|
PMID
|
Match String
|
Actual String
|
Score
|
Flanking text
|
Edited by
|
Edit
|
| 17634371 | p75 | p75 | 2.1 | factor (NGF) NGF can induce apoptosis by signaling through the p75 neurotrophin receptor (p75 p75 in several nerve cell populations | |  |
| 17634371 | p75 | p75 | 2.1 | induce apoptosis by signaling through the p75 neurotrophin receptor (p75 p75 in several nerve cell populations | | |
| 17634371 | p75 | p75 | 2.1 | Cultured embryonic motor neurons expressing p75 are not vulnerable to NGF unless they are exposed to | | |
| 17634371 | p75 | p75 | 2.1 | In the present study we show that p75 -mediated apoptosis in motor neurons involved neutral sphingomyelinase activation increased | | |
| 17634371 | p75 | p75 | 2.1 | Together our data indicate that p75 -mediated motor neuron apoptosis involves ceramide-dependent increased mitochondrial superoxide production | | |
| 17634371 | p75 | p75 | 2.1 | amyotrophic lateral sclerosis mitochondria motor neurons nerve growth factor Nrf2 p75 superoxide | | |
| 17634371 | p75 | p75 | 2.1 | nonhomologous transmembrane receptors the tyrosine kinase receptor TrkA and the p75 neurotrophin receptor (p75 p75 p75 is a member of the | | |
| 17634371 | p75 | p75 | 2.1 | tyrosine kinase receptor TrkA and the p75 neurotrophin receptor (p75 p75 p75 is a member of the tumor necrosis factor receptor | | |
| 17634371 | p75 | p75 | 2.1 | kinase receptor TrkA and the p75 neurotrophin receptor (p75 p75 p75 is a member of the tumor necrosis factor receptor superfamily | | |
| 17634371 | p75 | p75 | 2.1 | be unresponsive to NGF because they lack both TrkA and p75 receptors (Henderson Henderson et al. 1993 Yan et al. 1993 | | |
| 17634371 | p75 | p75 | 2.1 | However adult motor neurons can reexpress p75 after nerve injury (Koliatsos Koliatsos et al. 1991 Rende et | | |
| 17634371 | p75 | p75 | 2.1 | Induction of p75 renders motor neurons vulnerable to NGF-induced apoptosis p75 has been | | |
| 17634371 | p75 | p75 | 2.1 | Induction of p75 renders motor neurons vulnerable to NGF-induced apoptosis p75 has been implicated in motor neuron death occurring in transgenic | | |
| 17634371 | p75 | p75 | 2.1 | Pure motor neuron cultures expressing p75 are sensitive to NGF-induced apoptosis only when physiological concentrations of | | |
| 17634371 | p75 | p75 | 2.1 | These motor neurons also become immunoreactive for nitrotyrosine suggesting that p75 activation may be inducing a source of superoxide that converts | | |
| 17634371 | p75 | p75 | 2.1 | Astrocytes can protect motor neurons against p75 -induced apoptosis by the activation of the transcription factor nuclear | | |
| 17634371 | p75 | p75 | 2.1 | Thus the signaling pathway induced by p75 and its final outcome differs depending on the cell type | | |
| 17634371 | p75 | p75 | 2.1 | Ceramide production may also be a mediator of p75 -induced apoptosis (Dobrowsky Dobrowsky et al. 1994 Casaccia-Bonnefil et al. | | |
| 17634371 | p75 | p75 | 2.1 | We have previously shown that p75 -induced motor neuron death involves increased production of ROS and | | |
| 17634371 | p75 | p75 | 2.1 | However the source of the increased ROS production induced by p75 activation in motor neurons is currently unknown | | |
| 17634371 | p75 | p75 | 2.1 | the present study we investigated the apoptotic pathway mediated by p75 in motor neurons and the impact of ALS-linked SOD1 expression | | |
| 17634371 | p75 | p75 | 2.1 | neurons overexpressing ALS-linked SOD1 mutation showed greater susceptibility to the p75 -activated apoptotic pathway which was associated to decreased Nrf2 expression | | |
| 17634371 | p75 | p75 | 2.1 | Blocking antibodies to NGF and p75 were from Chemicon (Temecula, Temecula CA | | |
| 17634371 | p75 | p75 | 2.1 | gradient centrifugation and immunopanning with the monoclonal antibody IgG192 against p75 as described previously (Henderson Henderson et al. 1995 | | |
| 17634371 | p75 | p75 | 2.1 | Treatment with antisense oligonucleotides to downregulate p75 expression in motor neurons was performed as described previously (Pehar | | |
| 17634371 | p75 | p75 | 2.1 | To determine the efficiency of uptake cultures were incubated with p75 antisense oligonucleotides with a 5' 56-FAM fluorescent label | | |
| 17634371 | p75 | p75 | 2.1 | Sequences used were as follows p75 antisense 5'-ACCTGCCCTCCTCATTGCA-3' and p75 missense 5'-CTCCCACTCGTCATTCGAC-3' (Florez-McClure Florez-McClure et al. | | |
| 17634371 | p75 | p75 | 2.1 | Sequences used were as follows p75 antisense 5'-ACCTGCCCTCCTCATTGCA-3' and p75 missense 5'-CTCCCACTCGTCATTCGAC-3' (Florez-McClure Florez-McClure et al. 2004 | | |
| 17634371 | p75 | p75 | 2.1 | sequence has previously been shown to be effective at inhibiting p75 -induced apoptosis in motor neurons both in vivo and in | | |
| 17634371 | p75 | p75 | 2.1 | (405 405 bp actin 5'-CATGAAGATCCTGACCGAGCGTG-3' and 5'-TCTGCTGGAAGGTGGACAGTGAGG-3' (497 497 bp p75 primers were from Promega (Madison, Madison WI | | |
| 17634371 | p75 | p75 | 2.1 | as a central component of the apoptotic pathway mediated by p75 in other cell types we examined its role in p75 | | |
| 17634371 | p75 | p75 | 2.1 | p75 in other cell types we examined its role in p75 -mediated motor neuron apoptosis | | |
| 17634371 | p75 | p75 | 2.1 | indicate the involvement of ceramide production by nSMase activation in p75 -mediated motor neuron apoptosis | | |
| 17634371 | p75 | p75 | 2.1 | Reexpression of p75 under pathological conditions renders motor neurons vulnerable to NGF (Ferri | | |
| 17634371 | p75 | p75 | 2.1 | In the present study we show that the NGF/p75 NGF p75 -mediated motor neuron apoptosis involved increased production of mitochondrial superoxide | | |
| 17634371 | p75 | p75 | 2.1 | In accordance pharmacological activation of Nrf2 prevented NGF/p75 NGF p75 -induced motor neuron apoptosis suggesting a potential target to counteract | | |
| 17634371 | p75 | p75 | 2.1 | -induced motor neuron apoptosis suggesting a potential target to counteract p75 -mediated motor neuron death occurring in pathological conditions | | |
| 17634371 | p75 | p75 | 2.1 | p75 induces cell death by activating different signaling pathways depending on | | |
| 17634371 | p75 | p75 | 2.1 | et al 1998 Raoul et al. 2002 the mechanism of p75 -induced apoptosis in motor neurons involves downstream production of nitric | | |
| 17634371 | p75 | p75 | 2.1 | In the present study we found that the p75 apoptotic pathway in motor neurons involved increased ceramide production and | | |
| 17634371 | p75 | p75 | 2.1 | Hertel 1998 Brann et al. 2002 Bhakar et al. 2003 p75 -induced ceramide generation in motor neurons was mediated by activation | | |
| 17634371 | p75 | p75 | 2.1 | A similar p75 -mediated apoptotic pathway was described previously in hippocampal neurons involving | | |
| 17634371 | p75 | p75 | 2.1 | However in p75 -expressing NIH-3T3 and PC12 cell lines the acid isoform of | | |
| 17634371 | p75 | p75 | 2.1 | of SMase has been implicated in ceramide production induced by p75 signaling (Dobrowsky Dobrowsky and Carter 1998 | | |
| 17634371 | p75 | p75 | 2.1 | Thus it seems that p75 is able to activate different SMases depending on the cell | | |
| 17634371 | p75 | p75 | 2.1 | Therefore NGF signaling through p75 and the subsequent increase in ceramide production may also modulate | | |
| 17634371 | p75 | p75 | 2.1 | In motor neurons ceramide generation induced by p75 signaling increased superoxide production by mitochondria as evidenced by oxidation | | |
| 17634371 | p75 | p75 | 2.1 | scavengers completely prevent motor neuron death induced by NGF through p75 (Pehar Pehar et al. 2004 | | |
| 17634371 | p75 | p75 | 2.1 | mitochondrial oxidative damage and neuronal death induced by NGF/p75 NGF p75 -signaling in vivo | | |
| 17634371 | p75 | p75 | 2.1 | that transgenic SOD1 motor neurons also show increased susceptibility to p75 -mediated apoptosis | | |
| 17634371 | p75 | p75 | 2.1 | to NGF-induced apoptosis was not mediated by increased expression of p75 or nNOS mRNA | | |
| 17634371 | p75 | p75 | 2.1 | Together our results suggest a critical modulation of the p75 -apoptotic pathway in motor neurons that is specifically regulated by | | |
| 17634371 | p75 | p75 | 2.1 | of motor neuron death occurring in neuropathological conditions involving either p75 - or Fas-apoptotic signaling | | |
| 17634371 | p75 | p75 | 2.1 | cultures preincubated for 24 h with antisense oligonucleotides to downregulate p75 expression or GW4869 (100 100 n M | | |
| 17634371 | p75 | p75 | 2.1 | increase in mito-HE fluorescence emission was prevented by downregulation of p75 expression by antisense treatment or preincubation of motor neurons with | | |
| 17634371 | p75 | p75 | 2.1 | Fig 2 A suggesting that increased production by mitochondria follows p75 and nSMase activation | | |
| 17634371 | p75 | p75 | 2.1 | B strengthening the role of ROS production by mitochondria in p75 -mediated motor neuron apoptosis | | |
| 17634371 | p75 | p75 | 2.1 | SOD1 -expressing motor neurons was prevented by blocking antibodies to p75 (93 93 _amp_#177 6% of control | | |
| 17634371 | p75 | p75 | 2.1 | The effectiveness of the p75 blocking antibodies to prevent signaling through p75 in motor neuron | | |
| 17634371 | p75 | p75 | 2.1 | effectiveness of the p75 blocking antibodies to prevent signaling through p75 in motor neuron cultures has been previously established (Pehar Pehar | | |
| 17634371 | p75 | p75 | 2.1 | Moreover p75 -mediated apoptosis in SOD1 motor neurons was prevented by nSMase | | |
| 17634371 | p75 | p75 | 2.1 | to NGF could not be explained by differential expression of p75 or nNOS | | |
| 17634371 | p75 | p75 | 2.1 | No significant difference was observed in p75 and nNOS mRNA expression levels between nontransgenic and SOD1 motor | | |