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| 16227974 | SIRT1 | SIRT1 | 0.3 | The closest mammalian orthologue of SIR-2 is SIRT1 and it is presently not known whether overexpression of SIRT1 | |  |
| 16227974 | SIRT1 | SIRT1 | 0.3 | SIRT1 and it is presently not known whether overexpression of SIRT1 will extend mammalian lifespan | |  |
| 16227974 | SIRT1 | SIRT1 | 0.3 | cells from accumulation of oxidatively damaged proteins 50 and mammalian SIRT1 and SIRT3 might modulate mitochondrial activity 51 52 | |  |
| 16227974 | SIRT1 | SIRT1 | 0.3 | Recent studies have shown that overexpressing SIRT1 in mice seems to protect neurons from at least some | |  |
| 16227974 | SIRT1 | SIRT1 | 0.3 | alpha-synuclein APP ATM JunD parkin peroxiredoxin I PINK1 Ras seladin-1 SIRT1 SIRT3 SOD1 | |  |
| 17937892 | SIRT1 | SIRT1 | 1.0 | [SIRT1/PGC-1: SIRT1 PGC-1 a neuroprotective axis | |  |
| 17937892 | SIRT1 | SIRT1 | 1.0 | it has been recently demonstrated that activation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway in a metabolic context promotes mitochondrial function we | |  |
| 17937892 | SIRT1 | SIRT1 | 1.0 | As evidenced from independent investigations enhanced SIRT1 activity has been demonstrated to protect against axonal degeneration and | |  |
| 17937892 | SIRT1 | SIRT1 | 1.0 | addition several studies suggest that resveratrol a specific activator of SIRT1 could have protective effects in animal models of neurodegenerative diseases | |  |
| 17937892 | SIRT1 | SIRT1 | 1.0 | these results strongly suggest that the modulation of the SIRT1/PGC-1 SIRT1 PGC-1 pathway which has not been well documented in the | |  |