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| 10525172 | NOS | NOS | 3.0 | In the CNS three NO-synthase isoforms neuronal Type-I NOS inducible Type-II NOS and endothelial Type-III NOS can generate NO | |  |
| 10525172 | NOS | NOS | 3.0 | the CNS three NO-synthase isoforms neuronal Type-I NOS inducible Type-II NOS and endothelial Type-III NOS can generate NO | | |
| 10525172 | NOS | NOS | 3.0 | isoforms neuronal Type-I NOS inducible Type-II NOS and endothelial Type-III NOS can generate NO | | |
| 10525172 | NOS | NOSs | 1.2 | great deal of detail about the biochemistry and pharmacology of NOSs as there are many excellent review articles 53 78 80 | | |
| 10525172 | NOS | NOS | 3.0 | Type-I NOS has been detected in the cerebellum the hypothalamus the striatum | | |
| 10525172 | NOS | NOS | 3.0 | Type-II NOS is located predominantly in microglia and astrocytes 43 | | |
| 10525172 | NOS | NOS | 3.0 | Type-III NOS has been detected in microvessels and motor neurons from rodents | | |
| 10525172 | NOS | NOS | 3.0 | By reaction of NO from Type-I NOS with O 2 _amp_#x2212 from the mitochondrial respiratory chain | | |
| 10525172 | NOS | NOS | 3.0 | SOD the enzyme which scavengers O 2 _amp_#x2212 colocalizes with NOS in the hippocampus and the cerebellum where NO plays an | | |
| 10525172 | NOS | NOS | 3.0 | abnormal activation of Ca 2 -dependent enzymes including the Type-I NOS | | |
| 10525172 | NOS | NOS | 3.0 | on microglia cultures Walker et al 89 by measuring Type-I NOS gene expression on human microglia cultures and Vodovotz et al | | |
| 10525172 | NOS | NOS | 3.0 | the blood_amp_#x2013 brain barrier associated with enhanced expression of Type-III NOS in microvessels and the presence of numerous inducible Type-II NOS | | |
| 10525172 | NOS | NOS | 3.0 | NOS in microvessels and the presence of numerous inducible Type-II NOS immunoreactive microglia | | |
| 10525172 | NOS | NOS | 3.0 | By Type-I NOS activity in arginine- or tetrahydrobiopterin-depleted conditions | | |
| 10525172 | NOS | NOS | 3.0 | Type-I NOS and Type-II NOS catalyze electron transfer from NADPH to O | | |
| 10525172 | NOS | NOS | 3.0 | Type-I NOS and Type-II NOS catalyze electron transfer from NADPH to O 2 in the | | |
| 10525172 | NOS | NOS | 3.0 | At low arginine concentrations 62 67 however Type-II NOS strongly reduces the NADPH oxidation rate while Type-I NOS still | | |
| 10525172 | NOS | NOS | 3.0 | Type-II NOS strongly reduces the NADPH oxidation rate while Type-I NOS still oxidizes NADPH with an unmodified rate and then reduces | | |
| 10525172 | NOS | NOS-transfected | 1.2 | a 20-fold increase of O 2 _amp_#x2212 formation in Type-I NOS-transfected human kidney 293 cells as the cytosolic -arginine levels decreased | | |
| 10525172 | NOS | NOS | 3.0 | The NOS inhibitor N -nitro--arginine methyl ester virtually abolished the O 2 | | |
| 10525172 | NOS | NOS | 3.0 | Therefore at low arginine concentrations Type-I NOS produces simultaneously O 2 _amp_#x2212 and NO at the same | | |
| 10525172 | NOS | NOS | 3.0 | by Gorren and Mayer 32 in a study of Type-I NOS activity as a function of tetrahydrobiopterin (BH BH 4 concentration | | |
| 10525172 | NOS | NOS | 3.0 | Type-I NOS is a dimeric enzyme which exhibits strong anti-cooperative binding of | | |
| 10525172 | NOS | NOS | 3.0 | 10 _amp_#x2212 9 M no BH 4 molecule binds Type-I NOS and O 2 _amp_#x2212 is produced whereas at high BH | | |
| 10525172 | NOS | NOS | 3.0 | of mice with EAE by Lin et al 51 Type-II NOS mRNA has been detected in EAE models by Cross et | | |
| 10525172 | NOS | NOS | 3.0 | the anti-inflammatory cytokine TGF-_amp_#x3b2 associated with an increase in Type-II NOS mRNA expression and nitrite production in peripheral blood mononuclear cells | | |
| 10525172 | NOS | NOS | 3.0 | Beal 7 reported the protective effect of Type-I NOS inhibitors on the neurotoxicity of MPTP in both mice and | | |
| 10525172 | NOS | NOS | 3.0 | Under normal conditions neurons produce NO via Type-I NOS as an intracellular messenger which has an important role in | | |
| 10525172 | NOS | NOS | 3.0 | contrary under either -arginine- or BH 4 -depleted conditions Type-I NOS monomers can function independently of each other | | |
| 10525172 | NOS | NOS | 3.0 | second step of the neurodegenerative process by induction of Type-II NOS which produces large amounts of NO and stimulation of NADPH-oxidase | | |
| 10525172 | NOS | NOS | 3.0 | Type-III NOS expressed in microvessels and motor neurons can also generate NO | | |
| 10525172 | NOS | NOS | 3.0 | These authors observed an expression of Type-III NOS but not of Type-I NOS by motor neurons cultured with | | |
| 10525172 | NOS | NOS | 3.0 | observed an expression of Type-III NOS but not of Type-I NOS by motor neurons cultured with brain-derived neurotrophic factor (BDNF) BDNF | | |
| 10525172 | NOS | NOS | 3.0 | On the contrary trophic factor deprivation promoted Type-I NOS expression and cell death by apoptosis | | |
| 10525172 | NOS | NOS | 3.0 | motor neuron degeneration was promoted by NO produced by Type-I NOS and reversed by SOD suggesting that formation of peroxynitrite initiates | | |
| 10525172 | NOS | NOS | 3.0 | mechanism we described previously for generation of peroxynitrite by Type-I NOS under -arginine- or BH 4 -depleted conditions | | |
| 10525172 | NOS | NOS-catalyzed | 1.2 | Schematic representation of NOS-catalyzed reactions | | |
| 14739060 | nNOS | nNOS | 1.9 | account for NO production and include neuronal NO synthase (nNOS; nNOS type I inducible NO synthase (iNOS; iNOS typeII which is | | |
| 14739060 | nNOS | nNOS | 1.9 | endothelial NO synthase (eNOS; eNOS type III In the CNS nNOS whose expression is regulated by both physiological and pathophysiological stimuli | | |
| 14739060 | nNOS | nNOS | 1.9 | series of enzymes including protein kinase C proteases phosphatases phospholipases nNOS and xanthine oxidase 32 | | |
| 15572176 | NOS | NOS | 2.7 | express inflammatory makers such as COX-2 81 iNOS and neuronal NOS 5 and 115 | | |
| 15572176 | NOS | NOS | 2.7 | In cultured astrocytes the induction of NOS by pro-inflammatory stimulus or the exposure of astrocyte monolayers to | | |
| 15572176 | NOS | NOS | 2.7 | histocompatibility complex-encoded antigens 89 interferon gamma 70 and 89 and NOS 70 have been found elevated in motor neurons after nerve | | |
| 15572176 | NOS | NOS | 2.7 | as well as the production of nitric oxide by neuronal NOS 101 | | |
| 15572176 | NOS | NOS | 2.7 | For example the re-expression of p75 NTR and neuronal NOS may help to determine which neurons survive or undergo apoptosis | | |
| 15572176 | nNOS | nNOS | 2.7 | damage in motor neuron A which upregulates the expression of nNOS p75 NTR Fas cytokines and trophic factors | | |
| 16104843 | NOS | NOS | 0.9 | Among the three isoforms of NOS (NO NO synthase eNOS (endothelial endothelial NOS plays a predominant | | |
| 16104843 | NOS | NOS | 0.9 | three isoforms of NOS (NO NO synthase eNOS (endothelial endothelial NOS plays a predominant role in VEGF-induced angiogenesis and vascular permeability | | |
| 16104843 | NOS | NOS | 0.9 | metalloproteinase NFATc nuclear factor of activated T-cell NO nitric oxide NOS NO synthase eNOS endothelial NOS NRP neuropilin PAIP2 polyadenylated-binding protein-interacting | | |
| 16104843 | NOS | NOS | 0.9 | activated T-cell NO nitric oxide NOS NO synthase eNOS endothelial NOS NRP neuropilin PAIP2 polyadenylated-binding protein-interacting protein 2 PDK1 phosphoinositide-dependent kinase | | |
| 16179515 | nNOS | nNOS | 2.2 | receptor (TNFRp55) TNFRp55 and upregulated noninducible nitric oxide synthase (nNOS) nNOS and glutamine synthase (GS) GS | | |
| 17034351 | NOS | NOS | 1.2 | (COX-II) COX-II and 5-lipoxygenase (5LOX)]; 5LOX nitric oxide synthase (NOS) NOS isoforms cytokines (particularly particularly tumor necrosis factor alpha TNF-alpha chemokines | | |
| 17555556 | nNOS | nNOS | 2.2 | gene deletion of iNOS or neuronal nitric oxide synthase (nNOS) nNOS does not alter motoneuron disease in double transgenic iNOS _amp_#8722;/_amp_#8722; | | |
| 17555556 | nNOS | nNOS | 2.2 | double transgenic iNOS _amp_#8722;/_amp_#8722; _amp_#8722 _amp_#8722 /mSOD1 mSOD1 G93A or nNOS _amp_#8722;/_amp_#8722; _amp_#8722 _amp_#8722 /mSOD1 mSOD1 G93A mice ( Facchinetti et | | |
| 17555556 | nNOS | nNOS | 2.2 | Additionally up-regulation of nNOS was required in this Fas-triggered motoneuron death ( Raoul et | | |
| 18246426 | NOS | NOS | 2.7 | is synthesized from l -arginine by nitric oxide synthase (NOS) NOS 22 23 | | |
| 18246426 | NOS | NOS | 2.7 | Within the CNS two isoforms of NOS exist calcium dependent neuronal form (nNOS) nNOS and inducible calcium | | |
| 18246426 | nNOS | nNOS | 2.7 | two isoforms of NOS exist calcium dependent neuronal form (nNOS) nNOS and inducible calcium independent form (iNOS) iNOS | | |
| 18246426 | nNOS | nNOS | 2.7 | Under normal conditions neurons containing nNOS release relatively small quantities of NO which has neurotransmitter like | | |
| 18246426 | NOS | NOS | 2.7 | Considering that NO levels correlate closely with the activity of NOS in brain 34 the pronounced increases found in ALS patients | | |
| 18513389 | NOS | NOS | 1.2 | For NOS variants the position -922 in the promoter region was never | | |
| 18513389 | NOS | NOS | 1.2 | already been picked up by the systems e.g for PON1 NOS and TNF | | |
| 18513389 | NOS | NOS | 1.2 | the involvement of oxidative stress as well as angiogenesis (NOS) NOS and immune response (TNF) TNF pathways | | |
| 16510725 | neuronal nitric oxide synthase | neuronal nitric oxide synthase | 1.0 | fas triggers cell death in embryonic motoneurons by a pathway requiring upregulation of neuronal nitric oxide synthase and involving daxx apoptosis signal regulated kinase 1 and p38 as well as the fadd/caspase 8 pathway raoul et al. 2002 alpha upregulates fasl pinkoski et al. 2002 alpha immunostaining was found in th | | |
| 17555556 | neuronal nitric oxide synthase | neuronal nitric oxide synthase | 1.0 | although two earlier reports demonstrated that gene deletion of inos or neuronal nitric oxide synthase nnos does not alter motoneuron disease in double transgenic inos _amp_#8722;/_amp_#8722; /msod1 g93a or nnos _amp_#8722;/_amp_#8722; /msod1 g93a mice facchinetti et al 1999 ; son et al 2001 a recent | | |