HUGO ID Detailed Result 9594

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
15081582	EP2	EP2	0.6	2 induce apoptosis in a dose-dependent manner likely via the EP2 receptor and subsequent activation of caspase-3 ( Takadera et al.
16647138	EP2	EP2	0.6	glycine receptors occurred via a postsynaptic mechanism involving activation of EP2 receptors cholera-toxin-sensitive G-proteins and cAMP-dependent protein kinase
16647138	EP2	EP2-like	0.6	agonists had little effect on membrane currents confirming that an EP2-like receptor was involved
16647138	EP2	EP2	0.6	Mice lacking EP1 EP2 and EP4 receptors responded to PGE 2 injections with similar
16647138	EP2	EP2	0.6	PGE 2 receptors of the EP2 receptor subtype have been identified as key signaling elements in
16647138	EP2	EP2	0.6	Mice deficient in EP2 receptors completely lacked spinal PGE 2 -evoked hyperalgesia
16647138	EP2	EP2-deficient	0.6	EP2-deficient mice lost this response
16647138	EP2	EP2	0.6	After a peripheral inflammatory stimulus the EP2 _amp_#x2212;/_amp_#x2212; _amp_#x2212 _amp_#x2212 mice exhibited only a short-lasting peripheral hyperalgesic
16647138	EP2	EP2	0.6	and the apoptosis of cortical cells by acting on the EP2 receptor which in turn activates caspase-3 a pro-apoptotic agent (
16647138	EP2	EP2	0.6	However the finding that the PGE 2 EP2 receptor has a neuroprotective function in cerebral ischemia complicates the
16647138	EP2	EP2	0.6	2 are likely to be important because activation of the EP2 receptor which the cerebral cortex hippocampus and striatum express abundantly
16647138	EP2	EP2	0.6	Pharmacologic blockade of EP2 signaling by blockade of protein kinase A activation reversed this
16647138	EP2	EP2	0.6	In an MCAO mouse model genetic deletion of the EP2 receptor significantly increased cerebral infarction in the cerebral cortex and
16647138	EP2	EP2	0.6	and oxygen deprivation is mediated by the activation of an EP2 receptor one of the four PGE 2 receptor subtypes whose
17574754	EP2	EP2	0.3	EP receptor family where there are four subtypes (EP1, EP1 EP2 EP3 and EP4 and for the PGD 2 DP family
17574754	EP2	EP2	0.3	We have previously reported that the PGE 2 EP2 receptor rescues CA1 pyramidal neurons in organotypic hippocampal cultures treated
17574754	EP2	EP2	0.3	with NMDA or oxygen glucose deprivation 16 and both the EP2 and EP3 receptors rescue motor neurons in organotypic spinal cord
17574754	EP2	EP2	0.3	In vivo the EP2 receptor mediates a significant protective function in models of focal
17574754	EP2	EP2	0.3	Mechanistically EP2 and DP1 neuroprotection are dependent on intact cAMP signaling whereas
17574754	EP2	EP2	0.3	The EP2 receptor neuroprotective in models of glutamate toxicity enhances the inflammatory
17574754	EP2	EP2	0.3	a murine model of Familial Alzheimer's disease deletion of the EP2 receptor results decreased neuronal lipid peroxidation and A_amp_#x3b2 peptide load
17574754	EP2	EP2	0.3	previous studies we determined that PGE 2 signaling via its EP2 and EP3 receptors paradoxically protected motor neurons in a spinal
17574754	EP2	EP2	0.3	We have previously determined that activation of the PGE 2 EP2 receptor and the PGD 2 DP1 receptor protect CA1 neurons
17574754	EP2	EP2	0.3	Recent studies have demonstrated that the EP2 receptor enhances inflammatory oxidative stress and synaptotoxicity in innate immunity
17574754	EP2	EP2	0.3	These effects are distinct from the neuroprotective function of the EP2 receptor seen both in vitro in organotypic slices and in
17574754	EP2	EP2	0.3	We investigated the effect of PGE 2 and the EP2 and EP3 receptors in vitro in a model of LPS
17574754	EP2	EP2	0.3	Selective activation of the EP2 and EP3 receptors also increased LPS-mediated CA1 neurotoxicity ( Fig
17574754	EP2	EP2	0.3	in vitro model and from our previous studies 3 the EP2 and EP3 receptors can also be excluded since they too
17574754	EP2	EP2	0.3	dependent on cAMP signaling as is the case for the EP2 and DP1 receptors we hypothesize that this is the case
17574754	EP2	EP2	0.3	In hippocampal slices activation of the EP2 15 and 16 and EP3 ( Fig 2 receptor rescues
17574754	EP2	EP2	0.3	of neurotoxic cytokines and reactive oxygen species stimulation of the EP2 or EP3 receptor now increases LPS-mediated CA1 toxicity
17574754	EP2	EP2	0.3	addition of either PGE 2 (10_amp_#x2013;100 10_amp_#x2013 100 nM the EP2 agonist butaprost (200 200 nM or the EP3 agonist sulprostone
17574754	EP2	EP2	0.3	The increased toxicity of LPS with addition of EP2/EP3 EP2 EP3 receptor agonists is relevant to recent in vivo studies
17574754	EP2	EP2	0.3	For example in the LPS model of innate immunity the EP2 receptor mediates a major component of inflammatory oxidative stress and
17574754	EP2	EP2	0.3	In addition in a model of amyloid deposition the EP2 receptor similarly promotes an increase in neuronal lipid peroxidation 13
17574754	EP2	EP2	0.3	together these data suggest a dichotomy of function of the EP2 receptor in which the EP2 receptor promotes primary neuroprotection in
17574754	EP2	EP2	0.3	dichotomy of function of the EP2 receptor in which the EP2 receptor promotes primary neuroprotection in models of glutamate toxicity and
17574754	EP2	EP2	0.3	dispersed hippocampal neurons are protected from toxicity with application of EP2 receptor agonist suggesting that activation of the neuronal EP2 receptor
17574754	EP2	EP2	0.3	of EP2 receptor agonist suggesting that activation of the neuronal EP2 receptor promotes a neuroprotective response supporting this is the dependence
17574754	EP2	EP2	0.3	paracrine synaptic and neuronal injury and genetic ablation of the EP2 receptor in this paradigm is protective 20
17574754	EP2	EP2	0.3	The protective function of EP2 signaling in vivo in models of excitotoxicity and cerebral ischemia
17574754	EP2	EP2	0.3	cerebral ischemia 15 and 16 and the neurotoxic effect of EP2 receptor signaling in the LPS 17 19 and 20 and
17574754	EP2	EP2	0.3	anti-inflammatory drugs (NSAIDs), NSAIDs which should reduce signaling through the EP2 receptor by decreasing levels of PGE 2 would have similar
17574754	EP2	EP2	0.3	PGE 2 would have similar effects on neuronal viability as EP2 inhibition alone
17901552	EP2	EP2	0.6	Conversely in the context of an inflammatory stimulus the EP2 receptor enhances neuronal injury