rise including direct influx via n methyl aspartate nmda or rs amino 3 hydroxy 5 methyl 4 isoxazole propionic acid ampa receptors metabotropic glutamate receptor mediated release from the internal stores activation of voltage dependent ca 2+ channels and reversal of na + /ca 2+ exchange.  
10627601glutamate receptorglutamate receptor1.0considerable evidence supports a link between ca influx and glutamate receptor mediated neurodegeneration.  
10627601glutamate receptorglutamate receptor1.0exposures were terminated by replacing the exposure solution with mem + glucose along with the ionotropic glutamate receptor antagonists mk 801 and nbqx both at 10 micro m and returning the cultures to the 37degreec 5% co 2 incubator.  
10627601glutamate receptorglutamate receptor1.0although one must be careful in extrapolating findings in murine cultures to human disease it is notable that even across species motor neurons in vitro and in vivo seem to express similar glutamate receptor profiles and vulnerabilities to ampa/kainate receptor mediated injury.  
11513882glutamate receptorglutamate receptor1.0since the calcineurin inactivation is dependent on the presence of calcium motoneurons which are subject to glutamate receptor mediated ca 2+ influxes may be especially at risk for calcineurin inactivation.  
12684448glutamate receptorglutamate receptor1.0observations of elevated csf glutamate in amyotrophic lateral sclerosis als together with findings that motor neurons are selectively vulnerable to glutamate receptor mediated "excitotoxic" injury support an excitotoxic contribution to the motor neuron loss in the disease.  
12684448glutamate receptorglutamate receptor1.0mns seem to possess large numbers of unusual ampa type glutamate receptor channels that are directly permeable to ca carriedo et al. 1995 1996 ; williams et al. 1997 ; vandenberghe et al. 2000 and activation of these channels with the selective agonists ampa or kainate ind 
12684448glutamate receptorglutamate receptor1.0behave similarly to those in situ with both seeming to possess large numbers of ca permeable ampa channels to show poor intracellular ca buffering and to be selectively vulnerable to injury caused by glutamate receptor activation o'brien and fischbach 1986 ; hugon et al. 1989 ; rothstein et al. 1993 ; carriedo et al. 1996 2000 ; williams et al. 1997 ; vandenberghe et al. 1998 ; palecek et al. 1999 .  
12684448glutamate receptorglutamate receptor1.0thus the relatively selective ros generation we observe in cultured mns in response to glutamate receptor activation and the ability of this ros to escape the cell and affect the surrounding microenvironment is likely to model events that can occur in vivo .  
14739060glutamate receptorglutamate receptor1.0finally excessive response to glutamate receptor mediated stimulation occur intra cellularly [ 32 ].  
16764863glutamate receptorglutamate receptor1.0to further examine the mechanisms of bmaa induced injury to mns cultures were exposed to bmaa 100_amp_#xa0;_amp_#x3bc;m in the presence of the selective glutamate receptor antagonists mk 801 10_amp_#xa0;_amp_#x3bc;m and/or nbqx 10_amp_#xa0;_amp_#x3bc;m fig 1 c .  
16764863glutamate receptorglutamate receptor1.0fluorescence imaging techniques were used to address mechanisms of mn injury downstream from glutamate receptor activation.  
16764863glutamate receptorglutamate receptor1.0previous studies have demonstrated that glutamate receptor mediated ca 2+ entry triggers the generation of ros lafon cazal et al. 1993 dugan et al. 1995 reynolds and hastings 1995 carriedo et al. 1998 and carriedo et al. 2000 .  
16764863glutamate receptorglutamate receptor1.0enotypic development eagleson et al. 1985 schaffner et al. 1987 and martinou et al. 1989 and results in mns far more closely resembling mns in vivo in terms of such factors as axodendritic growth and glutamate receptor expression than occurs in pure mn cultures vandenberghe et al. 1998 .  
17719032glutamate receptorglutamate receptor1.0likely contributing to this vulnerability mns possess substantial numbers of unusual ca 2+ permeable ampa type glutamate receptor channels ca ampa channels [carriedo et al. 1995] [carriedo et al. 1996] [van den bosch et al. 2000] and [vandenberghe et al. 2000] .  
17956327glutamate receptorglutamate receptor1.0we postulate that these activated kinases phosphorylate glutamate receptors inducing glutamate receptor trafficking inserting more receptors in the post synaptic membrane and strengthening synapses between glutamatergic brainstem respiratory neurons and phrenic motor neurons.