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| 17634371 | nSMase | nSMase | 1.9 | We show that this pathway involved neutral sphingomyelinase (nSMase) nSMase activation and increased mitochondrial superoxide production | |  |
| 17634371 | nSMase | nSMase | 1.9 | M and GW4869 (100 100 n M specific inhibitors of nSMase (Arenz Arenz et al. 2001 Luberto et al. 2002 ( | |  |
| 17634371 | nSMase | nSMase | 1.9 | These results indicate the involvement of ceramide production by nSMase activation in p75 -mediated motor neuron apoptosis | |  |
| 17634371 | nSMase | nSMase | 1.9 | -mediated apoptotic pathway was described previously in hippocampal neurons involving nSMase activation increased ceramide generation and subsequent JNK activation (Brann Brann | |  |
| 17634371 | nSMase | nSMase | 1.9 | NGF-induced apoptosis in motor neurons involves nSMase activation and triggers cytochrome c release from mitochondria | |  |
| 17634371 | nSMase | nSMase | 1.9 | Immunofluorescence studies revealed that nSMase activation was followed by cytochrome c release from mitochondria ( | |  |
| 17634371 | nSMase | nSMase | 1.9 | of nitric oxide was prevented by the addition of the nSMase inhibitor GW4869 ( Fig 1 C indicating that cytochrome c | |  |
| 17634371 | nSMase | nSMase | 1.9 | by antisense treatment or preincubation of motor neurons with the nSMase inhibitor GW4869 (100 100 n M ( Fig 2 A | |  |
| 17634371 | nSMase | nSMase | 1.9 | A suggesting that increased production by mitochondria follows p75 and nSMase activation | |  |
| 17634371 | nSMase | nSMase | 1.9 | p75 -mediated apoptosis in SOD1 motor neurons was prevented by nSMase inhibitors ( Fig 3 B and involved mitochondrial production and | |  |