HUGO ID Detailed Result 11138

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
10742195	alpha synuclein	alpha synuclein	1.0	in familial pd a mutation of the alpha synuclein gene has been identified which is important because alpha synuclein is a component of lewy bodies which typify the neuropathology.
10742195	alpha synuclein	alpha synuclein	1.0	one recent report [ 49 ] proposes abnormal interaction of alpha synuclein with cu 2+ in the formation of lewy bodies but the concentrations of cu 2+ used in the study were far in excess of what is likely in the tissue.
11562447	alpha synuclein	alpha synuclein	1.0	1 but neither was inhibited by h 2 o 2 up to 1 mm this study or by similar concentrations of the no donors s nitroso n acetylpenicillamine and sodium nitroprusside morot gaudry talarmain et al. 1997 alpha synuclein by souza et al 2000 or proteolysis may occur requiring further studies.
15031734	alpha synuclein	alpha synuclein	1.0	we have proposed that the proteins implicated in several age dependent neurodegenerative disorders a beta in ad alpha synuclein in pd sod1 in als frataxin in friedreich's ataxia box 1 and alpha b crystallin in cataracts might abnormally present cu 2+ or fe 3+ ligands for inappropriate reaction with o 2 fig 1 .
15031734	alpha synuclein	alpha synuclein	1.0	the principal protein component of these deposits is alpha synuclein 65 which is ubiquitously expressed in the brain; mutations of alpha synuclein a30p and a53t contribute to familial forms of the disease 66 .
15031734	alpha synuclein	alpha synuclein	1.0	a diverse array of evidence is emerging that alpha synuclein has a role in modulating the activity of dopamine.
15031734	alpha synuclein	alpha synuclein	1.0	the mutations in alpha synuclein have been shown to alter the expression of dihydropteridine reductase which indirectly regulates the synthesis of dopamine 79 .
15031734	alpha synuclein	alpha synuclein	1.0	co immunoprecipitation experiments have shown that alpha synuclein forms stable complexes with the human dopamine transporter thereby inhibiting uptake of dopamine by its transporter 80 and that alpha synuclein can regulate dopamine synthesis by inhibiting tyrosine hydroxylase 81 .
15031734	alpha synuclein	alpha synuclein	1.0	the link between alpha synuclein and redox chemistry associated with iron bound dopamine/neuromelanin has been given further credence by a study showing that initiation of lewy body formation coincides with alpha synuclein depositio
15031734	alpha synuclein	alpha synuclein	1.0	and redox chemistry associated with iron bound dopamine/neuromelanin has been given further credence by a study showing that initiation of lewy body formation coincides with alpha synuclein deposition exclusively within lipofuscin and neuromelanin deposits 82 ; in addition alpha synuclein crosslinked to neuromelanin has been reported 83 .
15031734	alpha synuclein	alpha synuclein	1.0	deposition exclusively within lipofuscin and neuromelanin deposits 82 ; in addition alpha synuclein crosslinked to neuromelanin has been reported 83 .
15031734	alpha synuclein	alpha synuclein	1.0	the breakdown in alpha synuclein modulated dopamine homeostasis is consistent with the recent observation that the pathogenicity of mutant alpha synuclein is dopamine dependent 84 .
15031734	alpha synuclein	alpha synuclein	1.0	in addition to the regulation of dopamine by alpha synuclein studies have shown a direct interaction of alpha synuclein with metal ions leading to protein aggregation 85 86 87 .
15031734	alpha synuclein	alpha synuclein	1.0	methionine oxidation inhibits alpha synuclein aggregation; however in the presence of certain metal ions aggregation and fibrillization of alpha synuclein still occurs 88 which highlights a potential role of metals and oxidative stress in the deposition of alpha synuclein.
15031734	alpha synuclein	alpha synuclein	1.0	still occurs 88 which highlights a potential role of metals and oxidative stress in the deposition of alpha synuclein.
15031734	alpha synuclein	alpha synuclein	1.0	beta actin catalase creatine kinase frataxin glucose transporter type 3 glutathione peroxidase glutathione reductase mitogen activated protein kinase 1 sod alpha synuclein xanthine dehydrogenase
15031734	alpha synuclein	alpha synuclein	1.0	the equilibrium between vesicle bound dopamine and cytoplasmic dopamine is regulated by alpha synuclein; mutations in this protein shift the dopamine equilibrium in favour of the cytoplasm.
15031734	alpha synuclein	alpha synuclein	1.0	in the presence of fe and under conditions of oxidative stress alpha synuclein will aggregate and form deposits.
16227974	alpha synuclein	alpha synuclein	1.0	at least five separate genes that are associated with parkinson's disease have been identified including those encoding alpha synuclein parkin ubiquitin c terminal hydrolase 1 dj1 and pten induced kinase 1 pink1 refs 2 4 .
16227974	alpha synuclein	alpha synuclein	1.0	for instance in the brains of patients with parkinson's disease alpha synuclein is modified by oxidative and nitrative stress 2 3 4 .
16227974	alpha synuclein	alpha synuclein	1.0	inhibiting mitochondrial function leads to increased alpha synuclein aggregation which can in turn lead to impaired mitochondrial function 5 6 .
16227974	alpha synuclein	alpha synuclein	1.0	alpha synuclein app atm jund parkin peroxiredoxin i pink1 ras seladin 1 sirt1 sirt3 sod1
17099894	alpha synuclein	alpha synuclein	1.0	nitrated and aggregated cytochrome c oxidase subunit i and alpha synuclein as well as nitrated sod2 accumulate in msod1 mouse spinal cord.
17099894	alpha synuclein	alpha synuclein	1.0	olving blockade of apoptosis accumulation of mn mitochondria with enhanced toxic potential from distal terminals nos localization in mn mitochondria and peroxynitrite damage and early degeneration of alpha synuclein + interneurons.