HUGO ID Detailed Result 8893

HUGO ID 8893
Symbol PGF
Name placental growth factor
#Occurrence 50
#Paper 2

 

PMID Match String Actual String Score Flanking text Edited by Edit
16104843PlGFPlGF4.6Currently the VEGF family includes VEGF-A PlGF (placenta placenta growth factor VEGF-B VEGF-C VEGF-D VEGF-E and svVEGF 
16104843PlGFPlGF4.6PlGF 
16104843PlGFPlGF4.6PlGF was originally discovered in human placenta in 1991 33 
16104843PlGFPlGF4.6The PlGF gene is highly expressed in placenta at all stages of 
16104843PlGFPlGF4.6PlGF transcripts have also been detected in the heart lung thyroid 
16104843PlGFPlGF4.6PlGF binds VEGFR-1 but not VEGFR-2 35 36 
16104843PlGFPlGF4.6Alternative splicing of the human PlGF gene generates four isoforms which differ in size and binding 
16104843PlGFPlGF4.6isoforms which differ in size and binding properties PlGF-1 (PlGF PlGF 131 PlGF-2 (PlGF PlGF 152 PlGF-3 (PlGF PlGF 203 and 
16104843PlGF-2PlGF-23.1differ in size and binding properties PlGF-1 (PlGF PlGF 131 PlGF-2 (PlGF PlGF 152 PlGF-3 (PlGF PlGF 203 and PlGF-4 (PlGF 
16104843PlGFPlGF4.6size and binding properties PlGF-1 (PlGF PlGF 131 PlGF-2 (PlGF PlGF 152 PlGF-3 (PlGF PlGF 203 and PlGF-4 (PlGF PlGF 224 
16104843PlGFPlGF4.6PlGF-1 (PlGF PlGF 131 PlGF-2 (PlGF PlGF 152 PlGF-3 (PlGF PlGF 203 and PlGF-4 (PlGF PlGF 224 37-39 ( Figure 1 
16104843PlGFPlGF4.6(PlGF PlGF 152 PlGF-3 (PlGF PlGF 203 and PlGF-4 (PlGF PlGF 224 37-39 ( Figure 1 
16104843PlGF-2PlGF-23.1PlGF-2 is able to bind heparin and the co-receptors NRP-1 and 
16104843PlGFPlGF4.672-amino acid sequence between exons 4 and 5 of the PlGF gene but lacks the coding sequence of exon 6 is 
16104843PlGF-2PlGF-23.1a heparin-binding domain previously thought to be present only in PlGF-2 39 
16104843PlGFPlGF4.6Furthermore despite this moderate sequence conservation PlGF and VEGF-A bind to the same binding interface of VEGFR-1 
16104843PlGFPlGF4.6recent studies have reported that unlike in VEGF-A N-glycosylation in PlGF plays an important role in VEGFR-1 binding 42 
16104843PlGFPlGF4.6Carmeliet et al 43 have shown that a deficiency in PlGF (PlGF PlGF does not affect embryonic angiogenesis in mice 
16104843PlGFPlGF4.6al 43 have shown that a deficiency in PlGF (PlGF PlGF does not affect embryonic angiogenesis in mice 
16104843PlGFPlGF4.6However loss of PlGF impairs angiogenesis plasma extravasation and collateral growth during ischaemia inflammation 
16104843PlGFPlGF4.6VEGFR-1 is a 180 kDa high-affinity receptor for VEGF-A VEGF-B PlGF and Tf svVEGF 
16104843PlGFPlGF4.6of VEGFR-1 is the major binding site for VEGF-A and PlGF 16 41 67 
16104843PlGFPlGF4.6are associated with decreased circulating levels of free VEGF and PlGF resulting in general endothelial dysfunction 73 
16104843PlGF-2PlGF-23.1NRP-1 is able to bind VEGF 165 VEGF-B PlGF-2 and some VEGF-E variants whereas NRP-2 can bind VEGF 145 
16104843PlGF-2PlGF-23.1VEGF-E variants whereas NRP-2 can bind VEGF 145 VEGF 165 PlGF-2 and VEGF-C 
16104843PlGFPlGF4.6Autiero et al 131 have proposed that PlGF regulates inter- and intra-molecular cross-talk between VEGFR-1 and VEGFR-2 amplifying 
16104843PlGF-2PlGF-23.1Transgenic overexpression of PlGF-2 in epidermal keratinocytes also results in a significantly increased inflammatory 
16104843PlGFPlGF4.6in a significantly increased inflammatory response whereas a deficiency of PlGF results in a diminished and abbreviated inflammatory response 145 suggesting 
16104843PlGFPlGF4.6puromycin-intensive leucyl-specific aminopeptidase PKC protein kinase C PLC phospholipase C PlGF placenta growth factor pVHL von Hippel-Lindau tumour suppressor protein RA 
16104843PlGFPlGF4.6Currently the VEGF family consists of VEGF-A PlGF (placenta placenta growth factor VEGF-B VEGF-C VEGF-D VEGF-E and snake 
16647138PGFPGF0.62 whereas constrictor prostanoids include thromboxane (TXA TXA 2 and PGF 2_amp_#x3b1 
16647138PGFPGF0.6In human brain PGF 2_amp_#x3b1 is the most abundant prostanoid followed by PGE 2 
16647138PGFPGF0.6the brain through COX-1/COX-2 COX-1 COX-2 pathways (PGE PGE 2 PGF 2a and PGD 2 are modulators of synaptic activity and 
16647138PGFPGF0.6The addition of PGE 2 but not PGD 2 or PGF 2_amp_#x3b1 reverses COX-2-mediated suppression of LTP 
16647138PGFPGF0.6PGF 2_amp_#x3b1 and TXA 2 are constrictors and the effects of 
16647138PGFPGF0.6pressure cause the release of PGE 2 PGI 2 and PGF 2_amp_#x3b1 from brain ( Chemtob et al. 1990a 
16647138PGFPGF0.6as a specific target of PGE 2 but not of PGF 2_amp_#x3b1 PGD 2 or PGI 2 which reduced inhibitory glycinergic 
16647138PGFPGF0.6Exogenous application of PGE 2 but not PGD 2 or PGF 2_amp_#x3b1 effectively reversed all of these actions 
16647138PGFPGF0.6When small amounts of PGE 2 PGD 2 PGF 2_amp_#x3b1 or PGI 2 were injected intrathecally into the spinal 
16647138PGFPGF0.6PGE 1 6-keto-PGF 1_amp_#x3b1 and PGF 2_amp_#x3b1 levels in the cerebral cortex were increased and remained 
16647138PGFPGF0.6Although PGE 2 PGF 2_amp_#x3b1 6-keto-PGF 1_amp_#x3b1 and thromboxanes in the brain extracellular space 
16647138PGFPGF0.6The formation of immunoreactive PGF 2_amp_#x3b1 and leukotriene-like activity has been detected in the brains 
16104843placenta growth factorplacenta growth factor1.0currently the vegf family includes vegf a plgf placenta growth factor vegf b vegf c vegf d vegf e and svvegf snake venom vegf .  
16104843plgf 2plgf 21.0alternative splicing of the human plgf gene generates four isoforms which differ in size and binding properties: plgf 1 plgf 131 plgf 2 plgf 152 plgf 3 plgf 203 and plgf 4 plgf 224 [ 37 39 ] figure 1 .  
16104843plgf 2plgf 21.0plgf 2 is able to bind heparin and the co receptors nrp 1 and nrp 2 due to the insertion of a highly basic 21 amino acid sequence encoded by exon vi near the c terminus [ 37 ] figure 2 .  
16104843plgf 2plgf 21.0plgf 4 consists of the same sequence of plgf 3 plus a heparin binding domain previously thought to be present only in plgf 2 [ 39 ].  
16104843plgf 2plgf 21.0nrp 1 is able to bind vegf 165 vegf b plgf 2 and some vegf e variants whereas nrp 2 can bind vegf 145 vegf 165 plgf 2 and vegf c.  
16104843plgf 2plgf 21.0transgenic overexpression of plgf 2 in epidermal keratinocytes also results in a significantly increased inflammatory response whereas a deficiency of plgf results in a diminished and abbreviated inflammatory response [ 145 ] suggestin 
16104843placenta growth factorplacenta growth factor1.0racting protein 2; pdk1 phosphoinositide dependent kinase 1; pi3k phosphoinositide 3 kinase; pilsap puromycin intensive leucyl specific aminopeptidase; pkc protein kinase c; plc phospholipase c; plgf placenta growth factor; pvhl von hippel lindau tumour suppressor protein; ra rheumatoid arthritis; rtk receptor tyrosine kinase; s6k s6 kinase; tag t antigen; t h 2 t helper type 2; utr untranslated region; vegf vascular e 
16104843placenta growth factorplacenta growth factor1.0currently the vegf family consists of vegf a plgf placenta growth factor vegf b vegf c vegf d vegf e and snake venom vegf.