HUGO ID Detailed Result 12805

HUGO ID 12805
Symbol XDH
Name xanthine dehydrogenase
#Occurrence 16
#Paper 8

 

PMID Match String Actual String Score Flanking text Edited by Edit
9675268xanthine oxidasexanthine oxidase1.0oxidative insult to normal neurons also results from catalytically active redox metal ions i.e iron and copper and particular ros generating enzymes and peptides e.g nitric oxide synthase xanthine oxidase _amp_#x3b2; amyloid etc. present in the brain.  
9745361xanthine oxidasexanthine oxidase1.0toxic pathways include ca 2+ dependent activation of nitric oxide no synthase phospholipase a 2 and xanthine oxidase which can all contribute to an aberrant formation of reactive oxygen species.  
9745361xanthine oxidasexanthine oxidase1.0reactive oxygen species generated by hydrogen peroxide h 2 o 2 or by xanthine oxidase activation inhibit [ 3 h]glutamate uptake in cultured astrocytes and reduce the transport associated current under voltage clamp with minor or no effect on the resting membrane conductance [ 34 ].  
11050436xanthine oxidasexanthine oxidase1.0oxygen is initially converted to superoxide o 2 _amp_#x2212; either by xanthine oxidase respiratory chain complexes i and iii or other cellular enzymes.  
11562447xanthine oxidasexanthine oxidase1.0no can then combine with o 2 which is formed at sites of free radical generation beckman et al. 1990 ; pryor and squadrito 1995 such as mitochondria or through enzyme activity e.g. monoamine oxidase xanthine oxidase to form peroxynitrite onoo .  
14739060xanthine oxidasexanthine oxidase1.0neuronal increases in calcium can activate a series of enzymes including protein kinase c proteases phosphatases phospholipases nnos and xanthine oxidase [ 32 ].  
15031734xanthine dehydrogenasexanthine dehydrogenase1.0oxygen species via reactions such as the fenton and haber weiss reactions or via indirect pathways involving the calcium activation of metallo enzymes such as phospholipases nitric oxide synthase and xanthine dehydrogenase also known as xanthine oxidase 22 .  
15031734xanthine oxidasexanthine oxidase1.0the fenton and haber weiss reactions or via indirect pathways involving the calcium activation of metallo enzymes such as phospholipases nitric oxide synthase and xanthine dehydrogenase also known as xanthine oxidase 22 .  
15031734xanthine dehydrogenasexanthine dehydrogenase1.0beta actin catalase creatine kinase frataxin glucose transporter type 3 glutathione peroxidase glutathione reductase mitogen activated protein kinase 1 sod alpha synuclein xanthine dehydrogenase  
16188953xanthine oxidasexanthine oxidase1.0in a further set of experiments hydrogen peroxide ~80% and to a smaller extent superoxide ~20% were generated by xanthine oxidase 0.3 mu/ml and hypoxanthine 0.1 mm fridovich 1970 in a solution containing ppx snd or euk 134 at the indicated concentrations.  
16188953xanthine oxidasexanthine oxidase1.0we show that ppx and the equipotent snd are weak h 2 o 2 scavengers if generation and detoxification are measured in the same compartment in absence of a detection system xanthine oxidase .  
16188953xanthine oxidasexanthine oxidase1.0a ros were generated by xanthine oxidase in a solution containing euk 134 black bars ppx light gray bars or snd dark gray bars at the indicated concentrations.  
16188953xanthine oxidasexanthine oxidase1.0first h 2 o 2 and superoxide were generated by xanthine oxidase fridovich 1970 in a cell free assay where detoxifying enzymes and membranes are absent.  
16188953xanthine oxidasexanthine oxidase1.0as expected euk 134 was the most potent compound which at a concentration of 300 microm was able to detoxify >95% ros generated by xanthine oxidase.  
16188953xanthine oxidasexanthine oxidase1.0additionally both enantiomers showed equipotent efficacy in detoxification of xanthine oxidase generated ros fig 3a .  
17956327xanthine oxidasexanthine oxidase1.0ros are continuously generated in cells through enzymatic e.g nadph oxidase and xanthine oxidase and non enzymatic e.g mitochondrial electron transport chain and receptor activation processes [ 46 ].