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| 16647138 | COX3 | COX3 | 0.6 | Three forms of COX enzymes designated as COX-1 COX-2 and COX-3 occur in mammalian tissues | |  |
| 16647138 | COX3 | COX-3 | 4.6 | Three forms of COX enzymes designated as COX-1 COX-2 and COX-3 occur in mammalian tissues | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 is a new acetaminophen-sensitive isoform of the COX family | | |
| 16647138 | COX3 | COX-3 | 4.6 | Although different pharmacological properties have been described for COX-3 compared with COX-1 or COX-2 enzymes many investigators consider it | | |
| 16647138 | COX3 | COX-3 | 4.6 | Thus COX-3 is a product of the COX-1 gene but retains intron | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 is a glycoprotein | | |
| 16647138 | COX3 | COX-3 | 4.6 | Comparison of canine COX-3 activity with murine COX-1 and COX-2 demonstrates that analgesic/antipyretic analgesic | | |
| 16647138 | COX3 | COX-3 | 4.6 | drugs such as acetaminophen phenacetin antipyrine and dipyrone selectively inhibit COX-3 and some nonsteroidal anti-inflammatory drugs potently inhibit COX-3 | | |
| 16647138 | COX3 | COX-3 | 4.6 | selectively inhibit COX-3 and some nonsteroidal anti-inflammatory drugs potently inhibit COX-3 | | |
| 16647138 | COX3 | COX-3 | 4.6 | Thus inhibition of COX-3 could represent a primary central mechanism by which these drugs | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 mRNA expression is highest in choroid plexus and spinal cord | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 mRNA levels are also higher in major brain arteries and | | |
| 16647138 | COX3 | COX-3 | 4.6 | The expression pattern of COX-3 mRNA in the rat CNS primarily relates to the vascular | | |
| 16647138 | COX3 | COX-3 | 4.6 | The expression studies of COX-3 mRNA in primary cultures of neurons astrocytes endothelial cells pericytes | | |
| 16647138 | COX3 | COX-3 | 4.6 | pericytes and choroidal epithelial cells indicate that the mRNA of COX-3 is present in all of these cell types except neurons | | |
| 16647138 | COX3 | COX-3 | 4.6 | Cerebral endothelial cells showed the highest COX-3 expression ( Kis et al. 2003 | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 mRNA was cloned and sequenced from rat cerebral endothelial cells | | |
| 16647138 | COX3 | COX-3 | 4.6 | the 98-base-pair intron 1 of COX-1 gene remains unprocessed in COX-3 inducing a frameshift mutation and a 127-amino-acid open reading frame | | |
| 16647138 | COX3 | COX-3 | 4.6 | Rat COX-3 is a cytosolic glycoprotein | | |
| 16647138 | COX3 | COX-3 | 4.6 | Amino acid analysis also shows that COX-3 protein has a very basic character with a p I | | |
| 16647138 | COX3 | COX-3 | 4.6 | In addition to the abundance of basic amino acids the COX-3 protein is also very rich in proline (11.81%) 11.81% | | |
| 16647138 | COX3 | COX-3 | 4.6 | To determine the function of COX-3 COS-7 cells were transfected with COX-3 | | |
| 16647138 | COX3 | COX-3 | 4.6 | determine the function of COX-3 COS-7 cells were transfected with COX-3 | | |
| 16647138 | COX3 | COX-3 | 4.6 | by acetaminophen ( Snipes et al. 2005 suggesting that this COX-3 variant may not be involved in the generation of prostaglandins | | |
| 16647138 | COX3 | COX-3 | 4.6 | This is in contrast to the canine COX-3 which has COX activity | | |
| 16647138 | COX3 | COX-3 | 4.6 | Thus there are differences between rat and dog COX-3 proteins | | |
| 16647138 | COX3 | COX-3 | 4.6 | Collectively these studies suggest that dogs possess a COX-3 splice variant with cyclooxygenase activity whereas rats have a COX-3 | | |
| 16647138 | COX3 | COX-3 | 4.6 | COX-3 splice variant with cyclooxygenase activity whereas rats have a COX-3 splice variant that lacks cyclooxygenase activity | | |
| 16647138 | COX3 | COX-3 | 4.6 | settled only when information on expression properties and roles of COX-3 variants in various mammalian species becomes available ( Table 1 | | |
| 16647138 | COX3 | COX-3 | 4.6 | developing diffuse pain (writhing) writhing with COX-isozyme-deficient mice indicate that COX-3 plays an important role in chronic pain and inflammation in | | |