HUGO ID Detailed Result 9593


HUGO ID 9593
Symbol PTGER1
Name prostaglandin E receptor 1 (subtype EP1), 42kDa
#Occurrence 22
#Paper 2

 


PMID Match String Actual String Score Flanking text Edited by Edit
16647138EP1EP11.2The interaction of PGE 2 with a nuclear EP1 receptor also results in calcium mobilization and gene transcription ( 
16647138EP1EP11.2Collective evidence suggests that cross talk between NMDA and EP1 receptors and generation of AA metabolites may regulate gene expression 
16647138EP1EP11.2PGE 2 mediated through the EP1 receptor has a possible role in the spinal cord ( 
16647138EP1EP11.2EP1 receptors are coupled to calcium ion mobilization and their activation 
16647138EP1EP11.2(1994a) 1994a reported that an EP1 receptor antagonist dose-dependently antagonized PGE 2 -induced allodynia in the 
16647138EP1EP11.2(2004) 2004 demonstrated that a highly selective EP1 receptor antagonist ONO-8711 markedly suppressed PGE 2 -induced Ca 2 
16647138EP1EP11.2In addition hybridization in situ revealed EP1 receptor signals in the dorsal root ganglion (DRG) DRG neurons 
16647138EP1EP11.2DRG neurons but not in the spinal cord indicating that EP1 receptor mRNA is located at the terminals of DRG afferent 
16647138EP1EP11.2The EP1 antagonist also reduced mechanical allodynia induced by von Frey filaments 
16647138EP1EP11.2EP1 and EP3 agonists had little effect on membrane currents confirming 
16647138EP1EP11.2Mice lacking EP1 EP2 and EP4 receptors responded to PGE 2 injections with 
16647138EP1EP11.2(2001) 2001 proposed a role for the EP1 receptor in pain perception 
16647138EP1EP11.2EP1 _amp_#x2212;/_amp_#x2212; _amp_#x2212 _amp_#x2212 mice were healthy and fertile but with 
16647138EP1EP11.2The observation that both EP1 and IP receptors ( Oida et al. 1995 are expressed 
16647138EP1EP11.2to note that in addition to IP mRNA mRNAs for EP1 EP3 and EP4 were expressed in about 30% 50% and 
16647138EP1EP11.230% 50% and 20% of the IP-receptor-positive neurons coexpressing the EP1 EP3 and EP4 receptor respectively ( Oida et al. 1995 
16647138EP1EP11.2Prostaglandin EP1 receptors may be essential for the neurotoxic effects of COX-2-derived 
16647138EP1EP11.2EP1 receptor activation by PGE 2 disrupts neuronal calcium homeostasis by 
16647138EP1EP11.2Pharmacological inhibition or gene inactivation of EP1 receptors reduces brain injury induced by middle cerebral artery occlusion 
17574754EP1EP10.32 EP receptor family where there are four subtypes (EP1, EP1 EP2 EP3 and EP4 and for the PGD 2 DP 
17574754EP1EP10.3A toxic effect of the PGE 2 EP1 receptor has been demonstrated in a model of focal ischemia 
17574754EP1EP10.3has been demonstrated in a model of focal ischemia where EP1 impairs the Na _amp_#x2013 Ca 2 exchange critical in maintaining