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| 17191135 | NRF2 | Nrf2 | 2.1 | activation (via via acetylation of the redox sensitive transcription factor Nrf2 and its consequent binding to the antioxidant responsive element (ARE) | |  |
| 17191135 | NRF2 | Nrf2 | 2.1 | factors Bach-2 (positive) positive and Keap (negative) negative in the Nrf2 activation as well as the redox cycling between Bilirubin and | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | Nuclear factor-erythroid 2-related factor 2 (Nrf2) Nrf2 is a transcription factor responsible for the induction of several | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | Under normal conditions Nrf2 is sequestered in the cytoplasm by an actin-binding protein Kelch-like | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | (Keap1), Keap1 but upon exposure of cells to oxidative stress Nrf2 dissociates from Keap1 translocates to the nucleus binds to antioxidant | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | AP-1 nuclear factor-kB (NFkB) NFkB and the more recently identified Nrf2 proteins 24 -26 (Fig Fig 1 B contain cysteine residues | | |
| 17191135 | NRF2 | Nrf-2 | 1.6 | up-regulation of HO-1 and nuclear translocation of the transcription factor Nrf-2 27 | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | evidence to suggest that heterodimers of NF-E2-related factors 2 (Nrf2) Nrf2 and one or another of the small Maf proteins (i.e | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | A possible model centered on Nrf2 activity suggests that the heme protein Bach1 works as a | | |
| 17191135 | NF-E2 | NF-E2 | 1.6 | enhancers and allow activators such as heterodimer of Maf with NF-E2 related activators (Nrf2), Nrf2 to interact with the transcriptional promotion | Junguk Hur | |
| 17191135 | NRF2 | Nrf2 | 2.1 | such as heterodimer of Maf with NF-E2 related activators (Nrf2), Nrf2 to interact with the transcriptional promotion of HO-1 33 | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | the induction of Prx-1 appears to involve the transcription factor Nrf2 | | |
| 17191135 | NRF2 | Nrf2 | 2.1 | mechanism involving activation and nuclear translocation of the transcription factor Nrf2 27 | | |
| 17191135 | nf e2 | nf e2 | 1.0 | there is now evidence to suggest that heterodimers of nf e2 related factors 2 nrf2 and one or another of the small maf proteins i.e mafk maff and mafg are directly involved in induction of ho 1 gene through these mares [ 53 ]. | Junguk Hur | |
| 17191135 | nf e2 | nf e2 | 1.0 | mal physiological conditions expression of ho 1 is repressed by bach1/maf complex while increased levels of heme displace bach1 from the enhancers and allow activators such as heterodimer of maf with nf e2 related activators nrf2 to interact with the transcriptional promotion of ho 1 [ 33 ]. | Junguk Hur | |