HUGO ID Detailed Result 11121


HUGO ID 11121
Symbol SMPD2
Name sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
#Occurrence 10
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
17634371nSMasenSMase1.9We show that this pathway involved neutral sphingomyelinase (nSMase) nSMase activation and increased mitochondrial superoxide production 
17634371nSMasenSMase1.9M and GW4869 (100 100 n M specific inhibitors of nSMase (Arenz Arenz et al. 2001 Luberto et al. 2002 ( 
17634371nSMasenSMase1.9These results indicate the involvement of ceramide production by nSMase activation in p75 -mediated motor neuron apoptosis 
17634371nSMasenSMase1.9-mediated apoptotic pathway was described previously in hippocampal neurons involving nSMase activation increased ceramide generation and subsequent JNK activation (Brann Brann 
17634371nSMasenSMase1.9NGF-induced apoptosis in motor neurons involves nSMase activation and triggers cytochrome c release from mitochondria 
17634371nSMasenSMase1.9Immunofluorescence studies revealed that nSMase activation was followed by cytochrome c release from mitochondria ( 
17634371nSMasenSMase1.9of nitric oxide was prevented by the addition of the nSMase inhibitor GW4869 ( Fig 1 C indicating that cytochrome c 
17634371nSMasenSMase1.9by antisense treatment or preincubation of motor neurons with the nSMase inhibitor GW4869 (100 100 n M ( Fig 2 A 
17634371nSMasenSMase1.9A suggesting that increased production by mitochondria follows p75 and nSMase activation 
17634371nSMasenSMase1.9p75 -mediated apoptosis in SOD1 motor neurons was prevented by nSMase inhibitors ( Fig 3 B and involved mitochondrial production and