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| 11173059 | PS1 | PS-1 | 4.7 | for by mutations of the amyloid precursor protein presenilin-1 (PS-1), PS-1 or presenilin-2 gene (PS-2) PS-2 ( Rosenberg 2000 | |  |
| 11173059 | PS1 | PS-1 | 4.7 | The PS-1 gene locates on chromosome 14q24.3 and mutations in this gene | | |
| 11173059 | PS1 | PS-1 | 4.7 | PS-1 codes for a 467-amino acid protein that is an integral | | |
| 11173059 | PS1 | PS-1 | 4.7 | PS-1 function is not entirely known but it may be involved | | |
| 11173059 | PS1 | PS-1 | 4.7 | More than 60 mutations of the PS-1 gene have been associated with early-onset familial Alzheimer disease and | | |
| 11173059 | PS1 | PS-1 | 4.7 | for a 448-amino acid protein sharing 67% sequence homology with PS-1 protein | | |
| 11173059 | PS1 | PS-1 | 4.7 | The high degree of sequence homology between PS-1 and PS-2 protein implies similar functions and indirect evidence suggests | | |
| 11173059 | PS1 | PS-1 | 4.7 | on the hypothesis that missense mutations of amyloid precursor protein PS-1 and PS-2 genes may share a common pathogenetic mechanism finally | | |
| 11173059 | PS1 | PS-1 | 4.7 | Homozygotic polymorphism at the level of intron 8 of the PS-1 gene was first reported to double the risk of late-onset | | |
| 11173059 | PS1 | PS-1 | 4.7 | others did not and a meta-analysis concluded that such a PS-1 gene polymorphism is only slightly associated with Alzheimer disease ( | | |
| 11173059 | PS1 | PS-1 | 4.7 | Other polymorphisms in the 5_amp_#x2032 regulatory region of the PS-1 gene have also been detected and are associated with a | | |
| 11173059 | PS1 | PS-1 | 4.7 | Alzheimer disease probably mediated by an altered expression of the PS-1 protein ( van Duijn et al. 1999 | | |
| 11173059 | PS1 | PS1 | 0.9 | with Alzheimer disease carrying mutations of the amyloid precursor protein PS1 or PS2 gene | | |
| 11173059 | PS1 | PS-1 | 4.7 | In addition mutated PS-1 may promote apoptosis independently of _amp_#x3b2 -amyloid protein intervention by | | |
| 14739060 | PSEN1 | PSEN1 | 0.9 | _amp_#x3b2 -amyloid precursor protein as well as presenilin 1 (PSEN1) PSEN1 and presenilin 2 (PSEN2) PSEN2 | | |
| 15210305 | PS1 | PS1 | 0.6 | The amyloid precursor protein/presenilin-1 protein presenilin-1 (APP+PS1) APP PS1 transgenic mouse is a model for amyloid deposition and as | | |
| 17306794 | PS1 | PS1 | 0.9 | and the Alzheimer's disease double transgenic mouse model APP/PS1 APP PS1 | | |
| 17306794 | PS1 | PS1 | 0.9 | mutation (K670M/N671L) K670M N671L and the human presenilin 1 (PS1) PS1 carrying the mutation (M146L) M146L under the control of the | | |
| 17306794 | PS1 | PS1 | 0.9 | were crossed to generate mice carrying both transgenes (APP/PS1) APP PS1 | | |
| 17306794 | PS1 | PS1 | 0.9 | The presence of amyloid plaques in APP/PS1 APP PS1 transgenic mice and AD tissues was confirmed using thioflavine S | | |
| 17306794 | PS1 | PS1 | 0.9 | APP/PS1 APP PS1 and human AD tissue | | |
| 17306794 | PS1 | PS1 | 0.9 | overexpressing both mutant APP and mutant presenilin 1 (APP/PS1) APP PS1 showed numerous thioflavine S-positive plaques in the cerebral cortex and | | |
| 17306794 | PS1 | PS1 | 0.9 | In coincidence with the brain of APP/PS1 APP PS1 mice thioflavine S(+) S plaques were surrounded by CATX-loaded cells | | |
| 17306794 | PS1 | PS1 | 0.9 | and (v) v associated with plaques in the APP/PS1 APP PS1 transgenic mouse and human AD cerebral cortex | | |
| 17306794 | PS1 | PS1 | 0.9 | mouse model SOD1-G93A and around senile plaques of APP/PS1 APP PS1 transgenics and AD patients | | |
| 17306794 | PS1 | PS1 | 0.9 | Fig 8._amp_#xa0 CATX expression in APP/PS1 APP PS1 bigenic mice and Alzheimer patients | | |
| 17306794 | PS1 | PS1 | 0.9 | (A_amp_#x2013;D) A_amp_#x2013 D APP/PS1 APP PS1 bigenic animals | | |
| 17306794 | PS1 | PS1 | 0.9 | plaque in the cerebral cortex of a 9-month-old APP/PS1 APP PS1 bigenic animal | | |
| 11173059 | presenilin 1 | presenilin 1 | 1.0 | about half of the autosomal dominant inherited forms of alzheimer disease feature an early onset of disease and are accounted for by mutations of the amyloid precursor protein presenilin 1 ps 1 or presenilin 2 gene ps 2 rosenberg 2000 . | | |
| 14739060 | presenilin 1 | presenilin 1 | 1.0 | in familial forms missense mutation have been identified for gene encoding _amp_#x3b2; amyloid precursor protein as well as presenilin 1 psen1 and presenilin 2 psen2 . | | |
| 15210305 | presenilin 1 | presenilin 1 | 1.0 | the amyloid precursor protein/presenilin 1 app+ps1 transgenic mouse is a model for amyloid deposition and as in ad the mice develop memory deficits and amyloid deposits accumulate. | | |
| 17306794 | presenilin 1 | presenilin 1 | 1.0 | transgenic mice expressing the human amyloid precursor protein app with the swedish mutation k670m/n671l and the human presenilin 1 ps1 carrying the mutation m146l under the control of the murine thy1 promoter were generated on the b6d2f1 genetic background in our department. | | |
| 17306794 | presenilin 1 | presenilin 1 | 1.0 | at the age of 9_amp_#xa0;months mice overexpressing both mutant app and mutant presenilin 1 app/ps1 showed numerous thioflavine s positive plaques in the cerebral cortex and the hippocampus and this plaque load increased substantially with age data not shown . | | |
| 17555556 | presenilin 1 | presenilin 1 | 1.0 | they reported that microglia derived from mutant presenilin 1 mice were more sensitive to lps treatment than wild type microglia; microglia expressing mutant presenilin 1 exhibited a heightened sensitivity to lps as demonstrated by superinduction of inos and activation of mitogen activated protein kinase. | | |